Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

Diabetes

Volumn 58, Issue 5, 2009, Pages 1229-1236

  Brasacchio, Daniella ^a   Okabe, Jun ^a   Tikellis, Christos ^a   Balcerczyk, Aneta ^a   George, Prince ^a   Baker, Emma K ^a   Calkin, Anna C ^a   Brownlee, Michael ^b   Cooper, Mark E ^a,b   El Osta, Assam ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HISTONE; HISTONE DEMETHYLASE; HISTONE H3; HISTONE H3K4; HISTONE H3K9; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE SET7; HISTONE METHYLTRANSFERASE SUV39H1; LYSINE; LYSINE DERIVATIVE; LYSINE SPECIFIC DEMETHYLASE; METHYLTRANSFERASE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; HISTONE LYSINE METHYLTRANSFERASE; PRIMER DNA; RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHROMATIN; CONTROLLED STUDY; COOPERATION; DIABETES MELLITUS; ENDOTHELIUM CELL; EPIGENETICS; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; PROTEIN MODIFICATION; PURIFICATION; RECEPTOR UPREGULATION; ANIMAL; CATTLE; DIABETIC ANGIOPATHY; DNA METHYLATION; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

ANIMALS; CATTLE; DIABETIC ANGIOPATHIES; DNA METHYLATION; DNA PRIMERS; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENETIC PREDISPOSITION TO DISEASE; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; HYPERGLYCEMIA; LYSINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 65549170303     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-1666     Document Type: Article

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