Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice

Journal of Nutrition

Volumn 141, Issue 11, 2011, Pages 1947-1953

  Lee, Mak Soon ^a   Kim, In Hwan ^b   Kim, Chong Tai ^c   Kim, Yangha ^a  

^a Ewha Womans University   (South Korea)

^b Korea University   (South Korea)

^c Korea Food Research Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GARLIC EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; MESSENGER RNA;

ADIPOGENESIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; SKELETAL MUSCLE; THERMOGENESIS; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BODY WEIGHT; DIET; ENZYME ACTIVATION; GARLIC; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ALLIUM SATIVUM; MUS;

EID: 81055126886     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.146050     Document Type: Article

References (47)

1. Hill JO, John CP. Environmental contributions to the obesity epidemic. Science. 1998;280:1371-4.
2. Block E. The chemistry of garlic and onions. Sci Am. 1985;252:114-9.
3. Agarwal KC. Therapeutic actions of garlic constituents. Med Res Rev. 1996;16:111-24.
4. Yeh YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001;131: S989-93.
5. Jalal R, Bagheri SM, Moghimi A, Rasuli MB. Hypoglycemic effect of aqueous shallot and garlic extracts in rats with fructose-induced insulin resistance. J Clin Biochem Nutr. 2007;41:218-23.
6. Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens Res. 2009;32:433-7.
7. Milner JA. A historical perspective on garlic and cancer. J Nutr. 2001;131:S1027-31.
8. Banerjee SK, Mukherjee PK, Maulik SK. Garlic as an antioxidant: the good, the bad and the ugly. Phytother Res. 2003;17:97-106.
9. Yonezawa T, Kurata R, Hosomichi K, Kono A. Nutritional and hormonal regulation of uncoupling protein 2. IUBMB Life. 2009;61: 1123-31.
10. Wolf G. Brown adipose tissue: the molecular mechanism of its formation. Nutr Rev. 2009;67:167-71.
11. Gimeno RE, Dembski M, Weng X, Deng N. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 1997;46:900-6.
12. Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005;2:85-93.
13. Kola B, Grossman AB, Korbonits M. The role of AMP-activated protein kinase in obesity. Front Horm Res. 2008;36:198-211.
14. Villena JA, Viollet B, Andreelli F, Kahn A, Vaulont S, Sul HS. Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. Diabetes. 2004;53:2242-9.
15. Oi Y, Kawada T, Kitamura K, Oyama F, Nitta M, Kominato Y, Nishimura S, Iwai K. Garlic supplementation enhances norepinephrine secretion, growth of brown adipose tissue, and triglyceride catabolism in rats. J Nutr Biochem. 1995;6:250-5.
16. Oi Y, Kawada T, Shishido C, Wada K, Kominato Y, Nishimura S, Ariga T, Iwai K. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. J Nutr. 1999;129:336-42.
17. Oi Y, Okamoto M, Nitta M, Kominato Y, Nishimura S, Ariga T, Iwai K. Alliin and volatile sulfur-containing compounds in garlic enhance the thermogenesis by increasing norepinephrine secretion in rats. J Nutr Biochem. 1998;9:60-6.
18. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in BAT in vivo. J Biol Chem. 2011;286:8798-809.
19. Reeves PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 1997;127:S838-41.
20. NRC. Guide for the care and use of laboratory animals. Publication no. 85-23 (rev.). Washington, DC: National Institutes of Health; 1985. 1952 Lee et al.
21. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-7.
22. Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, editors. Bioinformatics methods and protocols: methods in molecular biology. Totowa (NJ): Humana Press; 2000. p. 365-86.
23. Kashiwagi H, McDunn JE, Simon PO Jr, Goedegebuure PS, Xu J, Jones L, Chang K, Johnston F, Trinkaus K, Hotchkiss RS, et al. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer. 2007; 6:48.
24. Kuda T, Iwai A, Yano T. Effect of red pepper Capsicum annuum var. conoides and garlic Allium sativum on plasma lipid levels and cecal microflora in mice fed beef tallow. Food Chem Toxicol. 2004;42:1695-700.
25. Ambati S, Yang JY, Rayalam S, Park HJ, Della-Fera MA, Baile CA. Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibting adipogenesis and inducing apoptosis. Phytother Res. 2009; 23:513-8.
26. Jisawa H, Suma K, Origuchi K, Kumagai H, Seki T, Ariga T. Biological and chemical stability of garlic-derived allicin. J Agric Food Chem. 2008;56:4229-35.
27. Yang JY, Della-Fera MA, Nelson-Dooley C, Baile CA. Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity (Silver Spring). 2006;14:388-97.
28. Han CY, Ki SH, Kim YW, Noh K, Lee da Y, Kang B, Ryu JH, Jeon R, Kim EH, Hwang SJ, et al. Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation. Antioxid Redox Signal. 2011;14: 187-202.
29. Keophiphath M, Priem F, Jacquemond-Collet I, Clément K, Lacasa D. 1,2-Vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr. 2009;139:2055-60.
30. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterol- emia: a meta-analysis of randomized clinical trials. Ann Intern Med. 2000;133:420-9.
31. Koseoglu M, Isleten F, Atay A, Kaplan YC. Effects of acute and subacute garlic supplement administration on serum total antioxidant capacity and lipid parameters in healthy volunteers. Phytother Res. 2010;24:374-8.
32. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differenti- ation. Physiol Rev. 1998;78:783-809.
33. Kim JB, Spiegelman BM. ADD1/SREBP1 promotes adipocyte differen- tiation and gene expression linked to fatty acid metabolism. Genes Dev. 1996;10:1096-107.
34. El Hadri K, Glorian M, Monsempes C, Dieudonné MN, Pecquery R, Giudicelli Y, Andreani M, Dugail I, Fève B. In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes. J Biol Chem. 2004;279:15130-41.
35. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9:203-9.
36. Kozak LP, Koza RA. Mitochondrial uncoupling proteins and obesity: molecular and genetic aspects of UCP1. Int J Obes Relat Metab Disord. 1999;23:S33-7.
37. Ünce DÜ, Tiryaki G, Nmez S, Ünce ML. Effects of garlic on aerobic performance. Turk J Med Sci. 2000;30:557-61.
38. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, et al. Superoxide activates mitochondrial uncoupling proteins. Nature. 2002; 415:96-9.
39. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, et al. A signaling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003;22:4103-10.
40. Mills EM, Banks ML, Sprague JE, Finkel T. Pharmacology uncoupling the agony from ecstasy. Nature. 2003;426:403-4.
41. Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett. 1994;353:33-6.
42. Yin W, Mu J, Birnbaum MJ. Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis in 3T3-L1 adipocytes. J Biol Chem. 2003;278:43074-80.
43. Gaidhu MP, Fediuc S, Anthony NM, So M, Mirpourian M, Perry RL, Ceddia RB. Prolonged AICAR-induced AMP-kinase activation pro- motes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. J Lipid Res. 2009;50:704-15.
44. Dagon Y, Avraham Y, Berry EM. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. Biochem Biophys Res Commun. 2006;340:43-7.
45. Putman CT, Kiricsi M, Pearcey J, MacLean IM, Bamford JA, Murdoch GK, Dixon WT, Pette D. AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions. J Physiol. 2003;551:169-78.
46. Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes. 2005;54: 1331-9.
47. Barnes BR, Marklund S, Steiler TL, Walter M, Hjälm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, et al. The 59-AMP- activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004;279:38441-7.