Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition

Free Radical Biology and Medicine

Volumn 45, Issue 5, 2008, Pages 627-635

  Cai, Yu Jun ^a   Lu, Jin Jian ^a   Zhu, Hong ^a   Xie, Hua ^a   Huang, Min ^a   Lin, Li Ping ^a   Zhang, Xiong Wen ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

DNA double strand breaks; Free radicals; Glutathione; H2O2; Salvicine; Topoisomerase II

Indexed keywords

CATALASE; COMPLEMENTARY DNA; DITERPENOID; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RNA; SALVICINE; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME INHIBITION; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NUCLEOTIDE SEQUENCE; PHYTOCHEMISTRY; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALVIA;

APOPTOSIS; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; NAPHTHOQUINONES;

EID: 48449089245     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.05.017     Document Type: Article

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