Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

Apoptosis

Volumn 15, Issue 2, 2010, Pages 183-195

  El Najjar, Nahed ^a,b   Chatila, Manal ^a   Moukadem, Hiba ^a   Vuorela, Heikki ^b   Ocker, Matthias ^c   Gandesiri, Muktheshwar ^d   Schneider Stock, Regine ^d   Gali Muhtasib, Hala ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b UNIVERSITY OF HELSINKI   (Finland)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Apoptosis; Colon cancer; MAPK; Oxidative stress; ROS; Thymoquinone

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 7; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THYMOQUINONE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 77949263613     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0421-z     Document Type: Article

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