Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo

Biochemical and Biophysical Research Communications

Volumn 417, Issue 2, 2012, Pages 864-868

  Lei, Xiaofei ^a   Lv, Xiaoguang ^a   Liu, Meng ^b   Yang, Zirong ^a   Ji, Mengyao ^a   Guo, Xufeng ^a   Dong, Weiguo ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b TONGREN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

5 Fluorouracil; Apoptosis; Chemosensitisation; Thymoquinone

Indexed keywords

CASPASE 3; CASPASE 9; FLUOROURACIL; PROTEIN BAX; PROTEIN BCL 2; THYMOQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CHEMOSENSITIZATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH CANCER; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOQUINONES; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; HUMANS; MICE; MICE, INBRED BALB C; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

NIGELLA SATIVA;

EID: 84855839231     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.063     Document Type: Article

References (21)

1. Leung W.K., Wu M.S., Kakugawa Y., et al. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008, 9:279-287.
2. Ohtsu A. Chemotherapy for metastatic gastric cancer: past, present, and future. J. Gastroenterol. 2008, 43:256-264.
3. Benson A.B. New approaches to the adjuvant therapy of colon cancer. Oncologist 2006, 11:973-980.
4. D.J. Park, H.J. Lenz, Determinants of chemosensitivity in gastric cancer, Curr. Opin. Pharmacol. 6 (2006) 337-344.
5. J. Ravindran, H.B. Nair, B. Sung, et al., Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential, Biochem. Pharmacol. 79 (2010) 1640-1647.
6. K. Effenberger-Neidnicht, R. Schobert, Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin, Cancer Chemother. Pharmacol. 67 (2011) 867-874.
7. Kruk I., Michalska T., Lichszteld K., et al. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere 2000, 41:1059-1064.
8. Connelly L., Barham W., Onishko H.M., et al. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene 2011, 30:1402-1412.
9. S.H. Jafri, J. Glass, R. Shi, et al., Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo, J. Exp. Clin. Cancer Res. 29 (2010) 87.
10. Torres M.P., Ponnusamy M.P., Chakraborty S., et al. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol. Cancer Ther. 2010, 9:1419-1431.
11. Gali-Muhtasib H., Ocker M., Kuester D., et al. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J. Cell. Mol. Med. 2008, 12:330-342.
12. S. Banerjee, A.O. Kaseb, Z. Wang, et al., Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer, Cancer Res. 69 (2009) 5575-5583.
13. Jackson C., Cunningham D., Oliveira J. Gastric cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann. Oncol. 2009, 20(Suppl. 4):34-36.
14. Wagner A.D., Grothe W., Haerting J., et al. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J. Clin. Oncol. 2006, 24:2903-2909.
15. Scartozzi M., Bittoni A., Pistelli M., et al. Toward molecularly selected chemotherapy for advanced gastric cancer: state of the art and future perspectives. Cancer Treat. Rev. 2009, 35:451-462.
16. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol. 2005, 5:1749-1770.
17. R.L. Gurung, S.N. Lim, A.K. Khaw, et al., Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells, PLoS One 5 (2010) e12124.
18. H. Gali-Muhtasib, D. Kuester, C. Mawrin, et al., Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells, Cancer Res. 68 (2008) 5609-5618.
19. A.O. Kaseb, K. Chinnakannu, D. Chen, et al., Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer, Cancer Res. 67 (2007) 7782-7788.
20. O.A. Badary, O.A. Al-Shabanah, M.N. Nagi, et al., Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone, Eur. J. Cancer Prev. 8 (1999) 435-440.
21. Tang D., Lotze M.T., Kang R., et al. Apoptosis promotes early tumorigenesis. Oncogene 2011, 30:1851-1854.