Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24)

In Vivo

Volumn 21, Issue 6, 2007, Pages 1011-1020

  Yeh, Chin Chung ^a   Kuo, Hsiu Maan ^b   Li, Te Mao ^b   Lin, Jing Pin ^b   Yu, Fu Shun ^b   Lu, Hsu Feng ^b   Chung, Jing Gung ^b   Yang, Jai Sing ^b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Caspase activated DNase; Human bladder cancer; Shikonin; Western blotting

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; PROTEIN P21; SHIKONIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; BLADDER CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; DNA CLEAVAGE; DNA SEQUENCE; DRUG MECHANISM; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

EID: 37349073187     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bhalla K, Ibrado AM, Tourkina E, Tang C, Mahoney ME and Huang Y: Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 7: 563-568, 1993.
2. Kaufman SH: Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 49: 5870-5878, 1989.
3. Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF and Sikorska M: Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51: 1078-1085, 1991.
4. Ling YH, Priebe W and Perze SR: Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. Cancer Res 53: 1845-1852, 1993.
5. Stevnsner T and Bohr VA: Studies on the role of topoisomerase in general, gene and strand-specific DNA repair. Carcinogenesis 14: 1841-1850, 1993.
6. Kerr JFR, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
7. Seto Y, Motoyoshi S, Nakamura H, Imuta J, Ishitoku T and Isayama S: Effect of shukonin and its derivatives, pentaacetylated and shikonin (MDS-004) on granuloma formation and delayed-type allergy in experimental animals. Yakugaku Zasshi 112: 259-271, 1992 (in Japanese).
8. Wang, WJ, Bai JY, Liu DP, Xue LM and Zhu XY: The antiinflammatory activity of shikonin and its inhibitory effect on leukotriene B4 biosynthesis. Yao Xue Xue Bao 29: 161-165, 1994.
9. Ahn BZ, Baik KU, Kweon GR, Lim K and Hwang BD: Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. J Med Chem 17: 1044-1047, 1995.
10. Hisa T, Kimura Y, Takada K, Suzuki F and Takigawa M: Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. Nippon Yakurigaku Zasshi 73: 193-203, 1998.
11. Yoon Y, Kim YO, Lim NY, Jeon WK and Sung HJ: Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line. Planta Medica 65: 532-535, 1999.
12. Subbaramaiah K, Bulic P, Lin Y, Darmenberg AJ and Pasco DS: Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription. J Biomol Screen 6: 101-110, 2001.
13. Gaddipati JP, Mani H, Shefali RK, Mathad VT, Bhaduri AP and Maheshwari PK: Inhibition of growth and regulation of IGFs and VEGF in human prostate cancer cell lines by shikonin analogue 93/637 (SA). Anticancer Res 20: 2547-2552, 2000.
14. Pettit GR, Hoard MS, Doubek DL, Schmidt JM, Pettit RK, Tackett LP and Chapuis JC: Antineoplastic agents 338: the cancer cell growth inhibitory constituents of Terminnalia arjuna. J Ethnopharmaco 53: 57-63, 1996.
15. Ormerod MG: Flow Cytometry: A Practical Approach. Oxford University Press, New York, pp. 69-81, 1990.
16. Chung JG: Effects of the butylated hydroxyanisole and butylated hydroxytoluene on the acetylation of 2-aminofluorene and DNA-2-aminofluorene adducts in the rat. Toxicological Science 51: 202-210, 1999.
17. Hsia TC, Chung JG, Lu HF, Ho HC, Yang CC, Lu KH and Hung CF: The effect of paclitaxel on 2-aminofluorene-DNA adducts formation and arylamine N-acetyltransferase activity and gene expression in human lung tumor cells (A549). Food and Chem Toxicol 40: 697-703, 2002.
18. Uehara T, Kikuchi Y and Nomura Y: Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J Neurochem 72: 196-205, 1999.
19. Kuida A, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MSS, Rakis P and Flavell RA: Reduced apoptosis and cytochrome-c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998.
20. Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S and Kojiro M: The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 54: 448-454, 1994.
21. McGill G, Shimamura A, Bates RC, Savage RE and Fisher L: Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. J Cell Biol 138: 901-911, 1997.
22. Cohen GM, Sun XM, Snowden RT, Dinsdale D and Skilleter DN: Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 286: 331-334, 1992.
23. Schulze-Osthoff K, Wakzak H, Droge W and Krammer PH: Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 127: 15-20, 1994.
24. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
25. Vander Heiden MG and Thompson CB: Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis. Nat Cell Biol 1: E209-216, 1999.
26. Zhang H, Huang Q, Ke N, Matsuyama S, Hammock B, Godzik A and Reed JC: Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanism. J Biol Chem 275: 27303-27306, 2000.
27. Solange D and Martinou JC: Mitochondria as the central control point of apoptosis. Trends. Cell Biol 10: 369-377, 2000.
28. Lee YS, Kim WH, Yu ES, Kim MR, Lee MJ and Jang JJ: Time course of cell cycle-related protein expression in diethylnitrosamine-initiated rat liver. J Hepatol 29: 464-469, 1998.
29. Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW and Jim SJ: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta 1 trigger apoptosis though the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem 274: 31775-31783, 1999.
30. Barnes EA, Kong M, Ollendorff V and Donoghue DJ: Patched 1 interacts with cyclin B1 to regulate cell cycle p rogression. EMBO J 20: 2214-2223, 2001.
31. Sankawa U, Ebizuka Y, Miyazaki T, Isomura Y and Otsuka H: Antitumor activity of shikonin and its derivatives. Chem. Pharm Bull (Tokyo) 25: 2392-2395, 1977.
32. Guo XP, Zhang XY and Zhang SD: Clinical trial on the effects of shikonin mixture on later stage lung cancer. Zhong Xi Yi Jie He Za Zhi (in Chinese) 11: 598-599, 1991.