The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

Investigational New Drugs

Volumn 29, Issue 6, 2011, Pages 1276-1283

  Lu, Jin Jian ^a   Chen, Si Meng ^a   Zhang, Xiao Wei ^a   Ding, Jian ^a   Meng, Ling Hua ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

2 DE; Dihydroartemisinin; ER stress; GADD153; GRP78

Indexed keywords

DEFEROXAMINE MESYLATE; DIHYDROARTEMISININ; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IRON; IRON CHELATING AGENT; MESSENGER RNA; ANTINEOPLASTIC AGENT; ARTEMISININ DERIVATIVE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL NUCLEUS MEMBRANE; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION REGULATION; GROWTH ARREST AND DNA DAMAGE INDUCIBLE GENE 153; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REDOX STRESS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HCT116; COLORECTAL TUMOR; ENDOPLASMIC RETICULUM; GENETICS; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PATHOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTEMISININS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM; G1 PHASE; HCT116 CELLS; HEAT-SHOCK PROTEINS; HUMANS; IRON; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UP-REGULATION;

EID: 84856035765     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9481-8     Document Type: Article

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