In vitro metabolism of β-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells

Rapid Communications in Mass Spectrometry

Volumn 23, Issue 1, 2009, Pages 12-22

  Miao, Xiu Sheng ^a,b   Zhong, Caiyun ^a   Wang, Yunxia ^a   Savage, Ronald E ^a   Yang, Rui Yang ^a   Kizer, Darin ^a   Volckova, Erika ^a   Ashwell, Mark A ^a   Chan, Thomas C K ^a  

^a ARQULE INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RATS; SULFUR COMPOUNDS;

ANTI-CANCER AGENTS; CLINICAL TRIAL; CULTURED HUMAN CELL; GLUCURONIDATION; GLUCURONIDES; HUMAN HEPATOCYTES; IN-VITRO; MAMMALIAN HEPATOCYTES; METABOLITE PROFILES; PHASE II;

METABOLITES;

EID: 60149091195     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.3835     Document Type: Article

References (34)

1. Li CJ, Averboukh L, Pardee AB. J. Biol. Chem. 1993; 268: 22463.
2. Don MJ, Chang YH, Chen KK, Ho LK, Chau YP. Mol. Pharmacol. 2001; 59: 784.
3. Choi YH, Kang HS, Yoo MA. J. Biochem. Mol. Biol. 2003; 36: 223.
4. Miao X-S, Song P, Savage RE, Zhong C, Yang R-Y, Kizer D, WuH, Volckova E, Ashwell MA, Supko JG, He X, Chan TCK. Drug Metab. Dispos. 2008; 36: 641.
5. Miao X-S, March RE, Metcalfe CD. Rapid Commun. Mass Spectrom. 2003; 17: 149.
6. Ansermot N, Fathi M, Veuthey J-L, Desmeules J, Hochstrasser D, Rudaz S. J. Chromatogr. B 2007; 857: 92.
7. Keski-Hynnilä H, Luukkanen L, Taskinen J, Kostiainen R. J. Am. Soc. Mass Spectrom. 1999; 10: 537.
8. Antignac J-P, Brosseaud A, Gaudin-Hirret I, André F, Bizec B. Steroids 2005; 70: 205.
9. Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Free Radical Biol. Med. 2008; 44: 1645.
10. Schug K, McNai HM. J. Sep. Sci. 2002; 25: 760.
11. Schug K, McNai HM. J. Chromatogr. A 2003; 985: 531.
12. Griffin RJ, Godfrey VB, Burka LT. Toxicol. Sci. 1998; 42: 73.
13. Dixon R, Hsiao J, Hsu HB, Smulkowski M, Tze-Ming-Chan, Pramanik B, Morton J. Pharm. Res. 1989; 6: 28.
14. Murthy SS, Mathur C, Kvalo LT, Lessor RA, Wilhelm JA. Xenobiotica 1996; 26: 779.
15. Murai T, Iwabuchi H, Ikeda T. Drug Metab. Pharmacokinet. 2005; 20: 282.
16. Murai T, Yamamura N, Nitanai T, Samata N, Takei M, Iwabuchi H, Tanaka K, Mikamoto K, Ikeda T. Drug Metab. Dispos. 2008; 36: 368.
17. Savage RE, Tyler AN, Miao X-S, Chan TCK. Drug Metab. Dispos. 2008; 36: 753.
18. Capps TM, Barringer VM, Eberle WJ, Brown DR, Sanson DR. J. Agric. Food Chem. 1996; 44: 2408.
19. Laurent F, Debrauwer L, Rathahao E, Scalla R. J. Agric. Food Chem. 2000; 48: 5307.
20. Ikenaka Y, Ishizaka M, Eun H, Miyabara Y. Biochem. Biophys. Res. Commun. 2007; 360: 490.
21. Shipkova M, Armstrong VM, Wielabd E, Niedmann PD, Schüta E, Brenner-Weiß G, Voihsel M, Braun F, Oellerich M. Br. J. Pharmacol. 1999; 126: 1075.
22. Boberg M, Angerbauer R, Kanhai WK, Karl W, Kern A, Radtke M, Steinke W. Drug Metab. Dispos. 1998; 26: 640.
23. Chmela Z, Vesely J, Lemv K, Rypka M, Hanus J, Havlicek L, Krystof V, Michnova L, Fuksova K, Lukes J. Drug Metab. Dispos. 2001; 29: 326.
24. Nakano K, Ohashi M, Harigaya S. Chem. Pharm. Bull. 1986; 34: 3949.
25. Tang C, Hochman JH, Ma B, Subramanian R, Vyas KP. Drug Metab. Dispos. 2003; 31: 37.
26. Tang B-K. Pharmacol. Ther. 1990; 46: 53.
27. Thor H, Smith MT, Hartzell P, Bellomo G, Jewell SA, Orrenius S. J. Biol. Chem. 1982; 257: 12419.
28. Monks TJ, Jones DC. Current Drug Metab. 2002; 3: 425.
29. Asche C. Antitumour quinones. Mini-Rev. Med. Chem. 2005; 5: 449.
30. Mutlib AE, Chen H, Nemeth G, Gan LS, Christ DD. Drug Metab. Dispos. 1999; 27: 1045.
31. Fisher IB, Pine IF, Strelevitz TJ, Wrighton S. Drug Metab. Rev. 2001; 33: 273.
32. Shipkova M, Strassburg CP, Braun F, Streit F, Gröne HJ, Armstrong VW, Tukey RH, Oellerich M, Wieland E. Br. J. Pharmacol. 2001; 132: 1027.
33. Liehr JG, Roy D. Free Radical Biol. Med. 1990; 8: 415.
34. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG. Proc. Natl. Acad. Sci. USA 1997; 94: 10937.