Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Gurung, Resham Lal ^a   Lim, Shi Ni ^a   Khaw, Aik Kia ^a   Soon, Jasmine Fen Fen ^a   Shenoy, Kirthan ^a   Ali, Safiyya Mohamed ^a   Jayapal, Manikandan ^a   Sethu, Swaminathan ^a   Baskar, Rajamanickam ^b   Prakash Hande, M ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; PROTEIN BAX; PROTEIN KINASE C; TELOMERASE; THYMOQUINONE; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BRAIN TUMOR; CANCER CELL; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHROMOSOME TRANSLOCATION; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; KARYOTYPE; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE STRANDED DNA BREAK; TELOMERE; BRAIN; CYTOLOGY; DNA REPAIR; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

NIGELLA SATIVA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOQUINONES; BRAIN; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; NUCLEAR PROTEINS; TELOMERASE; TELOMERE;

EID: 77957913537     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012124     Document Type: Article

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