SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor

International Journal of Cancer

Volumn 119, Issue 5, 2006, Pages 1184-1193

  Yang, Fan ^a,b   Chen, Yi ^a   Duan, Wenhu ^a,c   Zhang, Chao ^a,b   Zhu, Hong ^a,b   Ding, Jian ^a,c  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor; Mitochondria; SH 7; Shikonin; Topoisomerase II inhibitor

Indexed keywords

1 (1,4 DIHYDRO 5,8 DIHYDROXY 1,4 DIOXONAPHTHALEN 2 YL) 4 METHYLPENT 3 ENYLFURAN 2 CARBOXYLATE; 1,4 NAPHTHOQUINONE DERIVATIVE; DNA TOPOISOMERASE; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; LIPOCORTIN 5; SH 7; SHIKONIN; SHIKONIN DERIVATIVE; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL DNA DISORDER; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SARCOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, AGAR GEL; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKEMIA; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; NAPHTHOQUINONES; NEOPLASMS; PROSTATIC NEOPLASMS; SARCOMA; TRANSPLANTATION, HETEROLOGOUS;

EID: 33746377985     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.21943     Document Type: Article

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