Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells

Cancer Letters

Volumn 259, Issue 1, 2008, Pages 82-98

  Wang, Clay C C ^a   Chiang, Yi Ming ^a,b   Sung, Shu Chiao ^b   Hsu, Ya Ling ^b   Chang, Jiunn Kae ^b   Kuo, Po Lin ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Apoptosis; Cell cycle; JNK; Melanoma; Plumbagin

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; ASCORBIC ACID; CASPASE 9; CATALASE; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLUMBAGIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; INHIBITORY CONCENTRATION 50; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE KINASE 5; MELANOMA; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NAPHTHOQUINONES; NEOPLASTIC STEM CELLS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR STEM CELL ASSAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 37049005766     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.10.005     Document Type: Article

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