β-lapachone suppresses radiation-induced activation of nuclear factor-κB

Experimental and Molecular Medicine

Volumn 42, Issue 5, 2010, Pages 327-334

  Dong, Guang Zhi ^a   Oh, Eun Taex ^a   Lee, Hyemi ^a   Park, Moon Taek ^a   Song, Chang Won ^b   Park, Heon Joo ^a,b  

^a Inha University   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Ionizing radiation; NAD(P)H:quinone oxidoreductase; NF B; lapachone

Indexed keywords

BETA LAPACHONE; CYCLIN D1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 BETA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN NQO1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IRRADIATION; PROMOTER REGION; PROTEIN FUNCTION; RADIATION; RADIATION DOSE; RADIOSENSITIZATION; TRANSCRIPTION INITIATION;

EID: 77953520689     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.5.034     Document Type: Article

References (30)

1. Ahmed KM, Li JJ. NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med 2008;44:1-13
2. Ahn KS, Sethi G, Jain AK, Jaiswal AK, Aggarwal BB. Genetic deletion of NAD(P)H:Quinone Oxidoreductase 1 abrogates activation of nuclear factor-KBα kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. J Biol Chem 2006;281: 19798-808
3. Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994;12:141-79
4. Bentle MS, Reinicke KE, Bey EA, Spitz DR, Boothman DA. Calcium-dependent modulation of poly(ADP-ribose) poly-merase-1 alters cellular metabolism and DNA repair. J Biol Chem 2006;281:33684-96
5. Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc Natl Acad Sci USA 2007;104:11832-7
6. Boothman DA, Meyers M, Fukunaga N, Lee SW. Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells. Proc Natl Acad Sci USA 1993;90:7200-4
7. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe D. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest 1991;88: 691-695
8. Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM. Dual effect of oxidative stress on NF-kappakB activation in HeLa cells. Exp Mol Med. 2002;34:332-9
9. Choi EK, Terai K, Ji IM, Kook YH, Park KH, Oh ET, Griffin RJ, Lim BU, Kim JS, Lee DS, Boothman DA, Loren M, Song CW, Park HJ. Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells. Neoplasia 2007;9:634-42
10. Cross JV, Deak JC, Rich EA, Qian Y, Lewis M, Parrott LA, Mochida K, Gustafson D, Vande Pol S, Templeton DJ. Quinone reductase inhitiors block SAPK/JNK and NF-κB pathways and potentiate apoptosis. J Biol Chem 1999;274: 31150-4
11. Fan M, Ahmed KM, Coleman MC, Spitz DR, Li JJ. Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. Cancer Res 2007;67:3220-8
12. Flynn V Jr., Ramanitharan A, Moparty K, Davis R, Sikka S, Agrawal KC, Abdel-Mageed AB. Adenovirus-mediated inhibition of NF-kappaB confers chemo-sensitization and apoptosis in prostate cancer cells. Int J Oncol 2003;23: 317-23
13. Lopes JN, Cruz FS, Docampo R., Vasconcellos ME, Sampaio MC, Pinto AV, Gilbert B. In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi. Ann Trop Med Parasitol 1978;72:523-31
14. Manna SK, Gad YP, Mukhopadhyay A, Aggarwal BB. Suppression of tumor necrosis factor-activated nuclear transcription factor-kB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β-lapachone. Biochem Pharmacol 1999;57:763-74
15. Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Boothman DA, Song CW. Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation. Int J Radiat Oncol Biol Phys 2005a;61:212-9
16. Park HJ, Choi EK, Choi J, Ahn KJ, Kim EJ, Ji IM., Kook YH, Ahn SD, Williams B, Griffin R, Boothman DA, Lee CK, Song CW. Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapa-chone. Clin Cancer Res 2005b;11:8866-71
17. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta- lapachone cytotoxicity. J Biol Chem 2000;275:5416-24
18. Pircher PC, Kitto JL, Petrowski ML, Tangirala RK, Bischoff ED, Schulman IG, Westin SK. Farnesoid X receptor regulates bile acid-amino acid conjugation. J Biol Chem 2003;278:27703-11
19. Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G, Boothman DA. Beta-lapachone-mediated apoptosis in human promyelo-cytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer Res 1995;55:3706-11
20. Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA. beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. Exp Cell Res 2001;267:95-106
21. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705-16
22. Song CW, Chae JJ, Choi EK, Hwang TS, Kim C, Lim BU, Park HJ. Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock. Int J Hyperthermia 2008;24:161-9
23. Suzuki M, Amano M, Choi J, Park HJ, Williams BW, Ono K, Song CW. Synergistic effects of radiation and beta-lapa-chone in DU-145 human prostate cancer cells in vitro. Radiat Res 2006;165:525-31
24. Tagliarino C, Pink JJ, Dubyak GR, Nieminen AL, Boothman DA. Calcium is a key signaling molecule in beta-lapa-chone-mediated cell death. J Biol Chem 2001;276:19150-9
25. Terai K, Dong GZ, Oh ET, Park MT, Gu Y, Song CW, Park HJ. Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1. Anticancer Drugs 2009;20:901-9
26. Tirumalai R, Rajesh Kumar T, Mai KH, Biswal S. Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett 2002;132:27-36
27. Trush MA, Twerdok LE, Rembish SJ, Zhu H, Li Y. Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced he-matotoxicities. Environ Health Perspect 1996;104(Suppl 6): 1227-34
28. Wuerzberger SM, Pink JJ, Planchon SM, Byers KL, Bornmann WG, Boothman DA. Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone. Cancer Res 1998;58:1876-85
29. Wuerzberger-Davis SM, Nakamura Y, Seufzer BJ, Miyamoto S. NF-kappa;B activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 2007;26:641-51
30. Yang XY, Yang TT, Schubert W, Factor SM, Chow CW. Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol 2007;303:825-37