p53-Mediated Cell Cycle Arrest and Apoptosis Induced by Shikonin via a Caspase-9-Dependent Mechanism in Human Malignant Melanoma A375-S2 Cells

Journal of Pharmacological Sciences

Volumn 94, Issue 2, 2004, Pages 166-176

  Wu, Zhen ^a   Wu, Lijun ^a   Li, Linhao ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase; Cell cycle arrest; p53; Shikonin

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 9; CYCLIN DEPENDENT KINASE 4; CYTOCHROME C; DNA; LITHOSPERMUM ERYTHRORHIZON EXTRACT; LITHOSPERMUM EXTRACT; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; NATURAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SHIKONIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL STRAIN; CELL STRAIN A375 S2; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA CELL; TUMOR SUPPRESSOR GENE;

EID: 1642545128     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.94.166     Document Type: Article

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