Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 5, 2012, Pages 581-591

  Suboj, Priya ^a   Babykutty, Suboj ^a   Valiyaparambil Gopi, Deepak Roshan ^b   Nair, Rakesh S ^c   Srinivas, Priya ^c   Gopala, Srinivas ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

^b REGIONAL CANCER CENTRE   (India)

^c RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

AE; Angiogenesis; Colon cancer; Migration; MMP

Indexed keywords

ALOE EMODIN; COLLAGENASE 3; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 15; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTROPHIL COLLAGENASE; RHO KINASE; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER INVASION; CELL MIGRATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANGIOGENESIS INHIBITORS; ANTHRAQUINONES; CELL MOVEMENT; CELL NUCLEUS; COLONIC NEOPLASMS; DNA; DOWN-REGULATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN TRANSPORT; RHOB GTP-BINDING PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84857918973     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.12.012     Document Type: Article

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