Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells

Cancer Research

Volumn 68, Issue 14, 2008, Pages 5609-5618

  Gali Muhtasib, Hala ^a   Kuester, Doerthe ^b   Mawrin, Christian ^b,f   Bajbouj, Khuloud ^b   Diestel, Antje ^b   Ocker, Matthias ^c   Habold, Caroline ^a,d   Foltzer Jourdainne, Charlotte ^e   Schoenfeld, Peter ^b   Peters, Brigitte ^b   Diab Assaf, Mona ^b   Pommrich, Ulf ^b   Itani, Wafica ^b   Lippert, Hans ^b   Roessner, Albert ^b   Schneider Stock, Regine ^b  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d CEPE CNRS   (France)

^e INSERM   (France)

^f FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITATE HYDRATASE; CHECKPOINT KINASE 1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; THYMOQUINONE; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; MESSENGER RNA; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL STRAIN HCT116; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER MITOCHONDRION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; CELL NUCLEUS; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; CELL LINE, TUMOR; CELL NUCLEUS; COLORECTAL NEOPLASMS; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; PROPORTIONAL HAZARDS MODELS; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 48649088554     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0884     Document Type: Article

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