Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

International Journal of Cancer

Volumn 117, Issue 3, 2005, Pages 409-417

  El Mahdy, Mohamed A ^a   Zhu, Qianzheng ^a   Wang, Qi En ^a   Wani, Gulzar ^a   Wani, Altaf A ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; Cytochrome c; Mitochondria; p53; Thymoquinone

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; THYMOQUINONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CYTOPLASM; DOWN REGULATION; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; UPREGULATION;

APOPTOSIS; BENZOQUINONES; CASPASE 8; CASPASES; CELL DIVISION; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 26444457920     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21205     Document Type: Article

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