Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Biochemical Pharmacology

Volumn 79, Issue 9, 2010, Pages 1251-1260

  Alhosin, Mahmoud ^a   Abusnina, Abdurazzag ^a   Achour, Mayada ^a   Sharif, Tanveer ^a   Muller, Christian ^b   Peluso, Jean ^b   Chataigneau, Thierry ^a   Lugnier, Claire ^a   Schini Kerth, Valérie B ^a   Bronner, Christian ^a   Fuhrmann, Guy ^a  

^a Faculté de Pharmacie   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Apoptosis; Caspase; Thymoquinone; Tumor suppressor protein p73; UHRF1

Indexed keywords

CASPASE 3; DNA METHYLTRANSFERASE 1; GENE PRODUCT; HISTONE DEACETYLASE 1; PROTEIN P53; PROTEIN P73; PROTEIN UHRF1; REACTIVE OXYGEN METABOLITE; THYMOQUINONE; UBIQUITIN LIKE CONTAINING PHD AND RING FINGER DOMAIN 1; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DIPLOIDY; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; NUCLEAR PROTEINS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR SUPPRESSOR PROTEINS;

EID: 77649191011     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.12.015     Document Type: Article

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