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Volumn 148, Issue 2, 2012, Pages 97-109

Key molecules in the differentiation and commitment program of T helper 17 (Th17) cells up-to-date

Author keywords

CD4+ Th17 cytokines; Regulatory T cells; T cell differentiation; Transcription factors

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; B CELL ACTIVATING FACTOR; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR ALPHA; EOMESODERMIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; INDUCIBLE T CELL COSTIMULATOR LIGAND; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 27; INTERLEUKIN 6; KYNURENIC ACID; LIVER X RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA; RETINOIC ACID; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

EID: 84869782318     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.09.007     Document Type: Review
Times cited : (18)

References (219)
  • 1
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145-173.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 3
    • 65549123867 scopus 로고    scopus 로고
    • + regulatory T cells: more of the same or a division of labor?
    • + regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 4
    • 84857006554 scopus 로고    scopus 로고
    • Influence of dietary components on regulatory T cells
    • Issazadeh-Navikas S., Teimer R., Bockermann R. Influence of dietary components on regulatory T cells. Mol Med 2012, 18:95-110.
    • (2012) Mol Med , vol.18 , pp. 95-110
    • Issazadeh-Navikas, S.1    Teimer, R.2    Bockermann, R.3
  • 5
    • 77956124982 scopus 로고    scopus 로고
    • CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
    • Maggi L., Santarlasci V., Capone M., Peired A., Frosali F., Crome S.Q., et al. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol 2010, 40:2174-2181.
    • (2010) Eur J Immunol , vol.40 , pp. 2174-2181
    • Maggi, L.1    Santarlasci, V.2    Capone, M.3    Peired, A.4    Frosali, F.5    Crome, S.Q.6
  • 6
    • 0033083111 scopus 로고    scopus 로고
    • IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells
    • Aarvak T., Chabaud M., Miossec P., Natvig J.B. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 1999, 162:1246-1251.
    • (1999) J Immunol , vol.162 , pp. 1246-1251
    • Aarvak, T.1    Chabaud, M.2    Miossec, P.3    Natvig, J.B.4
  • 7
    • 36248965294 scopus 로고    scopus 로고
    • TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology
    • McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., et al. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nat Immunol 2007, 8:1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6
  • 8
    • 84864146194 scopus 로고    scopus 로고
    • Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment
    • Shi G., Lovaas J.D., Tan C., Vistica B.P., Wawrousek E.F., Aziz M.K., et al. Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment. J Immunol 2012, 189:1220-1227.
    • (2012) J Immunol , vol.189 , pp. 1220-1227
    • Shi, G.1    Lovaas, J.D.2    Tan, C.3    Vistica, B.P.4    Wawrousek, E.F.5    Aziz, M.K.6
  • 9
    • 78649752513 scopus 로고    scopus 로고
    • Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • Domingues H.S., Mues M., Lassmann H., Wekerle H., Krishnamoorthy G. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 2010, 5:e15531.
    • (2010) PLoS ONE , vol.5
    • Domingues, H.S.1    Mues, M.2    Lassmann, H.3    Wekerle, H.4    Krishnamoorthy, G.5
  • 10
  • 14
    • 70049112374 scopus 로고    scopus 로고
    • A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum
    • Zhang X., Gao L., Lei L., Zhong Y., Dube P., Berton M.T., et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol 2009, 183:1291-1300.
    • (2009) J Immunol , vol.183 , pp. 1291-1300
    • Zhang, X.1    Gao, L.2    Lei, L.3    Zhong, Y.4    Dube, P.5    Berton, M.T.6
  • 15
    • 79960131814 scopus 로고    scopus 로고
    • Identification of an innate T helper type 17 response to intestinal bacterial pathogens
    • Geddes K., Rubino S.J., Magalhaes J.G., Streutker C., Le B.L., Cho J.H., et al. Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med 2011, 17:837-844.
    • (2011) Nat Med , vol.17 , pp. 837-844
    • Geddes, K.1    Rubino, S.J.2    Magalhaes, J.G.3    Streutker, C.4    Le, B.L.5    Cho, J.H.6
  • 17
    • 80053065321 scopus 로고    scopus 로고
    • Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model
    • Van Belle T.L., Esplugues E., Liao J., Juntti T., Flavell R.A., von Herrath M.G. Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol 2011, 187:2915-2922.
    • (2011) J Immunol , vol.187 , pp. 2915-2922
    • Van Belle, T.L.1    Esplugues, E.2    Liao, J.3    Juntti, T.4    Flavell, R.A.5    von Herrath, M.G.6
  • 20
    • 41849142985 scopus 로고    scopus 로고
    • Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    • Raffatellu M., Santos R.L., Verhoeven D.E., George M.D., Wilson R.P., Winter S.E., et al. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med 2008, 14:421-428.
    • (2008) Nat Med , vol.14 , pp. 421-428
    • Raffatellu, M.1    Santos, R.L.2    Verhoeven, D.E.3    George, M.D.4    Wilson, R.P.5    Winter, S.E.6
  • 21
    • 80855140152 scopus 로고    scopus 로고
    • Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice
    • Dejima T., Shibata K., Yamada H., Hara H., Iwakura Y., Naito S., et al. Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice. Infect Immun 2011, 79:4503-4510.
    • (2011) Infect Immun , vol.79 , pp. 4503-4510
    • Dejima, T.1    Shibata, K.2    Yamada, H.3    Hara, H.4    Iwakura, Y.5    Naito, S.6
  • 23
    • 58449115208 scopus 로고    scopus 로고
    • Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine
    • Godinez I., Raffatellu M., Chu H., Paixao T.A., Haneda T., Santos R.L., et al. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun 2009, 77:387-398.
    • (2009) Infect Immun , vol.77 , pp. 387-398
    • Godinez, I.1    Raffatellu, M.2    Chu, H.3    Paixao, T.A.4    Haneda, T.5    Santos, R.L.6
  • 24
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye P., Rodriguez F.H., Kanaly S., Stocking K.L., Schurr J., Schwarzenberger P., et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 2001, 194:519-527.
    • (2001) J Exp Med , vol.194 , pp. 519-527
    • Ye, P.1    Rodriguez, F.H.2    Kanaly, S.3    Stocking, K.L.4    Schurr, J.5    Schwarzenberger, P.6
  • 25
    • 79953284685 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    • Puel A., Cypowyj S., Bustamante J., Wright J.F., Liu L., Lim H.K., et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332:65-68.
    • (2011) Science , vol.332 , pp. 65-68
    • Puel, A.1    Cypowyj, S.2    Bustamante, J.3    Wright, J.F.4    Liu, L.5    Lim, H.K.6
  • 26
    • 79961154447 scopus 로고    scopus 로고
    • Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
    • Liu L., Okada S., Kong X.F., Kreins A.Y., Cypowyj S., Abhyankar A., et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med 2011, 208:1635-1648.
    • (2011) J Exp Med , vol.208 , pp. 1635-1648
    • Liu, L.1    Okada, S.2    Kong, X.F.3    Kreins, A.Y.4    Cypowyj, S.5    Abhyankar, A.6
  • 29
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    • Avery D.T., Deenick E.K., Ma C.S., Suryani S., Simpson N., Chew G.Y., et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 2010, 207:155-171.
    • (2010) J Exp Med , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3    Suryani, S.4    Simpson, N.5    Chew, G.Y.6
  • 31
    • 84855225292 scopus 로고    scopus 로고
    • IL-21 enhances the potential of human γδ T cells to provide B-cell help
    • Bansal R.R., Mackay C.R., Moser B., Eberl M. IL-21 enhances the potential of human γδ T cells to provide B-cell help. Eur J Immunol 2012, 42:110-119.
    • (2012) Eur J Immunol , vol.42 , pp. 110-119
    • Bansal, R.R.1    Mackay, C.R.2    Moser, B.3    Eberl, M.4
  • 33
    • 78649881447 scopus 로고    scopus 로고
    • Interleukin-21: a multifunctional regulator of immunity to infections
    • Yi J.S., Cox M.A., Zajac A.J. Interleukin-21: a multifunctional regulator of immunity to infections. Microbes Infect 2010, 12:1111-1119.
    • (2010) Microbes Infect , vol.12 , pp. 1111-1119
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 35
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S., Eyerich K., Pennino D., Carbone T., Nasorri F., Pallotta S., et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009, 119:3573-3585.
    • (2009) J Clin Invest , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3    Carbone, T.4    Nasorri, F.5    Pallotta, S.6
  • 36
    • 73949103213 scopus 로고    scopus 로고
    • Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
    • Munoz M., Heimesaat M.M., Danker K., Struck D., Lohmann U., Plickert R., et al. Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med 2009, 206:3047-3059.
    • (2009) J Exp Med , vol.206 , pp. 3047-3059
    • Munoz, M.1    Heimesaat, M.M.2    Danker, K.3    Struck, D.4    Lohmann, U.5    Plickert, R.6
  • 37
    • 79959724313 scopus 로고    scopus 로고
    • IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection with Candida albicans
    • Eyerich S., Wagener J., Wenzel V., Scarponi C., Pennino D., Albanesi C., et al. IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection with Candida albicans. Eur J Immunol 2011, 41:1894-1901.
    • (2011) Eur J Immunol , vol.41 , pp. 1894-1901
    • Eyerich, S.1    Wagener, J.2    Wenzel, V.3    Scarponi, C.4    Pennino, D.5    Albanesi, C.6
  • 38
    • 84856421675 scopus 로고    scopus 로고
    • Regulation and function of innate and adaptive interleukin-17-producing cells
    • Hirota K., Ahlfors H., Duarte J.H., Stockinger B. Regulation and function of innate and adaptive interleukin-17-producing cells. EMBO Rep 2012, 13:113-120.
    • (2012) EMBO Rep , vol.13 , pp. 113-120
    • Hirota, K.1    Ahlfors, H.2    Duarte, J.H.3    Stockinger, B.4
  • 39
    • 34249799285 scopus 로고    scopus 로고
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J Immunol 2007, 178:6725-6729.
    • (2007) J Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 41
    • 44449131480 scopus 로고    scopus 로고
    • Isoform-specific inhibition of RORα-mediated transcriptional activation by human FOXP3
    • Du J., Huang C., Zhou B., Ziegler S.F. Isoform-specific inhibition of RORα-mediated transcriptional activation by human FOXP3. J Immunol 2008, 180:4785-4792.
    • (2008) J Immunol , vol.180 , pp. 4785-4792
    • Du, J.1    Huang, C.2    Zhou, B.3    Ziegler, S.F.4
  • 43
    • 80051486126 scopus 로고    scopus 로고
    • Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice
    • 662
    • Liu B., Tonkonogy S.L., Sartor R.B. Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice. Gastroenterology 2011, 141:653-662. 662.
    • (2011) Gastroenterology , vol.141 , pp. 653-662
    • Liu, B.1    Tonkonogy, S.L.2    Sartor, R.B.3
  • 44
  • 48
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: tolerance and tryptophan catabolism
    • Mellor A.L., Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004, 4:762-774.
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 49
    • 70149101645 scopus 로고    scopus 로고
    • IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
    • Baban B., Chandler P.R., Sharma M.D., Pihkala J., Koni P.A., Munn D.H., et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 2009, 183:2475-2483.
    • (2009) J Immunol , vol.183 , pp. 2475-2483
    • Baban, B.1    Chandler, P.R.2    Sharma, M.D.3    Pihkala, J.4    Koni, P.A.5    Munn, D.H.6
  • 50
    • 78649901580 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells
    • Curti A., Trabanelli S., Onofri C., Aluigi M., Salvestrini V., Ocadlikova D., et al. Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells. Haematologica 2010, 95:2022-2030.
    • (2010) Haematologica , vol.95 , pp. 2022-2030
    • Curti, A.1    Trabanelli, S.2    Onofri, C.3    Aluigi, M.4    Salvestrini, V.5    Ocadlikova, D.6
  • 51
    • 54049151564 scopus 로고    scopus 로고
    • The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    • Chen W., Liang X., Peterson A.J., Munn D.H., Blazar B.R. The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol 2008, 181:5396-5404.
    • (2008) J Immunol , vol.181 , pp. 5396-5404
    • Chen, W.1    Liang, X.2    Peterson, A.J.3    Munn, D.H.4    Blazar, B.R.5
  • 52
    • 77951737056 scopus 로고    scopus 로고
    • + dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
    • + dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 2010, 59:595-604.
    • (2010) Gut , vol.59 , pp. 595-604
    • Matteoli, G.1    Mazzini, E.2    Iliev, I.D.3    Mileti, E.4    Fallarino, F.5    Puccetti, P.6
  • 53
    • 79952247358 scopus 로고    scopus 로고
    • Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients
    • Smith A.W., Doonan B.P., Tyor W.R., Abou-Fayssal N., Haque A., Banik N.L. Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients. J Neuroimmunol 2011, 232:179-185.
    • (2011) J Neuroimmunol , vol.232 , pp. 179-185
    • Smith, A.W.1    Doonan, B.P.2    Tyor, W.R.3    Abou-Fayssal, N.4    Haque, A.5    Banik, N.L.6
  • 54
    • 80052671582 scopus 로고    scopus 로고
    • Physiologic control of IDO competence in splenic dendritic cells
    • Baban B., Chandler P.R., Johnson B.A., Huang L., Li M., Sharpe M.L., et al. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 2011, 187:2329-2335.
    • (2011) J Immunol , vol.187 , pp. 2329-2335
    • Baban, B.1    Chandler, P.R.2    Johnson, B.A.3    Huang, L.4    Li, M.5    Sharpe, M.L.6
  • 55
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D., Mold J., Hunt P.W., Kanwar B., Loke P., Seu L., et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010, 2:32ra36.
    • (2010) Sci Transl Med , vol.2
    • Favre, D.1    Mold, J.2    Hunt, P.W.3    Kanwar, B.4    Loke, P.5    Seu, L.6
  • 57
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • Mezrich J.D., Fechner J.H., Zhang X., Johnson B.P., Burlingham W.J., Bradfield C.A. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010, 185:3190-3198.
    • (2010) J Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1    Fechner, J.H.2    Zhang, X.3    Johnson, B.P.4    Burlingham, W.J.5    Bradfield, C.A.6
  • 58
    • 79551688725 scopus 로고    scopus 로고
    • Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
    • Dinatale B.C., Murray I.A., Schroeder J.C., Flaveny C.A., Lahoti T.S., Laurenzana E.M., et al. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 2010, 115:89-97.
    • (2010) Toxicol Sci , vol.115 , pp. 89-97
    • Dinatale, B.C.1    Murray, I.A.2    Schroeder, J.C.3    Flaveny, C.A.4    Lahoti, T.S.5    Laurenzana, E.M.6
  • 59
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317:256-260.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6
  • 60
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007, 204:1775-1785.
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 61
    • 84874088635 scopus 로고    scopus 로고
    • Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
    • Zhao J., Lloyd C.M., Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol 2012, 10.1038/mi.2012.76.
    • (2012) Mucosal Immunol
    • Zhao, J.1    Lloyd, C.M.2    Noble, A.3
  • 63
  • 64
    • 77949879961 scopus 로고    scopus 로고
    • Cutting edge: spontaneous development of IL-17-producing γδT cells in the thymus occurs via a TGF-β1-dependent mechanism
    • Do J.S., Fink P.J., Li L., Spolski R., Robinson J., Leonard W.J., et al. Cutting edge: spontaneous development of IL-17-producing γδT cells in the thymus occurs via a TGF-β1-dependent mechanism. J Immunol 2010, 184:1675-1679.
    • (2010) J Immunol , vol.184 , pp. 1675-1679
    • Do, J.S.1    Fink, P.J.2    Li, L.3    Spolski, R.4    Robinson, J.5    Leonard, W.J.6
  • 65
    • 70449711235 scopus 로고    scopus 로고
    • Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
    • Das J., Ren G., Zhang L., Roberts A.I., Zhao X., Bothwell A.L., et al. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009, 206:2407-2416.
    • (2009) J Exp Med , vol.206 , pp. 2407-2416
    • Das, J.1    Ren, G.2    Zhang, L.3    Roberts, A.I.4    Zhao, X.5    Bothwell, A.L.6
  • 66
    • 68149125252 scopus 로고    scopus 로고
    • Infection with a helminth parasite attenuates autoimmunity through TGF-β-mediated suppression of Th17 and Th1 responses
    • Walsh K.P., Brady M.T., Finlay C.M., Boon L., Mills K.H. Infection with a helminth parasite attenuates autoimmunity through TGF-β-mediated suppression of Th17 and Th1 responses. J Immunol 2009, 183:1577-1586.
    • (2009) J Immunol , vol.183 , pp. 1577-1586
    • Walsh, K.P.1    Brady, M.T.2    Finlay, C.M.3    Boon, L.4    Mills, K.H.5
  • 69
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007, 8:942-949.
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 70
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., Brereton C., Keogh B., Mills K.H., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006, 203:1685-1691.
    • (2006) J Exp Med , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 71
  • 73
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • Labelle M., Begum S., Hynes R.O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011, 20:576-590.
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 75
    • 79954459142 scopus 로고    scopus 로고
    • Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay
    • Oida T., Weiner H.L. Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay. PLoS ONE 2011, 6:e18365.
    • (2011) PLoS ONE , vol.6
    • Oida, T.1    Weiner, H.L.2
  • 77
    • 33845915104 scopus 로고    scopus 로고
    • Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-β T cell-transgenic mice
    • Carrier Y., Yuan J., Kuchroo V.K., Weiner H.L. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-β T cell-transgenic mice. J Immunol 2007, 178:179-185.
    • (2007) J Immunol , vol.178 , pp. 179-185
    • Carrier, Y.1    Yuan, J.2    Kuchroo, V.K.3    Weiner, H.L.4
  • 80
    • 68949149159 scopus 로고    scopus 로고
    • TGF-β promotes Th17 cell development through inhibition of SOCS3
    • Qin H., Wang L., Feng T., Elson C.O., Niyongere S.A., Lee S.J., et al. TGF-β promotes Th17 cell development through inhibition of SOCS3. J Immunol 2009, 183:97-105.
    • (2009) J Immunol , vol.183 , pp. 97-105
    • Qin, H.1    Wang, L.2    Feng, T.3    Elson, C.O.4    Niyongere, S.A.5    Lee, S.J.6
  • 82
    • 44849115688 scopus 로고    scopus 로고
    • Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-γ on STAT3 and Smads
    • Tanaka K., Ichiyama K., Hashimoto M., Yoshida H., Takimoto T., Takaesu G., et al. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-γ on STAT3 and Smads. J Immunol 2008, 180:3746-3756.
    • (2008) J Immunol , vol.180 , pp. 3746-3756
    • Tanaka, K.1    Ichiyama, K.2    Hashimoto, M.3    Yoshida, H.4    Takimoto, T.5    Takaesu, G.6
  • 83
    • 84859866114 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms
    • Liu Y., Islam E.A., Jarvis G.A., Gray-Owen S.D., Russell M.W. Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms. Mucosal Immunol 2012, 5:320-331.
    • (2012) Mucosal Immunol , vol.5 , pp. 320-331
    • Liu, Y.1    Islam, E.A.2    Jarvis, G.A.3    Gray-Owen, S.D.4    Russell, M.W.5
  • 84
    • 77956546075 scopus 로고    scopus 로고
    • SMAD2 is essential for TGFβ-mediated Th17 cell generation
    • Malhotra N., Robertson E., Kang J. SMAD2 is essential for TGFβ-mediated Th17 cell generation. J Biol Chem 2010, 285:29044-29048.
    • (2010) J Biol Chem , vol.285 , pp. 29044-29048
    • Malhotra, N.1    Robertson, E.2    Kang, J.3
  • 85
    • 72149124496 scopus 로고    scopus 로고
    • Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
    • Martinez G.J., Zhang Z., Chung Y., Reynolds J.M., Lin X., Jetten A.M., et al. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem 2009, 284:35283-35286.
    • (2009) J Biol Chem , vol.284 , pp. 35283-35286
    • Martinez, G.J.1    Zhang, Z.2    Chung, Y.3    Reynolds, J.M.4    Lin, X.5    Jetten, A.M.6
  • 87
    • 77955498891 scopus 로고    scopus 로고
    • Smad2 and Smad3 are redundantly essential for the TGF-β-mediated regulation of regulatory T plasticity and Th1 development
    • Takimoto T., Wakabayashi Y., Sekiya T., Inoue N., Morita R., Ichiyama K., et al. Smad2 and Smad3 are redundantly essential for the TGF-β-mediated regulation of regulatory T plasticity and Th1 development. J Immunol 2010, 185:842-855.
    • (2010) J Immunol , vol.185 , pp. 842-855
    • Takimoto, T.1    Wakabayashi, Y.2    Sekiya, T.3    Inoue, N.4    Morita, R.5    Ichiyama, K.6
  • 88
    • 80053430421 scopus 로고    scopus 로고
    • Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
    • Hahn J.N., Falck V.G., Jirik F.R. Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. J Clin Invest 2011, 121:4030-4042.
    • (2011) J Clin Invest , vol.121 , pp. 4030-4042
    • Hahn, J.N.1    Falck, V.G.2    Jirik, F.R.3
  • 89
    • 79956324792 scopus 로고    scopus 로고
    • Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin
    • Ichiyama K., Sekiya T., Inoue N., Tamiya T., Kashiwagi I., Kimura A., et al. Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin. Immunity 2011, 34:741-754.
    • (2011) Immunity , vol.34 , pp. 741-754
    • Ichiyama, K.1    Sekiya, T.2    Inoue, N.3    Tamiya, T.4    Kashiwagi, I.5    Kimura, A.6
  • 91
    • 82955189334 scopus 로고    scopus 로고
    • CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation
    • de Wit J., Souwer Y., van Beelen A.J., de G.R., Muller F.J., Klaasse B.H., et al. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood 2011, 118:6107-6114.
    • (2011) Blood , vol.118 , pp. 6107-6114
    • de Wit, J.1    Souwer, Y.2    van Beelen, A.J.3    de, G.R.4    Muller, F.J.5    Klaasse, B.H.6
  • 92
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • Lai Kwan L.Q., King Hung K.O., Zheng B.J., Lu L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc Natl Acad Sci U S A 2008, 105:14993-14998.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14993-14998
    • Lai Kwan, L.Q.1    King Hung, K.O.2    Zheng, B.J.3    Lu, L.4
  • 93
    • 84862496764 scopus 로고    scopus 로고
    • Immune regulation and B-cell depletion therapy in patients with primary Sjogren's syndrome
    • Abdulahad W.H., Kroese F.G., Vissink A., Bootsma H. Immune regulation and B-cell depletion therapy in patients with primary Sjogren's syndrome. J Autoimmun 2012, 39:103-111.
    • (2012) J Autoimmun , vol.39 , pp. 103-111
    • Abdulahad, W.H.1    Kroese, F.G.2    Vissink, A.3    Bootsma, H.4
  • 95
    • 77955458613 scopus 로고    scopus 로고
    • Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis
    • Frey O., Meisel J., Hutloff A., Bonhagen K., Bruns L., Kroczek R.A., et al. Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Ann Rheum Dis 2010, 69:1495-1501.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1495-1501
    • Frey, O.1    Meisel, J.2    Hutloff, A.3    Bonhagen, K.4    Bruns, L.5    Kroczek, R.A.6
  • 96
    • 84863981792 scopus 로고    scopus 로고
    • Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis
    • Li W.X., Pan H.F., Chen G.P., Tao J.H., Li X.P., Ye D.Q. Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis. Rheumatol Int 2012, 32:2051-2055.
    • (2012) Rheumatol Int , vol.32 , pp. 2051-2055
    • Li, W.X.1    Pan, H.F.2    Chen, G.P.3    Tao, J.H.4    Li, X.P.5    Ye, D.Q.6
  • 97
    • 79953323051 scopus 로고    scopus 로고
    • IL-17-producing T cells in lupus nephritis
    • Apostolidis S.A., Crispin J.C., Tsokos G.C. IL-17-producing T cells in lupus nephritis. Lupus 2011, 20:120-124.
    • (2011) Lupus , vol.20 , pp. 120-124
    • Apostolidis, S.A.1    Crispin, J.C.2    Tsokos, G.C.3
  • 99
    • 84863131186 scopus 로고    scopus 로고
    • Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression
    • Chen Y., Shen S., Gorentla B.K., Gao J., Zhong X.P. Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol 2012, 188:1698-1707.
    • (2012) J Immunol , vol.188 , pp. 1698-1707
    • Chen, Y.1    Shen, S.2    Gorentla, B.K.3    Gao, J.4    Zhong, X.P.5
  • 100
    • 84857364650 scopus 로고    scopus 로고
    • Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis
    • Nie X., Cai G., Zhang W., Wang H., Wu B., Li Q., et al. Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis. Clin Immunol 2012, 142:269-279.
    • (2012) Clin Immunol , vol.142 , pp. 269-279
    • Nie, X.1    Cai, G.2    Zhang, W.3    Wang, H.4    Wu, B.5    Li, Q.6
  • 101
    • 84455199735 scopus 로고    scopus 로고
    • IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease
    • Whitehead G.S., Wilson R.H., Nakano K., Burch L.H., Nakano H., Cook D.N. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol 2012, 129:207-215.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 207-215
    • Whitehead, G.S.1    Wilson, R.H.2    Nakano, K.3    Burch, L.H.4    Nakano, H.5    Cook, D.N.6
  • 102
    • 79953037866 scopus 로고    scopus 로고
    • Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection
    • Nouailles G., Day T.A., Kuhlmann S., Loewe D., Dorhoi A., Gamradt P., et al. Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection. Eur J Immunol 2011, 41:981-991.
    • (2011) Eur J Immunol , vol.41 , pp. 981-991
    • Nouailles, G.1    Day, T.A.2    Kuhlmann, S.3    Loewe, D.4    Dorhoi, A.5    Gamradt, P.6
  • 104
    • 84859515417 scopus 로고    scopus 로고
    • Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient mice
    • Ko H.J., Yang H., Yang J.Y., Seo S.U., Chang S.Y., Seong J.K., et al. Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient mice. Eur J Immunol 2012, 42:618-628.
    • (2012) Eur J Immunol , vol.42 , pp. 618-628
    • Ko, H.J.1    Yang, H.2    Yang, J.Y.3    Seo, S.U.4    Chang, S.Y.5    Seong, J.K.6
  • 108
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ
    • Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 2008, 28:29-39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 109
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt
    • Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., et al. Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt. J Biol Chem 2008, 283:17003-17008.
    • (2008) J Biol Chem , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3    Chinen, T.4    Saeki, K.5    Nakaya, M.6
  • 111
    • 67649216137 scopus 로고    scopus 로고
    • Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    • Mukherjee S., Schaller M.A., Neupane R., Kunkel S.L., Lukacs N.W. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol 2009, 182:7381-7388.
    • (2009) J Immunol , vol.182 , pp. 7381-7388
    • Mukherjee, S.1    Schaller, M.A.2    Neupane, R.3    Kunkel, S.L.4    Lukacs, N.W.5
  • 112
    • 66549106623 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
    • Stevens E.A., Mezrich J.D., Bradfield C.A. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 2009, 127:299-311.
    • (2009) Immunology , vol.127 , pp. 299-311
    • Stevens, E.A.1    Mezrich, J.D.2    Bradfield, C.A.3
  • 114
    • 77956469491 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells
    • Ramirez J.M., Brembilla N.C., Sorg O., Chicheportiche R., Matthes T., Dayer J.M., et al. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol 2010, 40:2450-2459.
    • (2010) Eur J Immunol , vol.40 , pp. 2450-2459
    • Ramirez, J.M.1    Brembilla, N.C.2    Sorg, O.3    Chicheportiche, R.4    Matthes, T.5    Dayer, J.M.6
  • 116
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals
    • Martin B., Hirota K., Cua D.J., Stockinger B., Veldhoen M. Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009, 31:321-330.
    • (2009) Immunity , vol.31 , pp. 321-330
    • Martin, B.1    Hirota, K.2    Cua, D.J.3    Stockinger, B.4    Veldhoen, M.5
  • 117
    • 50949098849 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase
    • Vogel C.F., Goth S.R., Dong B., Pessah I.N., Matsumura F. Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 2008, 375:331-335.
    • (2008) Biochem Biophys Res Commun , vol.375 , pp. 331-335
    • Vogel, C.F.1    Goth, S.R.2    Dong, B.3    Pessah, I.N.4    Matsumura, F.5
  • 118
    • 47749107262 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
    • Kimura A., Naka T., Nohara K., Fujii-Kuriyama Y., Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A 2008, 105:9721-9726.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9721-9726
    • Kimura, A.1    Naka, T.2    Nohara, K.3    Fujii-Kuriyama, Y.4    Kishimoto, T.5
  • 119
    • 80051676534 scopus 로고    scopus 로고
    • Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis
    • Singh N.P., Singh U.P., Singh B., Price R.L., Nagarkatti M., Nagarkatti P.S. Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. PLoS ONE 2011, 6:e23522.
    • (2011) PLoS ONE , vol.6
    • Singh, N.P.1    Singh, U.P.2    Singh, B.3    Price, R.L.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 121
    • 0345575181 scopus 로고    scopus 로고
    • Cytokines and STAT signaling
    • Schindler C., Strehlow I. Cytokines and STAT signaling. Adv Pharmacol 2000, 47:113-174.
    • (2000) Adv Pharmacol , vol.47 , pp. 113-174
    • Schindler, C.1    Strehlow, I.2
  • 122
    • 68949131070 scopus 로고    scopus 로고
    • + T helper cell differentiation and inflammatory diseases
    • + T helper cell differentiation and inflammatory diseases. Cytokine 2009, 47:149-156.
    • (2009) Cytokine , vol.47 , pp. 149-156
    • Egwuagu, C.E.1
  • 123
    • 34548317417 scopus 로고    scopus 로고
    • Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    • Minegishi Y., Saito M., Tsuchiya S., Tsuge I., Takada H., Hara T., et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 2007, 448:1058-1062.
    • (2007) Nature , vol.448 , pp. 1058-1062
    • Minegishi, Y.1    Saito, M.2    Tsuchiya, S.3    Tsuge, I.4    Takada, H.5    Hara, T.6
  • 125
    • 67449149963 scopus 로고    scopus 로고
    • Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    • Minegishi Y., Saito M., Nagasawa M., Takada H., Hara T., Tsuchiya S., et al. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med 2009, 206:1291-1301.
    • (2009) J Exp Med , vol.206 , pp. 1291-1301
    • Minegishi, Y.1    Saito, M.2    Nagasawa, M.3    Takada, H.4    Hara, T.5    Tsuchiya, S.6
  • 126
    • 44449136105 scopus 로고    scopus 로고
    • + T cells prevents development of experimental autoimmune diseases
    • + T cells prevents development of experimental autoimmune diseases. J Immunol 2008, 180:6070-6076.
    • (2008) J Immunol , vol.180 , pp. 6070-6076
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 129
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009, 10:595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 131
    • 77956361520 scopus 로고    scopus 로고
    • Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    • Biswas P.S., Gupta S., Chang E., Song L., Stirzaker R.A., Liao J.K., et al. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest 2010, 120:3280-3295.
    • (2010) J Clin Invest , vol.120 , pp. 3280-3295
    • Biswas, P.S.1    Gupta, S.2    Chang, E.3    Song, L.4    Stirzaker, R.A.5    Liao, J.K.6
  • 132
    • 57449105853 scopus 로고    scopus 로고
    • IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    • Chen Q., Yang W., Gupta S., Biswas P., Smith P., Bhagat G., et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 2008, 29:899-911.
    • (2008) Immunity , vol.29 , pp. 899-911
    • Chen, Q.1    Yang, W.2    Gupta, S.3    Biswas, P.4    Smith, P.5    Bhagat, G.6
  • 134
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H., Thierry-Mieg D., Thierry-Mieg J., Kim H.P., Oh J., Tunyaplin C., et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009, 31:941-952.
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1    Thierry-Mieg, D.2    Thierry-Mieg, J.3    Kim, H.P.4    Oh, J.5    Tunyaplin, C.6
  • 135
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt V., Bothur E., Klein M., Lingnau K., Reuter S., Grebe N., et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 2010, 33:192-202.
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1    Bothur, E.2    Klein, M.3    Lingnau, K.4    Reuter, S.5    Grebe, N.6
  • 136
    • 84861534971 scopus 로고    scopus 로고
    • Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs
    • Mao Z.J., Tang Q.J., Zhang C.A., Qin Z.F., Pang B., Wei P.K., et al. Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs. Int J Mol Sci 2012, 13:6521-6533.
    • (2012) Int J Mol Sci , vol.13 , pp. 6521-6533
    • Mao, Z.J.1    Tang, Q.J.2    Zhang, C.A.3    Qin, Z.F.4    Pang, B.5    Wei, P.K.6
  • 137
    • 84862868009 scopus 로고    scopus 로고
    • HIF-mediated endothelial response during cancer progression
    • Evans C.E., Branco-Price C., Johnson R.S. HIF-mediated endothelial response during cancer progression. Int J Hematol 2012, 95:471-477.
    • (2012) Int J Hematol , vol.95 , pp. 471-477
    • Evans, C.E.1    Branco-Price, C.2    Johnson, R.S.3
  • 138
    • 84860294684 scopus 로고    scopus 로고
    • Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
    • Harada H., Inoue M., Itasaka S., Hirota K., Morinibu A., Shinomiya K., et al. Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun 2012, 3:783.
    • (2012) Nat Commun , vol.3 , pp. 783
    • Harada, H.1    Inoue, M.2    Itasaka, S.3    Hirota, K.4    Morinibu, A.5    Shinomiya, K.6
  • 140
    • 84863821856 scopus 로고    scopus 로고
    • IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    • Hot A., Zrioual S., Lenief V., Miossec P. IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes. Ann Rheum Dis 2012, 71:1393-1401.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1393-1401
    • Hot, A.1    Zrioual, S.2    Lenief, V.3    Miossec, P.4
  • 142
    • 77149139874 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications
    • Westra J., Molema G., Kallenberg C.G. Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications. Curr Med Chem 2010, 17:254-263.
    • (2010) Curr Med Chem , vol.17 , pp. 254-263
    • Westra, J.1    Molema, G.2    Kallenberg, C.G.3
  • 143
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    • Semenza G.L. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012, 33:207-214.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 144
    • 0038756487 scopus 로고    scopus 로고
    • The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis
    • Salnikow K., Davidson T., Zhang Q., Chen L.C., Su W., Costa M. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 2003, 63:3524-3530.
    • (2003) Cancer Res , vol.63 , pp. 3524-3530
    • Salnikow, K.1    Davidson, T.2    Zhang, Q.3    Chen, L.C.4    Su, W.5    Costa, M.6
  • 145
    • 77449092116 scopus 로고    scopus 로고
    • BATF: bringing (in) another Th17-regulating factor
    • Martinez G.J., Dong C. BATF: bringing (in) another Th17-regulating factor. J Mol Cell Biol 2009, 1:66-68.
    • (2009) J Mol Cell Biol , vol.1 , pp. 66-68
    • Martinez, G.J.1    Dong, C.2
  • 147
    • 79956081339 scopus 로고    scopus 로고
    • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    • Ise W., Kohyama M., Schraml B.U., Zhang T., Schwer B., Basu U., et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol 2011, 12:536-543.
    • (2011) Nat Immunol , vol.12 , pp. 536-543
    • Ise, W.1    Kohyama, M.2    Schraml, B.U.3    Zhang, T.4    Schwer, B.5    Basu, U.6
  • 148
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang F., Meng G., Strober W. Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008, 9:1297-1306.
    • (2008) Nat Immunol , vol.9 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 150
    • 79952769599 scopus 로고    scopus 로고
    • RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells
    • Powolny-Budnicka I., Riemann M., Tanzer S., Schmid R.M., Hehlgans T., Weih F. RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells. Immunity 2011, 34:364-374.
    • (2011) Immunity , vol.34 , pp. 364-374
    • Powolny-Budnicka, I.1    Riemann, M.2    Tanzer, S.3    Schmid, R.M.4    Hehlgans, T.5    Weih, F.6
  • 151
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression
    • Luo J.L., Maeda S., Hsu L.C., Yagita H., Karin M. Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression. Cancer Cell 2004, 6:297-305.
    • (2004) Cancer Cell , vol.6 , pp. 297-305
    • Luo, J.L.1    Maeda, S.2    Hsu, L.C.3    Yagita, H.4    Karin, M.5
  • 152
    • 44849100198 scopus 로고    scopus 로고
    • NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
    • Rius J., Guma M., Schachtrup C., Akassoglou K., Zinkernagel A.S., Nizet V., et al. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 2008, 453:807-811.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 154
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S., Pettaway C.A., Uehara H., Bucana C.D., Fidler I.J. Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001, 20:4188-4197.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 155
    • 84867070588 scopus 로고    scopus 로고
    • NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model
    • Pacak K., Sirova M., Giubellino A., Lencesova L., Csaderova L., Laukova M., et al. NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model. Int J Cancer 2012, 131:2445-2455.
    • (2012) Int J Cancer , vol.131 , pp. 2445-2455
    • Pacak, K.1    Sirova, M.2    Giubellino, A.3    Lencesova, L.4    Csaderova, L.5    Laukova, M.6
  • 156
    • 84855395230 scopus 로고    scopus 로고
    • Defective NF-κB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA
    • Umemura N., Zhu J., Mburu Y.K., Forero A., Hsieh P.N., Muthuswamy R., et al. Defective NF-κB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by double-stranded RNA. Cancer Res 2012, 72:45-55.
    • (2012) Cancer Res , vol.72 , pp. 45-55
    • Umemura, N.1    Zhu, J.2    Mburu, Y.K.3    Forero, A.4    Hsieh, P.N.5    Muthuswamy, R.6
  • 157
    • 84858337114 scopus 로고    scopus 로고
    • Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
    • Jennewein C., Karl S., Baumann B., Micheau O., Debatin K.M., Fulda S. Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene 2012, 31:1468-1474.
    • (2012) Oncogene , vol.31 , pp. 1468-1474
    • Jennewein, C.1    Karl, S.2    Baumann, B.3    Micheau, O.4    Debatin, K.M.5    Fulda, S.6
  • 158
    • 83055194567 scopus 로고    scopus 로고
    • The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway
    • Sareddy G.R., Geeviman K., Ramulu C., Babu P.P. The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway. J Neurooncol 2012, 106:99-109.
    • (2012) J Neurooncol , vol.106 , pp. 99-109
    • Sareddy, G.R.1    Geeviman, K.2    Ramulu, C.3    Babu, P.P.4
  • 159
    • 77956944349 scopus 로고    scopus 로고
    • Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel
    • Chen G., Hardy K., Bunting K., Daley S., Ma L., Shannon M.F. Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol 2010, 185:2350-2359.
    • (2010) J Immunol , vol.185 , pp. 2350-2359
    • Chen, G.1    Hardy, K.2    Bunting, K.3    Daley, S.4    Ma, L.5    Shannon, M.F.6
  • 162
    • 64249090036 scopus 로고    scopus 로고
    • The cyclic AMP response element modulator α suppresses CD86 expression and APC function
    • Ahlmann M., Varga G., Sturm K., Lippe R., Benedyk K., Viemann D., et al. The cyclic AMP response element modulator α suppresses CD86 expression and APC function. J Immunol 2009, 182:4167-4174.
    • (2009) J Immunol , vol.182 , pp. 4167-4174
    • Ahlmann, M.1    Varga, G.2    Sturm, K.3    Lippe, R.4    Benedyk, K.5    Viemann, D.6
  • 163
    • 84856880805 scopus 로고    scopus 로고
    • CAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE)
    • Hedrich C.M., Rauen T., Kis-Toth K., Kyttaris V.C., Tsokos G.C. cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J Biol Chem 2012, 287:4715-4725.
    • (2012) J Biol Chem , vol.287 , pp. 4715-4725
    • Hedrich, C.M.1    Rauen, T.2    Kis-Toth, K.3    Kyttaris, V.C.4    Tsokos, G.C.5
  • 164
    • 83355166950 scopus 로고    scopus 로고
    • CAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus
    • Hedrich C.M., Rauen T., Tsokos G.C. cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J Biol Chem 2011, 286:43429-43436.
    • (2011) J Biol Chem , vol.286 , pp. 43429-43436
    • Hedrich, C.M.1    Rauen, T.2    Tsokos, G.C.3
  • 165
    • 83355166923 scopus 로고    scopus 로고
    • CAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
    • Rauen T., Hedrich C.M., Juang Y.T., Tenbrock K., Tsokos G.C. cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J Biol Chem 2011, 286:43437-43446.
    • (2011) J Biol Chem , vol.286 , pp. 43437-43446
    • Rauen, T.1    Hedrich, C.M.2    Juang, Y.T.3    Tenbrock, K.4    Tsokos, G.C.5
  • 166
    • 77954905757 scopus 로고    scopus 로고
    • Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells
    • Ishizu A., Abe A., Miyatake Y., Baba T., Iinuma C., Tomaru U., et al. Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells. Mod Rheumatol 2010, 20:134-138.
    • (2010) Mod Rheumatol , vol.20 , pp. 134-138
    • Ishizu, A.1    Abe, A.2    Miyatake, Y.3    Baba, T.4    Iinuma, C.5    Tomaru, U.6
  • 167
    • 79551545978 scopus 로고    scopus 로고
    • Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
    • Cui G., Qin X., Wu L., Zhang Y., Sheng X., Yu Q., et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest 2011, 121:658-670.
    • (2011) J Clin Invest , vol.121 , pp. 658-670
    • Cui, G.1    Qin, X.2    Wu, L.3    Zhang, Y.4    Sheng, X.5    Yu, Q.6
  • 169
    • 79955031250 scopus 로고    scopus 로고
    • T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis
    • Yu Q., Sharma A., Ghosh A., Sen J.M. T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis. J Immunol 2011, 186:3946-3952.
    • (2011) J Immunol , vol.186 , pp. 3946-3952
    • Yu, Q.1    Sharma, A.2    Ghosh, A.3    Sen, J.M.4
  • 170
    • 80052859027 scopus 로고    scopus 로고
    • Critical role of TCF-1 in repression of the IL-17 gene
    • Ma J., Wang R., Fang X., Ding Y., Sun Z. Critical role of TCF-1 in repression of the IL-17 gene. PLoS ONE 2011, 6:e24768.
    • (2011) PLoS ONE , vol.6
    • Ma, J.1    Wang, R.2    Fang, X.3    Ding, Y.4    Sun, Z.5
  • 171
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: components, mechanisms, and diseases
    • MacDonald B.T., Tamai K., He X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009, 17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 172
    • 11144357288 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α agonists as therapy for autoimmune disease
    • Lovett-Racke A.E., Hussain R.Z., Northrop S., Choy J., Rocchini A., Matthes L., et al. Peroxisome proliferator-activated receptor α agonists as therapy for autoimmune disease. J Immunol 2004, 172:5790-5798.
    • (2004) J Immunol , vol.172 , pp. 5790-5798
    • Lovett-Racke, A.E.1    Hussain, R.Z.2    Northrop, S.3    Choy, J.4    Rocchini, A.5    Matthes, L.6
  • 173
    • 1242317642 scopus 로고    scopus 로고
    • Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
    • Diab A., Hussain R.Z., Lovett-Racke A.E., Chavis J.A., Drew P.D., Racke M.K. Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. J Neuroimmunol 2004, 148:116-126.
    • (2004) J Neuroimmunol , vol.148 , pp. 116-126
    • Diab, A.1    Hussain, R.Z.2    Lovett-Racke, A.E.3    Chavis, J.A.4    Drew, P.D.5    Racke, M.K.6
  • 174
    • 33748119493 scopus 로고    scopus 로고
    • PPARγ antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Δ 12,14-prostaglandin J2
    • Raikwar H.P., Muthian G., Rajasingh J., Johnson C.N., Bright J.J. PPARγ antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Δ 12,14-prostaglandin J2. J Neuroimmunol 2006, 178:76-86.
    • (2006) J Neuroimmunol , vol.178 , pp. 76-86
    • Raikwar, H.P.1    Muthian, G.2    Rajasingh, J.3    Johnson, C.N.4    Bright, J.J.5
  • 175
    • 70350459594 scopus 로고    scopus 로고
    • The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    • Klotz L., Burgdorf S., Dani I., Saijo K., Flossdorf J., Hucke S., et al. The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 2009, 206:2079-2089.
    • (2009) J Exp Med , vol.206 , pp. 2079-2089
    • Klotz, L.1    Burgdorf, S.2    Dani, I.3    Saijo, K.4    Flossdorf, J.5    Hucke, S.6
  • 176
    • 79851512548 scopus 로고    scopus 로고
    • PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis
    • Kanakasabai S., Walline C.C., Chakraborty S., Bright J.J. PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis. Brain Res 2011, 1376:101-112.
    • (2011) Brain Res , vol.1376 , pp. 101-112
    • Kanakasabai, S.1    Walline, C.C.2    Chakraborty, S.3    Bright, J.J.4
  • 177
    • 84857037067 scopus 로고    scopus 로고
    • + T cells through PPARγ nuclear receptor activation and protects cardiac allografts
    • + T cells through PPARγ nuclear receptor activation and protects cardiac allografts. J Surg Res 2012, 173:161-170.
    • (2012) J Surg Res , vol.173 , pp. 161-170
    • Ye, P.1    Li, J.2    Wang, S.3    Xie, A.4    Sun, W.5    Xia, J.6
  • 179
    • 80053502126 scopus 로고    scopus 로고
    • CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation
    • Qui H.Z., Hagymasi A.T., Bandyopadhyay S., St Rose M.C., Ramanarasimhaiah R., Menoret A., et al. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol 2011, 187:3555-3564.
    • (2011) J Immunol , vol.187 , pp. 3555-3564
    • Qui, H.Z.1    Hagymasi, A.T.2    Bandyopadhyay, S.3    St Rose, M.C.4    Ramanarasimhaiah, R.5    Menoret, A.6
  • 180
    • 84862777436 scopus 로고    scopus 로고
    • The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation
    • Gordon S.M., Chaix J., Rupp L.J., Wu J., Madera S., Sun J.C., et al. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 2012, 36:55-67.
    • (2012) Immunity , vol.36 , pp. 55-67
    • Gordon, S.M.1    Chaix, J.2    Rupp, L.J.3    Wu, J.4    Madera, S.5    Sun, J.C.6
  • 181
    • 82055197492 scopus 로고    scopus 로고
    • Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3
    • Endo Y., Iwamura C., Kuwahara M., Suzuki A., Sugaya K., Tumes D.J., et al. Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 2011, 35:733-745.
    • (2011) Immunity , vol.35 , pp. 733-745
    • Endo, Y.1    Iwamura, C.2    Kuwahara, M.3    Suzuki, A.4    Sugaya, K.5    Tumes, D.J.6
  • 183
    • 84155170679 scopus 로고    scopus 로고
    • IL-4 acts as a potent stimulator of IFN-γ expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet
    • Oliver J.A., Stolberg V.R., Chensue S.W., King P.D. IL-4 acts as a potent stimulator of IFN-γ expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet. Cytokine 2012, 57:191-199.
    • (2012) Cytokine , vol.57 , pp. 191-199
    • Oliver, J.A.1    Stolberg, V.R.2    Chensue, S.W.3    King, P.D.4
  • 185
    • 80052508971 scopus 로고    scopus 로고
    • IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease
    • Mukherjee S., Lindell D.M., Berlin A.A., Morris S.B., Shanley T.P., Hershenson M.B., et al. IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease. Am J Pathol 2011, 179:248-258.
    • (2011) Am J Pathol , vol.179 , pp. 248-258
    • Mukherjee, S.1    Lindell, D.M.2    Berlin, A.A.3    Morris, S.B.4    Shanley, T.P.5    Hershenson, M.B.6
  • 186
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
    • Powell J.D., Delgoffe G.M. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 2010, 33:301-311.
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 187
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe G.M., Pollizzi K.N., Waickman A.T., Heikamp E., Meyers D.J., Horton M.R., et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 2011, 12:295-303.
    • (2011) Nat Immunol , vol.12 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6
  • 188
    • 84555189464 scopus 로고    scopus 로고
    • Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes
    • Delgoffe G.M., Powell J.D. Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes. Methods Mol Biol 2012, 821:317-327.
    • (2012) Methods Mol Biol , vol.821 , pp. 317-327
    • Delgoffe, G.M.1    Powell, J.D.2
  • 189
    • 74649086985 scopus 로고    scopus 로고
    • The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
    • Gulen M.F., Kang Z., Bulek K., Youzhong W., Kim T.W., Chen Y., et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010, 32:54-66.
    • (2010) Immunity , vol.32 , pp. 54-66
    • Gulen, M.F.1    Kang, Z.2    Bulek, K.3    Youzhong, W.4    Kim, T.W.5    Chen, Y.6
  • 190
    • 79952320231 scopus 로고    scopus 로고
    • The evolving role of mTOR inhibition in transplantation tolerance
    • McMahon G., Weir M.R., Li X.C., Mandelbrot D.A. The evolving role of mTOR inhibition in transplantation tolerance. J Am Soc Nephrol 2011, 22:408-415.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 408-415
    • McMahon, G.1    Weir, M.R.2    Li, X.C.3    Mandelbrot, D.A.4
  • 191
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma J., Meng Y., Kwiatkowski D.J., Chen X., Peng H., Sun Q., et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 2010, 120:103-114.
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3    Chen, X.4    Peng, H.5    Sun, Q.6
  • 192
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Lee K., Gudapati P., Dragovic S., Spencer C., Joyce S., Killeen N., et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010, 32:743-753.
    • (2010) Immunity , vol.32 , pp. 743-753
    • Lee, K.1    Gudapati, P.2    Dragovic, S.3    Spencer, C.4    Joyce, S.5    Killeen, N.6
  • 193
    • 79955559622 scopus 로고    scopus 로고
    • Interleukin-17-induced proliferation of fibroblast-like synovial cells is mTOR dependent
    • Saxena A., Raychaudhuri S.K., Raychaudhuri S.P. Interleukin-17-induced proliferation of fibroblast-like synovial cells is mTOR dependent. Arthritis Rheum 2011, 63:1465-1466.
    • (2011) Arthritis Rheum , vol.63 , pp. 1465-1466
    • Saxena, A.1    Raychaudhuri, S.K.2    Raychaudhuri, S.P.3
  • 194
    • 80052608274 scopus 로고    scopus 로고
    • Involvement of mTOR in CXCL12 mediated T cell signaling and migration
    • Munk R., Ghosh P., Ghosh M.C., Saito T., Xu M., Carter A., et al. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS ONE 2011, 6:e24667.
    • (2011) PLoS ONE , vol.6
    • Munk, R.1    Ghosh, P.2    Ghosh, M.C.3    Saito, T.4    Xu, M.5    Carter, A.6
  • 195
    • 84859508518 scopus 로고    scopus 로고
    • Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells
    • Chen G., Chen S.M., Wang X., Ding X.F., Ding J., Meng L.H. Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. J Biol Chem 2012, 287:12132-12141.
    • (2012) J Biol Chem , vol.287 , pp. 12132-12141
    • Chen, G.1    Chen, S.M.2    Wang, X.3    Ding, X.F.4    Ding, J.5    Meng, L.H.6
  • 196
    • 7944223834 scopus 로고    scopus 로고
    • Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
    • Chan S. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer 2004, 91:1420-1424.
    • (2004) Br J Cancer , vol.91 , pp. 1420-1424
    • Chan, S.1
  • 197
    • 79953800720 scopus 로고    scopus 로고
    • Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation
    • Bestard O., Cassis L., Cruzado J.M., Torras J., Franquesa M., Gil-Vernet S., et al. Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int 2011, 24:451-460.
    • (2011) Transpl Int , vol.24 , pp. 451-460
    • Bestard, O.1    Cassis, L.2    Cruzado, J.M.3    Torras, J.4    Franquesa, M.5    Gil-Vernet, S.6
  • 198
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe G.M., Kole T.P., Zheng Y., Zarek P.E., Matthews K.L., Xiao B., et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009, 30:832-844.
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3    Zarek, P.E.4    Matthews, K.L.5    Xiao, B.6
  • 200
    • 79960725910 scopus 로고    scopus 로고
    • The influence of mTOR on T helper cell differentiation and dendritic cell function
    • Salmond R.J., Zamoyska R. The influence of mTOR on T helper cell differentiation and dendritic cell function. Eur J Immunol 2011, 41:2137-2141.
    • (2011) Eur J Immunol , vol.41 , pp. 2137-2141
    • Salmond, R.J.1    Zamoyska, R.2
  • 201
    • 84864120321 scopus 로고    scopus 로고
    • The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite
    • Simarro M., Giannattasio G., Xing W., Lundequist E.M., Stewart S., Stevens R.L., et al. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett 2012, 146:8-14.
    • (2012) Immunol Lett , vol.146 , pp. 8-14
    • Simarro, M.1    Giannattasio, G.2    Xing, W.3    Lundequist, E.M.4    Stewart, S.5    Stevens, R.L.6
  • 202
    • 80053625750 scopus 로고    scopus 로고
    • Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR
    • Damgaard C.K., Lykke-Andersen J. Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev 2011, 25:2057-2068.
    • (2011) Genes Dev , vol.25 , pp. 2057-2068
    • Damgaard, C.K.1    Lykke-Andersen, J.2
  • 203
    • 80053608499 scopus 로고    scopus 로고
    • IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
    • Liao W., Lin J.X., Leonard W.J. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol 2011, 23:598-604.
    • (2011) Curr Opin Immunol , vol.23 , pp. 598-604
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 204
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007, 26:371-381.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 205
    • 79956085895 scopus 로고    scopus 로고
    • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    • Liao W., Lin J.X., Wang L., Li P., Leonard W.J. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol 2011, 12:551-559.
    • (2011) Nat Immunol , vol.12 , pp. 551-559
    • Liao, W.1    Lin, J.X.2    Wang, L.3    Li, P.4    Leonard, W.J.5
  • 207
    • 33845942398 scopus 로고    scopus 로고
    • Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity
    • Carrier Y., Yuan J., Kuchroo V.K., Weiner H.L. Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J Immunol 2007, 178:172-178.
    • (2007) J Immunol , vol.178 , pp. 172-178
    • Carrier, Y.1    Yuan, J.2    Kuchroo, V.K.3    Weiner, H.L.4
  • 208
    • 41449113342 scopus 로고    scopus 로고
    • Advances in understanding the anti-inflammatory properties of IL-27
    • Stumhofer J.S., Hunter C.A. Advances in understanding the anti-inflammatory properties of IL-27. Immunol Lett 2008, 117:123-130.
    • (2008) Immunol Lett , vol.117 , pp. 123-130
    • Stumhofer, J.S.1    Hunter, C.A.2
  • 209
    • 79955756479 scopus 로고    scopus 로고
    • Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1
    • Liu H., Rohowsky-Kochan C. Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J Interferon Cytokine Res 2011, 31:459-469.
    • (2011) J Interferon Cytokine Res , vol.31 , pp. 459-469
    • Liu, H.1    Rohowsky-Kochan, C.2
  • 211
    • 75749091859 scopus 로고    scopus 로고
    • Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    • Kalliolias G.D., Zhao B., Triantafyllopoulou A., Park-Min K.H., Ivashkiv L.B. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum 2010, 62:402-413.
    • (2010) Arthritis Rheum , vol.62 , pp. 402-413
    • Kalliolias, G.D.1    Zhao, B.2    Triantafyllopoulou, A.3    Park-Min, K.H.4    Ivashkiv, L.B.5
  • 212
    • 79955064497 scopus 로고    scopus 로고
    • Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells
    • Sasaoka T., Ito M., Yamashita J., Nakajima K., Tanaka I., Narita M., et al. Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells. Am J Physiol Gastrointest Liver Physiol 2011, 300:568-576.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. 568-576
    • Sasaoka, T.1    Ito, M.2    Yamashita, J.3    Nakajima, K.4    Tanaka, I.5    Narita, M.6
  • 213
    • 84857774124 scopus 로고    scopus 로고
    • The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases
    • Toussirot E. The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases. Inflamm Allergy Drug Targets 2012, 11:159-168.
    • (2012) Inflamm Allergy Drug Targets , vol.11 , pp. 159-168
    • Toussirot, E.1
  • 214
    • 79953164591 scopus 로고    scopus 로고
    • External influences on the immune system via activation of the aryl hydrocarbon receptor
    • Stockinger B., Hirota K., Duarte J., Veldhoen M. External influences on the immune system via activation of the aryl hydrocarbon receptor. Semin Immunol 2011, 23:99-105.
    • (2011) Semin Immunol , vol.23 , pp. 99-105
    • Stockinger, B.1    Hirota, K.2    Duarte, J.3    Veldhoen, M.4
  • 215
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov I.I., Atarashi K., Manel N., Brodie E.L., Shima T., Karaoz U., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 216
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • Ziolkowska M., Koc A., Luszczykiewicz G., Ksiezopolska-Pietrzak K., Klimczak E., Chwalinska-Sadowska H., et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000, 164:2832-2838.
    • (2000) J Immunol , vol.164 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3    Ksiezopolska-Pietrzak, K.4    Klimczak, E.5    Chwalinska-Sadowska, H.6
  • 217
    • 83555174764 scopus 로고    scopus 로고
    • IL-17 receptor and its functional significance in psoriatic arthritis
    • Raychaudhuri S.P., Raychaudhuri S.K., Genovese M.C. IL-17 receptor and its functional significance in psoriatic arthritis. Mol Cell Biochem 2012, 359:419-429.
    • (2012) Mol Cell Biochem , vol.359 , pp. 419-429
    • Raychaudhuri, S.P.1    Raychaudhuri, S.K.2    Genovese, M.C.3
  • 218
    • 79952314412 scopus 로고    scopus 로고
    • Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitro
    • Freysdottir J., Sigurpalsson M.B., Omarsdottir S., Olafsdottir E.S., Vikingsson A., Hardardottir I. Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitro. Immunol Lett 2011, 136:90-96.
    • (2011) Immunol Lett , vol.136 , pp. 90-96
    • Freysdottir, J.1    Sigurpalsson, M.B.2    Omarsdottir, S.3    Olafsdottir, E.S.4    Vikingsson, A.5    Hardardottir, I.6


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