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Volumn 60, Issue 2, 2010, Pages 61-66

IL-21 in the pathogenesis and treatment of skin diseases

Author keywords

Atopic dermatitis; IL 21; Immune mediated skin diseases; Melanoma; Psoriasis

Indexed keywords

INTERLEUKIN 21; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 18; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 21; UNCLASSIFIED DRUG;

EID: 77958512341     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.08.016     Document Type: Review
Times cited : (32)

References (58)
  • 1
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3    Hammond, A.4    Sprecher, C.5    Gross, J.A.6
  • 2
    • 33845903869 scopus 로고    scopus 로고
    • IL-21-induced B cell apoptosis mediated by natural killer T cells suppresses IgE responses
    • Harada M., Magara-Koyanagi K., Watarai H., Nagata Y., Ishii Y., Kojo S., et al. IL-21-induced B cell apoptosis mediated by natural killer T cells suppresses IgE responses. J Exp Med 2006, 203:2929-2937.
    • (2006) J Exp Med , vol.203 , pp. 2929-2937
    • Harada, M.1    Magara-Koyanagi, K.2    Watarai, H.3    Nagata, Y.4    Ishii, Y.5    Kojo, S.6
  • 3
    • 34250761481 scopus 로고    scopus 로고
    • An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma
    • Davis I.D., Skrumsager B.K., Cebon J., Nicholaou T., Barlow J.W., Moller N.P., et al. An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma. Clin Cancer Res 2007, 13:3630-3636.
    • (2007) Clin Cancer Res , vol.13 , pp. 3630-3636
    • Davis, I.D.1    Skrumsager, B.K.2    Cebon, J.3    Nicholaou, T.4    Barlow, J.W.5    Moller, N.P.6
  • 5
    • 33847074166 scopus 로고    scopus 로고
    • Regulation of IL-21signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes
    • Gagnon J., Ramanathan S., Leblanc C., Ilangumaran S. Regulation of IL-21signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes. Cell Signal 2007, 19:806-816.
    • (2007) Cell Signal , vol.19 , pp. 806-816
    • Gagnon, J.1    Ramanathan, S.2    Leblanc, C.3    Ilangumaran, S.4
  • 6
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R., Sims G.P., Fairhurst A.M., Robbins R., da Silva Y.S., Spolski R., et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005, 175:7867-7879.
    • (2005) J Immunol , vol.175 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3    Robbins, R.4    da Silva, Y.S.5    Spolski, R.6
  • 7
    • 23444445913 scopus 로고    scopus 로고
    • IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
    • Li Y., Bleakley M., Yee C. IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response. J Immunol 2005, 175:2261-2269.
    • (2005) J Immunol , vol.175 , pp. 2261-2269
    • Li, Y.1    Bleakley, M.2    Yee, C.3
  • 9
    • 34547232503 scopus 로고    scopus 로고
    • IL-21initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T., Bettelli E., Gao W., Awasthi A., Jäger A., Strom T.B., et al. IL-21initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448:484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jäger, A.5    Strom, T.B.6
  • 10
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007, 448:480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 11
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell M., Sareneva T., Foster D., Julkunen I., Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002, 169:3600-3605.
    • (2002) J Immunol , vol.169 , pp. 3600-3605
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 12
    • 33846196712 scopus 로고    scopus 로고
    • IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
    • Peluso I., Fantini M.C., Fina D., Caruso R., Boirivant M., MacDonald T.T., et al. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 2007, 178:732-739.
    • (2007) J Immunol , vol.178 , pp. 732-739
    • Peluso, I.1    Fantini, M.C.2    Fina, D.3    Caruso, R.4    Boirivant, M.5    MacDonald, T.T.6
  • 13
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady J., Hayakawa Y., Smyth M.J., Nutt S.L. IL-21 induces the functional maturation of murine NK cells. J Immunol 2004, 172:2048-2058.
    • (2004) J Immunol , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 14
    • 69949142054 scopus 로고    scopus 로고
    • Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis
    • Caruso R., Botti E., Sarra M., Esposito M., Stolfi C., Diluvio L., et al. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med 2009, 15:1013-1015.
    • (2009) Nat Med , vol.15 , pp. 1013-1015
    • Caruso, R.1    Botti, E.2    Sarra, M.3    Esposito, M.4    Stolfi, C.5    Diluvio, L.6
  • 15
    • 33846248387 scopus 로고    scopus 로고
    • A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
    • Caruso R., Fina D., Peluso I., Stolfi C., Fantini M.C., Gioia V., et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 2007, 132:166-175.
    • (2007) Gastroenterology , vol.132 , pp. 166-175
    • Caruso, R.1    Fina, D.2    Peluso, I.3    Stolfi, C.4    Fantini, M.C.5    Gioia, V.6
  • 16
    • 33845447347 scopus 로고    scopus 로고
    • Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21
    • Monteleone G., Caruso R., Fina D., Peluso I., Gioia V., Stolfi C., et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 2006, 55:1774-1780.
    • (2006) Gut , vol.55 , pp. 1774-1780
    • Monteleone, G.1    Caruso, R.2    Fina, D.3    Peluso, I.4    Gioia, V.5    Stolfi, C.6
  • 17
    • 34247588626 scopus 로고    scopus 로고
    • IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis
    • Caruso R., Fina D., Peluso I., Fantini M.C., Tosti C., Del Vecchio Blanco G., et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol 2007, 178:5957-5965.
    • (2007) J Immunol , vol.178 , pp. 5957-5965
    • Caruso, R.1    Fina, D.2    Peluso, I.3    Fantini, M.C.4    Tosti, C.5    Del Vecchio Blanco, G.6
  • 18
    • 33749552196 scopus 로고    scopus 로고
    • Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    • Li J., Shen W., Kong K., Liu Z. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006, 64:515-522.
    • (2006) Scand J Immunol , vol.64 , pp. 515-522
    • Li, J.1    Shen, W.2    Kong, K.3    Liu, Z.4
  • 19
    • 33750360839 scopus 로고    scopus 로고
    • Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells
    • Ozaki K., Hishiya A., Hatanaka K., Nakajima H., Wang G., Hwu P., et al. Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol 2006, 84:224-230.
    • (2006) Int J Hematol , vol.84 , pp. 224-230
    • Ozaki, K.1    Hishiya, A.2    Hatanaka, K.3    Nakajima, H.4    Wang, G.5    Hwu, P.6
  • 22
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K., Spolski R., Ettinger R., Kim H.P., Wang G., Qi C.F., et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 2004, 173:5361-5371.
    • (2004) J Immunol , vol.173 , pp. 5361-5371
    • Ozaki, K.1    Spolski, R.2    Ettinger, R.3    Kim, H.P.4    Wang, G.5    Qi, C.F.6
  • 23
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D., Brown T.P., Liang S., Young D.A., Collins M., Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007, 178:3822-3830.
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6
  • 24
    • 77249098290 scopus 로고    scopus 로고
    • Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity
    • Wong C.K., Wong P.T., Tam L.S., Li E.K., Chen D.P., Lam C.W. Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity. J Clin Immunol 2010, 30:45-52.
    • (2010) J Clin Immunol , vol.30 , pp. 45-52
    • Wong, C.K.1    Wong, P.T.2    Tam, L.S.3    Li, E.K.4    Chen, D.P.5    Lam, C.W.6
  • 25
    • 64549104048 scopus 로고    scopus 로고
    • Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    • Festen E.A., Goyette P., Scott R., Annese V., Zhernakova A., Lian J., et al. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009, 58:799-804.
    • (2009) Gut , vol.58 , pp. 799-804
    • Festen, E.A.1    Goyette, P.2    Scott, R.3    Annese, V.4    Zhernakova, A.5    Lian, J.6
  • 26
    • 34347324029 scopus 로고    scopus 로고
    • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    • van Heel D.A., Franke L., Hunt K.A., Gwilliam R., Zhernakova A., Inouye M., et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007, 39:827-829.
    • (2007) Nat Genet , vol.39 , pp. 827-829
    • van Heel, D.A.1    Franke, L.2    Hunt, K.A.3    Gwilliam, R.4    Zhernakova, A.5    Inouye, M.6
  • 27
    • 43249083380 scopus 로고    scopus 로고
    • A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    • Liu Y., Helms C., Liao W., Zaba L.C., Duan S., Gardner J., et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008, 4:e1000041.
    • (2008) PLoS Genet , vol.4
    • Liu, Y.1    Helms, C.2    Liao, W.3    Zaba, L.C.4    Duan, S.5    Gardner, J.6
  • 28
    • 34247186263 scopus 로고    scopus 로고
    • Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes
    • Asano K., Ikegami H., Fujisawa T., Nishino M., Nojima K., Kawabata Y., et al. Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. Hum Immunol 2007, 68:384-391.
    • (2007) Hum Immunol , vol.68 , pp. 384-391
    • Asano, K.1    Ikegami, H.2    Fujisawa, T.3    Nishino, M.4    Nojima, K.5    Kawabata, Y.6
  • 29
    • 64549089608 scopus 로고    scopus 로고
    • Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
    • Teixeira V.H., Pierlot C., Migliorini P., Balsa A., Westhovens R., Barrera P., et al. Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study. Arthritis Res Ther 2009, 11:R45.
    • (2009) Arthritis Res Ther , vol.11
    • Teixeira, V.H.1    Pierlot, C.2    Migliorini, P.3    Balsa, A.4    Westhovens, R.5    Barrera, P.6
  • 30
    • 51849118676 scopus 로고    scopus 로고
    • A common exonic variant of interleukin21 confers susceptibility to atopic asthma
    • Chatterjee R., Batra J., Ghosh B. A common exonic variant of interleukin21 confers susceptibility to atopic asthma. Int Arch Allergy Immunol 2009, 148:137-146.
    • (2009) Int Arch Allergy Immunol , vol.148 , pp. 137-146
    • Chatterjee, R.1    Batra, J.2    Ghosh, B.3
  • 31
  • 33
    • 22344438901 scopus 로고    scopus 로고
    • Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    • Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 2005, 202:135-143.
    • (2005) J Exp Med , vol.202 , pp. 135-143
    • Nestle, F.O.1    Conrad, C.2    Tun-Kyi, A.3    Homey, B.4    Gombert, M.5    Boyman, O.6
  • 34
    • 3442901047 scopus 로고    scopus 로고
    • IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells
    • Strengell M., Julkunen I., Matikainen S. IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. J Leukoc Biol 2004, 76:416-422.
    • (2004) J Leukoc Biol , vol.76 , pp. 416-422
    • Strengell, M.1    Julkunen, I.2    Matikainen, S.3
  • 35
    • 77950538932 scopus 로고    scopus 로고
    • IL-21 regulates Th17 cells in rheumatoid arthritis
    • Niu X., He D., Zhang X., Yue T., Li N., Zhang J.Z., et al. IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol 2010, 71:334-341.
    • (2010) Hum Immunol , vol.71 , pp. 334-341
    • Niu, X.1    He, D.2    Zhang, X.3    Yue, T.4    Li, N.5    Zhang, J.Z.6
  • 36
    • 65249180981 scopus 로고    scopus 로고
    • A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+
    • Jang E., Cho S.H., Park H., Paik D.J., Kim J.M., Youn J. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+. J Immunol 2009, 182:4649-4656.
    • (2009) J Immunol , vol.182 , pp. 4649-4656
    • Jang, E.1    Cho, S.H.2    Park, H.3    Paik, D.J.4    Kim, J.M.5    Youn, J.6
  • 37
    • 14044262247 scopus 로고    scopus 로고
    • Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
    • Vollmer T.L., Liu R., Price M., Rhodes S., La C.A., Shi F.D. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 2005, 174:2696-2701.
    • (2005) J Immunol , vol.174 , pp. 2696-2701
    • Vollmer, T.L.1    Liu, R.2    Price, M.3    Rhodes, S.4    La, C.A.5    Shi, F.D.6
  • 38
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203:2673-2682.
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5    Kadono, Y.6
  • 39
    • 0035182727 scopus 로고    scopus 로고
    • Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint
    • Nickoloff B.J. Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint. J Cutan Pathol 2001, 28:57-64.
    • (2001) J Cutan Pathol , vol.28 , pp. 57-64
    • Nickoloff, B.J.1
  • 40
    • 67849120058 scopus 로고    scopus 로고
    • Interleukin-21 as a new therapeutic target for immune-mediated diseases
    • Monteleone G., Pallone F., Macdonald T.T. Interleukin-21 as a new therapeutic target for immune-mediated diseases. Trends Pharmacol Sci 2009, 30:441-447.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 441-447
    • Monteleone, G.1    Pallone, F.2    Macdonald, T.T.3
  • 41
    • 44549084734 scopus 로고    scopus 로고
    • Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses
    • Monteleone G., Pallone F., MacDonald T.T. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol 2008, 29:290-294.
    • (2008) Trends Immunol , vol.29 , pp. 290-294
    • Monteleone, G.1    Pallone, F.2    MacDonald, T.T.3
  • 42
    • 0345800718 scopus 로고    scopus 로고
    • Immune mechanisms leading to atopic dermatitis
    • Novak N., Bieber T., Leung D.Y. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 2003, 112(Suppl):S128-S139.
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.SUPPL
    • Novak, N.1    Bieber, T.2    Leung, D.Y.3
  • 43
    • 44649119864 scopus 로고    scopus 로고
    • Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms
    • Elias P.M., Hatano Y., Williams M.L. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008, 121:1337-1343.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1337-1343
    • Elias, P.M.1    Hatano, Y.2    Williams, M.L.3
  • 44
    • 33745353511 scopus 로고    scopus 로고
    • Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    • Weidinger S., Illig T., Baurecht H., Irvine A.D., Rodriguez E., Diaz-Lacava A., et al. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol 2006, 118:214-219.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 214-219
    • Weidinger, S.1    Illig, T.2    Baurecht, H.3    Irvine, A.D.4    Rodriguez, E.5    Diaz-Lacava, A.6
  • 45
    • 61749085092 scopus 로고    scopus 로고
    • IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice
    • Jin H., Oyoshi M.K., Le Y., Bianchi T., Koduru S., Mathias C.B., et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest 2009, 119:47-60.
    • (2009) J Clin Invest , vol.119 , pp. 47-60
    • Jin, H.1    Oyoshi, M.K.2    Le, Y.3    Bianchi, T.4    Koduru, S.5    Mathias, C.B.6
  • 46
    • 71649086164 scopus 로고    scopus 로고
    • Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases
    • Cooper G.S., Bynum M.L., Somers E.C. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun 2009, 33:197-207.
    • (2009) J Autoimmun , vol.33 , pp. 197-207
    • Cooper, G.S.1    Bynum, M.L.2    Somers, E.C.3
  • 47
    • 0345700834 scopus 로고    scopus 로고
    • Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response
    • Gilhar A., Landau M., Assy B., Ullmann Y., Shalaginov R., Serafimovich S., et al. Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response. Clin Immunol 2003, 106:181-187.
    • (2003) Clin Immunol , vol.106 , pp. 181-187
    • Gilhar, A.1    Landau, M.2    Assy, B.3    Ullmann, Y.4    Shalaginov, R.5    Serafimovich, S.6
  • 48
    • 0036634504 scopus 로고    scopus 로고
    • Epidemiology and genetics of alopecia areata
    • McDonagh A.J., Tazi-Ahnini R. Epidemiology and genetics of alopecia areata. Clin Exp Dermatol 2002, 27:405-409.
    • (2002) Clin Exp Dermatol , vol.27 , pp. 405-409
    • McDonagh, A.J.1    Tazi-Ahnini, R.2
  • 50
    • 33846623330 scopus 로고    scopus 로고
    • Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata
    • Martinez-Mir A., Zlotogorski A., Gordon D., Petukhova L., Mo J., Gilliam T.C., et al. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet 2007, 80:316-328.
    • (2007) Am J Hum Genet , vol.80 , pp. 316-328
    • Martinez-Mir, A.1    Zlotogorski, A.2    Gordon, D.3    Petukhova, L.4    Mo, J.5    Gilliam, T.C.6
  • 51
    • 77954223152 scopus 로고    scopus 로고
    • Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    • Petukhova L., Duvic M., Hordinsky M., Norris D., Price V., Shimomura Y., et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010, 466:113-117.
    • (2010) Nature , vol.466 , pp. 113-117
    • Petukhova, L.1    Duvic, M.2    Hordinsky, M.3    Norris, D.4    Price, V.5    Shimomura, Y.6
  • 52
    • 77949407794 scopus 로고    scopus 로고
    • Multivariate evaluation of pharmacological responses in early clinical trials - a study of rIL-21 in the treatment of patients with metastatic melanoma
    • Rasmussen M.A., Colding-Jørgensen M., Hansen L.T., Bro R. Multivariate evaluation of pharmacological responses in early clinical trials - a study of rIL-21 in the treatment of patients with metastatic melanoma. Br J Clin Pharmacol 2010, 69:379-390.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 379-390
    • Rasmussen, M.A.1    Colding-Jørgensen, M.2    Hansen, L.T.3    Bro, R.4
  • 53
    • 77951134921 scopus 로고    scopus 로고
    • Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma
    • Hashmi M.H., Van Veldhuizen P.J. Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma. Expert Opin Biol Ther 2010, 10:807-817.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 807-817
    • Hashmi, M.H.1    Van Veldhuizen, P.J.2
  • 54
    • 19944434230 scopus 로고    scopus 로고
    • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    • Zeng R., Spolski R., Finkelstein S.E., Oh S., Kovanen P.E., Hinrichs C.S., et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 2005, 201:139-148.
    • (2005) J Exp Med , vol.201 , pp. 139-148
    • Zeng, R.1    Spolski, R.2    Finkelstein, S.E.3    Oh, S.4    Kovanen, P.E.5    Hinrichs, C.S.6
  • 55
    • 0347320749 scopus 로고    scopus 로고
    • In vivo antitumor activity of interleukin 21 mediated by natural killer cells
    • Wang G., Tschoi M., Spolski R., Lou Y., Ozaki K., Feng C., et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res 2003, 63:9016-9022.
    • (2003) Cancer Res , vol.63 , pp. 9016-9022
    • Wang, G.1    Tschoi, M.2    Spolski, R.3    Lou, Y.4    Ozaki, K.5    Feng, C.6
  • 56
    • 77954913436 scopus 로고    scopus 로고
    • Intratumoral interleukin-21 increases antitumor immunity, tumor-infiltrating CD8+ T-cell density and activity, and enlarges draining lymph nodes
    • Søndergaard H., Galsgaard E.D., Bartholomaeussen M., Straten P.T., Odum N., Skak K. Intratumoral interleukin-21 increases antitumor immunity, tumor-infiltrating CD8+ T-cell density and activity, and enlarges draining lymph nodes. J Immunother 2010, 33:236-249.
    • (2010) J Immunother , vol.33 , pp. 236-249
    • Søndergaard, H.1    Galsgaard, E.D.2    Bartholomaeussen, M.3    Straten, P.T.4    Odum, N.5    Skak, K.6
  • 57
    • 77949655286 scopus 로고    scopus 로고
    • Enhancing therapy of B16F10 melanoma efficacy through tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model
    • Zhao F., Dou J., He X.F., Wang J., Chu L., Hu W., et al. Enhancing therapy of B16F10 melanoma efficacy through tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model. Vaccine 2010, 28:2846-2852.
    • (2010) Vaccine , vol.28 , pp. 2846-2852
    • Zhao, F.1    Dou, J.2    He, X.F.3    Wang, J.4    Chu, L.5    Hu, W.6
  • 58
    • 77954242768 scopus 로고    scopus 로고
    • A fusion of GMCSF and IL-21 initiates hypersignaling through the IL-21Ralpha chain with immune activating and tumoricidal effects in vivo
    • Williams P., Rafei M., Bouchentouf M., Raven J., Yuan S., Cuerquis J., et al. A fusion of GMCSF and IL-21 initiates hypersignaling through the IL-21Ralpha chain with immune activating and tumoricidal effects in vivo. Mol Ther 2010, 18:1293-1301.
    • (2010) Mol Ther , vol.18 , pp. 1293-1301
    • Williams, P.1    Rafei, M.2    Bouchentouf, M.3    Raven, J.4    Yuan, S.5    Cuerquis, J.6


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