cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: Implications in systemic lupus erythematosus

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43429-43436

  Hedrich, Christian M ^a   Rauen, Thomas ^a,b   Tsokos, George C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; CYTOKINE EXPRESSION; CYTOKINES; DEACETYLATION; DNA HYPERMETHYLATION; DNA METHYLTRANSFERASES; GROWTH FACTOR; GUANOSINES; HISTONE DEACETYLASES; INTERLEUKIN-2; PARACRINE; PROTEIN SIGNALING; REGULATORY FACTORS; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELLS; T LYMPHOCYTES;

ACETYLATION; ALKYLATION; CHEMICAL ACTIVATION; DNA; DNA SEQUENCES; GENES; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

AZATHIOPRINE; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR ALPHA; DNA; DNA METHYLTRANSFERASE 3A; GLUCOCORTICOID; HISTONE DEACETYLASE 1; HISTONE H3; HYDROXYCHLOROQUINE; INTERLEUKIN 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; EMBRYO; EPIGENETICS; FEMALE; GENE; GENE SILENCING; HUMAN; HUMAN CELL; IL2 GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

ACETYLATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; COMPUTATIONAL BIOLOGY; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONES; HUMANS; IMMUNOPRECIPITATION; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; PROTEIN BINDING; T-LYMPHOCYTES;

EID: 83355166950     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.299339     Document Type: Article

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