Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4 + Th cells cytotoxic by activating both perforin- and FasL-pathways

Immunology Letters

Volumn 144, Issue 1-2, 2012, Pages 7-15

  Eshima, Koji ^a   Chiba, Sayuri ^a,c   Suzuki, Harumi ^b   Kokubo, Kenichi ^c   Kobayashi, Hirosuke ^c   Iizuka, Misao ^a   Iwabuchi, Kazuya ^a   Shinohara, Nobukata ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

Cytotoxic T lymphocyte (CTL); Cytotoxicity; Differentiation; Eomesodermin; Transcription factor

Indexed keywords

CD40 LIGAND; CONCANAVALIN A; EOMESODERMIN; FAS LIGAND; MESSENGER RNA; PERFORIN; T BOX TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HELPER CELL; HYBRIDOMA; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PERFORIN; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFECTION;

EID: 84863415045     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.02.013     Document Type: Article

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