메뉴 건너뛰기




Volumn 105, Issue 39, 2008, Pages 14993-14998

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; INTERLEUKIN 17; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TNFSF13B PROTEIN, MOUSE;

EID: 54449087291     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806044105     Document Type: Article
Times cited : (164)

References (38)
  • 1
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356-361.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 2
    • 0034694088 scopus 로고    scopus 로고
    • BAFF mediates survival of peripheral immature B lymphocytes
    • Batten M, et al. (2000) BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 192:1453-1466.
    • (2000) J Exp Med , vol.192 , pp. 1453-1466
    • Batten, M.1
  • 3
    • 23844518421 scopus 로고    scopus 로고
    • Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis
    • Zhang M, et al. (2005) Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int Immunol 17:1081-1092.
    • (2005) Int Immunol , vol.17 , pp. 1081-1092
    • Zhang, M.1
  • 4
    • 3142671331 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    • Ng LG, et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173:807-817.
    • (2004) J Immunol , vol.173 , pp. 807-817
    • Ng, L.G.1
  • 5
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B, Veldhoen M (2007) Differentiation and function of Th17 T cells. Curr Opin Immunol 19:281-286.
    • (2007) Curr Opin Immunol , vol.19 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 6
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y (2003) Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171:6173-6177.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 7
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts E, Koenders MI, van den Berg WB (2005) The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models. Arthritis Res Ther 7:29-37.
    • (2005) Arthritis Res Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    van den Berg, W.B.3
  • 8
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-442.
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 9
    • 0038131975 scopus 로고    scopus 로고
    • Therapeutic strategies for rheumatoid arthritis
    • Smolen JS, Steiner G (2003) Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2:473-488.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 473-488
    • Smolen, J.S.1    Steiner, G.2
  • 10
    • 0042858250 scopus 로고    scopus 로고
    • Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF
    • Pelletier M, et al. (2003) Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. J Biol Chem 278:33127-33133.
    • (2003) J Biol Chem , vol.278 , pp. 33127-33133
    • Pelletier, M.1
  • 11
    • 0034918211 scopus 로고    scopus 로고
    • TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
    • Wang H, et al. (2001) TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol 2:632-637.
    • (2001) Nat Immunol , vol.2 , pp. 632-637
    • Wang, H.1
  • 12
    • 33748746856 scopus 로고    scopus 로고
    • Treatment of autoimmune hyperthyroidism in amurine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathology
    • Gilbert JA, et al. (2006) Treatment of autoimmune hyperthyroidism in amurine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathology. Endocrinology 147:4561-4568.
    • (2006) Endocrinology , vol.147 , pp. 4561-4568
    • Gilbert, J.A.1
  • 13
    • 33748997648 scopus 로고    scopus 로고
    • A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses
    • Huntington ND, et al. (2006) A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int Immunol 18:1473-1485.
    • (2006) Int Immunol , vol.18 , pp. 1473-1485
    • Huntington, N.D.1
  • 14
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, et al. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials. J Am Med Assoc 295:2275-2285.
    • (2006) J Am Med Assoc , vol.295 , pp. 2275-2285
    • Bongartz, T.1
  • 15
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 16
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 17
    • 17844381069 scopus 로고    scopus 로고
    • BAFF augments certain Th1-associated inflammatory responses
    • Sutherland AP, et al. (2005) BAFF augments certain Th1-associated inflammatory responses. J Immunol 174:5537-5544.
    • (2005) J Immunol , vol.174 , pp. 5537-5544
    • Sutherland, A.P.1
  • 18
    • 0036634390 scopus 로고    scopus 로고
    • BAFF: A fundamental survival factor for B cells
    • Mackay F, Browning JL (2002) BAFF: A fundamental survival factor for B cells. Nat Rev Immunol 2:465-475.
    • (2002) Nat Rev Immunol , vol.2 , pp. 465-475
    • Mackay, F.1    Browning, J.L.2
  • 19
    • 33645268682 scopus 로고    scopus 로고
    • Novel function of TNF cytokines in regulating bone marrow B cell survival
    • Zhang M, et al. (2004) Novel function of TNF cytokines in regulating bone marrow B cell survival. Cell Mol Immunol 1:447-453.
    • (2004) Cell Mol Immunol , vol.1 , pp. 447-453
    • Zhang, M.1
  • 20
    • 85047690330 scopus 로고    scopus 로고
    • BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    • Avery DT, et al. (2003) BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 112:286-297.
    • (2003) J Clin Invest , vol.112 , pp. 286-297
    • Avery, D.T.1
  • 21
    • 0036753722 scopus 로고    scopus 로고
    • Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses
    • MacLennan I, Vinuesa C (2002) Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses. Immunity 17:235-238.
    • (2002) Immunity , vol.17 , pp. 235-238
    • MacLennan, I.1    Vinuesa, C.2
  • 22
    • 33746932893 scopus 로고    scopus 로고
    • Gene delivery to the spinal cord: Comparison between lentiviral, adenoviral, and retroviral vector delivery systems
    • Abdellatif AA, et al. (2006) Gene delivery to the spinal cord: Comparison between lentiviral, adenoviral, and retroviral vector delivery systems. J Neurosci Res 84:553-567.
    • (2006) J Neurosci Res , vol.84 , pp. 553-567
    • Abdellatif, A.A.1
  • 23
    • 0033780546 scopus 로고    scopus 로고
    • Cotransduction of nondividing cells using lentiviral vectors
    • Frimpong K, Spector SA (2000) Cotransduction of nondividing cells using lentiviral vectors. Gene Ther 7:1562-1569.
    • (2000) Gene Ther , vol.7 , pp. 1562-1569
    • Frimpong, K.1    Spector, S.A.2
  • 24
    • 0030070295 scopus 로고    scopus 로고
    • Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
    • Schroder AE, Greiner A, Seyfert C, Berek C (1996) Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 93:221-225.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 221-225
    • Schroder, A.E.1    Greiner, A.2    Seyfert, C.3    Berek, C.4
  • 25
    • 0038240921 scopus 로고    scopus 로고
    • Ectopic germinal center formation in rheumatoid synovitis
    • Weyand CM, Goronzy JJ (2003) Ectopic germinal center formation in rheumatoid synovitis. Ann NY Acad Sci 987:140-149.
    • (2003) Ann NY Acad Sci , vol.987 , pp. 140-149
    • Weyand, C.M.1    Goronzy, J.J.2
  • 27
    • 2442433618 scopus 로고    scopus 로고
    • Pathogenic roles of B cells in human autoimmunity; Insights from the clinic
    • Martin F, Chan AC (2004) Pathogenic roles of B cells in human autoimmunity; Insights from the clinic. Immunity 20:517-527.
    • (2004) Immunity , vol.20 , pp. 517-527
    • Martin, F.1    Chan, A.C.2
  • 28
    • 31544445804 scopus 로고    scopus 로고
    • B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus
    • Eisenberg R, Albert D (2006) B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus. Nat Clin Pract Rheumatol 2:20-27.
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 20-27
    • Eisenberg, R.1    Albert, D.2
  • 29
    • 41949133387 scopus 로고    scopus 로고
    • BAFF enhances chemotaxis of primary human B cells: A particular synergy between BAFF and CXCL13 on memory B cells
    • Badr G, et al. (2008) BAFF enhances chemotaxis of primary human B cells: A particular synergy between BAFF and CXCL13 on memory B cells. Blood 111:2744-2754.
    • (2008) Blood , vol.111 , pp. 2744-2754
    • Badr, G.1
  • 30
    • 33846456970 scopus 로고    scopus 로고
    • T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    • Hirota K, et al. (2007) T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204:41-47.
    • (2007) J Exp Med , vol.204 , pp. 41-47
    • Hirota, K.1
  • 31
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T, et al. (1998) Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 187:461-468.
    • (1998) J Exp Med , vol.187 , pp. 461-468
    • Alonzi, T.1
  • 32
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T, et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 33
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 34
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 35
    • 24744435115 scopus 로고    scopus 로고
    • Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    • Camps M, et al. (2005) Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11:936-943.
    • (2005) Nat Med , vol.11 , pp. 936-943
    • Camps, M.1
  • 36
    • 34948818333 scopus 로고    scopus 로고
    • Leptin induces CD40 expression through the activation of Akt in murine dendritic cells
    • Lam QL, Zheng BJ, Jin DY, Cao X, Lu L (2007) Leptin induces CD40 expression through the activation of Akt in murine dendritic cells. J Biol Chem 282:27587-27597.
    • (2007) J Biol Chem , vol.282 , pp. 27587-27597
    • Lam, Q.L.1    Zheng, B.J.2    Jin, D.Y.3    Cao, X.4    Lu, L.5
  • 37
    • 33845566273 scopus 로고    scopus 로고
    • Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells
    • Lam QL, Liu S, Cao X, Lu L (2006) Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 36:3118-3130.
    • (2006) Eur J Immunol , vol.36 , pp. 3118-3130
    • Lam, Q.L.1    Liu, S.2    Cao, X.3    Lu, L.4
  • 38
    • 34547514211 scopus 로고    scopus 로고
    • IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
    • Kimura A, Naka T, Kishimoto T (2007) IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci USA 104:12099-12104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12099-12104
    • Kimura, A.1    Naka, T.2    Kishimoto, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.