-
2
-
-
42649134105
-
Interleukin-21: basic biology and implications for cancer and autoimmunity
-
Spolski R., Leonard W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 2008, 26:57-79.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 57-79
-
-
Spolski, R.1
Leonard, W.J.2
-
3
-
-
0034633734
-
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
-
Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:11439-11444.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 11439-11444
-
-
Ozaki, K.1
Kikly, K.2
Michalovich, D.3
Young, P.R.4
Leonard, W.J.5
-
4
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R., Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C., Moore M., Grant F.J., Lofton-Day C., Gilbert T., Rayond F., Ching A., Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K., Holly R.D., Foster D. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63.
-
(2000)
Nature
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
Dillon, S.R.2
Nelson, A.3
Hammond, A.4
Sprecher, C.5
Gross, J.A.6
Johnston, J.7
Madden, K.8
Xu, W.9
West, J.10
Schrader, S.11
Burkhead, S.12
Heipel, M.13
Brandt, C.14
Kuijper, J.L.15
Kramer, J.16
Conklin, D.17
Presnell, S.R.18
Berry, J.19
Shiota, F.20
Bort, S.21
Hambly, K.22
Mudri, S.23
Clegg, C.24
Moore, M.25
Grant, F.J.26
Lofton-Day, C.27
Gilbert, T.28
Rayond, F.29
Ching, A.30
Yao, L.31
Smith, D.32
Webster, P.33
Whitmore, T.34
Maurer, M.35
Kaushansky, K.36
Holly, R.D.37
Foster, D.38
more..
-
5
-
-
0035400054
-
Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
-
Asao H., Okuyama C., Kumaki S., Ishii N., Tsuchiya S., Foster D., Sugamura K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 2001, 167:1-5.
-
(2001)
J. Immunol.
, vol.167
, pp. 1-5
-
-
Asao, H.1
Okuyama, C.2
Kumaki, S.3
Ishii, N.4
Tsuchiya, S.5
Foster, D.6
Sugamura, K.7
-
6
-
-
0346993779
-
Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo
-
Brandt K., Bulfone-Paus S., Jenckel A., Foster D.C., Paus R., Ruckert R. Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J. Invest. Dermatol. 2003, 121:1379-1382.
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 1379-1382
-
-
Brandt, K.1
Bulfone-Paus, S.2
Jenckel, A.3
Foster, D.C.4
Paus, R.5
Ruckert, R.6
-
7
-
-
33845447347
-
Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21
-
Monteleone G., Caruso R., Fina D., Peluso I., Gioia V., Stolfi C., Fantini M.C., Caprioli F., Tersigni R., Alessandroni L., MacDonald T.T., Pallone F. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 2006, 55:1774-1780.
-
(2006)
Gut
, vol.55
, pp. 1774-1780
-
-
Monteleone, G.1
Caruso, R.2
Fina, D.3
Peluso, I.4
Gioia, V.5
Stolfi, C.6
Fantini, M.C.7
Caprioli, F.8
Tersigni, R.9
Alessandroni, L.10
MacDonald, T.T.11
Pallone, F.12
-
8
-
-
34247588626
-
IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis
-
Caruso R., Fina D., Peluso I., Fantini M.C., Tosti C., Del Vecchio Blanco G., Paoluzi O.A., Caprioli F., Andrei F., Stolfi C., Romano M., Ricci V., MacDonald T.T., Pallone F., Monteleone G. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol. 2007, 178:5957-5965.
-
(2007)
J. Immunol.
, vol.178
, pp. 5957-5965
-
-
Caruso, R.1
Fina, D.2
Peluso, I.3
Fantini, M.C.4
Tosti, C.5
Del Vecchio Blanco, G.6
Paoluzi, O.A.7
Caprioli, F.8
Andrei, F.9
Stolfi, C.10
Romano, M.11
Ricci, V.12
MacDonald, T.T.13
Pallone, F.14
Monteleone, G.15
-
9
-
-
38549125955
-
Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages
-
Ruckert R., Bulfone-Paus S., Brandt K. Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages. Clin. Exp. Immunol. 2008, 151:487-495.
-
(2008)
Clin. Exp. Immunol.
, vol.151
, pp. 487-495
-
-
Ruckert, R.1
Bulfone-Paus, S.2
Brandt, K.3
-
10
-
-
33847367120
-
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
-
Coquet J.M., Kyparissoudis K., Pellicci D.G., Besra G., Berzins S.P., Smyth M.J., Godfrey D.I. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol. 2007, 178:2827-2834.
-
(2007)
J. Immunol.
, vol.178
, pp. 2827-2834
-
-
Coquet, J.M.1
Kyparissoudis, K.2
Pellicci, D.G.3
Besra, G.4
Berzins, S.P.5
Smyth, M.J.6
Godfrey, D.I.7
-
11
-
-
67649234772
-
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
-
Frohlich A., Kisielow J., Schmitz I., Freigang S., Shamshiev A.T., Weber J., Marsland B.J., Oxenius A., Kopf M. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 2009, 324:1576-1580.
-
(2009)
Science
, vol.324
, pp. 1576-1580
-
-
Frohlich, A.1
Kisielow, J.2
Schmitz, I.3
Freigang, S.4
Shamshiev, A.T.5
Weber, J.6
Marsland, B.J.7
Oxenius, A.8
Kopf, M.9
-
12
-
-
69449095507
-
IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines
-
Ortega C., Fernandez A.S., Carrillo J.M., Romero P., Molina I.J., Moreno J.C., Santamaria M. IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J. Leukoc. Biol. 2009, 86:435-443.
-
(2009)
J. Leukoc. Biol.
, vol.86
, pp. 435-443
-
-
Ortega, C.1
Fernandez, A.S.2
Carrillo, J.M.3
Romero, P.4
Molina, I.J.5
Moreno, J.C.6
Santamaria, M.7
-
13
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
-
Ozaki K., Spolski R., Ettinger R., Kim H.P., Wang G., Qi C.F., Hwu P., Shaffer D.J., Akilesh S., Roopenian D.C., Morse H.C., Lipsky P.E., Leonard W.J. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 2004, 173:5361-5371.
-
(2004)
J. Immunol.
, vol.173
, pp. 5361-5371
-
-
Ozaki, K.1
Spolski, R.2
Ettinger, R.3
Kim, H.P.4
Wang, G.5
Qi, C.F.6
Hwu, P.7
Shaffer, D.J.8
Akilesh, S.9
Roopenian, D.C.10
Morse, H.C.11
Lipsky, P.E.12
Leonard, W.J.13
-
14
-
-
45449087723
-
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
-
Hinrichs C.S., Spolski R., Paulos C.M., Gattinoni L., Kerstann K.W., Palmer D.C., Klebanoff C.A., Rosenberg S.A., Leonard W.J., Restifo N.P. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 2008, 111:5326-5333.
-
(2008)
Blood
, vol.111
, pp. 5326-5333
-
-
Hinrichs, C.S.1
Spolski, R.2
Paulos, C.M.3
Gattinoni, L.4
Kerstann, K.W.5
Palmer, D.C.6
Klebanoff, C.A.7
Rosenberg, S.A.8
Leonard, W.J.9
Restifo, N.P.10
-
15
-
-
58449124804
-
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
-
Bauquet A.T., Jin H., Paterson A.M., Mitsdoerffer M., Ho I.C., Sharpe A.H., Kuchroo V.K. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 2009, 10:167-175.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 167-175
-
-
Bauquet, A.T.1
Jin, H.2
Paterson, A.M.3
Mitsdoerffer, M.4
Ho, I.C.5
Sharpe, A.H.6
Kuchroo, V.K.7
-
16
-
-
71749089605
-
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
-
Kwon H., Thierry-Mieg D., Thierry-Mieg J., Kim H.P., Oh J., Tunyaplin C., Carotta S., Donovan C.E., Goldman M.L., Tailor P., Ozato K., Levy D.E., Nutt S.L., Calame K., Leonard W.J. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009, 31:941-952.
-
(2009)
Immunity
, vol.31
, pp. 941-952
-
-
Kwon, H.1
Thierry-Mieg, D.2
Thierry-Mieg, J.3
Kim, H.P.4
Oh, J.5
Tunyaplin, C.6
Carotta, S.7
Donovan, C.E.8
Goldman, M.L.9
Tailor, P.10
Ozato, K.11
Levy, D.E.12
Nutt, S.L.13
Calame, K.14
Leonard, W.J.15
-
17
-
-
33746875244
-
IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
-
Strengell M., Lehtonen A., Matikainen S., Julkunen I. IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells. J. Leukoc. Biol. 2006, 79:1279-1285.
-
(2006)
J. Leukoc. Biol.
, vol.79
, pp. 1279-1285
-
-
Strengell, M.1
Lehtonen, A.2
Matikainen, S.3
Julkunen, I.4
-
18
-
-
18344394955
-
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
-
Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002, 16:559-569.
-
(2002)
Immunity
, vol.16
, pp. 559-569
-
-
Kasaian, M.T.1
Whitters, M.J.2
Carter, L.L.3
Lowe, L.D.4
Jussif, J.M.5
Deng, B.6
Johnson, K.A.7
Witek, J.S.8
Senices, M.9
Konz, R.F.10
Wurster, A.L.11
Donaldson, D.D.12
Collins, M.13
Young, D.A.14
Grusby, M.J.15
-
19
-
-
0842278642
-
IL-21 induces the functional maturation of murine NK cells
-
Brady J., Hayakawa Y., Smyth M.J., Nutt S.L. IL-21 induces the functional maturation of murine NK cells. J. Immunol. 2004, 172:2048-2058.
-
(2004)
J. Immunol.
, vol.172
, pp. 2048-2058
-
-
Brady, J.1
Hayakawa, Y.2
Smyth, M.J.3
Nutt, S.L.4
-
20
-
-
0348013081
-
IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors
-
Sivori S., Cantoni C., Parolini S., Marcenaro E., Conte R., Moretta L., Moretta A. IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur. J. Immunol. 2003, 33:3439-3447.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 3439-3447
-
-
Sivori, S.1
Cantoni, C.2
Parolini, S.3
Marcenaro, E.4
Conte, R.5
Moretta, L.6
Moretta, A.7
-
21
-
-
0037514399
-
IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
-
Strengell M., Matikainen S., Siren J., Lehtonen A., Foster D., Julkunen I., Sareneva T. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J. Immunol. 2003, 170:5464-5469.
-
(2003)
J. Immunol.
, vol.170
, pp. 5464-5469
-
-
Strengell, M.1
Matikainen, S.2
Siren, J.3
Lehtonen, A.4
Foster, D.5
Julkunen, I.6
Sareneva, T.7
-
22
-
-
35848937653
-
Interleukin-21 differentially affects human natural killer cell subsets
-
Wendt K., Wilk E., Buyny S., Schmidt R.E., Jacobs R. Interleukin-21 differentially affects human natural killer cell subsets. Immunology 2007, 122:486-495.
-
(2007)
Immunology
, vol.122
, pp. 486-495
-
-
Wendt, K.1
Wilk, E.2
Buyny, S.3
Schmidt, R.E.4
Jacobs, R.5
-
23
-
-
22344451592
-
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
-
Smyth M.J., Wallace M.E., Nutt S.L., Yagita H., Godfrey D.I., Hayakawa Y. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J. Exp. Med. 2005, 201:1973-1985.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1973-1985
-
-
Smyth, M.J.1
Wallace, M.E.2
Nutt, S.L.3
Yagita, H.4
Godfrey, D.I.5
Hayakawa, Y.6
-
24
-
-
0037446642
-
IL-21 induces the apoptosis of resting and activated primary B cells
-
Mehta D.S., Wurster A.L., Whitters M.J., Young D.A., Collins M., Grusby M.J. IL-21 induces the apoptosis of resting and activated primary B cells. J. Immunol. 2003, 170:4111-4118.
-
(2003)
J. Immunol.
, vol.170
, pp. 4111-4118
-
-
Mehta, D.S.1
Wurster, A.L.2
Whitters, M.J.3
Young, D.A.4
Collins, M.5
Grusby, M.J.6
-
25
-
-
2942709751
-
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
-
Jin H., Carrio R., Yu A., Malek T.R. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J. Immunol. 2004, 173:657-665.
-
(2004)
J. Immunol.
, vol.173
, pp. 657-665
-
-
Jin, H.1
Carrio, R.2
Yu, A.3
Malek, T.R.4
-
26
-
-
0037159687
-
A critical role for IL-21 in regulating immunoglobulin production
-
Ozaki K., Spolski R., Feng C.G., Qi C.F., Cheng J., Sher A., Morse H.C., Liu C., Schwartzberg P.L., Leonard W.J. A critical role for IL-21 in regulating immunoglobulin production. Science 2002, 298:1630-1634.
-
(2002)
Science
, vol.298
, pp. 1630-1634
-
-
Ozaki, K.1
Spolski, R.2
Feng, C.G.3
Qi, C.F.4
Cheng, J.5
Sher, A.6
Morse, H.C.7
Liu, C.8
Schwartzberg, P.L.9
Leonard, W.J.10
-
27
-
-
69249109601
-
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
-
Johnston R.J., Poholek A.C., DiToro D., Yusuf I., Eto D., Barnett B., Dent A.L., Craft J., Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009, 325:1006-1010.
-
(2009)
Science
, vol.325
, pp. 1006-1010
-
-
Johnston, R.J.1
Poholek, A.C.2
DiToro, D.3
Yusuf, I.4
Eto, D.5
Barnett, B.6
Dent, A.L.7
Craft, J.8
Crotty, S.9
-
28
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva R.I., Chung Y., Martinez G.J., Yang X.O., Tanaka S., Matskevitch T.D., Wang Y.H., Dong C. Bcl6 mediates the development of T follicular helper cells. Science 2009, 325:1001-1005.
-
(2009)
Science
, vol.325
, pp. 1001-1005
-
-
Nurieva, R.I.1
Chung, Y.2
Martinez, G.J.3
Yang, X.O.4
Tanaka, S.5
Matskevitch, T.D.6
Wang, Y.H.7
Dong, C.8
-
29
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
Linterman M.A., Beaton L., Yu D., Ramiscal R.R., Srivastava M., Hogan J.J., Verma N.K., Smyth M.J., Rigby R.J., Vinuesa C.G. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 2010, 207:353-363.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 353-363
-
-
Linterman, M.A.1
Beaton, L.2
Yu, D.3
Ramiscal, R.R.4
Srivastava, M.5
Hogan, J.J.6
Verma, N.K.7
Smyth, M.J.8
Rigby, R.J.9
Vinuesa, C.G.10
-
30
-
-
77149142640
-
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
-
Zotos D., Coquet J.M., Zhang Y., Light A., DCosta K., Kallies A., Corcoran L.M., Godfrey D.I., Toellner K.M., Smyth M.J., Nutt S.L., Tarlinton D.M. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med. 2010, 207:365-378.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 365-378
-
-
Zotos, D.1
Coquet, J.M.2
Zhang, Y.3
Light, A.4
Dcosta, K.5
Kallies, A.6
Corcoran, L.M.7
Godfrey, D.I.8
Toellner, K.M.9
Smyth, M.J.10
Nutt, S.L.11
Tarlinton, D.M.12
-
31
-
-
29144519767
-
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
-
Ettinger R., Sims G.P., Fairhurst A.M., Robbins R., da Silva Y.S., Spolski R., Leonard W.J., Lipsky P.E. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J. Immunol. 2005, 175:7867-7879.
-
(2005)
J. Immunol.
, vol.175
, pp. 7867-7879
-
-
Ettinger, R.1
Sims, G.P.2
Fairhurst, A.M.3
Robbins, R.4
da Silva, Y.S.5
Spolski, R.6
Leonard, W.J.7
Lipsky, P.E.8
-
32
-
-
38049101408
-
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
-
Bryant V.L., Ma C.S., Avery D.T., Li Y., Good K.L., Corcoran L.M., de Waal Malefyt R., Tangye S.G. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 2007, 179:8180-8190.
-
(2007)
J. Immunol.
, vol.179
, pp. 8180-8190
-
-
Bryant, V.L.1
Ma, C.S.2
Avery, D.T.3
Li, Y.4
Good, K.L.5
Corcoran, L.M.6
de Waal Malefyt, R.7
Tangye, S.G.8
-
33
-
-
44449145063
-
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
-
Diehl S.A., Schmidlin H., Nagasawa M., van Haren S.D., Kwakkenbos M.J., Yasuda E., Beaumont T., Scheeren F.A., Spits H. STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J. Immunol. 2008, 180:4805-4815.
-
(2008)
J. Immunol.
, vol.180
, pp. 4805-4815
-
-
Diehl, S.A.1
Schmidlin, H.2
Nagasawa, M.3
van Haren, S.D.4
Kwakkenbos, M.J.5
Yasuda, E.6
Beaumont, T.7
Scheeren, F.A.8
Spits, H.9
-
34
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., Levy D.E., Leonard W.J., Littman D.R. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007, 8:967-974.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
35
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T., Bettelli E., Gao W., Awasthi A., Jager A., Strom T.B., Oukka M., Kuchroo V.K. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448:484-487.
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jager, A.5
Strom, T.B.6
Oukka, M.7
Kuchroo, V.K.8
-
36
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., Schluns K., Tian Q., Watowich S.S., Jetten A.M., Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007, 448:480-483.
-
(2007)
Nature
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
Dong, C.11
-
37
-
-
47549112840
-
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
-
Yang L., Anderson D.E., Baecher-Allan C., Hastings W.D., Bettelli E., Oukka M., Kuchroo V.K., Hafler D.A. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008, 454:350-352.
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
Anderson, D.E.2
Baecher-Allan, C.3
Hastings, W.D.4
Bettelli, E.5
Oukka, M.6
Kuchroo, V.K.7
Hafler, D.A.8
-
38
-
-
45149123617
-
Development and characterization of IL-21-producing CD4+ T cells
-
Suto A., Kashiwakuma D., Kagami S., Hirose K., Watanabe N., Yokote K., Saito Y., Nakayama T., Grusby M.J., Iwamoto I., Nakajima H. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 2008, 205:1369-1379.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1369-1379
-
-
Suto, A.1
Kashiwakuma, D.2
Kagami, S.3
Hirose, K.4
Watanabe, N.5
Yokote, K.6
Saito, Y.7
Nakayama, T.8
Grusby, M.J.9
Iwamoto, I.10
Nakajima, H.11
-
39
-
-
38049120319
-
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
-
Li Y., Yee C. IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 2008, 111:229-235.
-
(2008)
Blood
, vol.111
, pp. 229-235
-
-
Li, Y.1
Yee, C.2
-
40
-
-
41549131849
-
T follicular helper (TFH) cells in normal and dysregulated immune responses
-
King C., Tangye S.G., Mackay C.R. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 2008, 26:741-766.
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 741-766
-
-
King, C.1
Tangye, S.G.2
Mackay, C.R.3
-
41
-
-
46749151286
-
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
-
Nurieva R.I., Chung Y., Hwang D., Yang X.O., Kang H.S., Ma L., Wang Y.H., Watowich S.S., Jetten A.M., Tian Q., Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29:138-149.
-
(2008)
Immunity
, vol.29
, pp. 138-149
-
-
Nurieva, R.I.1
Chung, Y.2
Hwang, D.3
Yang, X.O.4
Kang, H.S.5
Ma, L.6
Wang, Y.H.7
Watowich, S.S.8
Jetten, A.M.9
Tian, Q.10
Dong, C.11
-
42
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
Vogelzang A., McGuire H.M., Yu D., Sprent J., Mackay C.R., King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008, 29:127-137.
-
(2008)
Immunity
, vol.29
, pp. 127-137
-
-
Vogelzang, A.1
McGuire, H.M.2
Yu, D.3
Sprent, J.4
Mackay, C.R.5
King, C.6
-
43
-
-
65549114338
-
IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
-
King I.L., Mohrs M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 2009, 206:1001-1007.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1001-1007
-
-
King, I.L.1
Mohrs, M.2
-
44
-
-
65549134481
-
T follicular helper cells differentiate from Th2 cells in response to helminth antigens
-
Zaretsky A.G., Taylor J.J., King I.L., Marshall F.A., Mohrs M., Pearce E.J. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J. Exp. Med. 2009, 206:991-999.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 991-999
-
-
Zaretsky, A.G.1
Taylor, J.J.2
King, I.L.3
Marshall, F.A.4
Mohrs, M.5
Pearce, E.J.6
-
45
-
-
34250173393
-
IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype
-
Casey K.A., Mescher M.F. IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J. Immunol. 2007, 178:7640-7648.
-
(2007)
J. Immunol.
, vol.178
, pp. 7640-7648
-
-
Casey, K.A.1
Mescher, M.F.2
-
46
-
-
19944434230
-
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
-
Zeng R., Spolski R., Finkelstein S.E., Oh S., Kovanen P.E., Hinrichs C.S., Pise-Masison C.A., Radonovich M.F., Brady J.N., Restifo N.P., Berzofsky J.A., Leonard W.J. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J. Exp. Med. 2005, 201:139-148.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 139-148
-
-
Zeng, R.1
Spolski, R.2
Finkelstein, S.E.3
Oh, S.4
Kovanen, P.E.5
Hinrichs, C.S.6
Pise-Masison, C.A.7
Radonovich, M.F.8
Brady, J.N.9
Restifo, N.P.10
Berzofsky, J.A.11
Leonard, W.J.12
-
47
-
-
23444445913
-
IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
-
Li Y., Bleakley M., Yee C. IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response. J. Immunol. 2005, 175:2261-2269.
-
(2005)
J. Immunol.
, vol.175
, pp. 2261-2269
-
-
Li, Y.1
Bleakley, M.2
Yee, C.3
-
48
-
-
78049511872
-
-
IL-21-deficiency influences CD8 T Cell quality and recall responses following an acute viral infection, J. Immunol.
-
J.S. Yi, J.T. Ingram, A.J. Zajac, IL-21-deficiency influences CD8 T Cell quality and recall responses following an acute viral infection, J. Immunol. 185 (2010), doi:10.4049/jimmunol.1001032.
-
(2010)
, vol.185
-
-
Yi, J.S.1
Ingram, J.T.2
Zajac, A.J.3
-
49
-
-
64849083153
-
IL-21 mediates suppressive effects via its induction of IL-10
-
Spolski R., Kim H.P., Zhu W., Levy D.E., Leonard W.J. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 2009, 182:2859-2867.
-
(2009)
J. Immunol.
, vol.182
, pp. 2859-2867
-
-
Spolski, R.1
Kim, H.P.2
Zhu, W.3
Levy, D.E.4
Leonard, W.J.5
-
50
-
-
36348991440
-
Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation
-
Allard E.L., Hardy M.P., Leignadier J., Marquis M., Rooney J., Lehoux D., Labrecque N. Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation. Eur. J. Immunol. 2007, 37:3069-3077.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 3069-3077
-
-
Allard, E.L.1
Hardy, M.P.2
Leignadier, J.3
Marquis, M.4
Rooney, J.5
Lehoux, D.6
Labrecque, N.7
-
51
-
-
23244444668
-
IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells
-
Alves N.L., Arosa F.A., van Lier R.A. IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J. Immunol. 2005, 175:755-762.
-
(2005)
J. Immunol.
, vol.175
, pp. 755-762
-
-
Alves, N.L.1
Arosa, F.A.2
van Lier, R.A.3
-
52
-
-
74949112138
-
IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span
-
Nguyen H., Weng N.P. IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span. J. Leukoc. Biol. 2010, 87:43-49.
-
(2010)
J. Leukoc. Biol.
, vol.87
, pp. 43-49
-
-
Nguyen, H.1
Weng, N.P.2
-
53
-
-
77949357362
-
T-cell exhaustion: characteristics, causes and conversion
-
Yi J.S., Cox M.A., Zajac A.J. T-cell exhaustion: characteristics, causes and conversion. Immunology 2010, 129:474-481.
-
(2010)
Immunology
, vol.129
, pp. 474-481
-
-
Yi, J.S.1
Cox, M.A.2
Zajac, A.J.3
-
54
-
-
67649217469
-
IL-21 is required to control chronic viral infection
-
Elsaesser H., Sauer K., Brooks D.G. IL-21 is required to control chronic viral infection. Science 2009, 324:1569-1572.
-
(2009)
Science
, vol.324
, pp. 1569-1572
-
-
Elsaesser, H.1
Sauer, K.2
Brooks, D.G.3
-
55
-
-
67649203681
-
A vital role for interleukin-21 in the control of a chronic viral infection
-
Yi J.S., Du M., Zajac A.J. A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009, 324:1572-1576.
-
(2009)
Science
, vol.324
, pp. 1572-1576
-
-
Yi, J.S.1
Du, M.2
Zajac, A.J.3
-
56
-
-
32344445359
-
Interleukin-21 mRNA expression during virus infections
-
Holm C., Nyvold C.G., Paludan S.R., Thomsen A.R., Hokland M. Interleukin-21 mRNA expression during virus infections. Cytokine 2006, 33:41-45.
-
(2006)
Cytokine
, vol.33
, pp. 41-45
-
-
Holm, C.1
Nyvold, C.G.2
Paludan, S.R.3
Thomsen, A.R.4
Hokland, M.5
-
57
-
-
73949110184
-
Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
-
Iannello A., Boulassel M.R., Samarani S., Debbeche O., Tremblay C., Toma E., Routy J.P., Ahmad A. Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. J. Immunol. 2010, 184:114-126.
-
(2010)
J. Immunol.
, vol.184
, pp. 114-126
-
-
Iannello, A.1
Boulassel, M.R.2
Samarani, S.3
Debbeche, O.4
Tremblay, C.5
Toma, E.6
Routy, J.P.7
Ahmad, A.8
-
58
-
-
77956198865
-
HIV-specific IL-21 producing CD4(+) T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control
-
Yue F.Y., Lo C., Sakhdari A., Lee E.Y., Kovacs C.M., Benko E., Liu J., Song H., Jones R.B., Sheth P., Chege D., Kaul R., Ostrowski M.A. HIV-specific IL-21 producing CD4(+) T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J. Immunol. 2010, 185:498-506.
-
(2010)
J. Immunol.
, vol.185
, pp. 498-506
-
-
Yue, F.Y.1
Lo, C.2
Sakhdari, A.3
Lee, E.Y.4
Kovacs, C.M.5
Benko, E.6
Liu, J.7
Song, H.8
Jones, R.B.9
Sheth, P.10
Chege, D.11
Kaul, R.12
Ostrowski, M.A.13
-
59
-
-
34247370175
-
Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)
-
White L., Krishnan S., Strbo N., Liu H., Kolber M.A., Lichtenheld M.G., Pahwa R.N., Pahwa S. Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV). Blood 2007, 109:3873-3880.
-
(2007)
Blood
, vol.109
, pp. 3873-3880
-
-
White, L.1
Krishnan, S.2
Strbo, N.3
Liu, H.4
Kolber, M.A.5
Lichtenheld, M.G.6
Pahwa, R.N.7
Pahwa, S.8
-
60
-
-
70350702821
-
Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1
-
Hogg A.E., Bowick G.C., Herzog N.K., Cloyd M.W., Endsley J.J. Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1. J. Leukoc. Biol. 2009, 86:1191-1203.
-
(2009)
J. Leukoc. Biol.
, vol.86
, pp. 1191-1203
-
-
Hogg, A.E.1
Bowick, G.C.2
Herzog, N.K.3
Cloyd, M.W.4
Endsley, J.J.5
-
61
-
-
57449101496
-
NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection
-
Alter G., Altfeld M. NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection. J. Intern. Med. 2009, 265:29-42.
-
(2009)
J. Intern. Med.
, vol.265
, pp. 29-42
-
-
Alter, G.1
Altfeld, M.2
-
62
-
-
52249084769
-
IL-21 augments natural killer effector functions in chronically HIV-infected individuals
-
Strbo N., de Armas L., Liu H., Kolber M.A., Lichtenheld M., Pahwa S. IL-21 augments natural killer effector functions in chronically HIV-infected individuals. AIDS 2008, 22:1551-1560.
-
(2008)
AIDS
, vol.22
, pp. 1551-1560
-
-
Strbo, N.1
de Armas, L.2
Liu, H.3
Kolber, M.A.4
Lichtenheld, M.5
Pahwa, S.6
-
63
-
-
77952540913
-
IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication
-
Iannello A., Boulassel M.R., Samarani S., Tremblay C., Toma E., Routy J.P., Ahmad A. IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication. J. Leukoc. Biol. 2010.
-
(2010)
J. Leukoc. Biol.
-
-
Iannello, A.1
Boulassel, M.R.2
Samarani, S.3
Tremblay, C.4
Toma, E.5
Routy, J.P.6
Ahmad, A.7
-
64
-
-
61449115882
-
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
-
e1000295
-
Favre D., Lederer S., Kanwar B., Ma Z.M., Proll S., Kasakow Z., Mold J., Swainson L., Barbour J.D., Baskin C.R., Palermo R., Pandrea I., Miller C.J., Katze M.G., McCune J.M. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009, 5. e1000295.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Favre, D.1
Lederer, S.2
Kanwar, B.3
Ma, Z.M.4
Proll, S.5
Kasakow, Z.6
Mold, J.7
Swainson, L.8
Barbour, J.D.9
Baskin, C.R.10
Palermo, R.11
Pandrea, I.12
Miller, C.J.13
Katze, M.G.14
McCune, J.M.15
-
65
-
-
53449093632
-
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
-
Brenchley J.M., Paiardini M., Knox K.S., Asher A.I., Cervasi B., Asher T.E., Scheinberg P., Price D.A., Hage C.A., Kholi L.M., Khoruts A., Frank I., Else J., Schacker T., Silvestri G., Douek D.C. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 2008, 112:2826-2835.
-
(2008)
Blood
, vol.112
, pp. 2826-2835
-
-
Brenchley, J.M.1
Paiardini, M.2
Knox, K.S.3
Asher, A.I.4
Cervasi, B.5
Asher, T.E.6
Scheinberg, P.7
Price, D.A.8
Hage, C.A.9
Kholi, L.M.10
Khoruts, A.11
Frank, I.12
Else, J.13
Schacker, T.14
Silvestri, G.15
Douek, D.C.16
-
66
-
-
33745840137
-
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
-
Pesce J., Kaviratne M., Ramalingam T.R., Thompson R.W., Urban J.F., Cheever A.W., Young D.A., Collins M., Grusby M.J., Wynn T.A. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J. Clin. Invest. 2006, 116:2044-2055.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2044-2055
-
-
Pesce, J.1
Kaviratne, M.2
Ramalingam, T.R.3
Thompson, R.W.4
Urban, J.F.5
Cheever, A.W.6
Young, D.A.7
Collins, M.8
Grusby, M.J.9
Wynn, T.A.10
-
67
-
-
33847412873
-
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
-
Frohlich A., Marsland B.J., Sonderegger I., Kurrer M., Hodge M.R., Harris N.L., Kopf M. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 2007, 109:2023-2031.
-
(2007)
Blood
, vol.109
, pp. 2023-2031
-
-
Frohlich, A.1
Marsland, B.J.2
Sonderegger, I.3
Kurrer, M.4
Hodge, M.R.5
Harris, N.L.6
Kopf, M.7
|