Tracing functional antigen-specific CCR6+ Th17 cells after vaccination

PLoS ONE

Volumn 3, Issue 8, 2008, Pages

  Pötzl, Johann ^a   Botteron, Catherine ^a   Tausch, Eugen ^a   Pedré, Xiomara ^a   Mueller, André M ^a,b   Männel, Daniela N ^a   Lechner, Anja ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b Multiple Sclerosis Research Center of New York Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR6; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 17; OVALBUMIN; CCR6 PROTEIN, MOUSE; GAMMA INTERFERON; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL SELECTION; CELL STIMULATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DISEASE SEVERITY; DONOR; FLOW CYTOMETRY; HELPER CELL; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IN VITRO STUDY; IN VIVO STUDY; INFECTION RESISTANCE; LEUKOCYTE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE HOMING; LYMPHOCYTE PROLIFERATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; VACCINATION; ANIMAL; ANTIBODY PRODUCTION; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL DIVISION; DRUG EFFECT; IMMUNIZATION; IMMUNOLOGY; LYMPH NODE; MOUSE STRAIN;

ANIMALIA; MUS;

ANIMALS; ANTIBODY FORMATION; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOCOMPETENCE; INTERFERON-GAMMA; IONOMYCIN; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; OVALBUMIN; RECEPTORS, CCR6; T-LYMPHOCYTES, HELPER-INDUCER; TETRADECANOYLPHORBOL ACETATE;

EID: 51449086403     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002951     Document Type: Article

References (44)

1. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145-173.
2. Leavings MK, Roncarolo MG (2005) Phenotypic and functional differences between human CD4+CD25+ and type I regulatory T cells. Curr Top Microbiol Immunol 293: 303-326.
3. Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, et al. (2003) Cutting edge: roles or Toll-like receptor 4 and IL-23 in IL,17 expression in response to Klebsiella pneumoniae infection. J Immunol 170: 4432-4436.
4. Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK , et al. (2005) IL-23 compensates for the absence of IL-12p7O and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p7O is available. J Immunol 175: 788-795.
5. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
6. Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, et al. (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL- 12 in joint autoimmune inflammation. J Exp Med 198: 1951-1957.
7. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201: 233-240.
8. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
9. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189.
10. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, et al. (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-483.
11. Bettelli E, Carrier Y, Gao W, Kom T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
12. Abdollahi-Roodsaz S, Jooster, LA, Koenders MI, Devesa I, Roelofs MF, et al. (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118: 205-216.
13. van Berlen AJ, Zelinkova Z, Taanman-Kueter EW, Muller FJ, Hommes DW, et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27: 660-669.
14. Bogdan C, Gessner A, Solbach W, Rollinghoff M (1996) Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol 8: 517-525.
15. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, et al. (2007) Surface phenotype and antigenic specificity of human interleukin 17-roducing T helper memory cells. Nat Immunol 8, 639-646.
16. Hirota K., Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, et al. (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204: 2803-2812.
17. Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, et al. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A 98: 9237-9242.
18. Lechner A, Ritter U, Varona R, Marquez G, Bogdan C, et al. (2007) Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice. Microbes Infect 9: 291-299.
19. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712.
20. Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, et al. (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177: 566-573.
21. Sallusto F, Kremmer E, Palermo B, Hoy A, Ponath P, et al. (1999) Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 29: 2037-2045.
22. Kim CH, Rott L, Kunkel EJ, Genovese MC, Andrew DP, et al. (2001) Rides ol chemokine receptor association with T cell polarization in vivo. J Clin Invest 108: 1331-1339.
23. Fitzhugh DJ, Naik S, Caughman SW, Hwang ST (2000) Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro. J Immunol 165: 6677-6681.
24. Bettelli E, Kom T, Kirchroo VK (2007) Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 19: 652-657.
25. Homey B, Dieu-Nosjean MC, Wiesenbom A, Massacrier C, Pin JJ, et al. (2000) Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164: 6621-6632.
26. Matsui T, Akahoshi T, Namai R, Hashimoto A, Kurihara Y, et al. (2001) Selective recruitment of CCR6-expressing cells by increased production of MIP-3 alpha in rheumatoid arthritis. Clin Exp Immunol 125: 155-161.
27. Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, et al. (2007) T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204: 41-47.
28. Chen X, Howard OM, Oppenheim JJ (2007) Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells. J Immunol 178: 6123-6129.
29. Cai G, Hafler DA (2007) Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes. Eur J Immunol 37: 602-612.
30. Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, et al. (2007) Polyspecificity of T cell and B cell receptor recognition. Semin Immunol 19: 216-224.
31. Dorfman JR, Germain RN (2002) MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect 4: 547-554.
32. Kieper WC, Burghardt JT, Surh CD (2004) A role for TCR affinity in regulating naive T cell homeostasis. J Immunol 172: 40-44.
33. Wucherpfennig KW, Strominger JL (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80: 695-705.
34. Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, et al. (1994) Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol 152: 5581-5592.
35. Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK (2006) Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 203: 2785-2791.
36. Witowski J, Pawlaczyk K, Breborowicz A, Scheuren A, Kuzlan-Pawlaczyk M, et al. (2000) IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J Immunol 165: 5814-5821.
37. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, et al. (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183: 2593-2603.
38. Laan M, Cui ZH, Hoshino H, Lotvall J, Sjostrand M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 162: 2347-2352.
39. Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, et al. (2001) Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol 25: 335-340.
40. Kohler RE, Caon AC, Willenborg DO, Clark-Lewis I, McColl SR (2003) A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system. J Immunol 170: 6298-6306.
41. Ambrosini E, Columba-Cabezas S, Serafini B, Muscella A, Aloisi F (2003) Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomy-elitis and in vitro. Glia 41: 290-300.
42. Varona R, Villares R, Carramolino L, Goya I, Zaballos A, et al. (2001) CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J Clin Invest 107: 37-45.
43. Bettelli E, Oukka M, Kuchroo VK (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8: 345-350.
44. Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, et al. (2005) CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood 105: 2877-2886.