IL-4 acts as a potent stimulator of IFN-γ expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet

Cytokine

Volumn 57, Issue 1, 2012, Pages 191-199

  Oliver, Jennifer A ^a   Stolberg, Valerie R ^b   Chensue, Stephen W ^b   King, Philip D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

CD8 T cell; Cytokines; Knock out mice; Signal transduction

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; EOMESODERMIN; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; STAT6 PROTEIN; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; LYMPHOCYTE CULTURE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; ENZYME ACTIVATION; INTERFERON-GAMMA; INTERLEUKIN-2; INTERLEUKIN-4; INTRACELLULAR SPACE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, ANTIGEN, T-CELL; STAT6 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS;

MURINAE; MUS;

EID: 84155170679     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.10.006     Document Type: Article

References (30)

1. Allan W., Tabi Z., Cleary A., Doherty P.C. Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells. J Immunol 1990, 144:3980-3986.
2. Buller R.M., Holmes K.L., Hugin A., Frederickson T.N., Morse H.C. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 1987, 328:77-79.
3. Cardin R.D., Brooks J.W., Sarawar S.R., Doherty P.C. Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells. J Exp Med 1996, 184:863-871.
4. Riberdy J.M., Christensen J.P., Branum K., Doherty P.C. Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(-/-) mice. J Virol 2000, 74:9762-9765.
5. Shedlock D.J., Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003, 300:337-339.
6. Taniguchi T., Minami Y. The IL-2/IL-2 receptor system: a current overview. Cell 1993, 73:5-8.
7. Kopf M., Le Gros G., Bachmann M., Lamers M.C., Bluethmann H., Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993, 362:245-248.
8. Le Gros G., Ben-Sasson S.Z., Seder R., Finkelman F.D., Paul W.E. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 1990, 172:921-929.
9. Bachmann M.F., Schorle H., Kuhn R., Muller W., Hengartner H., Zinkernagel R.M., et al. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J Virol 1995, 69:4842-4846.
10. Marsland B.J., Schmitz N., Kopf M. IL-4Ralpha signaling is important for CD8+ T cell cytotoxicity in the absence of CD4+ T cell help. Eur J Immunol 2005, 35:1391-1398.
11. Carvalho L.H., Sano G., Hafalla J.C., Morrot A., Curotto de Lafaille M.A., Zavala F. IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. Nat Med 2002, 8:166-170.
12. Pedras-Vasconcelos J.A., Brunet L.R., Pearce E.J. Profound effect of the absence of IL-4 on T cell responses during infection with Schistosoma mansoni. J Leukoc Biol 2001, 70:737-744.
13. Stager S., Alexander J., Kirby A.C., Botto M., Rooijen N.V., Smith D.F., et al. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med 2003, 9:1287-1292.
14. Huang L.R., Chen F.L., Chen Y.T., Lin Y.M., Kung J.T. Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation. Proc Natl Acad Sci USA 2000, 97:3406-3411.
15. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108.
16. Rochman Y., Spolski R., Leonard W.J. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol 2009, 9:480-490.
17. Wang X., Lupardus P., Laporte S.L., Garcia K.C. Structural biology of shared cytokine receptors. Annu Rev Immunol 2009, 27:29-60.
18. Taniguchi M., Harada M., Kojo S., Nakayama T., Wakao H. The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol 2003, 21:483-513.
19. Das R., Sant'Angelo D.B., Nichols K.E. Transcriptional control of invariant NKT cell development. Immunol Rev 2010, 238:195-215.
20. Betts M.R., Koup R.A. Detection of T-cell degranulation: CD107a and b. Methods Cell Biol 2004, 75:497-512.
21. Banerjee A., Gordon S.M., Intlekofer A.M., Paley M.A., Mooney E.C., Lindsten T., et al. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol 2010, 185:4988-4992.
22. Glimcher L.H., Townsend M.J., Sullivan B.M., Lord G.M. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004, 4:900-911.
23. Acacia de Sa Pinheiro A., Morrot A., Chakravarty S., Overstreet M., Bream J.H., Irusta P.M., et al. IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells. J Leukoc Biol 2007, 81:1102-1110.
24. Wurster A.L., Withers D.J., Uchida T., White M.F., Grusby M.J. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol 2002, 22:117-126.
25. Chuang L.M., Tai T.Y., Kahn R.C., Wu H.P., Lee S.C., Lin B.J. Signal transduction pathways for interleukin 4 and insulin in human hepatoma cells. J Biochem 1996, 120:111-116.
26. Dong C., Davis R.J., Flavell R.A. MAP kinases in the immune response. Annu Rev Immunol 2002, 20:55-72.
27. Okkenhaug K., Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 2003, 3:317-330.
28. Weinreich M.A., Odumade O.A., Jameson S.C., Hogquist K.A. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol 2010, 11:709-716.
29. Morris S.C., Heidorn S.M., Herbert D.R., Perkins C., Hildeman D.A., Khodoun M.V., et al. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. J Immunol 2009, 182:1429-1438.
30. Morrot A., Hafalla J.C., Cockburn I.A., Carvalho L.H., Zavala F. IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med 2005, 202:551-560.