Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12132-12141

  Chen, Guang ^a,b   Chen, Si Meng ^a   Wang, Xiang ^a   Ding, Xiao Fei ^b   Ding, Jian ^a   Meng, Ling Hua ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b TAIZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MIGRATION; CHEMOKINES; CHEMOTACTIC RESPONSE; DOWN-REGULATION; F-ACTIN; FUSION PROTEINS; GASTRIC CANCER CELLS; GASTRIC CANCERS; GASTRIC CARCINOMA; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL; POSITIVE FEEDBACK LOOP; PROTEIN INHIBITORS; RAPAMYCIN; SPECIFIC INHIBITORS; TRIPHOSPHATE;

CELLS; CHEMICAL ACTIVATION; CYTOLOGY; DRUG THERAPY; ENZYME INHIBITION; PHOSPHORYLATION; PROTEINS;

ANTIBIOTICS;

CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; F ACTIN; G PROTEIN COUPLED RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN P110; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1; TESTIS DETERMINING FACTOR; THREONINE; TRANSCRIPTION FACTOR SOX1;

ARTICLE; CARCINOMA CELL; CATALYSIS; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; METASTASIS POTENTIAL; MOLECULAR INTERACTION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STOMACH CARCINOMA;

ACTINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL12; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DOWN-REGULATION; FEEDBACK, PHYSIOLOGICAL; FURANS; GENE EXPRESSION; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; PYRIMIDINES; RECEPTORS, CXCR4; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; STOMACH NEOPLASMS; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84859508518     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.302299     Document Type: Article

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