CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation

Blood

Volumn 118, Issue 23, 2011, Pages 6107-6114

  De Wit, Jelle ^a   Souwer, Yuri ^a   Van Beelen, Astrid J ^a   De Groot, Rosa ^a   Muller, Femke J M ^a   Bos, Hanny Klaasse ^a   Jorritsma, Tineke ^a   Kapsenberg, Martien L ^a   De Jong, Esther C ^a   Van Ham, S Marieke ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD5 ANTIGEN; CD6 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL;

EID: 82955189334     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-352682     Document Type: Article

References (43)

1. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol. 2008;9(6):641-649. (Pubitemid 351714729)
2. Volpe E, Servant N, Zollinger R, et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol. 2008;9(6):650-657. (Pubitemid 351712635)
3. Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007;8(9):950-957.
4. Yang L, Anderson DE, Baecher-Allan C, et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008; 454(7202):350-352.
5. Bouguermouh S, Fortin G, Baba N, Rubio M, Sarfati M. CD28 co-stimulation down regulates Th17 development. PLoS One. 2009;4(3):e5087.
6. Paulos CM, Carpenito C, Plesa G, et al. The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells. Sci Transl Med. 2010;2(55):55ra78.
7. Ceuppens JL, Baroja ML. Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase-bound OKT3. J Immunol. 1986;137(6):1816-1821. (Pubitemid 16021089)
8. Spertini F, Stohl W, Ramesh N, Moody C, Geha RS. Induction of human T cell proliferation by a monoclonal antibody to CD5. J Immunol. 1991;146(1):47-52.
9. Brossard C, Semichon M, Trautmann A, Bismuth G. CD5 inhibits signaling at the immunological synapse without impairing its formation. J Immunol. 2003;170(9):4623-4629. (Pubitemid 36519968)
10. Gimferrer I, Farnos M, Calvo M, et al. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. J Biol Chem. 2003;278(10):8564-8571. (Pubitemid 36800610)
11. Verwilghen J, Kingsley GH, Ceuppens JL, Panayi GS. Inhibition of synovial fluid T cell proliferation by anti-CD5 monoclonal antibodies.Apotential mechanism for their immunotherapeutic action in vivo. Arthritis Rheum. 1992;35(12):1445-1451. (Pubitemid 23013651)
12. Stanton T, Stevens TL, Ledbetter JA, Wofsy D. Anti-Ly-1 antibody induces interleukin 2 release from T cells. J Immunol. 1986;136(5):1734-1737. (Pubitemid 16119583)
13. Axtell RC, Xu L, Barnum SR, Raman C. CD5- CK2 binding/activation- deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006;177(12): 8542-8549. (Pubitemid 44893816)
14. Souwer Y, Chamuleau ME, van de Loosdrecht AA, et al. Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOAmRNAas a prognostic factor for survival. Br J Haematol. 2009;145(3):334-343.
15. McMichael AJ, Beverley PCL, Cobbold S, et al. Leucocyte Typing III: White Cell Differentiation Antigens. Oxford, United Kingdom; Oxford University Press; 1987.
16. Kryczek I, Wei S, Zou L, et al. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol. 2007;178(11):6730-6733. (Pubitemid 46847396)
17. Yang XO, Panopoulos AD, Nurieva R, et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007; 282(13):9358-9363. (Pubitemid 47104613)
18. Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967-974. (Pubitemid 47300011)
19. McGeachy MJ, Chen Y, Tato CM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol. 2009;10(3):314-324.
20. Stritesky GL, Yeh N, Kaplan MH. IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol. 2008;181(9):5948-5955.
21. Harris TJ, Grosso JF, Yen HR, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179(7):4313-4317.
22. Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126(6):1121-1133. (Pubitemid 44380299)
23. Yang XO, Pappu BP, Nurieva R, et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008;28(1):29-39.
24. Freeman M, Ashkenas J, Rees DJ, et al. An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990;87(22):8810-8814. (Pubitemid 120007598)
25. Jones NH, Clabby ML, Dialynas DP, et al. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. Nature. 1986;323(6086):346-349. (Pubitemid 16033134)
26. Aruffo A, Melnick MB, Linsley PS, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med. 1991;174(4):949-952.
27. Laffont S, Siddiqui KR, Powrie F. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur J Immunol. 2010;40(7):1877-1883.
28. Hall JA, Cannons JL, Grainger JR, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34(3):435-447.
29. Monteleone I, Platt AM, Jaensson E, Agace WW, Mowat AM. IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function. Eur J Immunol. 2008; 38(6):1533-1547.
30. van de Veerdonk FL, Lauwerys B, Marijnissen RJ, et al. The anti-CD20 antibody rituximab reduces the T helper 17 response. Arthritis Rheum. 2011; 63(6): 1507-15160
31. Brown MH, Lacey E. A ligand for CD5 is CD5. J Immunol. 2010;185(10):6068-6074.
32. Van de Velde H, von Hoegen I, LuoW, Parnes JR, Thielemans K. The B-cell surface protein CD72/ Lyb-2 is the ligand for CD5. Nature. 1991;351(6328): 662-665. (Pubitemid 21896665)
33. Saifullah MK, Fox DA, Sarkar S, et al. Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues. J Immunol. 2004;173(10):6125-6133. (Pubitemid 39487769)
34. Vera J, Fenutria R, Canadas O, et al. The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosaninduced septic shock-like syndrome. Proc Natl Acad Sci U S A. 2009;106(5):1506-1511.
35. Sarrias MR, Farnos M, Mota R, et al. CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci U S A. 2007;104(28):11724-11729. (Pubitemid 47175080)
36. Dubin PJ, Kolls JK. Th17 cytokines and mucosal immunity. Immunol Rev. 2008;226:160-171.
37. Puel A, Picard C, Cypowyj S, et al. Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr Opin Immunol. 2010;22(4):467-474.
38. Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139(3):485-498.
39. Ivanov II, Frutos RL, Manel N, et al. Specific micro biota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008;4(4):337-349.
40. Chassaing B, Darfeuille-Michaud A. The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1720-1728.
41. Dasu T, Qualls JE, Tuna H, et al. CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. Immunol Lett. 2008;119(1-2):103-113.
42. Biancone L, Bowen MA, Lim A, et al. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. J Exp Med. 1996;184(3): 811-819.
43. Paust HJ, Turner JE, Steinmetz OM, et al. The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol. 2009;20(5):969-979.