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Volumn 180, Issue 7, 2008, Pages 4785-4792

Isoform-specific inhibition of RORα-mediated transcriptional activation by human FOXP3

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CELL RECEPTOR; FACTOR AF2; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; RAR RELATED ORPHAN RECEPTOR A; RAR-RELATED ORPHAN RECEPTOR A; TISSUE EXTRACT; TRANSACTIVATOR PROTEIN;

EID: 44449131480     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4785     Document Type: Article
Times cited : (204)

References (45)
  • 1
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach, E. M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18: 423-449.
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 2
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh, M., T. Takahashi, N. Sakaguchi, Y. Kuniyasu, J. Shimizu, F. Otsuka, and S. Sakaguchi. 1999. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
    • (1999) J. Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3    Kuniyasu, Y.4    Shimizu, J.5    Otsuka, F.6    Sakaguchi, S.7
  • 6
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adapted regulatory T cells
    • Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adapted regulatory T cells. Nat. Rev. Immunol. 3: 253-257.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 8
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor FoxP3
    • Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 9
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., T. Cox, S.-A. Yasayko, and F. Ramsdell. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4: 337-342.
    • (2003) Nat. Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.-A.3    Ramsdell, F.4
  • 11
    • 0035167967 scopus 로고    scopus 로고
    • Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. F. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FOXP3. Nat. Genet. 27: 20-21.
    • Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. F. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FOXP3. Nat. Genet. 27: 20-21.
  • 12
  • 16
    • 1842847181 scopus 로고    scopus 로고
    • Retinoid-related orphan receptors (RORs): Roles in cell survival, differentiation, and disease
    • Jetten, A. M., and E. Ueda. 2002. Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation, and disease. Cell Death Differ. 9: 1167-1171.
    • (2002) Cell Death Differ , vol.9 , pp. 1167-1171
    • Jetten, A.M.1    Ueda, E.2
  • 18
    • 4344667111 scopus 로고    scopus 로고
    • Lymphocyte development and function in the absence of retinoic acid-related orphan receptor
    • Dzhagalov, I., V. Giguere, and Y. He. 2004. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor. J. Immunol. 173: 2952-2959.
    • (2004) J. Immunol , vol.173 , pp. 2952-2959
    • Dzhagalov, I.1    Giguere, V.2    He, Y.3
  • 19
    • 0032527749 scopus 로고    scopus 로고
    • Disruption of retinoid-related orphan receptor changes circadian behavior, causes retinal degeneration, and leads to vacillans phenotype in mice
    • Andre, E., F. Conquet, M. Steinmayr, S. C. Stratton, V. Porciatti, and M. Becker-Andre. 1998. Disruption of retinoid-related orphan receptor changes circadian behavior, causes retinal degeneration, and leads to vacillans phenotype in mice. EMBO J. 17: 3867-3877.
    • (1998) EMBO J , vol.17 , pp. 3867-3877
    • Andre, E.1    Conquet, F.2    Steinmayr, M.3    Stratton, S.C.4    Porciatti, V.5    Becker-Andre, M.6
  • 21
    • 0034730131 scopus 로고    scopus 로고
    • Retinoid-related orphan receptor y (RORγ) is essential for lymphoid organogenesis and control apoptosis during thymopoiesis
    • Kuribayashi, S., E. Ueda, M. Sakaue, D. D. Patel, A. Medvedev, F. Zhang, and A. M. Jetten. 2000. Retinoid-related orphan receptor y (RORγ) is essential for lymphoid organogenesis and control apoptosis during thymopoiesis. Proc. Natl. Acad. Sci. USA 97: 10132-10137.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10132-10137
    • Kuribayashi, S.1    Ueda, E.2    Sakaue, M.3    Patel, D.D.4    Medvedev, A.5    Zhang, F.6    Jetten, A.M.7
  • 22
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORyt in the generation of fetal lymphoid tissue inducer cells
    • Eberl, G., S. Marmon, M. J. Sunshine, P. D. Rennert, Y. Choi, and D. R. Littman. 2004. An essential function for the nuclear receptor RORyt in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5: 64-73.
    • (2004) Nat. Immunol , vol.5 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.J.3    Rennert, P.D.4    Choi, Y.5    Littman, D.R.6
  • 23
    • 33846512988 scopus 로고    scopus 로고
    • Inducible expression of the proallergic cy-tokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NF-κB
    • Lee, H. C., and S. F. Ziegler. 2007. Inducible expression of the proallergic cy-tokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NF-κB.Proc. Natl. Acad. Sci. USA 104: 914-919.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 914-919
    • Lee, H.C.1    Ziegler, S.F.2
  • 25
    • 1542274137 scopus 로고    scopus 로고
    • RORα1 and RORα4 suppress TNF-induced VCAM-1 and ICAM-1 expression in human endothelial cells
    • Migita, H., N. Satozawa, J. Lin, J. Morser, and K. Kawai. 2004. RORα1 and RORα4 suppress TNF-induced VCAM-1 and ICAM-1 expression in human endothelial cells. FEBS Lett. 557: 269-274.
    • (2004) FEBS Lett , vol.557 , pp. 269-274
    • Migita, H.1    Satozawa, N.2    Lin, J.3    Morser, J.4    Kawai, K.5
  • 26
    • 0035238364 scopus 로고    scopus 로고
    • The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes
    • Jetten, A. M., K. Kuribayashi, and E. Ueda. 2001. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog. Nucleic Acid Res. Mol. Biol. 69: 205-247.
    • (2001) Prog. Nucleic Acid Res. Mol. Biol , vol.69 , pp. 205-247
    • Jetten, A.M.1    Kuribayashi, K.2    Ueda, E.3
  • 27
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert, L. A., E. W. Jeffery, Y. Zhang, F. Ramsdell, and S. F. Ziegler. 2001. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276: 37672-37679.
    • (2001) J. Biol. Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.W.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 28
    • 0038646966 scopus 로고    scopus 로고
    • Activation of nuclear receptors: A perspective from structural genomics
    • Li, Y., M. H. Lambert, and J. E. Xu. 2003. Activation of nuclear receptors: a perspective from structural genomics. Structure 11: 741-746.
    • (2003) Structure , vol.11 , pp. 741-746
    • Li, Y.1    Lambert, M.H.2    Xu, J.E.3
  • 29
    • 0030950531 scopus 로고    scopus 로고
    • AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
    • Henttu, P. M. A., E. Kalkhoven, and M. G. Parker. 1997. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol. 17: 1832-1839.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 1832-1839
    • Henttu, P.M.A.1    Kalkhoven, E.2    Parker, M.G.3
  • 31
    • 0036246250 scopus 로고    scopus 로고
    • Characterization of the retinoid orphan-related receptor-α coactivator binding interface: A structural basis for ligand-independent transcription
    • Harris, J. M., P. Lau, S. L. Chen, and G. E. O. Muscat. 2002. Characterization of the retinoid orphan-related receptor-α coactivator binding interface: a structural basis for ligand-independent transcription. Mol. Endocrinol. 16: 998-1012.
    • (2002) Mol. Endocrinol , vol.16 , pp. 998-1012
    • Harris, J.M.1    Lau, P.2    Chen, S.L.3    Muscat, G.E.O.4
  • 33
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scrufy (sf) mutant mouse
    • Godfrey, V., J. E. Wilkinson, and L. B. Russell. 1991. X-linked lymphoreticular disease in the scrufy (sf) mutant mouse. Am. J. Pathol. 138: 1379-1387.
    • (1991) Am. J. Pathol , vol.138 , pp. 1379-1387
    • Godfrey, V.1    Wilkinson, J.E.2    Russell, L.B.3
  • 34
    • 0036961493 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocri-nopathy, enteropathy, X-linked syndrome: A model of immune dysregulation
    • Torgerson, T. R., and H. D. Ochs. 2002. Immune dysregulation, polyendocri-nopathy, enteropathy, X-linked syndrome: a model of immune dysregulation. Curr. Opin. Allergy Clin. Immunol. 2: 481-487.
    • (2002) Curr. Opin. Allergy Clin. Immunol , vol.2 , pp. 481-487
    • Torgerson, T.R.1    Ochs, H.D.2
  • 36
    • 33745463549 scopus 로고    scopus 로고
    • The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
    • Chae, W.-J., O. Henegariu, S.-K. Lee, and A. L. M. Bothwell. 2006. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. USA 103: 9631-9636.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9631-9636
    • Chae, W.-J.1    Henegariu, O.2    Lee, S.-K.3    Bothwell, A.L.M.4
  • 37
    • 17044393922 scopus 로고    scopus 로고
    • Bettelli, E., M. Dastrange, and M. Oukka. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102: 5138-5143. 38. Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan, J. C. Stroud, D. L. Bates, L. Guo, A. Han, S. F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387.
    • Bettelli, E., M. Dastrange, and M. Oukka. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102: 5138-5143. 38. Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan, J. C. Stroud, D. L. Bates, L. Guo, A. Han, S. F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387.
  • 38
    • 18244378309 scopus 로고    scopus 로고
    • Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)
    • Kobayashi, I., R. Shiari, M. Yamada, N. Kawamura, M. Okano, A. Yara, A. Iguchi, N. Ishidawa, T. Ariga, Y. Sakiyama, et al. 2001. Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). J. Med. Genet. 38: 874-876.
    • (2001) J. Med. Genet , vol.38 , pp. 874-876
    • Kobayashi, I.1    Shiari, R.2    Yamada, M.3    Kawamura, N.4    Okano, M.5    Yara, A.6    Iguchi, A.7    Ishidawa, N.8    Ariga, T.9    Sakiyama, Y.10
  • 40
    • 0033523917 scopus 로고    scopus 로고
    • The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
    • Hu, X., and M. A. Lazar. 1999. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402: 93-96.
    • (1999) Nature , vol.402 , pp. 93-96
    • Hu, X.1    Lazar, M.A.2
  • 43
    • 0030986236 scopus 로고    scopus 로고
    • A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    • Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387: 733-737.
    • (1997) Nature , vol.387 , pp. 733-737
    • Heery, D.M.1    Kalkhoven, E.2    Hoare, S.3    Parker, M.G.4
  • 45
    • 0031194108 scopus 로고    scopus 로고
    • The structural integrity of ROR iso-forms is mutated in staggerer mice: Cerebellar coexpression of ROR1 and ROR4
    • Matysiak-Scholze, U., and M. Nehls. 1997. The structural integrity of ROR iso-forms is mutated in staggerer mice: cerebellar coexpression of ROR1 and ROR4. Genomics 43: 78-84.
    • (1997) Genomics , vol.43 , pp. 78-84
    • Matysiak-Scholze, U.1    Nehls, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.