-
1
-
-
17444413067
-
In vitro generation of infectious scrapie prions
-
Castilla, J.; Saa, P.; Hetz, C.; Soto, C. In vitro generation of infectious scrapie prions. Cell, 2005, 121(2), 195-206.
-
(2005)
Cell,
, vol.121
, Issue.2
, pp. 195-206
-
-
Castilla, J.1
Saa, P.2
Hetz, C.3
Soto, C.4
-
2
-
-
34547491652
-
Formation of native prions from minimal components in vitro
-
Deleault, N.R.; Harris, B.T.; Rees, J.R.; Supattapone, S. Formation of native prions from minimal components in vitro. Proc. Natl. Acad. Sci. USA, 2007, 104(23), 9741-9746.
-
(2007)
Proc. Natl. Acad. Sci. USA,
, vol.104
, Issue.23
, pp. 9741-9746
-
-
Deleault, N.R.1
Harris, B.T.2
Rees, J.R.3
Supattapone, S.4
-
3
-
-
0036705807
-
Lack of plasma membrane targeting of a G172D mutant thiamine transporter derived from Rogers syndrome family
-
Baron, D.; Assaraf, Y.G.; Cohen, N.; Aronheim, A. Lack of plasma membrane targeting of a G172D mutant thiamine transporter derived from Rogers syndrome family. Mol. Med., 2002, 8(8), 462-474.
-
(2002)
Mol. Med.
, vol.8
, Issue.8
, pp. 462-474
-
-
Baron, D.1
Assaraf, Y.G.2
Cohen, N.3
Aronheim, A.4
-
4
-
-
0025991466
-
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease-and phospholipase-sensitive
-
Caughey, B.; Raymond, G.J. The scrapie-associated form of PrP is made from a cell surface precursor that is both protease-and phospholipase-sensitive. J. Biol. Chem., 1991, 266(27), 18217-18223.
-
(1991)
J. Biol. Chem.
, vol.266
, Issue.27
, pp. 18217-18223
-
-
Caughey, B.1
Raymond, G.J.2
-
5
-
-
0025876226
-
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): Implications regarding the site of conversion of PrP to the protease-resistant state
-
Caughey, B.; Raymond, G.J.; Ernst, D.; Race, R.E. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J. Virol., 1991, 65(12), 6597-6603.
-
(1991)
J. Virol.
, vol.65
, Issue.12
, pp. 6597-6603
-
-
Caughey, B.1
Raymond, G.J.2
Ernst, D.3
Race, R.E.4
-
6
-
-
0026775909
-
Evidence for synthesis of scrapie prion proteins in the endocytic pathway
-
Borchelt, D.R.; Taraboulos, A.; Prusiner, S.B. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J. Biol. Chem., 1992, 267(23), 16188-16199.
-
(1992)
J. Biol. Chem.
, vol.267
, Issue.23
, pp. 16188-16199
-
-
Borchelt, D.R.1
Taraboulos, A.2
Prusiner, S.B.3
-
7
-
-
20344394154
-
Anchorless prion protein results in infectious amyloid disease without clinical scrapie
-
Chesebro, B.; Trifilo, M.; Race, R.; Meade-White, K.; Teng, C.; LaCasse, R.; Raymond, L.; Favara, C.; Baron, G.; Priola, S.; Caughey, B.; Masliah, E.; Oldstone, M. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science, 2005, 308(5727), 1435-1439.
-
(2005)
Science,
, vol.308
, Issue.5727
, pp. 1435-1439
-
-
Chesebro, B.1
Trifilo, M.2
Race, R.3
Meade-White, K.4
Teng, C.5
LaCasse, R.6
Raymond, L.7
Favara, C.8
Baron, G.9
Priola, S.10
Caughey, B.11
Masliah, E.12
Oldstone, M.13
-
8
-
-
33645305159
-
Preparation of soluble infectious samples from scrapie-infected brain: A new tool to study the clearance of transmissible spongiform encephalopathy agents during plasma fractionation
-
Berardi, V.A.; Cardone, F.; Valanzano, A.; Lu, M.; Pocchiari, M. Preparation of soluble infectious samples from scrapie-infected brain: a new tool to study the clearance of transmissible spongiform encephalopathy agents during plasma fractionation. Transfusion, 2006, 46(4), 652-658.
-
(2006)
Transfusion,
, vol.46
, Issue.4
, pp. 652-658
-
-
Berardi, V.A.1
Cardone, F.2
Valanzano, A.3
Lu, M.4
Pocchiari, M.5
-
9
-
-
24644448839
-
The most infectious prion protein particles
-
Silveira, J.R.; Raymond, G.J.; Hughson, A.G.; Race, R.E.; Sim, V.L.; Hayes, S.F.; Caughey, B. The most infectious prion protein particles. Nature, 2005, 437(7056), 257-261.
-
(2005)
Nature,
, vol.437
, Issue.7056
, pp. 257-261
-
-
Silveira, J.R.1
Raymond, G.J.2
Hughson, A.G.3
Race, R.E.4
Sim, V.L.5
Hayes, S.F.6
Caughey, B.7
-
10
-
-
33845915792
-
Isolation and characterization of a proteinase K-sensitive PrPSc fraction
-
Pastrana, M.A.; Sajnani, G.; Onisko, B.; Castilla, J.; Morales, R.; Soto, C.; Requena, J.R. Isolation and characterization of a proteinase K-sensitive PrPSc fraction. Biochemistry, 2006, 45(51), 15710-15717.
-
(2006)
Biochemistry,
, vol.45
, Issue.51
, pp. 15710-15717
-
-
Pastrana, M.A.1
Sajnani, G.2
Onisko, B.3
Castilla, J.4
Morales, R.5
Soto, C.6
Requena, J.R.7
-
11
-
-
0037159185
-
Proteasesensitive scrapie prion protein in aggregates of heterogeneous sizes
-
Tzaban, S.; Friedlander, G.; Schonberger, O.; Horonchik, L.; Yedidia, Y.; Shaked, G.; Gabizon, R.; Taraboulos, A. Proteasesensitive scrapie prion protein in aggregates of heterogeneous sizes. Biochemistry, 2002, 41(42), 12868-12875.
-
(2002)
Biochemistry,
, vol.41
, Issue.42
, pp. 12868-12875
-
-
Tzaban, S.1
Friedlander, G.2
Schonberger, O.3
Horonchik, L.4
Yedidia, Y.5
Shaked, G.6
Gabizon, R.7
Taraboulos, A.8
-
12
-
-
33744961169
-
Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons
-
Novitskaya, V.; Bocharova, O.V.; Bronstein, I.; Baskakov, I.V. Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons. J. Biol. Chem., 2006, 281(19), 13828-13836.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.19
, pp. 13828-13836
-
-
Novitskaya, V.1
Bocharova, O.V.2
Bronstein, I.3
Baskakov, I.V.4
-
13
-
-
0141632823
-
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products
-
Kocisko, D.A.; Baron, G.S.; Rubenstein, R.; Chen, J.; Kuizon, S.; Caughey, B. New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J. Virol., 2003, 77(19), 10288-10294.
-
(2003)
J. Virol.
, vol.77
, Issue.19
, pp. 10288-10294
-
-
Kocisko, D.A.1
Baron, G.S.2
Rubenstein, R.3
Chen, J.4
Kuizon, S.5
Caughey, B.6
-
14
-
-
33749642848
-
Searching for anti-prion compounds: Cell-based high-throughput in vitro assays and animal testing strategies
-
Kocisko, D.A.; Caughey, B. Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies. Methods Enzymol., 2006, 412, 223-234.
-
(2006)
Methods Enzymol.
, vol.412
, pp. 223-234
-
-
Kocisko, D.A.1
Caughey, B.2
-
15
-
-
79960982077
-
A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets
-
Poncet-Montange, G.; St Martin, S.J.; Bogatova, O.V.; Prusiner, S.B.; Shoichet, B.K.; Ghaemmaghami, S. A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets. J. Biol. Chem., 2011, 286(31), 27718-27728.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.31
, pp. 27718-27728
-
-
Poncet-Montange, G.1
St Martin, S.J.2
Bogatova, O.V.3
Prusiner, S.B.4
Shoichet, B.K.5
Ghaemmaghami, S.6
-
16
-
-
80053389802
-
From high-throughput cell culture screening to mouse model: Identification of new inhibitor classes against prion disease
-
Geissen, M.; Leidel, F.; Eiden, M.; Hirschberger, T.; Fast, C.; Bertsch, U.; Tavan, P.; Giese, A.; Kretzschmar, H.; Schatzl, H.M.; Groschup, M.H. From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease. ChemMedChem, 2011, 6(10), 1928-1937.
-
(2011)
ChemMedChem,
, vol.6
, Issue.10
, pp. 1928-1937
-
-
Geissen, M.1
Leidel, F.2
Eiden, M.3
Hirschberger, T.4
Fast, C.5
Bertsch, U.6
Tavan, P.7
Giese, A.8
Kretzschmar, H.9
Schatzl, H.M.10
Groschup, M.H.11
-
17
-
-
10744225913
-
Isolation of drugs active against mammalian prions using a yeast-based screening assay 2
-
Bach, S.; Talarek, N.; Andrieu, T.; Vierfond, J.M.; Mettey, Y.; Galons, H.; Dormont, D.; Meijer, L.; Cullin, C.; Blondel, M. Isolation of drugs active against mammalian prions using a yeast-based screening assay 2. Nat. Biotechnol., 2003, 21(9), 1075-1081.
-
(2003)
Nat. Biotechnol.
, vol.21
, Issue.9
, pp. 1075-1081
-
-
Bach, S.1
Talarek, N.2
Andrieu, T.3
Vierfond, J.M.4
Mettey, Y.5
Galons, H.6
Dormont, D.7
Meijer, L.8
Cullin, C.9
Blondel, M.10
-
18
-
-
33646441879
-
Surface plasmon resonance analysis for the screening of anti-prion compounds
-
Kawatake, S.; Nishimura, Y.; Sakaguchi, S.; Iwaki, T.; Doh-ura, K. Surface plasmon resonance analysis for the screening of anti-prion compounds. Biol. Pharm. Bull., 2006, 29(5), 927-932.
-
(2006)
Biol. Pharm. Bull.
, vol.29
, Issue.5
, pp. 927-932
-
-
Kawatake, S.1
Nishimura, Y.2
Sakaguchi, S.3
Iwaki, T.4
Doh-ura, K.5
-
19
-
-
59749105286
-
Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity
-
Hosokawa-Muto, J.; Kamatari, Y.O.; Nakamura, H.K.; Kuwata, K. Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity. Antimicrob. Agents Chemother., 2009, 53(2), 765-771.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, Issue.2
, pp. 765-771
-
-
Hosokawa-Muto, J.1
Kamatari, Y.O.2
Nakamura, H.K.3
Kuwata, K.4
-
20
-
-
19944405458
-
Systematic identification of antiprion drugs by highthroughput screening based on scanning for intensely fluorescent targets 1
-
Bertsch, U.; Winklhofer, K.F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F.U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H.A.; Giese, A. Systematic identification of antiprion drugs by highthroughput screening based on scanning for intensely fluorescent targets 1. J. Virol., 2005, 79(12), 7785-7791.
-
(2005)
J. Virol.
, vol.79
, Issue.12
, pp. 7785-7791
-
-
Bertsch, U.1
Winklhofer, K.F.2
Hirschberger, T.3
Bieschke, J.4
Weber, P.5
Hartl, F.U.6
Tavan, P.7
Tatzelt, J.8
Kretzschmar, H.A.9
Giese, A.10
-
21
-
-
14844286460
-
Semiautomated cellfree conversion of prion protein: Applications for high-throughput screening of potential antiprion drugs 1
-
Breydo, L.; Bocharova, O.V.; Baskakov, I.V. Semiautomated cellfree conversion of prion protein: applications for high-throughput screening of potential antiprion drugs 1. Anal. Biochem., 2005, 339(1), 165-173.
-
(2005)
Anal. Biochem.
, vol.339
, Issue.1
, pp. 165-173
-
-
Breydo, L.1
Bocharova, O.V.2
Baskakov, I.V.3
-
22
-
-
33847389700
-
Identification of prion inhibitors by a fluorescence-polarizationbased competitive binding assay
-
Kocisko, D.A.; Bertholet, N.; Moore, R.A.; Caughey, B.; Vaillant, A. Identification of prion inhibitors by a fluorescence-polarizationbased competitive binding assay. Anal. Biochem., 2007, 363(1), 154-156.
-
(2007)
Anal. Biochem.
, vol.363
, Issue.1
, pp. 154-156
-
-
Kocisko, D.A.1
Bertholet, N.2
Moore, R.A.3
Caughey, B.4
Vaillant, A.5
-
23
-
-
0034705043
-
Mimicking dominant negative inhibition of prion replication through structure-based drug design
-
Perrier, V.; Wallace, A.C.; Kaneko, K.; Safar, J.; Prusiner, S.B.; Cohen, F.E. Mimicking dominant negative inhibition of prion replication through structure-based drug design. Proc. Natl. Acad. Sci. USA, 2000, 97(11), 6073-6078.
-
(2000)
Proc. Natl. Acad. Sci. USA,
, vol.97
, Issue.11
, pp. 6073-6078
-
-
Perrier, V.1
Wallace, A.C.2
Kaneko, K.3
Safar, J.4
Prusiner, S.B.5
Cohen, F.E.6
-
24
-
-
31544475731
-
Library design, synthesis, and screening: Pyridine dicarbonitriles as potential prion disease therapeutics
-
Reddy, T.R.; Mutter, R.; Heal, W.; Guo, K.; Gillet, V.J.; Pratt, S.; Chen, B. Library design, synthesis, and screening: pyridine dicarbonitriles as potential prion disease therapeutics. J. Med. Chem., 2006, 49(2), 607-615.
-
(2006)
J. Med. Chem.
, vol.49
, Issue.2
, pp. 607-615
-
-
Reddy, T.R.1
Mutter, R.2
Heal, W.3
Guo, K.4
Gillet, V.J.5
Pratt, S.6
Chen, B.7
-
25
-
-
40149090017
-
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
-
Atarashi, R.; Wilham, J.M.; Christensen, L.; Hughson, A.G.; Moore, R.A.; Johnson, L.M.; Onwubiko, H.A.; Priola, S.A.; Caughey, B. Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat. Methods, 2008, 5(3), 211-212.
-
(2008)
Nat. Methods,
, vol.5
, Issue.3
, pp. 211-212
-
-
Atarashi, R.1
Wilham, J.M.2
Christensen, L.3
Hughson, A.G.4
Moore, R.A.5
Johnson, L.M.6
Onwubiko, H.A.7
Priola, S.A.8
Caughey, B.9
-
26
-
-
78651249792
-
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
-
Wilham, J.M.; Orru, C.D.; Bessen, R.A.; Atarashi, R.; Sano, K.; Race, B.; Meade-White, K.D.; Taubner, L.M.; Timmes, A.; Caughey, B. Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog., 2010, 6(12), e1001217.
-
(2010)
PLoS Pathog.
, vol.6
, Issue.12
-
-
Wilham, J.M.1
Orru, C.D.2
Bessen, R.A.3
Atarashi, R.4
Sano, K.5
Race, B.6
Meade-White, K.D.7
Taubner, L.M.8
Timmes, A.9
Caughey, B.10
-
27
-
-
80052802802
-
Real-time quakinginduced conversion: A highly sensitive assay for prion detection
-
Atarashi, R.; Sano, K.; Satoh, K.; Nishida, N. Real-time quakinginduced conversion: A highly sensitive assay for prion detection. Prion, 2011, 5(3), 150-153.
-
(2011)
Prion,
, vol.5
, Issue.3
, pp. 150-153
-
-
Atarashi, R.1
Sano, K.2
Satoh, K.3
Nishida, N.4
-
28
-
-
79751535822
-
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
-
Atarashi, R.; Satoh, K.; Sano, K.; Fuse, T.; Yamaguchi, N.; Ishibashi, D.; Matsubara, T.; Nakagaki, T.; Yamanaka, H.; Shirabe, S.; Yamada, M.; Mizusawa, H.; Kitamoto, T.; Klug, G.; McGlade, A.; Collins, S.J.; Nishida, N. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat. Med., 2011, 17(2), 175-178.
-
(2011)
Nat. Med.
, vol.17
, Issue.2
, pp. 175-178
-
-
Atarashi, R.1
Satoh, K.2
Sano, K.3
Fuse, T.4
Yamaguchi, N.5
Ishibashi, D.6
Matsubara, T.7
Nakagaki, T.8
Yamanaka, H.9
Shirabe, S.10
Yamada, M.11
Mizusawa, H.12
Kitamoto, T.13
Klug, G.14
McGlade, A.15
Collins, S.J.16
Nishida, N.17
-
29
-
-
79960163849
-
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
-
Orru, C.D.; Wilham, J.M.; Raymond, L.D.; Kuhn, F.; Schroeder, B.; Raeber, A.J.; Caughey, B. Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. MBio, 2011, 2(3), e00078-11.
-
(2011)
MBio,
, vol.2
, Issue.3
-
-
Orru, C.D.1
Wilham, J.M.2
Raymond, L.D.3
Kuhn, F.4
Schroeder, B.5
Raeber, A.J.6
Caughey, B.7
-
30
-
-
33747040538
-
Iatrogenic Creutzfeldt-Jakob disease: The waning of an era
-
Brown, P.; Brandel, J.P.; Preece, M.; Sato, T. Iatrogenic Creutzfeldt-Jakob disease: the waning of an era. Neurology, 2006, 67(3), 389-393.
-
(2006)
Neurology,
, vol.67
, Issue.3
, pp. 389-393
-
-
Brown, P.1
Brandel, J.P.2
Preece, M.3
Sato, T.4
-
31
-
-
33748369869
-
Creutzfeldt-Jakob disease and blood transfusion: Results of the UK Transfusion Medicine Epidemiological Review study
-
Hewitt, P.E.; Llewelyn, C.A.; Mackenzie, J.; Will, R.G. Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. Vox Sang., 2006, 91(3), 221-230.
-
(2006)
Vox Sang.
, vol.91
, Issue.3
, pp. 221-230
-
-
Hewitt, P.E.1
Llewelyn, C.A.2
Mackenzie, J.3
Will, R.G.4
-
32
-
-
77749322732
-
Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia
-
Peden, A.; McCardle, L.; Head, M.W.; Love, S.; Ward, H.J.; Cousens, S.N.; Keeling, D.M.; Millar, C.M.; Hill, F.G.; Ironside, J.W. Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia. Haemophilia, 2010, 16(2), 296-304.
-
(2010)
Haemophilia,
, vol.16
, Issue.2
, pp. 296-304
-
-
Peden, A.1
McCardle, L.2
Head, M.W.3
Love, S.4
Ward, H.J.5
Cousens, S.N.6
Keeling, D.M.7
Millar, C.M.8
Hill, F.G.9
Ironside, J.W.10
-
33
-
-
33749839721
-
Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds?
-
Caughey, B.; Caughey, W.S.; Kocisko, D.A.; Lee, K.S.; Silveira, J.R.; Morrey, J.D. Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: a common mechanism for anti-TSE compounds? Accts. Chem. Res., 2006, 39, 646-653.
-
(2006)
Accts. Chem. Res.
, vol.39
, pp. 646-653
-
-
Caughey, B.1
Caughey, W.S.2
Kocisko, D.A.3
Lee, K.S.4
Silveira, J.R.5
Morrey, J.D.6
-
34
-
-
35848949273
-
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity
-
Caughey, W.S.; Priola, S.A.; Kocisko, D.A.; Raymond, L.D.; Ward, A.; Caughey, B. Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity. Antimicrob. Agents Chemother., 2007, 51(11), 3887-3894.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, Issue.11
, pp. 3887-3894
-
-
Caughey, W.S.1
Priola, S.A.2
Kocisko, D.A.3
Raymond, L.D.4
Ward, A.5
Caughey, B.6
-
35
-
-
0035253848
-
Scdependent cell-free formation of proteaseresistant prion protein
-
Scdependent cell-free formation of proteaseresistant prion protein. EMBO J., 2001, 20, 377-386.
-
(2001)
EMBO J.
, vol.20
, pp. 377-386
-
-
Wong, C.1
Xiong, L.-.2
Horiuchi, M.3
Raymond, L.D.4
Wehrly, K.5
Chesebro, B.6
Caughey, B.7
-
36
-
-
0142184333
-
RNA molecules stimulate prion protein conversion
-
Deleault, N.R.; Lucassen, R.W.; Supattapone, S. RNA molecules stimulate prion protein conversion. Nature, 2003, 425(6959), 717-720.
-
(2003)
Nature,
, vol.425
, Issue.6959
, pp. 717-720
-
-
Deleault, N.R.1
Lucassen, R.W.2
Supattapone, S.3
-
37
-
-
0142215488
-
Prion diseases: A nucleic-acid accomplice?
-
Caughey, B.; Kocisko, D.A. Prion diseases: a nucleic-acid accomplice? Nature, 2003, 425(6959), 673-674.
-
(2003)
Nature
, vol.425
, Issue.6959
, pp. 673-674
-
-
Caughey, B.1
Kocisko, D.A.2
-
38
-
-
0029564913
-
Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells
-
Shyng, S.L.; Lehmann, S.; Moulder, K.L.; Harris, D.A. Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells. J. Biol. Chem., 1995, 270(50), 30221-30229.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.50
, pp. 30221-30229
-
-
Shyng, S.L.1
Lehmann, S.2
Moulder, K.L.3
Harris, D.A.4
-
39
-
-
0027535855
-
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
-
Caughey, B.; Raymond, G.J. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J. Virol., 1993, 67(2), 643-650.
-
(1993)
J. Virol.
, vol.67
, Issue.2
, pp. 643-650
-
-
Caughey, B.1
Raymond, G.J.2
-
40
-
-
0027458091
-
Heparin-like molecules bind differentially to prion proteins and change their intracellular metabolic-fate
-
Gabizon, R.; Meiner, Z.; Halimi, M.; Bensasson, S.A. Heparin-like molecules bind differentially to prion proteins and change their intracellular metabolic-fate. J. Cell. Physiol., 1993, 157, 319-325.
-
(1993)
J. Cell. Physiol.
, vol.157
, pp. 319-325
-
-
Gabizon, R.1
Meiner, Z.2
Halimi, M.3
Bensasson, S.A.4
-
41
-
-
0028256222
-
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red
-
Caughey, B.; Brown, K.; Raymond, G.J.; Katzenstein, G.E.; Thresher, W. Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red. J. Virol., 1994, 68(4), 2135-2141.
-
(1994)
J. Virol.
, vol.68
, Issue.4
, pp. 2135-2141
-
-
Caughey, B.1
Brown, K.2
Raymond, G.J.3
Katzenstein, G.E.4
Thresher, W.5
-
42
-
-
0141994735
-
Cellular heparan sulfate participates in the metabolism of prions
-
Ben-Zaken, O.; Tzaban, S.; Tal, Y.; Horonchik, L.; Esko, J.D.; Vlodavsky, I.; Taraboulos, A. Cellular heparan sulfate participates in the metabolism of prions. J. Biol. Chem., 2003, 278(41), 40041-40049.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.41
, pp. 40041-40049
-
-
Ben-Zaken, O.1
Tzaban, S.2
Tal, Y.3
Horonchik, L.4
Esko, J.D.5
Vlodavsky, I.6
Taraboulos, A.7
-
43
-
-
79953201184
-
Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides
-
Karpuj, M.V.; Gelibter-Niv, S.; Tiran, A.; Rambold, A.; Tatzelt, J.; Nunziante, M.; Schatzl, H.M. Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides. J. Biol. Chem., 2011, 286(9), 6911-6917.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.9
, pp. 6911-6917
-
-
Karpuj, M.V.1
Gelibter-Niv, S.2
Tiran, A.3
Rambold, A.4
Tatzelt, J.5
Nunziante, M.6
Schatzl, H.M.7
-
44
-
-
2342623474
-
Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models
-
Doh-ura, K.; Ishikawa, K.; Murakami-Kubo, I.; Sasaki, K.; Mohri, S.; Race, R.; Iwaki, T. Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models. J. Virol., 2004, 78(10), 4999-5006.
-
(2004)
J. Virol.
, vol.78
, Issue.10
, pp. 4999-5006
-
-
Doh-ura, K.1
Ishikawa, K.2
Murakami-Kubo, I.3
Sasaki, K.4
Mohri, S.5
Race, R.6
Iwaki, T.7
-
45
-
-
0021282464
-
Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen
-
Ehlers, B.; Diringer, H. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J. Gen. Virol., 1984, 65, 1325-1330.
-
(1984)
J. Gen. Virol.
, vol.65
, pp. 1325-1330
-
-
Ehlers, B.1
Diringer, H.2
-
46
-
-
0025971881
-
Chemoprophylaxis of scrapie in mice
-
Diringer, H.; Ehlers, B. Chemoprophylaxis of scrapie in mice. J. Gen. Virol., 1991, 72, 457-460.
-
(1991)
J. Gen. Virol.
, vol.72
, pp. 457-460
-
-
Diringer, H.1
Ehlers, B.2
-
47
-
-
0033537348
-
Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies
-
Farquhar, C.; Dickinson, A.; Bruce, M. Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies. Lancet, 1999, 353(9147), 117.
-
(1999)
Lancet,
, vol.353
, Issue.9147
, pp. 117
-
-
Farquhar, C.1
Dickinson, A.2
Bruce, M.3
-
48
-
-
0026510098
-
Sulphate polyanions prolong the incubation period of scrapie-infected hamsters
-
Ladogana, A.; Casaccia, P.; Ingrosso, L.; Cibati, M.; Salvatore, M.; Xi, Y.G.; Masullo, C.; Pocchiari, M. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J. Gen. Virol., 1992, 73, 661-665.
-
(1992)
J. Gen. Virol.
, vol.73
, pp. 661-665
-
-
Ladogana, A.1
Casaccia, P.2
Ingrosso, L.3
Cibati, M.4
Salvatore, M.5
Xi, Y.G.6
Masullo, C.7
Pocchiari, M.8
-
49
-
-
30344443997
-
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
-
Raymond, G.J.; Olsen, E.A.; Lee, K.S.; Raymond, L.D.; Bryant, P.K., III; Baron, G.S.; Caughey, W.S.; Kocisko, D.A.; McHolland, L.E.; Favara, C.; Langeveld, J.P.; van Zijderveld, F.G.; Mayer, R.T.; Miller, M.W.; Williams, E.S.; Caughey, B. Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J. Virol., 2006, 80(2), 596-604.
-
(2006)
J. Virol.
, vol.80
, Issue.2
, pp. 596-604
-
-
Raymond, G.J.1
Olsen, E.A.2
Lee, K.S.3
Raymond, L.D.4
Bryant III, P.K.5
Baron, G.S.6
Caughey, W.S.7
Kocisko, D.A.8
McHolland, L.E.9
Favara, C.10
Langeveld, J.P.11
van Zijderveld, F.G.12
Mayer, R.T.13
Miller, M.W.14
Williams, E.S.15
Caughey, B.16
-
50
-
-
33847607573
-
Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases
-
Larramendy-Gozalo, C.; Barret, A.; Daudigeos, E.; Mathieu, E.; Antonangeli, L.; Riffet, C.; Petit, E.; Papy-Garcia, D.; Barritault, D.; Brown, P.; Deslys, J.P. Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases. J. Gen. Virol., 2007, 88, 1062-1067.
-
(2007)
J. Gen. Virol.
, vol.88
, pp. 1062-1067
-
-
Larramendy-Gozalo, C.1
Barret, A.2
Daudigeos, E.3
Mathieu, E.4
Antonangeli, L.5
Riffet, C.6
Petit, E.7
Papy-Garcia, D.8
Barritault, D.9
Brown, P.10
Deslys, J.P.11
-
51
-
-
18844434701
-
Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease
-
Todd, N.V.; Morrow, J.; Doh-ura, K.; Dealler, S.; O'Hare, S.; Farling, P.; Duddy, M.; Rainov, N.G. Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease. J. Infect., 2005, 50(5), 394-396.
-
(2005)
J. Infect.
, vol.50
, Issue.5
, pp. 394-396
-
-
Todd, N.V.1
Morrow, J.2
Doh-ura, K.3
Dealler, S.4
O'Hare, S.5
Farling, P.6
Duddy, M.7
Rainov, N.G.8
-
52
-
-
34248180644
-
Experimental treatments for human transmissible spongiform encephalopathies: Is there a role for pentosan polysulfate?
-
Rainov, N.G.; Tsuboi, Y.; Krolak-Salmon, P.; Vighetto, A.; Doh-Ura, K. Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate? Expert Opin. Biol. Ther., 2007, 7(5), 713-726.
-
(2007)
Expert Opin. Biol. Ther.
, vol.7
, Issue.5
, pp. 713-726
-
-
Rainov, N.G.1
Tsuboi, Y.2
Krolak-Salmon, P.3
Vighetto, A.4
Doh-Ura, K.5
-
53
-
-
41849091490
-
Intraventricular pentosan polysulphate in human prion diseases: An observational study in the UK
-
Bone, I.; Belton, L.; Walker, A.S.; Darbyshire, J. Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK. Eur. J. Neurol., 2008, 15(5), 458-464.
-
(2008)
Eur. J. Neurol.
, vol.15
, Issue.5
, pp. 458-464
-
-
Bone, I.1
Belton, L.2
Walker, A.S.3
Darbyshire, J.4
-
54
-
-
70349325881
-
Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases
-
Tsuboi, Y.; Doh-Ura, K.; Yamada, T. Continuous intraventricular infusion of pentosan polysulfate: clinical trial against prion diseases. Neuropathology, 2009, 29(5), 632-636.
-
(2009)
Neuropathology,
, vol.29
, Issue.5
, pp. 632-636
-
-
Tsuboi, Y.1
Doh-Ura, K.2
Yamada, T.3
-
55
-
-
84859005785
-
Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion
-
doi: 10.1111/j.1440-1789.2011.01245.x
-
Honda, H.; Sasaki, K.; Minaki, H.; Masui, K.; Suzuki, S.O.; Doh-Ura, K.; Iwaki, T. Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion. Neuropathology, 2011, doi: 10.1111/j.1440-1789.2011.01245.x.
-
(2011)
Neuropathology
-
-
Honda, H.1
Sasaki, K.2
Minaki, H.3
Masui, K.4
Suzuki, S.O.5
Doh-Ura, K.6
Iwaki, T.7
-
56
-
-
35148878615
-
Cyclodextrins inhibit replication of scrapie prion protein in cell culture
-
Prior, M.; Lehmann, S.; Sy, M.S.; Molloy, B.; McMahon, H.E. Cyclodextrins inhibit replication of scrapie prion protein in cell culture. J. Virol., 2007, 81(20), 11195-11207.
-
(2007)
J. Virol.
, vol.81
, Issue.20
, pp. 11195-11207
-
-
Prior, M.1
Lehmann, S.2
Sy, M.S.3
Molloy, B.4
McMahon, H.E.5
-
57
-
-
69949103566
-
Antiprion action of new cyclodextrin analogues
-
McEvoy, K.; McMahon, H.E. Antiprion action of new cyclodextrin analogues. Biochim. Biophys. Acta, 2009, 1790(10), 1382-1386.
-
(2009)
Biochim. Biophys. Acta,
, vol.1790
, Issue.10
, pp. 1382-1386
-
-
McEvoy, K.1
McMahon, H.E.2
-
58
-
-
33644655659
-
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides
-
Kocisko, D.A.; Vaillant, A.; Lee, K.S.; Arnold, K.M.; Bertholet, N.; Race, R.E.; Olsen, E.A.; Juteau, J.M.; Caughey, B. Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. Antimicrob. Agents Chemother., 2006, 50(3), 1034-1044.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, Issue.3
, pp. 1034-1044
-
-
Kocisko, D.A.1
Vaillant, A.2
Lee, K.S.3
Arnold, K.M.4
Bertholet, N.5
Race, R.E.6
Olsen, E.A.7
Juteau, J.M.8
Caughey, B.9
-
59
-
-
77649213673
-
Generating a prion with bacterially expressed recombinant prion protein
-
Wang, F.; Wang, X.; Yuan, C.G.; Ma, J. Generating a prion with bacterially expressed recombinant prion protein. Science, 2010, 327(5969), 1132-1135.
-
(2010)
Science,
, vol.327
, Issue.5969
, pp. 1132-1135
-
-
Wang, F.1
Wang, X.2
Yuan, C.G.3
Ma, J.4
-
60
-
-
84863116444
-
Genetic informational RNA is not required for recombinant prion infectivity
-
Wang, F.; Zhang, Z.; Wang, X.; Li, J.; Zha, L.; Yuan, C.G.; Weissmann, C.; Ma, J. Genetic informational RNA is not required for recombinant prion infectivity. J. Virol., 2012, 86(3), 1874-1876.
-
(2012)
J. Virol.
, vol.86
, Issue.3
, pp. 1874-1876
-
-
Wang, F.1
Zhang, Z.2
Wang, X.3
Li, J.4
Zha, L.5
Yuan, C.G.6
Weissmann, C.7
Ma, J.8
-
61
-
-
69449099838
-
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: Implications for RNA in prion diseases
-
Jeong, B.H.; Kim, N.H.; Jin, J.K.; Choi, J.K.; Lee, Y.J.; Kim, J.I.; Choi, E.K.; Carp, R.I.; Kim, Y.S. Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. J. Neuropathol. Exp. Neurol., 2009, 68(8), 870-879.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, Issue.8
, pp. 870-879
-
-
Jeong, B.H.1
Kim, N.H.2
Jin, J.K.3
Choi, J.K.4
Lee, Y.J.5
Kim, J.I.6
Choi, E.K.7
Carp, R.I.8
Kim, Y.S.9
-
62
-
-
0026638150
-
Potent inhibition of scrapie-associated PrP accumulation by Congo red
-
Caughey, B.; Race, R.E. Potent inhibition of scrapie-associated PrP accumulation by Congo red. J. Neurochem., 1992, 59, 768-771.
-
(1992)
J. Neurochem.
, vol.59
, pp. 768-771
-
-
Caughey, B.1
Race, R.E.2
-
63
-
-
0019889727
-
Spectroscopic studies of Congo red binding to RNA polymerase
-
Woody, A.M.; Reisbig, R.R.; Woody, R.W. Spectroscopic studies of Congo red binding to RNA polymerase. Biochim. Biophys. Acta, 1981, 655, 82-88.
-
(1981)
Biochim. Biophys. Acta,
, vol.655
, pp. 82-88
-
-
Woody, A.M.1
Reisbig, R.R.2
Woody, R.W.3
-
64
-
-
0028420936
-
Inhibition of scrapie-associated PrP accumulation: Probing the role of glycosaminoglycans in amyloidogenesis
-
Priola, S.A.; Caughey, B. Inhibition of scrapie-associated PrP accumulation: Probing the role of glycosaminoglycans in amyloidogenesis. Mol. Neurobiol., 1994, 8, 113-120.
-
(1994)
Mol. Neurobiol.
, vol.8
, pp. 113-120
-
-
Priola, S.A.1
Caughey, B.2
-
65
-
-
0032488921
-
The anti-prion activity of Congo red. Putative mechanism
-
Caspi, S.; Halimi, M.; Yanai, A.; Sasson, S.B.; Taraboulos, A.; Gabizon, R. The anti-prion activity of Congo red. Putative mechanism. J. Biol. Chem., 1998, 273(6), 3484-3489.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.6
, pp. 3484-3489
-
-
Caspi, S.1
Halimi, M.2
Yanai, A.3
Sasson, S.B.4
Taraboulos, A.5
Gabizon, R.6
-
66
-
-
0027280172
-
Congo red inhibition of scrapie agent replication
-
Caughey, B.; Ernst, D.; Race, R.E. Congo red inhibition of scrapie agent replication. J. Virol., 1993, 67, 6270-6272.
-
(1993)
J. Virol.
, vol.67
, pp. 6270-6272
-
-
Caughey, B.1
Ernst, D.2
Race, R.E.3
-
67
-
-
0031797266
-
Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation
-
Demaimay, R.; Harper, J.; Gordon, H.; Weaver, D.; Chesebro, B.; Caughey, B. Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation. J. Neurochem., 1998, 71(6), 2534-2541.
-
(1998)
J. Neurochem.
, vol.71
, Issue.6
, pp. 2534-2541
-
-
Demaimay, R.1
Harper, J.2
Gordon, H.3
Weaver, D.4
Chesebro, B.5
Caughey, B.6
-
68
-
-
28444498432
-
Inhibition of formation of protease-resistant prion protein by trypan blue, sirius red and other Congo red analogs
-
Demaimay, R.; Chesebro, B.; Caughey, B. Inhibition of formation of protease-resistant prion protein by trypan blue, sirius red and other Congo red analogs. Arch. Virol. [Suppl], 2000, 16, 277-283.
-
(2000)
Arch. Virol. [Suppl],
, vol.16
, pp. 277-283
-
-
Demaimay, R.1
Chesebro, B.2
Caughey, B.3
-
69
-
-
0034109546
-
Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells
-
Rudyk, H.; Vasiljevic, S.; Hennion, R.M.; Birkett, C.R.; Hope, J.; Gilbert, I.H. Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells. J. Gen. Virol., 2000, 81, 1155-1164.
-
(2000)
J. Gen. Virol.
, vol.81
, pp. 1155-1164
-
-
Rudyk, H.1
Vasiljevic, S.2
Hennion, R.M.3
Birkett, C.R.4
Hope, J.5
Gilbert, I.H.6
-
70
-
-
9144223018
-
In vitro evaluation of the antiprionic activity of newly synthesized congo red derivatives
-
Poli, G.; Ponti, W.; Carcassola, G.; Ceciliani, F.; Colombo, L.; Dall'Ara, P.; Gervasoni, M.; Giannino, M.L.; Martino, P.A.; Pollera, C.; Villa, S.; Salmona, M. In vitro evaluation of the antiprionic activity of newly synthesized congo red derivatives. Arzneimittelforschung, 2003, 53(12), 875-888.
-
(2003)
Arzneimittelforschung,
, vol.53
, Issue.12
, pp. 875-888
-
-
Poli, G.1
Ponti, W.2
Carcassola, G.3
Ceciliani, F.4
Colombo, L.5
Dall'Ara, P.6
Gervasoni, M.7
Giannino, M.L.8
Martino, P.A.9
Pollera, C.10
Villa, S.11
Salmona, M.12
-
71
-
-
0037385673
-
In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion
-
Kirby, L.; Birkett, C.R.; Rudyk, H.; Gilbert, I.H.; Hope, J. In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion. J. Gen. Virol., 2003, 84, 1013-1020.
-
(2003)
J. Gen. Virol.
, vol.84
, pp. 1013-1020
-
-
Kirby, L.1
Birkett, C.R.2
Rudyk, H.3
Gilbert, I.H.4
Hope, J.5
-
72
-
-
0037446508
-
In vitro amplification of protease-resistant prion protein requires free sulfhydryl groups
-
Lucassen, R.; Nishina, K.; Supattapone, S. In vitro amplification of protease-resistant prion protein requires free sulfhydryl groups. Biochemistry (N. Y.), 2003, 42(14), 4127-4135.
-
(2003)
Biochemistry (N. Y.),
, vol.42
, Issue.14
, pp. 4127-4135
-
-
Lucassen, R.1
Nishina, K.2
Supattapone, S.3
-
73
-
-
0028970386
-
Congo red prolongs the incubation period in scrapie-infected hamsters
-
Ingrosso, L.; Ladogana, A.; Pocchiari, M. Congo red prolongs the incubation period in scrapie-infected hamsters. J. Virol., 1995, 69, 506-508.
-
(1995)
J. Virol.
, vol.69
, pp. 506-508
-
-
Ingrosso, L.1
Ladogana, A.2
Pocchiari, M.3
-
74
-
-
3242786318
-
Evaluation of anti-prion activity of congo red and its derivatives in experimentally infected hamsters
-
Poli, G.; Martino, P.A.; Villa, S.; Carcassola, G.; Giannino, M.L.; Dall'Ara, P.; Pollera, C.; Iussich, S.; Tranquillo, V.M.; Bareggi, S.; Mantegazza, P.; Ponti, W. Evaluation of anti-prion activity of congo red and its derivatives in experimentally infected hamsters. Arzneimittelforschung, 2004, 54(7), 406-415.
-
(2004)
Arzneimittelforschung,
, vol.54
, Issue.7
, pp. 406-415
-
-
Poli, G.1
Martino, P.A.2
Villa, S.3
Carcassola, G.4
Giannino, M.L.5
Dall'Ara, P.6
Pollera, C.7
Iussich, S.8
Tranquillo, V.M.9
Bareggi, S.10
Mantegazza, P.11
Ponti, W.12
-
75
-
-
17844392850
-
Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease
-
Gilch, S.; Winklhofer, K.F.; Groschup, M.H.; Nunziante, M.; Lucassen, R.; Spielhaupter, C.; Muranyi, W.; Riesner, D.; Tatzelt, J.; Schatzl, H.M. Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease. EMBO J., 2001, 20(15), 3957-3966.
-
(2001)
EMBO J.
, vol.20
, Issue.15
, pp. 3957-3966
-
-
Gilch, S.1
Winklhofer, K.F.2
Groschup, M.H.3
Nunziante, M.4
Lucassen, R.5
Spielhaupter, C.6
Muranyi, W.7
Riesner, D.8
Tatzelt, J.9
Schatzl, H.M.10
-
76
-
-
0037405847
-
Inhibition of protease-resistant prion protein accumulation in vitro by curcumin
-
Caughey, B.; Raymond, L.D.; Raymond, G.J.; Maxson, L.; Silveira, J.; Baron, G.S. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J. Virol., 2003, 77(9), 5499-5502.
-
(2003)
J. Virol.
, vol.77
, Issue.9
, pp. 5499-5502
-
-
Caughey, B.1
Raymond, L.D.2
Raymond, G.J.3
Maxson, L.4
Silveira, J.5
Baron, G.S.6
-
77
-
-
39849110292
-
Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein-a new mechanism for the inhibition of PrP(Sc) accumulation
-
Hafner-Bratkovic, I.; Gaspersic, J.; Smid, L.M.; Bresjanac, M.; Jerala, R. Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein-a new mechanism for the inhibition of PrP(Sc) accumulation. J. Neurochem., 2008, 104(6), 1553-1564.
-
(2008)
J. Neurochem.
, vol.104
, Issue.6
, pp. 1553-1564
-
-
Hafner-Bratkovic, I.1
Gaspersic, J.2
Smid, L.M.3
Bresjanac, M.4
Jerala, R.5
-
78
-
-
41649119833
-
Evaluation of drugs for treatment of prion infections of the central nervous system
-
Riemer, C.; Burwinkel, M.; Schwarz, A.; Gultner, S.; Mok, S.W.; Heise, I.; Holtkamp, N.; Baier, M. Evaluation of drugs for treatment of prion infections of the central nervous system. J. Gen. Virol., 2008, 89, 594-597.
-
(2008)
J. Gen. Virol.
, vol.89
, pp. 594-597
-
-
Riemer, C.1
Burwinkel, M.2
Schwarz, A.3
Gultner, S.4
Mok, S.W.5
Heise, I.6
Holtkamp, N.7
Baier, M.8
-
79
-
-
27944434883
-
Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication
-
Nunziante, M.; Kehler, C.; Maas, E.; Kassack, M.U.; Groschup, M.; Schatzl, H.M. Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication. J. Cell. Sci., 2005, 118(, 4959-4973.
-
(2005)
J. Cell. Sci.
, vol.118
, pp. 4959-4973
-
-
Nunziante, M.1
Kehler, C.2
Maas, E.3
Kassack, M.U.4
Groschup, M.5
Schatzl, H.M.6
-
80
-
-
84887212372
-
Inoculation of scrapie with the selfassembling RADA-peptide disrupts prion accumulation and extends hamster survival
-
Hnasko, R.; Bruederle, C.E. Inoculation of scrapie with the selfassembling RADA-peptide disrupts prion accumulation and extends hamster survival. PLoS One, 2009, 4(2), e4440.
-
(2009)
PLoS One,
, vol.4
, Issue.2
-
-
Hnasko, R.1
Bruederle, C.E.2
-
81
-
-
80053991142
-
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
-
Berg, K.; Nordstrand, S.; Selbo, P.K.; Tran, D.T.; Angell-Petersen, E.; Hogset, A. Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization. Photochem. Photobiol. Sci., 2011, 10(10), 1637-1651.
-
(2011)
Photochem. Photobiol. Sci.
, vol.10
, Issue.10
, pp. 1637-1651
-
-
Berg, K.1
Nordstrand, S.2
Selbo, P.K.3
Tran, D.T.4
Angell-Petersen, E.5
Hogset, A.6
-
82
-
-
37549057381
-
Hemin interactions and alterations of the subcellular localization of prion protein
-
Lee, K.S.; Raymond, L.D.; Schoen, B.; Raymond, G.J.; Kett, L.; Moore, R.A.; Johnson, L.M.; Taubner, L.; Speare, J.O.; Onwubiko, H.A.; Baron, G.S.; Caughey, W.S.; Caughey, B. Hemin interactions and alterations of the subcellular localization of prion protein. J. Biol. Chem., 2007, 282(50), 36525-36533.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.50
, pp. 36525-36533
-
-
Lee, K.S.1
Raymond, L.D.2
Schoen, B.3
Raymond, G.J.4
Kett, L.5
Moore, R.A.6
Johnson, L.M.7
Taubner, L.8
Speare, J.O.9
Onwubiko, H.A.10
Baron, G.S.11
Caughey, W.S.12
Caughey, B.13
-
83
-
-
0032514682
-
Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines
-
Caughey, W.S.; Raymond, L.D.; Horiuchi, M.; Caughey, B. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proc. Natl. Acad. Sci. USA, 1998, 95(21), 12117-12122.
-
(1998)
Proc. Natl. Acad. Sci. USA,
, vol.95
, Issue.21
, pp. 12117-12122
-
-
Caughey, W.S.1
Raymond, L.D.2
Horiuchi, M.3
Caughey, B.4
-
84
-
-
31944440581
-
A porphyrin increases survival time of mice after intracerebral prion infection
-
Kocisko, D.A.; Caughey, W.S.; Race, R.E.; Roper, G.; Caughey, B.; Morrey, J.D. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrob. Agents Chemother., 2006, 50(2), 759-761.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, Issue.2
, pp. 759-761
-
-
Kocisko, D.A.1
Caughey, W.S.2
Race, R.E.3
Roper, G.4
Caughey, B.5
Morrey, J.D.6
-
85
-
-
0034711993
-
Porphyrin and phthalocyanine antiscrapie compounds
-
Priola, S.A.; Raines, A.; Caughey, W.S. Porphyrin and phthalocyanine antiscrapie compounds. Science, 2000, 287(5457), 1503-1506.
-
(2000)
Science,
, vol.287
, Issue.5457
, pp. 1503-1506
-
-
Priola, S.A.1
Raines, A.2
Caughey, W.S.3
-
86
-
-
0141501149
-
Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice
-
Priola, S.A.; Raines, A.; Caughey, W. Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice. J. Infect. Dis., 2003, 188(5), 699-705.
-
(2003)
J. Infect. Dis.
, vol.188
, Issue.5
, pp. 699-705
-
-
Priola, S.A.1
Raines, A.2
Caughey, W.3
-
87
-
-
67349234148
-
Efficacy of phthalocyanine tetrasulfonate against mouseadapted human prion strains
-
Abdel-Haq, H.; Lu, M.; Cardone, F.; Liu, Q.G.; Puopolo, M.; Pocchiari, M. Efficacy of phthalocyanine tetrasulfonate against mouseadapted human prion strains. Arch. Virol., 2009, 154(6), 1005-1007.
-
(2009)
Arch. Virol.
, vol.154
, Issue.6
, pp. 1005-1007
-
-
Abdel-Haq, H.1
Lu, M.2
Cardone, F.3
Liu, Q.G.4
Puopolo, M.5
Pocchiari, M.6
-
88
-
-
33749508480
-
Enhanced antiscrapie effect using combination drug treatment
-
Kocisko, D.A.; Caughey, B.; Morrey, J.D.; Race, R.E. Enhanced antiscrapie effect using combination drug treatment. Antimicrob. Agents Chemother., 2006, 50(10), 3447-3449.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, Issue.10
, pp. 3447-3449
-
-
Kocisko, D.A.1
Caughey, B.2
Morrey, J.D.3
Race, R.E.4
-
89
-
-
0036678451
-
Tetracyclines affect prion infectivity
-
Forloni, G.; Iussich, S.; Awan, T.; Colombo, L.; Angeretti, N.; Girola, L.; Bertani, I.; Poli, G.; Caramelli, M.; Grazia, B.M.; Farina, L.; Limido, L.; Rossi, G.; Giaccone, G.; Ironside, J.W.; Bugiani, O.; Salmona, M.; Tagliavini, F. Tetracyclines affect prion infectivity. Proc. Natl. Acad. Sci. USA, 2002, 99(16), 10849-10854.
-
(2002)
Proc. Natl. Acad. Sci. USA,
, vol.99
, Issue.16
, pp. 10849-10854
-
-
Forloni, G.1
Iussich, S.2
Awan, T.3
Colombo, L.4
Angeretti, N.5
Girola, L.6
Bertani, I.7
Poli, G.8
Caramelli, M.9
Grazia, B.M.10
Farina, L.11
Limido, L.12
Rossi, G.13
Giaccone, G.14
Ironside, J.W.15
Bugiani, O.16
Salmona, M.17
Tagliavini, F.18
-
90
-
-
34547917174
-
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo
-
Guo, Y.J.; Han, J.; Yao, H.L.; Zhang, B.Y.; Gao, J.M.; Zhang, J.; Xiao, X.L.; Wang, X.F.; Zhao, W.Q.; Wang, D.X.; Dong, X.P. Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. Biomed. Environ. Sci., 2007, 20(3), 198-202.
-
(2007)
Biomed. Environ. Sci.
, vol.20
, Issue.3
, pp. 198-202
-
-
Guo, Y.J.1
Han, J.2
Yao, H.L.3
Zhang, B.Y.4
Gao, J.M.5
Zhang, J.6
Xiao, X.L.7
Wang, X.F.8
Zhao, W.Q.9
Wang, D.X.10
Dong, X.P.11
-
91
-
-
0034725536
-
Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro
-
Tagliavini, F.; Forloni, G.; Colombo, L.; Rossi, G.; Girola, L.; Canciani, B.; Angeretti, N.; Giampaolo, L.; Peressini, E.; Awan, T.; De, G.L.; Ragg, E.; Bugiani, O.; Salmona, M. Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro. J. Mol. Biol., 2000, 300(5), 1309-1322.
-
(2000)
J. Mol. Biol.
, vol.300
, Issue.5
, pp. 1309-1322
-
-
Tagliavini, F.1
Forloni, G.2
Colombo, L.3
Rossi, G.4
Girola, L.5
Canciani, B.6
Angeretti, N.7
Giampaolo, L.8
Peressini, E.9
Awan, T.10
de, G.L.11
Ragg, E.12
Bugiani, O.13
Salmona, M.14
-
92
-
-
69249168008
-
Doxorubicin and congo red effectiveness on prion infectivity in golden Syrian hamster
-
Corato, M.; Ogliari, P.; Ceciliani, F.; Cova, E.; Bellotti, V.; Cereda, C.; Merlini, G.; Ceroni, M. Doxorubicin and congo red effectiveness on prion infectivity in golden Syrian hamster. Anticancer Res., 2009, 29(7), 2507-2512.
-
(2009)
Anticancer Res.
, vol.29
, Issue.7
, pp. 2507-2512
-
-
Corato, M.1
Ogliari, P.2
Ceciliani, F.3
Cova, E.4
Bellotti, V.5
Cereda, C.6
Merlini, G.7
Ceroni, M.8
-
93
-
-
0034001444
-
Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation
-
Doh-Ura, K.; Iwaki, T.; Caughey, B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J. Virol., 2000, 74(10), 4894-4897.
-
(2000)
J. Virol.
, vol.74
, Issue.10
, pp. 4894-4897
-
-
Doh-Ura, K.1
Iwaki, T.2
Caughey, B.3
-
94
-
-
0035859806
-
Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease
-
Korth, C.; May, B.C.; Cohen, F.E.; Prusiner, S.B. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc. Natl. Acad. Sci. USA, 2001, 98(17), 9836-9841.
-
(2001)
Proc. Natl. Acad. Sci. USA,
, vol.98
, Issue.17
, pp. 9836-9841
-
-
Korth, C.1
May, B.C.2
Cohen, F.E.3
Prusiner, S.B.4
-
95
-
-
0038340656
-
Differential inhibition of prion propagation by enantiomers of quinacrine
-
Ryou, C.; Legname, G.; Peretz, D.; Craig, J.C.; Baldwin, M.A.; Prusiner, S.B. Differential inhibition of prion propagation by enantiomers of quinacrine. Lab. Invest., 2003, 83(6), 837-843.
-
(2003)
Lab. Invest.
, vol.83
, Issue.6
, pp. 837-843
-
-
Ryou, C.1
Legname, G.2
Peretz, D.3
Craig, J.C.4
Baldwin, M.A.5
Prusiner, S.B.6
-
96
-
-
30344442464
-
Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo
-
Kocisko, D.A.; Caughey, B. Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo. J. Virol., 2006, 80(2), 1044-1046.
-
(2006)
J. Virol.
, vol.80
, Issue.2
, pp. 1044-1046
-
-
Kocisko, D.A.1
Caughey, B.2
-
97
-
-
0036791880
-
Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model
-
Collins, S.J.; Lewis, V.; Brazier, M.; Hill, A.F.; Fletcher, A.; Masters, C.L. Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model. Ann. Neurol., 2002, 52(4), 503-506.
-
(2002)
Ann. Neurol.
, vol.52
, Issue.4
, pp. 503-506
-
-
Collins, S.J.1
Lewis, V.2
Brazier, M.3
Hill, A.F.4
Fletcher, A.5
Masters, C.L.6
-
98
-
-
0038447100
-
Evaluation of quinacrine treatment for prion diseases
-
Barret, A.; Tagliavini, F.; Forloni, G.; Bate, C.; Salmona, M.; Colombo, L.; De Luigi, A.; Limido, L.; Suardi, S.; Rossi, G.; Auvre, F.; Adjou, K.T.; Sales, N.; Williams, A.; Lasmezas, C.; Deslys, J.P. Evaluation of quinacrine treatment for prion diseases. J. Virol., 2003, 77(15), 8462-8469.
-
(2003)
J. Virol.
, vol.77
, Issue.15
, pp. 8462-8469
-
-
Barret, A.1
Tagliavini, F.2
Forloni, G.3
Bate, C.4
Salmona, M.5
Colombo, L.6
de Luigi, A.7
Limido, L.8
Suardi, S.9
Rossi, G.10
Auvre, F.11
Adjou, K.T.12
Sales, N.13
Williams, A.14
Lasmezas, C.15
Deslys, J.P.16
-
99
-
-
0021133672
-
Influence of aminasine on experimental scrapie in mice
-
Roikhel, V.M.; Fokina, G.I.; Pogodina, V.V. Influence of aminasine on experimental scrapie in mice. Acta Virol., 1984, 28(4), 321-324.
-
(1984)
Acta Virol.
, vol.28
, Issue.4
, pp. 321-324
-
-
Roikhel, V.M.1
Fokina, G.I.2
Pogodina, V.V.3
-
100
-
-
62149105940
-
Safety and efficacy of quinacrine in human prion disease (PRION-1 study): A patient-preference trial
-
Collinge, J.; Gorham, M.; Hudson, F.; Kennedy, A.; Keogh, G.; Pal, S.; Rossor, M.; Rudge, P.; Siddique, D.; Spyer, M.; Thomas, D.; Walker, S.; Webb, T.; Wroe, S.; Darbyshire, J. Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial. Lancet Neurol., 2009, 8(4), 334-344.
-
(2009)
Lancet Neurol.
, vol.8
, Issue.4
, pp. 334-344
-
-
Collinge, J.1
Gorham, M.2
Hudson, F.3
Kennedy, A.4
Keogh, G.5
Pal, S.6
Rossor, M.7
Rudge, P.8
Siddique, D.9
Spyer, M.10
Thomas, D.11
Walker, S.12
Webb, T.13
Wroe, S.14
Darbyshire, J.15
-
101
-
-
82955243998
-
PRION-1 scales analysis supports use of functional outcome measures in prion disease
-
Mead, S.; Ranopa, M.; Gopalakrishnan, G.S.; Thompson, A.G.; Rudge, P.; Wroe, S.; Kennedy, A.; Hudson, F.; MacKay, A.; Darbyshire, J.H.; Collinge, J.; Walker, A.S. PRION-1 scales analysis supports use of functional outcome measures in prion disease. Neurology, 2011, 77(18), 1674-1683.
-
(2011)
Neurology,
, vol.77
, Issue.18
, pp. 1674-1683
-
-
Mead, S.1
Ranopa, M.2
Gopalakrishnan, G.S.3
Thompson, A.G.4
Rudge, P.5
Wroe, S.6
Kennedy, A.7
Hudson, F.8
MacKay, A.9
Darbyshire, J.H.10
Collinge, J.11
Walker, A.S.12
-
102
-
-
72649091794
-
Continuous quinacrine treatment results in the formation of drug-resistant prions
-
Ghaemmaghami, S.; Ahn, M.; Lessard, P.; Giles, K.; Legname, G.; DeArmond, S.J.; Prusiner, S.B. Continuous quinacrine treatment results in the formation of drug-resistant prions. PLoS Pathog., 2009, 5(11), e1000673.
-
(2009)
PLoS Pathog.
, vol.5
, Issue.11
-
-
Ghaemmaghami, S.1
Ahn, M.2
Lessard, P.3
Giles, K.4
Legname, G.5
DeArmond, S.J.6
Prusiner, S.B.7
-
103
-
-
33745926817
-
Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments
-
Klingenstein, R.; Lober, S.; Kujala, P.; Godsave, S.; Leliveld, S.R.; Gmeiner, P.; Peters, P.J.; Korth, C. Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments. J. Neurochem., 2006, 98(3), 748-759.
-
(2006)
J. Neurochem.
, vol.98
, Issue.3
, pp. 748-759
-
-
Klingenstein, R.1
Lober, S.2
Kujala, P.3
Godsave, S.4
Leliveld, S.R.5
Gmeiner, P.6
Peters, P.J.7
Korth, C.8
-
104
-
-
2542423998
-
Nonglycosylphosphatidylinositol (GPI)-anchored recombinant prion protein with dominant-negative mutation inhibits PrPSc replication in vitro
-
Kishida, H.; Sakasegawa, Y.; Watanabe, K.; Yamakawa, Y.; Nishijima, M.; Kuroiwa, Y.; Hachiya, N.S.; Kaneko, K. Nonglycosylphosphatidylinositol (GPI)-anchored recombinant prion protein with dominant-negative mutation inhibits PrPSc replication in vitro. Amyloid, 2004, 11(1), 14-20.
-
(2004)
Amyloid,
, vol.11
, Issue.1
, pp. 14-20
-
-
Kishida, H.1
Sakasegawa, Y.2
Watanabe, K.3
Yamakawa, Y.4
Nishijima, M.5
Kuroiwa, Y.6
Hachiya, N.S.7
Kaneko, K.8
-
105
-
-
0347003596
-
Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies
-
Murakami-Kubo, I.; Doh-ura, K.; Ishikawa, K.; Kawatake, S.; Sasaki, K.; Kira, J.; Ohta, S.; Iwaki, T. Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies. J. Virol., 2004, 78(3), 1281-1288.
-
(2004)
J. Virol.
, vol.78
, Issue.3
, pp. 1281-1288
-
-
Murakami-Kubo, I.1
Doh-ura, K.2
Ishikawa, K.3
Kawatake, S.4
Sasaki, K.5
Kira, J.6
Ohta, S.7
Iwaki, T.8
-
106
-
-
80052821738
-
Styryl-based and tricyclic compounds as potential antiprion agents
-
Chung, E.; Prelli, F.; Dealler, S.; Lee, W.S.; Chang, Y.T.; Wisniewski, T. Styryl-based and tricyclic compounds as potential antiprion agents. PLoS One, 2011, 6(9), e24844.
-
(2011)
PLoS One,
, vol.6
, Issue.9
-
-
Chung, E.1
Prelli, F.2
Dealler, S.3
Lee, W.S.4
Chang, Y.T.5
Wisniewski, T.6
-
107
-
-
72249086573
-
Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease
-
Thompson, M.J.; Borsenberger, V.; Louth, J.C.; Judd, K.E.; Chen, B. Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease. J. Med. Chem., 2009, 52(23), 7503-7511.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.23
, pp. 7503-7511
-
-
Thompson, M.J.1
Borsenberger, V.2
Louth, J.C.3
Judd, K.E.4
Chen, B.5
-
108
-
-
78650535724
-
Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease
-
Thompson, M.J.; Louth, J.C.; Ferrara, S.; Sorrell, F.J.; Irving, B.J.; Cochrane, E.J.; Meijer, A.J.; Chen, B. Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease. ChemMedChem, 2011, 6(1), 115-130.
-
(2011)
ChemMedChem,
, vol.6
, Issue.1
, pp. 115-130
-
-
Thompson, M.J.1
Louth, J.C.2
Ferrara, S.3
Sorrell, F.J.4
Irving, B.J.5
Cochrane, E.J.6
Meijer, A.J.7
Chen, B.8
-
109
-
-
80052959006
-
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
-
Thompson, M.J.; Louth, J.C.; Ferrara, S.; Jackson, M.P.; Sorrell, F.J.; Cochrane, E.J.; Gever, J.; Baxendale, S.; Silber, B.M.; Roehl, H.H.; Chen, B. Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity. Eur. J. Med. Chem., 2011, 46(9), 4125-4132.
-
(2011)
Eur. J. Med. Chem.
, vol.46
, Issue.9
, pp. 4125-4132
-
-
Thompson, M.J.1
Louth, J.C.2
Ferrara, S.3
Jackson, M.P.4
Sorrell, F.J.5
Cochrane, E.J.6
Gever, J.7
Baxendale, S.8
Silber, B.M.9
Roehl, H.H.10
Chen, B.11
-
110
-
-
60249101701
-
PLASMA Investigators Effects of 1-Hindole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): A phase II double-blind, randomised, placebo-controlled trial
-
Rosenson, R.S.; Hislop, C.; McConnell, D.; Elliott, M.; Stasiv, Y.; Wang, N.; Waters, D.D.; PLASMA Investigators Effects of 1-Hindole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a phase II double-blind, randomised, placebo-controlled trial. Lancet, 2009, 373(9664), 649-658.
-
(2009)
Lancet
, vol.373
, Issue.9664
, pp. 649-658
-
-
Rosenson, R.S.1
Hislop, C.2
McConnell, D.3
Elliott, M.4
Stasiv, Y.5
Wang, N.6
Waters, D.D.7
-
111
-
-
84857792744
-
Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: Rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial
-
Nicholls, S.J.; Cavender, M.A.; Kastelein, J.J.; Schwartz, G.; Waters, D.D.; Rosenson, R.S.; Bash, D.; Hislop, C. Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial. Cardiovasc. Drugs Ther., 2012, 26(1), 71-75.
-
(2012)
Cardiovasc. Drugs Ther.
, vol.26
, Issue.1
, pp. 71-75
-
-
Nicholls, S.J.1
Cavender, M.A.2
Kastelein, J.J.3
Schwartz, G.4
Waters, D.D.5
Rosenson, R.S.6
Bash, D.7
Hislop, C.8
-
112
-
-
72249103816
-
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects
-
Wang, T.; Yin, Z.; Zhang, Z.; Bender, J.A.; Yang, Z.; Johnson, G.; Yang, Z.; Zadjura, L.M.; D'Arienzo, C.J.; DiGiugno Parker, D.; Gesenberg, C.; Yamanaka, G.A.; Gong, Y.F.; Ho, H.T.; Fang, H.; Zhou, N.; McAuliffe, B.V.; Eggers, B.J.; Fan, L.; Nowicka-Sans, B.; Dicker, I.B.; Gao, Q.; Colonno, R.J.; Lin, P.F.; Meanwell, N.A.; Kadow, J.F. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects. J. Med. Chem., 2009, 52(23), 7778-7787.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.23
, pp. 7778-7787
-
-
Wang, T.1
Yin, Z.2
Zhang, Z.3
Bender, J.A.4
Yang, Z.5
Johnson, G.6
Yang, Z.7
Zadjura, L.M.8
D'Arienzo, C.J.9
DiGiugno Parker, D.10
Gesenberg, C.11
Yamanaka, G.A.12
Gong, Y.F.13
Ho, H.T.14
Fang, H.15
Zhou, N.16
McAuliffe, B.V.17
Eggers, B.J.18
Fan, L.19
Nowicka-Sans, B.20
Dicker, I.B.21
Gao, Q.22
Colonno, R.J.23
Lin, P.F.24
Meanwell, N.A.25
Kadow, J.F.26
more..
-
113
-
-
77952241570
-
Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors
-
Oostendorp, R.L.; Witteveen, P.O.; Schwartz, B.; Vainchtein, L.D.; Schot, M.; Nol, A.; Rosing, H.; Beijnen, J.H.; Voest, E.E.; Schellens, J.H. Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors. Invest. New Drugs, 2010, 28(2), 163-170.
-
(2010)
Invest. New Drugs,
, vol.28
, Issue.2
, pp. 163-170
-
-
Oostendorp, R.L.1
Witteveen, P.O.2
Schwartz, B.3
Vainchtein, L.D.4
Schot, M.5
Nol, A.6
Rosing, H.7
Beijnen, J.H.8
Voest, E.E.9
Schellens, J.H.10
-
114
-
-
77949357105
-
Discovery of 2-aminothiazoles as potent antiprion compounds
-
Ghaemmaghami, S.; May, B.C.; Renslo, A.R.; Prusiner, S.B. Discovery of 2-aminothiazoles as potent antiprion compounds. J. Virol., 2010, 84(7), 3408-3412.
-
(2010)
J. Virol.
, vol.84
, Issue.7
, pp. 3408-3412
-
-
Ghaemmaghami, S.1
May, B.C.2
Renslo, A.R.3
Prusiner, S.B.4
-
115
-
-
77956412327
-
Improved 2,4-diarylthiazolebased antiprion agents: Switching the sense of the amide group at C5 leads to an increase in potency
-
Thompson, M.J.; Louth, J.C.; Greenwood, G.K.; Sorrell, F.J.; Knight, S.G.; Adams, N.B.; Chen, B. Improved 2,4-diarylthiazolebased antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency. ChemMedChem, 2010, 5(9), 1476-1488.
-
(2010)
ChemMedChem,
, vol.5
, Issue.9
, pp. 1476-1488
-
-
Thompson, M.J.1
Louth, J.C.2
Greenwood, G.K.3
Sorrell, F.J.4
Knight, S.G.5
Adams, N.B.6
Chen, B.7
-
116
-
-
79951821156
-
2-Aminothiazoles as therapeutic leads for prion diseases
-
Gallardo-Godoy, A.; Gever, J.; Fife, K.L.; Silber, B.M.; Prusiner, S.B.; Renslo, A.R. 2-Aminothiazoles as therapeutic leads for prion diseases. J. Med. Chem., 2011, 54(4), 1010-1021.
-
(2011)
J. Med. Chem.
, vol.54
, Issue.4
, pp. 1010-1021
-
-
Gallardo-Godoy, A.1
Gever, J.2
Fife, K.L.3
Silber, B.M.4
Prusiner, S.B.5
Renslo, A.R.6
-
117
-
-
0032557457
-
Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides
-
Chabry, J.; Caughey, B.; Chesebro, B. Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides. J. Biol. Chem., 1998, 273, 13203-13207.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13203-13207
-
-
Chabry, J.1
Caughey, B.2
Chesebro, B.3
-
118
-
-
0032775473
-
Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence
-
Chabry, J.; Priola, S.A.; Wehrly, K.; Nishio, J.; Hope, J.; Chesebro, B. Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence. J. Virol., 1999, 73(8), 6245-6250.
-
(1999)
J. Virol.
, vol.73
, Issue.8
, pp. 6245-6250
-
-
Chabry, J.1
Priola, S.A.2
Wehrly, K.3
Nishio, J.4
Hope, J.5
Chesebro, B.6
-
119
-
-
0035805643
-
Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain
-
Horiuchi, M.; Baron, G.S.; Xiong, L.W.; Caughey, B. Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain. J. Biol. Chem., 2001, 276(18), 15489-15497.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.18
, pp. 15489-15497
-
-
Horiuchi, M.1
Baron, G.S.2
Xiong, L.W.3
Caughey, B.4
-
120
-
-
34447274298
-
Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation
-
Gilch, S.; Kehler, C.; Schatzl, H.M. Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation. J. Mol. Biol., 2007, 371(2), 362-373.
-
(2007)
J. Mol. Biol.
, vol.371
, Issue.2
, pp. 362-373
-
-
Gilch, S.1
Kehler, C.2
Schatzl, H.M.3
-
121
-
-
0034650634
-
Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides
-
Soto, C.; Kascsak, R.J.; Saborio, G.P.; Aucouturier, P.; Wisniewski, T.; Prelli, F.; Kascsak, R.; Mendez, E.; Harris, D.A.; Ironside, J.; Tagliavini, F.; Carp, R.I.; Frangione, B. Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides. Lancet, 2000, 355(9199), 192-197.
-
(2000)
Lancet,
, vol.355
, Issue.9199
, pp. 192-197
-
-
Soto, C.1
Kascsak, R.J.2
Saborio, G.P.3
Aucouturier, P.4
Wisniewski, T.5
Prelli, F.6
Kascsak, R.7
Mendez, E.8
Harris, D.A.9
Ironside, J.10
Tagliavini, F.11
Carp, R.I.12
Frangione, B.13
-
122
-
-
0141507087
-
Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145)
-
Oishi, T.; Hagiwara, K.; Kinumi, T.; Yamakawa, Y.; Nishijima, M.; Nakamura, K.; Arimoto, H. Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145). Org. Biomol. Chem., 2003, 1(15), 2626-2629.
-
(2003)
Org. Biomol. Chem.
, vol.1
, Issue.15
, pp. 2626-2629
-
-
Oishi, T.1
Hagiwara, K.2
Kinumi, T.3
Yamakawa, Y.4
Nishijima, M.5
Nakamura, K.6
Arimoto, H.7
-
123
-
-
60349131486
-
Cryptic peptides of the kringle domains preferentially bind to disease-associated prion protein
-
Hatcher, K.; Zheng, J.; Chen, S.G. Cryptic peptides of the kringle domains preferentially bind to disease-associated prion protein. J. Alzheimers Dis., 2009, 16(2), 421-431.
-
(2009)
J. Alzheimers Dis.
, vol.16
, Issue.2
, pp. 421-431
-
-
Hatcher, K.1
Zheng, J.2
Chen, S.G.3
-
124
-
-
83755162371
-
A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation
-
Westergard, L.; Turnbaugh, J.A.; Harris, D.A. A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation. J. Biol. Chem., 2011, 286(51), 44234-44242.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.51
, pp. 44234-44242
-
-
Westergard, L.1
Turnbaugh, J.A.2
Harris, D.A.3
-
125
-
-
0035979274
-
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
-
Enari, M.; Flechsig, E.; Weissmann, C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc. Natl. Acad. Sci. USA, 2001, 98(16), 9295-9299.
-
(2001)
Proc. Natl. Acad. Sci. USA,
, vol.98
, Issue.16
, pp. 9295-9299
-
-
Enari, M.1
Flechsig, E.2
Weissmann, C.3
-
126
-
-
10444277192
-
Concealment of epitope by reduction and alkylation in prion protein
-
Yuan, J.; Kinter, M.; McGeehan, J.; Perry, G.; Kneale, G.; Gambetti, P.; Zou, W.Q. Concealment of epitope by reduction and alkylation in prion protein. Biochem. Biophys. Res. Commun., 2005, 326(3), 652-659.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.326
, Issue.3
, pp. 652-659
-
-
Yuan, J.1
Kinter, M.2
McGeehan, J.3
Perry, G.4
Kneale, G.5
Gambetti, P.6
Zou, W.Q.7
-
127
-
-
81255152420
-
Alkylating antitumor drug mechlorethamine conceals a structured PrP domain and inhibits in vitro prion amplification
-
Zhou, X.; Bi, H.; Wong, J.; Shimoji, M.; Wang, Y.; Yuan, J.; Xiao, X.; Wang, G.X.; Zou, W.Q. Alkylating antitumor drug mechlorethamine conceals a structured PrP domain and inhibits in vitro prion amplification. J. Toxicol. Environ. Health A, 2011, 74(22-24), 1493-1503.
-
(2011)
J. Toxicol. Environ. Health A
, vol.74
, Issue.22-24
, pp. 1493-1503
-
-
Zhou, X.1
Bi, H.2
Wong, J.3
Shimoji, M.4
Wang, Y.5
Yuan, J.6
Xiao, X.7
Wang, G.X.8
Zou, W.Q.9
-
128
-
-
32244434927
-
The prion protein requires cholesterol for cell surface localization
-
Gilch, S.; Kehler, C.; Schatzl, H.M. The prion protein requires cholesterol for cell surface localization. Mol. Cell. Neurosci., 2006, 31(2), 346-353.
-
(2006)
Mol. Cell. Neurosci.
, vol.31
, Issue.2
, pp. 346-353
-
-
Gilch, S.1
Kehler, C.2
Schatzl, H.M.3
-
129
-
-
0028966735
-
Cholesterol depletion and modification of COOHterminal targeting sequence of the prion protein inhibit formation of the scrapie isoform
-
Taraboulos, A.; Scott, M.; Semenov, A.; Avraham, D.; Laszlo, L.; Prusiner, S.B. Cholesterol depletion and modification of COOHterminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell Biol., 1995, 129, 121-132.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 121-132
-
-
Taraboulos, A.1
Scott, M.2
Semenov, A.3
Avraham, D.4
Laszlo, L.5
Prusiner, S.B.6
-
130
-
-
2442483932
-
Squalestatin cures prion-infected neurones and protects against prion neurotoxicity
-
Bate, C.; Salmona, M.; Diomede, L.; Williams, A. Squalestatin cures prion-infected neurones and protects against prion neurotoxicity. J. Biol. Chem., 2004, 279(15), 14983-14990.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.15
, pp. 14983-14990
-
-
Bate, C.1
Salmona, M.2
Diomede, L.3
Williams, A.4
-
131
-
-
35848936977
-
Antiprion activity of cholesterol esterification modulators: A comparative study using ex vivo sheep fibroblasts and lymphocytes and mouse neuroblastoma cell lines
-
Pani, A.; Norfo, C.; Abete, C.; Mulas, C.; Putzolu, M.; Laconi, S.; Orru, C.D.; Cannas, M.D.; Vascellari, S.; La, C.P.; Dessi, S. Antiprion activity of cholesterol esterification modulators: a comparative study using ex vivo sheep fibroblasts and lymphocytes and mouse neuroblastoma cell lines. Antimicrob. Agents Chemother., 2007, 51(11), 4141-4147.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, Issue.11
, pp. 4141-4147
-
-
Pani, A.1
Norfo, C.2
Abete, C.3
Mulas, C.4
Putzolu, M.5
Laconi, S.6
Orru, C.D.7
Cannas, M.D.8
Vascellari, S.9
La, C.P.10
Dessi, S.11
-
132
-
-
34147171715
-
Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice
-
Hagiwara, K.; Nakamura, Y.; Nishijima, M.; Yamakawa, Y. Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice. Biol. Pharm. Bull., 2007, 30(4), 835-838.
-
(2007)
Biol. Pharm. Bull.
, vol.30
, Issue.4
, pp. 835-838
-
-
Hagiwara, K.1
Nakamura, Y.2
Nishijima, M.3
Yamakawa, Y.4
-
133
-
-
34247589262
-
Simvastatin treatment prolongs the survival of scrapie-infected mice
-
Kempster, S.; Bate, C.; Williams, A. Simvastatin treatment prolongs the survival of scrapie-infected mice. Neuroreport, 2007, 18(5), 479-482.
-
(2007)
Neuroreport,
, vol.18
, Issue.5
, pp. 479-482
-
-
Kempster, S.1
Bate, C.2
Williams, A.3
-
134
-
-
33746890495
-
Simvastatin prolongs survival times in prion infections of the central nervous system
-
Mok, S.W.; Thelen, K.M.; Riemer, C.; Bamme, T.; Gultner, S.; Lutjohann, D.; Baier, M. Simvastatin prolongs survival times in prion infections of the central nervous system. Biochem. Biophys. Res. Commun., 2006, 348(2), 697-702.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.348
, Issue.2
, pp. 697-702
-
-
Mok, S.W.1
Thelen, K.M.2
Riemer, C.3
Bamme, T.4
Gultner, S.5
Lutjohann, D.6
Baier, M.7
-
135
-
-
70849121219
-
Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation
-
Gilch, S.; Bach, C.; Lutzny, G.; Vorberg, I.; Schatzl, H.M. Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation. Cell Mol. Life Sci., 2009, 66(24), 3979-3991.
-
(2009)
Cell Mol. Life Sci.
, vol.66
, Issue.24
, pp. 3979-3991
-
-
Gilch, S.1
Bach, C.2
Lutzny, G.3
Vorberg, I.4
Schatzl, H.M.5
-
136
-
-
0028015941
-
Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie
-
Demaimay, R.; Adjou, K.; Lasmezas, C.; Lazarini, F.; Cherifi, K.; Seman, M.; Deslys, J.P.; Dormont, D. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J. Gen. Virol., 1994, 75, 2499-2503.
-
(1994)
J. Gen. Virol.
, vol.75
, pp. 2499-2503
-
-
Demaimay, R.1
Adjou, K.2
Lasmezas, C.3
Lazarini, F.4
Cherifi, K.5
Seman, M.6
Deslys, J.P.7
Dormont, D.8
-
137
-
-
0030778819
-
Late treatment with polyene antibiotics can prolong the survival time of scrapieinfected animals
-
Demaimay, R.; Adjou, K.T.; Beringue, V.; Demart, S.; Lasmezas, C.I.; Deslys, J.-.; Seman, M.; Dormont, D. Late treatment with polyene antibiotics can prolong the survival time of scrapieinfected animals. J. Virol., 1997, 71, 9685-9689.
-
(1997)
J. Virol.
, vol.71
, pp. 9685-9689
-
-
Demaimay, R.1
Adjou, K.T.2
Beringue, V.3
Demart, S.4
Lasmezas, C.I.5
Deslys, J.-.6
Seman, M.7
Dormont, D.8
-
138
-
-
0037067743
-
Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release
-
Marella, M.; Lehmann, S.; Grassi, J.; Chabry, J. Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release. J. Biol. Chem., 2002, 277(28), 25457-25464.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.28
, pp. 25457-25464
-
-
Marella, M.1
Lehmann, S.2
Grassi, J.3
Chabry, J.4
-
139
-
-
0029683335
-
Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: Implications for the mechanism of action of polyene antibiotics
-
Adjou, K.T.; Demaimay, R.; Lasmezas, C.I.; Seman, M.; Deslys, J.P.; Dormont, D. Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: implications for the mechanism of action of polyene antibiotics. Res. Virol., 1996, 147(4), 213-218.
-
(1996)
Res. Virol.
, vol.147
, Issue.4
, pp. 213-218
-
-
Adjou, K.T.1
Demaimay, R.2
Lasmezas, C.I.3
Seman, M.4
Deslys, J.P.5
Dormont, D.6
-
140
-
-
0026719975
-
Failure to ameliorate Creutzfeldt-Jakob disease with amphotericin B therapy
-
Masullo, C.; Macchi, G.; Xi, Y.G.; Pocchiari, M. Failure to ameliorate Creutzfeldt-Jakob disease with amphotericin B therapy. J. Infect. Dis., 1992, 165(4), 784-785.
-
(1992)
J. Infect. Dis.
, vol.165
, Issue.4
, pp. 784-785
-
-
Masullo, C.1
Macchi, G.2
Xi, Y.G.3
Pocchiari, M.4
-
141
-
-
0030054010
-
Normal host prion protein necessary for scrapie-induced neurotoxicity
-
Brandner, S.; Isenmann, S.; Raeber, A.; Fischer, M.; Sailer, A.; Kobayashi, Y.; Marino, S.; Weissmann, C.; Aguzzi, A. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature, 1996, 379(6563), 339-343.
-
(1996)
Nature,
, vol.379
, Issue.6563
, pp. 339-343
-
-
Brandner, S.1
Isenmann, S.2
Raeber, A.3
Fischer, M.4
Sailer, A.5
Kobayashi, Y.6
Marino, S.7
Weissmann, C.8
Aguzzi, A.9
-
142
-
-
0036470471
-
Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
-
Mallucci, G.R.; Ratte, S.; Asante, E.A.; Linehan, J.; Gowland, I.; Jefferys, J.G.; Collinge, J. Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J., 2002, 21(3), 202-210.
-
(2002)
EMBO J.
, vol.21
, Issue.3
, pp. 202-210
-
-
Mallucci, G.R.1
Ratte, S.2
Asante, E.A.3
Linehan, J.4
Gowland, I.5
Jefferys, J.G.6
Collinge, J.7
-
143
-
-
0242363656
-
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
-
Mallucci, G.; Dickinson, A.; Linehan, J.; Klohn, P.C.; Brandner, S.; Collinge, J. Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science, 2003, 302(5646), 871-874.
-
(2003)
Science,
, vol.302
, Issue.5646
, pp. 871-874
-
-
Mallucci, G.1
Dickinson, A.2
Linehan, J.3
Klohn, P.C.4
Brandner, S.5
Collinge, J.6
-
144
-
-
33846538022
-
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice
-
Mallucci, G.R.; White, M.D.; Farmer, M.; Dickinson, A.; Khatun, H.; Powell, A.D.; Brandner, S.; Jefferys, J.G.; Collinge, J. Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron, 2007, 53(3), 325-335.
-
(2007)
Neuron,
, vol.53
, Issue.3
, pp. 325-335
-
-
Mallucci, G.R.1
White, M.D.2
Farmer, M.3
Dickinson, A.4
Khatun, H.5
Powell, A.D.6
Brandner, S.7
Jefferys, J.G.8
Collinge, J.9
-
145
-
-
0038578675
-
Efficient and specific down-regulation of prion protein expression by RNAi
-
Tilly, G.; Chapuis, J.; Vilette, D.; Laude, H.; Vilotte, J.L. Efficient and specific down-regulation of prion protein expression by RNAi. Biochem. Biophys. Res. Commun., 2003, 305(3), 548-551.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.305
, Issue.3
, pp. 548-551
-
-
Tilly, G.1
Chapuis, J.2
Vilette, D.3
Laude, H.4
Vilotte, J.L.5
-
146
-
-
0038783253
-
Specific inhibition of pathological prion protein accumulation by small interfering RNAs
-
Daude, N.; Marella, M.; Chabry, J. Specific inhibition of pathological prion protein accumulation by small interfering RNAs. J. Cell. Sci., 2003, 116, 2775-2779.
-
(2003)
J. Cell. Sci.
, vol.116
, pp. 2775-2779
-
-
Daude, N.1
Marella, M.2
Chabry, J.3
-
147
-
-
33845346122
-
Lentivectormediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice
-
Pfeifer, A.; Eigenbrod, S.; Al-Khadra, S.; Hofmann, A.; Mitteregger, G.; Moser, M.; Bertsch, U.; Kretzschmar, H. Lentivectormediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice. J. Clin. Invest., 2006, 116(12), 3204-3210.
-
(2006)
J. Clin. Invest.
, vol.116
, Issue.12
, pp. 3204-3210
-
-
Pfeifer, A.1
Eigenbrod, S.2
Al-Khadra, S.3
Hofmann, A.4
Mitteregger, G.5
Moser, M.6
Bertsch, U.7
Kretzschmar, H.8
-
148
-
-
84863116075
-
Abeta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
-
You, H.; Tsutsui, S.; Hameed, S.; Kannanayakal, T.J.; Chen, L.; Xia, P.; Engbers, J.D.; Lipton, S.A.; Stys, P.K.; Zamponi, G.W. Abeta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA, 2012, 109(5), 1737-1742.
-
(2012)
Proc. Natl. Acad. Sci. USA,
, vol.109
, Issue.5
, pp. 1737-1742
-
-
You, H.1
Tsutsui, S.2
Hameed, S.3
Kannanayakal, T.J.4
Chen, L.5
Xia, P.6
Engbers, J.D.7
Lipton, S.A.8
Stys, P.K.9
Zamponi, G.W.10
-
149
-
-
0345714734
-
Copper binding to PrPC may inhibit prion disease propagation
-
Hijazi, N.; Shaked, Y.; Rosenmann, H.; Ben-Hur, T.; Gabizon, R. Copper binding to PrPC may inhibit prion disease propagation. Brain Res., 2003, 993(1-2), 192-200.
-
(2003)
Brain Res.
, vol.993
, Issue.1-2
, pp. 192-200
-
-
Hijazi, N.1
Shaked, Y.2
Rosenmann, H.3
Ben-Hur, T.4
Gabizon, R.5
-
150
-
-
0345306739
-
Copper chelation delays the onset of prion disease
-
Sigurdsson, E.M.; Brown, D.R.; Alim, M.A.; Scholtzova, H.; Carp, R.; Meeker, H.C.; Prelli, F.; Frangione, B.; Wisniewski, T. Copper chelation delays the onset of prion disease. J. Biol. Chem., 2003, 278(47), 46199-46202.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.47
, pp. 46199-46202
-
-
Sigurdsson, E.M.1
Brown, D.R.2
Alim, M.A.3
Scholtzova, H.4
Carp, R.5
Meeker, H.C.6
Prelli, F.7
Frangione, B.8
Wisniewski, T.9
-
151
-
-
27744516184
-
Evaluation of anti-prionic activity of clioquinol in an in vivo model (Mesocricetus auratus)
-
Pollera, C.; Lucchini, B.; Formentin, E.; Bareggi, S.; Poli, G.; Ponti, W. Evaluation of anti-prionic activity of clioquinol in an in vivo model (Mesocricetus auratus). Vet. Res. Commun., 2005, 29(Suppl 2), 253-255.
-
(2005)
Vet. Res. Commun.
, vol.29
, Issue.SUPPL. 2
, pp. 253-255
-
-
Pollera, C.1
Lucchini, B.2
Formentin, E.3
Bareggi, S.4
Poli, G.5
Ponti, W.6
-
152
-
-
34248512609
-
Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine
-
Doh-ura, K.; Tamura, K.; Karube, Y.; Naito, M.; Tsuruo, T.; Kataoka, Y. Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine. Cell. Mol. Neurobiol., 2007, 27(3), 303-316.
-
(2007)
Cell. Mol. Neurobiol.
, vol.27
, Issue.3
, pp. 303-316
-
-
Doh-ura, K.1
Tamura, K.2
Karube, Y.3
Naito, M.4
Tsuruo, T.5
Kataoka, Y.6
-
153
-
-
33750521766
-
Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug
-
Fukuuchi, T.; Doh-ura, K.; Yoshihara, S.; Ohta, S. Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug. Bioorg. Med. Chem. Lett., 2006, 16(23), 5982-5987.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, Issue.23
, pp. 5982-5987
-
-
Fukuuchi, T.1
Doh-ura, K.2
Yoshihara, S.3
Ohta, S.4
-
154
-
-
67649439146
-
Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters
-
Bareggi, S.R.; Braida, D.; Pollera, C.; Bondiolotti, G.; Formentin, E.; Puricelli, M.; Poli, G.; Ponti, W.; Sala, M. Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters. Brain Res., 2009, 1280, 195-200.
-
(2009)
Brain Res.
, vol.1280
, pp. 195-200
-
-
Bareggi, S.R.1
Braida, D.2
Pollera, C.3
Bondiolotti, G.4
Formentin, E.5
Puricelli, M.6
Poli, G.7
Ponti, W.8
Sala, M.9
-
155
-
-
77953855429
-
Manganese chelation therapy extends survival in a mouse model of M1000 prion disease
-
Brazier, M.W.; Volitakis, I.; Kvasnicka, M.; White, A.R.; Underwood, J.R.; Green, J.E.; Han, S.; Hill, A.F.; Masters, C.L.; Collins, S.J. Manganese chelation therapy extends survival in a mouse model of M1000 prion disease. J. Neurochem., 2010, 114(2), 440-451.
-
(2010)
J. Neurochem.
, vol.114
, Issue.2
, pp. 440-451
-
-
Brazier, M.W.1
Volitakis, I.2
Kvasnicka, M.3
White, A.R.4
Underwood, J.R.5
Green, J.E.6
Han, S.7
Hill, A.F.8
Masters, C.L.9
Collins, S.J.10
-
156
-
-
0019944533
-
Repeated suppression of Creutzfeldt-Jakob disease with vidarabine
-
Furlow, T.W., Jr.; Whitley, R.J.; Wilmes, F.J. Repeated suppression of Creutzfeldt-Jakob disease with vidarabine. Lancet, 1982, 2(8297), 564-565.
-
(1982)
Lancet,
, vol.2
, Issue.8297
, pp. 564-565
-
-
Furlow Jr., T.W.1
Whitley, R.J.2
Wilmes, F.J.3
-
157
-
-
84960586189
-
Amphotericin B: A novel class of antiscrapie drugs
-
Pocchiari, M.; Casaccia, P.; Ladogana, A. Amphotericin B: a novel class of antiscrapie drugs. J. Infect. Dis., 1989, 160(5), 795-802.
-
(1989)
J. Infect. Dis.
, vol.160
, Issue.5
, pp. 795-802
-
-
Pocchiari, M.1
Casaccia, P.2
Ladogana, A.3
-
158
-
-
0014331517
-
The effect of beta-propiolactone on the scrapie agent
-
Haig, D.A.; Clarke, M.C. The effect of beta-propiolactone on the scrapie agent. J. Gen. Virol., 1968, 3, 281-283.
-
(1968)
J. Gen. Virol.
, vol.3
, pp. 281-283
-
-
Haig, D.A.1
Clarke, M.C.2
-
159
-
-
0015153753
-
Failure of adenine arabinoside to modify scrapie in mice
-
Cochran, K.W. Failure of adenine arabinoside to modify scrapie in mice. J. Gen. Virol., 1971, 13(2), 353-354.
-
(1971)
J. Gen. Virol.
, vol.13
, Issue.2
, pp. 353-354
-
-
Cochran, K.W.1
-
160
-
-
0018717725
-
Antiviral compound effective against experimental scrapie
-
Kimberlin, R.H.; Walker, C.A. Antiviral compound effective against experimental scrapie. Lancet, 1979, 2(8142), 591-592.
-
(1979)
Lancet,
, vol.2
, Issue.8142
, pp. 591-592
-
-
Kimberlin, R.H.1
Walker, C.A.2
-
161
-
-
0019458747
-
Antibiotics and antivirals do not modify experimentally-induced Creutzfeldt-Jakob disease in mice
-
Tateishi, J. Antibiotics and antivirals do not modify experimentally-induced Creutzfeldt-Jakob disease in mice. J. Neurol. Neurosurg. Psychiatry, 1981, 44(8), 723-724.
-
(1981)
J. Neurol. Neurosurg. Psychiatry,
, vol.44
, Issue.8
, pp. 723-724
-
-
Tateishi, J.1
-
162
-
-
79651470773
-
Anti-prion activity of protein-bound polysaccharide K in prion-infected cells and animals
-
Hamanaka, T.; Sakasegawa, Y.; Ohmoto, A.; Kimura, T.; Ando, T.; Doh-ura, K. Anti-prion activity of protein-bound polysaccharide K in prion-infected cells and animals. Biochem. Biophys. Res. Commun., 2011, 405(2), 285-290.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.405
, Issue.2
, pp. 285-290
-
-
Hamanaka, T.1
Sakasegawa, Y.2
Ohmoto, A.3
Kimura, T.4
Ando, T.5
Doh-ura, K.6
-
163
-
-
0031436335
-
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
-
Rieger, R.; Edenhofer, F.; Lasmezas, C.I.; Weiss, S. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat. Med., 1997, 3(12), 1383-1388.
-
(1997)
Nat. Med.
, vol.3
, Issue.12
, pp. 1383-1388
-
-
Rieger, R.1
Edenhofer, F.2
Lasmezas, C.I.3
Weiss, S.4
-
164
-
-
17944377091
-
Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor
-
Hundt, C.; Peyrin, J.M.; Haik, S.; Gauczynski, S.; Leucht, C.; Rieger, R.; Riley, M.L.; Deslys, J.P.; Dormont, D.; Lasmezas, C.I.; Weiss, S. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor. EMBO J., 2001, 20(21), 5876-5886.
-
(2001)
EMBO J.
, vol.20
, Issue.21
, pp. 5876-5886
-
-
Hundt, C.1
Peyrin, J.M.2
Haik, S.3
Gauczynski, S.4
Leucht, C.5
Rieger, R.6
Riley, M.L.7
Deslys, J.P.8
Dormont, D.9
Lasmezas, C.I.10
Weiss, S.11
-
165
-
-
0242585507
-
The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells
-
Leucht, C.; Simoneau, S.; Rey, C.; Vana, K.; Rieger, R.; Lasmezas, C.I.; Weiss, S. The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells. EMBO Rep., 2003, 4(3), 290-295.
-
(2003)
EMBO Rep.
, vol.4
, Issue.3
, pp. 290-295
-
-
Leucht, C.1
Simoneau, S.2
Rey, C.3
Vana, K.4
Rieger, R.5
Lasmezas, C.I.6
Weiss, S.7
-
166
-
-
33748074456
-
The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes
-
Gauczynski, S.; Nikles, D.; El-Gogo, S.; Papy-Garcia, D.; Rey, C.; Alban, S.; Barritault, D.; Lasmezas, C.I.; Weiss, S. The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes. J. Infect. Dis., 2006, 194(5), 702-709.
-
(2006)
J. Infect. Dis.
, vol.194
, Issue.5
, pp. 702-709
-
-
Gauczynski, S.1
Nikles, D.2
El-Gogo, S.3
Papy-Garcia, D.4
Rey, C.5
Alban, S.6
Barritault, D.7
Lasmezas, C.I.8
Weiss, S.9
-
167
-
-
34447650047
-
Therapeutic approaches targeting the prion receptor LRP/LR
-
Zuber, C.; Ludewigs, H.; Weiss, S. Therapeutic approaches targeting the prion receptor LRP/LR. Vet. Microbiol., 2007, 123(4), 387-393.
-
(2007)
Vet. Microbiol.
, vol.123
, Issue.4
, pp. 387-393
-
-
Zuber, C.1
Ludewigs, H.2
Weiss, S.3
-
168
-
-
34548331958
-
Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases
-
Zuber, C.; Knackmuss, S.; Rey, C.; Reusch, U.; Rottgen, P.; Frohlich, T.; Arnold, G.J.; Pace, C.; Mitteregger, G.; Kretzschmar, H.A.; Little, M.; Weiss, S. Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases. Mol. Immunol., 2008, 45(1), 144-151.
-
(2008)
Mol. Immunol.
, vol.45
, Issue.1
, pp. 144-151
-
-
Zuber, C.1
Knackmuss, S.2
Rey, C.3
Reusch, U.4
Rottgen, P.5
Frohlich, T.6
Arnold, G.J.7
Pace, C.8
Mitteregger, G.9
Kretzschmar, H.A.10
Little, M.11
Weiss, S.12
-
169
-
-
80051585052
-
The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD)
-
Yun, J.; Jin, H.T.; Lee, Y.J.; Choi, E.K.; Carp, R.I.; Jeong, B.H.; Kim, Y.S. The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD). BMC Med. Genet., 2011, 12, 108.
-
(2011)
BMC Med. Genet.
, vol.12
, pp. 108
-
-
Yun, J.1
Jin, H.T.2
Lee, Y.J.3
Choi, E.K.4
Carp, R.I.5
Jeong, B.H.6
Kim, Y.S.7
-
170
-
-
24944524825
-
Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc
-
Nordstrom, E.K.; Luhr, K.M.; Ibanez, C.; Kristensson, K. Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc. J. Neurosci., 2005, 25(37), 8451-8456.
-
(2005)
J. Neurosci.
, vol.25
, Issue.37
, pp. 8451-8456
-
-
Nordstrom, E.K.1
Luhr, K.M.2
Ibanez, C.3
Kristensson, K.4
-
171
-
-
4344624313
-
Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication
-
Bate, C.; Reid, S.; Williams, A. Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. J. Biol. Chem., 2004, 279(35), 36405-36411.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.35
, pp. 36405-36411
-
-
Bate, C.1
Reid, S.2
Williams, A.3
-
172
-
-
15944386993
-
Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time
-
Engelstein, R.; Grigoriadis, N.; Greig, N.H.; Ovadia, H.; Gabizon, R. Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiol. Dis., 2005, 18(2), 282-285.
-
(2005)
Neurobiol. Dis.
, vol.18
, Issue.2
, pp. 282-285
-
-
Engelstein, R.1
Grigoriadis, N.2
Greig, N.H.3
Ovadia, H.4
Gabizon, R.5
-
173
-
-
4744361580
-
The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prioninfected cells
-
Ertmer, A.; Gilch, S.; Yun, S.W.; Flechsig, E.; Klebl, B.; Stein-Gerlach, M.; Klein, M.A.; Schatzl, H.M. The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prioninfected cells. J. Biol. Chem., 2004, 279(40), 41918-41927.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.40
, pp. 41918-41927
-
-
Ertmer, A.1
Gilch, S.2
Yun, S.W.3
Flechsig, E.4
Klebl, B.5
Stein-Gerlach, M.6
Klein, M.A.7
Schatzl, H.M.8
-
174
-
-
34548633461
-
The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery
-
Yun, S.W.; Ertmer, A.; Flechsig, E.; Gilch, S.; Riederer, P.; Gerlach, M.; Schatzl, H.M.; Klein, M.A. The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery. J. Neurovirol., 2007, 13(4), 328-337.
-
(2007)
J. Neurovirol.
, vol.13
, Issue.4
, pp. 328-337
-
-
Yun, S.W.1
Ertmer, A.2
Flechsig, E.3
Gilch, S.4
Riederer, P.5
Gerlach, M.6
Schatzl, H.M.7
Klein, M.A.8
-
175
-
-
78649726198
-
Plasminogen stimulates propagation of protease-resistant prion protein in vitro
-
Mays, C.E.; Ryou, C. Plasminogen stimulates propagation of protease-resistant prion protein in vitro. FASEB J., 2010, 24(12), 5102-5112.
-
(2010)
FASEB J.
, vol.24
, Issue.12
, pp. 5102-5112
-
-
Mays, C.E.1
Ryou, C.2
-
176
-
-
78651401382
-
Plasminogen: A cellular protein cofactor for PrPSc propagation
-
Mays, C.E.; Ryou, C. Plasminogen: A cellular protein cofactor for PrPSc propagation. Prion, 2011, 5(1), 22-27.
-
(2011)
Prion,
, vol.5
, Issue.1
, pp. 22-27
-
-
Mays, C.E.1
Ryou, C.2
-
177
-
-
0034707048
-
Binding of disease-associated prion protein to plasminogen
-
Fischer, M.B.; Roeckl, C.; Parizek, P.; Schwarz, H.P.; Aguzzi, A. Binding of disease-associated prion protein to plasminogen. Nature, 2000, 408(6811), 479-483.
-
(2000)
Nature,
, vol.408
, Issue.6811
, pp. 479-483
-
-
Fischer, M.B.1
Roeckl, C.2
Parizek, P.3
Schwarz, H.P.4
Aguzzi, A.5
-
178
-
-
0038399786
-
Cooperative binding of dominant-negative prion protein to kringle domains
-
Ryou, C.; Prusiner, S.B.; Legname, G. Cooperative binding of dominant-negative prion protein to kringle domains. J. Mol. Biol., 2003, 329(2), 323-333.
-
(2003)
J. Mol. Biol.
, vol.329
, Issue.2
, pp. 323-333
-
-
Ryou, C.1
Prusiner, S.B.2
Legname, G.3
-
179
-
-
79951578113
-
The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion
-
Ryou, C.; Titlow, W.B.; Mays, C.E.; Bae, Y.; Kim, S. The suppression of prion propagation using poly-L-lysine by targeting plasminogen that stimulates prion protein conversion. Biomaterials, 2011, 32(11), 3141-3149.
-
(2011)
Biomaterials,
, vol.32
, Issue.11
, pp. 3141-3149
-
-
Ryou, C.1
Titlow, W.B.2
Mays, C.E.3
Bae, Y.4
Kim, S.5
-
180
-
-
80054736911
-
Oligomeric-induced activity by thienyl pyrimidine compounds traps prion infectivity
-
Ayrolles-Torro, A.; Imberdis, T.; Torrent, J.; Toupet, K.; Baskakov, I.V.; Poncet-Montange, G.; Gregoire, C.; Roquet-Baneres, F.; Lehmann, S.; Rognan, D.; Pugniere, M.; Verdier, J.M.; Perrier, V. Oligomeric-induced activity by thienyl pyrimidine compounds traps prion infectivity. J. Neurosci., 2011, 31(42), 14882-14892.
-
(2011)
J. Neurosci.
, vol.31
, Issue.42
, pp. 14882-14892
-
-
Ayrolles-Torro, A.1
Imberdis, T.2
Torrent, J.3
Toupet, K.4
Baskakov, I.V.5
Poncet-Montange, G.6
Gregoire, C.7
Roquet-Baneres, F.8
Lehmann, S.9
Rognan, D.10
Pugniere, M.11
Verdier, J.M.12
Perrier, V.13
-
181
-
-
65249103439
-
Autophagy induction by trehalose counteracts cellular prion infection
-
Aguib, Y.; Heiseke, A.; Gilch, S.; Riemer, C.; Baier, M.; Schatzl, H.M.; Ertmer, A. Autophagy induction by trehalose counteracts cellular prion infection. Autophagy, 2009, 5(3), 361-369.
-
(2009)
Autophagy,
, vol.5
, Issue.3
, pp. 361-369
-
-
Aguib, Y.1
Heiseke, A.2
Gilch, S.3
Riemer, C.4
Baier, M.5
Schatzl, H.M.6
Ertmer, A.7
-
182
-
-
0033460187
-
Elimination of prions by branched polyamines and implications for therapeutics
-
Supattapone, S.; Nguyen, H.O.; Cohen, F.E.; Prusiner, S.B.; Scott, M.R. Elimination of prions by branched polyamines and implications for therapeutics. Proc. Natl. Acad. Sci. USA, 1999, 96(25), 14529-14534.
-
(1999)
Proc. Natl. Acad. Sci. USA,
, vol.96
, Issue.25
, pp. 14529-14534
-
-
Supattapone, S.1
Nguyen, H.O.2
Cohen, F.E.3
Prusiner, S.B.4
Scott, M.R.5
-
183
-
-
0035108195
-
Branched polyamines cure prion-infected neuroblastoma cells
-
Supattapone, S.; Wille, H.; Uyechi, L.; Safar, J.; Tremblay, P.; Szoka, F.C.; Cohen, F.E.; Prusiner, S.B.; Scott, M.R. Branched polyamines cure prion-infected neuroblastoma cells. J. Virol., 2001, 75(7), 3453-3461.
-
(2001)
J. Virol.
, vol.75
, Issue.7
, pp. 3453-3461
-
-
Supattapone, S.1
Wille, H.2
Uyechi, L.3
Safar, J.4
Tremblay, P.5
Szoka, F.C.6
Cohen, F.E.7
Prusiner, S.B.8
Scott, M.R.9
-
184
-
-
2942672631
-
Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapie
-
Solassol, J.; Crozet, C.; Perrier, V.; Leclaire, J.; Beranger, F.; Caminade, A.M.; Meunier, B.; Dormont, D.; Majoral, J.P.; Lehmann, S. Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapie. J. Gen. Virol., 2004, 85, 1791-1799.
-
(2004)
J. Gen. Virol.
, vol.85
, pp. 1791-1799
-
-
Solassol, J.1
Crozet, C.2
Perrier, V.3
Leclaire, J.4
Beranger, F.5
Caminade, A.M.6
Meunier, B.7
Dormont, D.8
Majoral, J.P.9
Lehmann, S.10
-
185
-
-
33947361587
-
Biological polyamines inhibit nucleic-acidinduced polymerisation of prion protein
-
Bera, A.; Nandi, P.K. Biological polyamines inhibit nucleic-acidinduced polymerisation of prion protein. Arch. Virol., 2007, 152(4), 655-668.
-
(2007)
Arch. Virol.
, vol.152
, Issue.4
, pp. 655-668
-
-
Bera, A.1
Nandi, P.K.2
-
186
-
-
0033923319
-
Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells
-
Winklhofer, K.F.; Tatzelt, J. Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells. Biol. Chem., 2000, 381(5-6), 463-469.
-
(2000)
Biol. Chem.
, vol.381
, Issue.5-6
, pp. 463-469
-
-
Winklhofer, K.F.1
Tatzelt, J.2
-
187
-
-
74449085875
-
The inhibition of prions through blocking prion conversion by permanently charged branched polyamines of low cytotoxicity
-
Lim, Y.B.; Mays, C.E.; Kim, Y.; Titlow, W.B.; Ryou, C. The inhibition of prions through blocking prion conversion by permanently charged branched polyamines of low cytotoxicity. Biomaterials, 2010, 31(8), 2025-2033.
-
(2010)
Biomaterials,
, vol.31
, Issue.8
, pp. 2025-2033
-
-
Lim, Y.B.1
Mays, C.E.2
Kim, Y.3
Titlow, W.B.4
Ryou, C.5
-
188
-
-
0033499931
-
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
-
Chai, Y.; Koppenhafer, S.L.; Bonini, N.M.; Paulson, H.L. Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease. J. Neurosci., 1999, 19(23), 10338-10347.
-
(1999)
J. Neurosci.
, vol.19
, Issue.23
, pp. 10338-10347
-
-
Chai, Y.1
Koppenhafer, S.L.2
Bonini, N.M.3
Paulson, H.L.4
-
189
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
-
Warrick, J.M.; Chan, H.Y.; Gray-Board, G.L.; Chai, Y.; Paulson, H.L.; Bonini, N.M. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat. Genet., 1999, 23(4), 425-428.
-
(1999)
Nat. Genet.
, vol.23
, Issue.4
, pp. 425-428
-
-
Warrick, J.M.1
Chan, H.Y.2
Gray-Board, G.L.3
Chai, Y.4
Paulson, H.L.5
Bonini, N.M.6
-
190
-
-
0036501074
-
Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy
-
Bailey, C.K.; Andriola, I.F.; Kampinga, H.H.; Merry, D.E. Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy. Hum. Mol. Genet., 2002, 11(5), 515-523.
-
(2002)
Hum. Mol. Genet.
, vol.11
, Issue.5
, pp. 515-523
-
-
Bailey, C.K.1
Andriola, I.F.2
Kampinga, H.H.3
Merry, D.E.4
-
191
-
-
27144524290
-
Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models
-
Fujimoto, M.; Takaki, E.; Hayashi, T.; Kitaura, Y.; Tanaka, Y.; Inouye, S.; Nakai, A. Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J. Biol. Chem., 2005, 280(41), 34908-34916.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.41
, pp. 34908-34916
-
-
Fujimoto, M.1
Takaki, E.2
Hayashi, T.3
Kitaura, Y.4
Tanaka, Y.5
Inouye, S.6
Nakai, A.7
-
192
-
-
0034608868
-
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
-
Muchowski, P.J.; Schaffar, G.; Sittler, A.; Wanker, E.E.; Hayer-Hartl, M.K.; Hartl, F.U. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc. Natl. Acad. Sci. USA, 2000, 97(14), 7841-7846.
-
(2000)
Proc. Natl. Acad. Sci. USA,
, vol.97
, Issue.14
, pp. 7841-7846
-
-
Muchowski, P.J.1
Schaffar, G.2
Sittler, A.3
Wanker, E.E.4
Hayer-Hartl, M.K.5
Hartl, F.U.6
-
193
-
-
16544383250
-
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer
-
Wacker, J.L.; Zareie, M.H.; Fong, H.; Sarikaya, M.; Muchowski, P.J. Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat. Struct. Mol. Biol., 2004, 11(12), 1215-1222.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, Issue.12
, pp. 1215-1222
-
-
Wacker, J.L.1
Zareie, M.H.2
Fong, H.3
Sarikaya, M.4
Muchowski, P.J.5
-
194
-
-
0034646426
-
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
-
Wyttenbach, A.; Carmichael, J.; Swartz, J.; Furlong, R.A.; Narain, Y.; Rankin, J.; Rubinsztein, D.C. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. Proc. Natl. Acad. Sci. USA, 2000, 97(6), 2898-2903.
-
(2000)
Proc. Natl. Acad. Sci. USA,
, vol.97
, Issue.6
, pp. 2898-2903
-
-
Wyttenbach, A.1
Carmichael, J.2
Swartz, J.3
Furlong, R.A.4
Narain, Y.5
Rankin, J.6
Rubinsztein, D.C.7
-
195
-
-
8844252438
-
Molecular classification of scrapie strains in mice using gene expression profiling
-
Booth, S.; Bowman, C.; Baumgartner, R.; Dolenko, B.; Sorensen, G.; Robertson, C.; Coulthart, M.; Phillipson, C.; Somorjai, R. Molecular classification of scrapie strains in mice using gene expression profiling. Biochem. Biophys. Res. Commun., 2004, 325(4), 1339-1345.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.325
, Issue.4
, pp. 1339-1345
-
-
Booth, S.1
Bowman, C.2
Baumgartner, R.3
Dolenko, B.4
Sorensen, G.5
Robertson, C.6
Coulthart, M.7
Phillipson, C.8
Somorjai, R.9
-
196
-
-
0027291414
-
Increased expression of heat shock protein, transferrin, and beta 2-microglobulin in astrocytes during scrapie
-
Diedrich, J.F.; Carp, R.I.; Haase, A.T. Increased expression of heat shock protein, transferrin, and beta 2-microglobulin in astrocytes during scrapie. Microb. Pathog., 1993, 15(1), 1-6.
-
(1993)
Microb. Pathog.
, vol.15
, Issue.1
, pp. 1-6
-
-
Diedrich, J.F.1
Carp, R.I.2
Haase, A.T.3
-
197
-
-
0028288494
-
Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain
-
Kenward, N.; Hope, J.; Landon, M.; Mayer, R.J. Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain. J. Neurochem., 1994, 62(5), 1870-1877.
-
(1994)
J. Neurochem.
, vol.62
, Issue.5
, pp. 1870-1877
-
-
Kenward, N.1
Hope, J.2
Landon, M.3
Mayer, R.J.4
-
198
-
-
34047128649
-
Molecular analysis of bovine spongiform encephalopathy infection by cDNA arrays
-
Sawiris, G.P.; Becker, K.G.; Elliott, E.J.; Moulden, R.; Rohwer, R.G. Molecular analysis of bovine spongiform encephalopathy infection by cDNA arrays. J. Gen. Virol., 2007, 88(Pt 4), 1356-1362.
-
(2007)
J. Gen. Virol.
, vol.88
, Issue.PART 4
, pp. 1356-1362
-
-
Sawiris, G.P.1
Becker, K.G.2
Elliott, E.J.3
Moulden, R.4
Rohwer, R.G.5
-
199
-
-
0032428513
-
Abnormalities in stress proteins in prion diseases
-
Tatzelt, J.; Voellmy, R.; Welch, W.J. Abnormalities in stress proteins in prion diseases. Cell Mol. Neurobiol., 1998, 18(6), 721-729.
-
(1998)
Cell Mol. Neurobiol.
, vol.18
, Issue.6
, pp. 721-729
-
-
Tatzelt, J.1
Voellmy, R.2
Welch, W.J.3
-
200
-
-
80051999994
-
Changes in HSP gene and protein expression in natural scrapie with brain damage
-
Serrano, C.; Bolea, R.; Lyahyai, J.; Filali, H.; Varona, L.; Marcos-Carcavilla, A.; Acin, C.; Calvo, J.H.; Serrano, M.; Badiola, J.J.; Zaragoza, P.; Martin-Burriel, I. Changes in HSP gene and protein expression in natural scrapie with brain damage. Vet. Res., 2011, 42(1), 13.
-
(2011)
Vet. Res.
, vol.42
, Issue.1
, pp. 13
-
-
Serrano, C.1
Bolea, R.2
Lyahyai, J.3
Filali, H.4
Varona, L.5
Marcos-Carcavilla, A.6
Acin, C.7
Calvo, J.H.8
Serrano, M.9
Badiola, J.J.10
Zaragoza, P.11
Martin-Burriel, I.12
-
201
-
-
82455210670
-
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
-
Neef, D.W.; Jaeger, A.M.; Thiele, D.J. Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat. Rev. Drug Discov., 2011, 10(12), 930-944.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, Issue.12
, pp. 930-944
-
-
Neef, D.W.1
Jaeger, A.M.2
Thiele, D.J.3
-
202
-
-
80052404375
-
Stem cell therapy extends incubation and survival time in prion-infected mice in a time window-dependant manner
-
Relano-Gines, A.; Lehmann, S.; Bencsik, A.; Herva, M.E.; Torres, J.M.; Crozet, C.A. Stem cell therapy extends incubation and survival time in prion-infected mice in a time window-dependant manner. J. Infect. Dis., 2011, 204(7), 1038-1045.
-
(2011)
J. Infect. Dis.
, vol.204
, Issue.7
, pp. 1038-1045
-
-
Relano-Gines, A.1
Lehmann, S.2
Bencsik, A.3
Herva, M.E.4
Torres, J.M.5
Crozet, C.A.6
-
203
-
-
79960085864
-
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders
-
Torres, M.; Encina, G.; Soto, C.; Hetz, C. Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders. Commun. Integr. Biol., 2011, 4(3), 258-261.
-
(2011)
Commun. Integr. Biol.
, vol.4
, Issue.3
, pp. 258-261
-
-
Torres, M.1
Encina, G.2
Soto, C.3
Hetz, C.4
-
204
-
-
78449257695
-
Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival
-
Mukherjee, A.; Morales-Scheihing, D.; Gonzalez-Romero, D.; Green, K.; Taglialatela, G.; Soto, C. Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival. PLoS Pathog., 2010, 6(10), e1001138.
-
(2010)
PLoS Pathog.
, vol.6
, Issue.10
-
-
Mukherjee, A.1
Morales-Scheihing, D.2
Gonzalez-Romero, D.3
Green, K.4
Taglialatela, G.5
Soto, C.6
-
205
-
-
10744219944
-
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
-
Otto, M.; Cepek, L.; Ratzka, P.; Doehlinger, S.; Boekhoff, I.; Wiltfang, J.; Irle, E.; Pergande, G.; Ellers-Lenz, B.; Windl, O.; Kretzschmar, H.A.; Poser, S.; Prange, H. Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. Neurology, 2004, 62(5), 714-718.
-
(2004)
Neurology,
, vol.62
, Issue.5
, pp. 714-718
-
-
Otto, M.1
Cepek, L.2
Ratzka, P.3
Doehlinger, S.4
Boekhoff, I.5
Wiltfang, J.6
Irle, E.7
Pergande, G.8
Ellers-Lenz, B.9
Windl, O.10
Kretzschmar, H.A.11
Poser, S.12
Prange, H.13
-
206
-
-
1842371505
-
Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: Prevention of amyloid-induced glutathione depletion
-
Muller, W.E.; Romero, F.J.; Perovic, S.; Pergande, G.; Pialoglou, P. Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion. J. Neurochem., 1997, 68(6), 2371-2377.
-
(1997)
J. Neurochem.
, vol.68
, Issue.6
, pp. 2371-2377
-
-
Muller, W.E.1
Romero, F.J.2
Perovic, S.3
Pergande, G.4
Pialoglou, P.5
-
207
-
-
0031257755
-
Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126)
-
Perovic, S.; Schroder, H.C.; Pergande, G.; Ushijima, H.; Muller, W.E. Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126). Exp. Neurol., 1997, 147(2), 518-524.
-
(1997)
Exp. Neurol.
, vol.147
, Issue.2
, pp. 518-524
-
-
Perovic, S.1
Schroder, H.C.2
Pergande, G.3
Ushijima, H.4
Muller, W.E.5
-
208
-
-
34848832040
-
Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
-
Dirikoc, S.; Priola, S.A.; Marella, M.; Zsurger, N.; Chabry, J. Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. J. Neurosci., 2007, 27(36), 9537-9544.
-
(2007)
J. Neurosci.
, vol.27
, Issue.36
, pp. 9537-9544
-
-
Dirikoc, S.1
Priola, S.A.2
Marella, M.3
Zsurger, N.4
Chabry, J.5
-
209
-
-
30944453898
-
Neurodegeneration and oxidative stress: Prion disease results from loss of antioxidant defence
-
Brown, D.R. Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence. Folia Neuropathol., 2005, 43(4), 229-243.
-
(2005)
Folia Neuropathol.
, vol.43
, Issue.4
, pp. 229-243
-
-
Brown, D.R.1
-
210
-
-
72649090409
-
Structure-activity relationship of tocopherol derivatives suggesting a novel nonantioxidant mechanism in antiprion potency
-
Muyrers, J.; Klingenstein, R.; Stitz, L.; Korth, C. Structure-activity relationship of tocopherol derivatives suggesting a novel nonantioxidant mechanism in antiprion potency. Neurosci. Lett., 2010, 469(1), 122-126.
-
(2010)
Neurosci. Lett.
, vol.469
, Issue.1
, pp. 122-126
-
-
Muyrers, J.1
Klingenstein, R.2
Stitz, L.3
Korth, C.4
-
211
-
-
10944262733
-
Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations
-
Crozet, C.; Lin, Y.L.; Mettling, C.; Mourton-Gilles, C.; Corbeau, P.; Lehmann, S.; Perrier, V. Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations. J. Cell. Sci., 2004, 117, 5591-5597.
-
(2004)
J. Cell. Sci.
, vol.117
, pp. 5591-5597
-
-
Crozet, C.1
Lin, Y.L.2
Mettling, C.3
Mourton-Gilles, C.4
Corbeau, P.5
Lehmann, S.6
Perrier, V.7
-
212
-
-
58149481475
-
Quinpramine is a novel compound effective in ameliorating brain autoimmune disease
-
Singh, M.P.; Meyer zu Horste, G.; Hu, W.; Mausberg, A.K.; Cravens, P.D.; Eagar, T.; Lober, S.; Klingenstein, R.; Gmeiner, P.; Korth, C.; Kieseier, B.C.; Stuve, O. Quinpramine is a novel compound effective in ameliorating brain autoimmune disease. Exp. Neurol., 2009, 215(2), 397-400.
-
(2009)
Exp. Neurol.
, vol.215
, Issue.2
, pp. 397-400
-
-
Singh, M.P.1
Meyer zu Horste, G.2
Hu, W.3
Mausberg, A.K.4
Cravens, P.D.5
Eagar, T.6
Lober, S.7
Klingenstein, R.8
Gmeiner, P.9
Korth, C.10
Kieseier, B.C.11
Stuve, O.12
-
213
-
-
79959193075
-
Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules
-
Meyer zu Horste, G.; Mausberg, A.K.; Muller, J.I.; Lehmann, H.C.; Lober, S.; Gmeiner, P.; Hartung, H.P.; Stuve, O.; Korth, C.; Kieseier, B.C. Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. PLoS One, 2011, 6(6), e21223.
-
(2011)
PLoS One,
, vol.6
, Issue.6
-
-
Meyer zu Horste, G.1
Mausberg, A.K.2
Muller, J.I.3
Lehmann, H.C.4
Lober, S.5
Gmeiner, P.6
Hartung, H.P.7
Stuve, O.8
Korth, C.9
Kieseier, B.C.10
-
214
-
-
0035796463
-
Scrapie strains maintain biological phenotypes on propagation in a cell line in culture
-
Birkett, C.R.; Hennion, R.M.; Bembridge, D.A.; Clarke, M.C.; Chree, A.; Bruce, M.E.; Bostock, C.J. Scrapie strains maintain biological phenotypes on propagation in a cell line in culture. EMBO J., 2001, 20(13), 3351-3358.
-
(2001)
EMBO J.
, vol.20
, Issue.13
, pp. 3351-3358
-
-
Birkett, C.R.1
Hennion, R.M.2
Bembridge, D.A.3
Clarke, M.C.4
Chree, A.5
Bruce, M.E.6
Bostock, C.J.7
-
215
-
-
0022450560
-
Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions
-
Kimberlin, R.H.; Walker, C.A. Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob. Agents Chemother., 1986, 30, 409-413.
-
(1986)
Antimicrob. Agents Chemother.
, vol.30
, pp. 409-413
-
-
Kimberlin, R.H.1
Walker, C.A.2
-
216
-
-
0042854755
-
A novel generation of heparan sulfate mimetics for the treatment of prion diseases
-
Adjou, K.T.; Simoneau, S.; Sales, N.; Lamoury, F.; Dormont, D.; Papy-Garcia, D.; Barritault, D.; Deslys, J.P.; Lasmezas, C.I. A novel generation of heparan sulfate mimetics for the treatment of prion diseases. J. Gen. Virol., 2003, 84, 2595-2603.
-
(2003)
J. Gen. Virol.
, vol.84
, pp. 2595-2603
-
-
Adjou, K.T.1
Simoneau, S.2
Sales, N.3
Lamoury, F.4
Dormont, D.5
Papy-Garcia, D.6
Barritault, D.7
Deslys, J.P.8
Lasmezas, C.I.9
-
217
-
-
0344845037
-
Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis
-
Schonberger, O.; Horonchik, L.; Gabizon, R.; Papy-Garcia, D.; Barritault, D.; Taraboulos, A. Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis. Biochem. Biophys. Res. Commun., 2003, 312(2), 473-479.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, Issue.2
, pp. 473-479
-
-
Schonberger, O.1
Horonchik, L.2
Gabizon, R.3
Papy-Garcia, D.4
Barritault, D.5
Taraboulos, A.6
-
218
-
-
34250174184
-
Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection
-
Doh-ura, K.; Kuge, T.; Uomoto, M.; Nishizawa, K.; Kawasaki, Y.; Iha, M. Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection. Antimicrob. Agents Chemother., 2007, 51(6), 2274-2277.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, Issue.6
, pp. 2274-2277
-
-
Doh-ura, K.1
Kuge, T.2
Uomoto, M.3
Nishizawa, K.4
Kawasaki, Y.5
Iha, M.6
-
219
-
-
0021046367
-
The antiviral compound HPA-23 can prevent scrapie when administered at the time of infection
-
Kimberlin, R.H.; Walker, C.A. The antiviral compound HPA-23 can prevent scrapie when administered at the time of infection. Arch. Virol., 1983, 78, 9-18.
-
(1983)
Arch. Virol.
, vol.78
, pp. 9-18
-
-
Kimberlin, R.H.1
Walker, C.A.2
-
220
-
-
0036902277
-
Prion-protein-specific aptamer reduces PrPSc formation
-
Proske, D.; Gilch, S.; Wopfner, F.; Schatzl, H.M.; Winnacker, E.L.; Famulok, M. Prion-protein-specific aptamer reduces PrPSc formation. Chembiochem., 2002, 3(8), 717-725.
-
(2002)
Chembiochem.
, vol.3
, Issue.8
, pp. 717-725
-
-
Proske, D.1
Gilch, S.2
Wopfner, F.3
Schatzl, H.M.4
Winnacker, E.L.5
Famulok, M.6
-
221
-
-
0141891211
-
Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion
-
Rhie, A.; Kirby, L.; Sayer, N.; Wellesley, R.; Disterer, P.; Sylvester, I.; Gill, A.; Hope, J.; James, W.; Tahiri-Alaoui, A. Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. J. Biol. Chem., 2003, 278(41), 39697-39705.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.41
, pp. 39697-39705
-
-
Rhie, A.1
Kirby, L.2
Sayer, N.3
Wellesley, R.4
Disterer, P.5
Sylvester, I.6
Gill, A.7
Hope, J.8
James, W.9
Tahiri-Alaoui, A.10
-
222
-
-
34547125777
-
Copaxone interferes with the PrP Sc-GAG interaction
-
Engelstein, R.; Ovadia, H.; Gabizon, R. Copaxone interferes with the PrP Sc-GAG interaction. Eur. J. Neurol., 2007, 14(8), 877-884.
-
(2007)
Eur. J. Neurol.
, vol.14
, Issue.8
, pp. 877-884
-
-
Engelstein, R.1
Ovadia, H.2
Gabizon, R.3
-
223
-
-
19944375077
-
Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects
-
Haik, S.; Brandel, J.P.; Salomon, D.; Sazdovitch, V.; asnerie-Laupretre, N.; Laplanche, J.L.; Faucheux, B.A.; Soubrie, C.; Boher, E.; Belorgey, C.; Hauw, J.J.; Alperovitch, A. Compassionate use of quinacrine in Creutzfeldt-Jakob disease fails to show significant effects. Neurology, 2004, 63(12), 2413-2415.
-
(2004)
Neurology,
, vol.63
, Issue.12
, pp. 2413-2415
-
-
Haik, S.1
Brandel, J.P.2
Salomon, D.3
Sazdovitch, V.4
snerie-Laupretre, N.5
Laplanche, J.L.6
Faucheux, B.A.7
Soubrie, C.8
Boher, E.9
Belorgey, C.10
Hauw, J.J.11
Alperovitch, A.12
-
224
-
-
0034097242
-
Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures
-
Mange, A.; Nishida, N.; Milhavet, O.; McMahon, H.E.; Casanova, D.; Lehmann, S. Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures. J. Virol., 2000, 74(7), 3135-3140.
-
(2000)
J. Virol.
, vol.74
, Issue.7
, pp. 3135-3140
-
-
Mange, A.1
Nishida, N.2
Milhavet, O.3
McMahon, H.E.4
Casanova, D.5
Lehmann, S.6
-
225
-
-
0023243085
-
Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters
-
Pocchiari, M.; Schmittinger, S.; Masullo, C. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J. Gen. Virol., 1987, 68, 219-223.
-
(1987)
J. Gen. Virol.
, vol.68
, pp. 219-223
-
-
Pocchiari, M.1
Schmittinger, S.2
Masullo, C.3
-
226
-
-
0026600866
-
Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation
-
Xi, Y.G.; Ingrosso, L.; Ladogana, A.; Masullo, C.; Pocchiari, M. Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Nature, 1992, 356(6370), 598-601.
-
(1992)
Nature,
, vol.356
, Issue.6370
, pp. 598-601
-
-
Xi, Y.G.1
Ingrosso, L.2
Ladogana, A.3
Masullo, C.4
Pocchiari, M.5
-
227
-
-
0027996860
-
Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection
-
McKenzie, D.; Kaczkowski, J.; Marsh, R.; Aiken, J.M. Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection. J. Virol., 1994, 68, 7534-7536.
-
(1994)
J. Virol.
, vol.68
, pp. 7534-7536
-
-
McKenzie, D.1
Kaczkowski, J.2
Marsh, R.3
Aiken, J.M.4
-
228
-
-
0028783577
-
MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie
-
Adjou, K.T.; Demaimay, R.; Lasmezas, C.; Deslys, J.-.; Seman, M.; Dormont, D. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrob. Agents Chemother., 1995, 39, 2810-2812.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2810-2812
-
-
Adjou, K.T.1
Demaimay, R.2
Lasmezas, C.3
Deslys, J.-.4
Seman, M.5
Dormont, D.6
-
229
-
-
0032934347
-
MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie
-
Adjou, K.T.; Demaimay, R.; Deslys, J.P.; Lasmezas, C.I.; Beringue, V.; Demart, S.; Lamoury, F.; Seman, M.; Dormont, D. MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie. J. Gen. Virol., 1999, 80(Pt 4), 1079-1085.
-
(1999)
J. Gen. Virol.
, vol.80
, Issue.PART 4
, pp. 1079-1085
-
-
Adjou, K.T.1
Demaimay, R.2
Deslys, J.P.3
Lasmezas, C.I.4
Beringue, V.5
Demart, S.6
Lamoury, F.7
Seman, M.8
Dormont, D.9
-
230
-
-
0034054377
-
MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters
-
Adjou, K.T.; Privat, N.; Demart, S.; Deslys, J.P.; Seman, M.; Hauw, J.J.; Dormont, D. MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters. J. Comp. Pathol., 2000, 122(1), 3-8.
-
(2000)
J. Comp. Pathol.
, vol.122
, Issue.1
, pp. 3-8
-
-
Adjou, K.T.1
Privat, N.2
Demart, S.3
Deslys, J.P.4
Seman, M.5
Hauw, J.J.6
Dormont, D.7
-
231
-
-
0034705438
-
Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation
-
Qin, K.; Yang, D.S.; Yang, Y.; Chishti, M.A.; Meng, L.J.; Kretzschmar, H.A.; Yip, C.M.; Fraser, P.E.; Westaway, D. Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation. J. Biol. Chem., 2000, 275(25), 19121-19131.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.25
, pp. 19121-19131
-
-
Qin, K.1
Yang, D.S.2
Yang, Y.3
Chishti, M.A.4
Meng, L.J.5
Kretzschmar, H.A.6
Yip, C.M.7
Fraser, P.E.8
Westaway, D.9
-
232
-
-
3142727624
-
Conformational variation between allelic variants of cell-surface ovine prion protein
-
Thackray, A.M.; Yang, S.; Wong, E.; Fitzmaurice, T.J.; Morgan-Warren, R.J.; Bujdoso, R. Conformational variation between allelic variants of cell-surface ovine prion protein. Biochem. J., 2004, 381, 221-229.
-
(2004)
Biochem. J.
, vol.381
, pp. 221-229
-
-
Thackray, A.M.1
Yang, S.2
Wong, E.3
Fitzmaurice, T.J.4
Morgan-Warren, R.J.5
Bujdoso, R.6
-
233
-
-
3142774200
-
Effect of metal ions on de novo aggregation of full-length prion protein
-
Giese, A.; Levin, J.; Bertsch, U.; Kretzschmar, H. Effect of metal ions on de novo aggregation of full-length prion protein. Biochem. Biophys. Res. Commun., 2004, 320(4), 1240-1246.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.320
, Issue.4
, pp. 1240-1246
-
-
Giese, A.1
Levin, J.2
Bertsch, U.3
Kretzschmar, H.4
-
234
-
-
4544335297
-
Cellular prion protein acquires resistance to proteolytic degradation following copper ion binding
-
Kuczius, T.; Buschmann, A.; Zhang, W.; Karch, H.; Becker, K.; Peters, G.; Groschup, M.H. Cellular prion protein acquires resistance to proteolytic degradation following copper ion binding. Biol. Chem., 2004, 385(8), 739-747.
-
(2004)
Biol. Chem.
, vol.385
, Issue.8
, pp. 739-747
-
-
Kuczius, T.1
Buschmann, A.2
Zhang, W.3
Karch, H.4
Becker, K.5
Peters, G.6
Groschup, M.H.7
-
235
-
-
18144362825
-
Effect of transition metals (Mn, Cu, Fe) and deoxycholic acid (DA) on the conversion of PrPC to PrPres
-
Kim, N.H.; Choi, J.K.; Jeong, B.H.; Kim, J.I.; Kwon, M.S.; Carp, R.I.; Kim, Y.S. Effect of transition metals (Mn, Cu, Fe) and deoxycholic acid (DA) on the conversion of PrPC to PrPres. FASEB J., 2005, 19(7), 783-785.
-
(2005)
FASEB J.
, vol.19
, Issue.7
, pp. 783-785
-
-
Kim, N.H.1
Choi, J.K.2
Jeong, B.H.3
Kim, J.I.4
Kwon, M.S.5
Carp, R.I.6
Kim, Y.S.7
-
236
-
-
18344391235
-
Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils
-
Bocharova, O.V.; Breydo, L.; Salnikov, V.V.; Baskakov, I.V. Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils. Biochemistry (N. Y.), 2005, 44(18), 6776-6787.
-
(2005)
Biochemistry (N. Y.),
, vol.44
, Issue.18
, pp. 6776-6787
-
-
Bocharova, O.V.1
Breydo, L.2
Salnikov, V.V.3
Baskakov, I.V.4
-
237
-
-
33645107632
-
Copper (II) ions potently inhibit purified PrPres amplification
-
Orem, N.R.; Geoghegan, J.C.; Deleault, N.R.; Kascsak, R.; Supattapone, S. Copper (II) ions potently inhibit purified PrPres amplification. J. Neurochem., 2006, 96(5), 1409-1415.
-
(2006)
J. Neurochem.
, vol.96
, Issue.5
, pp. 1409-1415
-
-
Orem, N.R.1
Geoghegan, J.C.2
Deleault, N.R.3
Kascsak, R.4
Supattapone, S.5
-
238
-
-
33744766845
-
Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells
-
Treiber, C.; Simons, A.; Multhaup, G. Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells. Biochemistry (N. Y.), 2006, 45(21), 6674-6680.
-
(2006)
Biochemistry (N. Y.),
, vol.45
, Issue.21
, pp. 6674-6680
-
-
Treiber, C.1
Simons, A.2
Multhaup, G.3
-
239
-
-
67649795561
-
Recent advances in prion chemotherapeutics
-
Sim, V.L.; Caughey, B. Recent advances in prion chemotherapeutics. Infect. Disord. Drug Targets, 2009, 9(1), 81-91.
-
(2009)
Infect. Disord. Drug Targets,
, vol.9
, Issue.1
, pp. 81-91
-
-
Sim, V.L.1
Caughey, B.2
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