Characterization of 2′-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 39697-39705

  Rhie, Alexandre ^a,b   Kirby, Louise ^b   Sayer, Natalie ^a   Wellesley, Rosanna ^a   Disterer, Petra ^a   Sylvester, Ian ^b   Gill, Andrew ^b   Hope, James ^b,c   James, William ^a   Tahiri Alaoui, Abdessamad ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^c VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; OLIGOMERS; RNA;

PRION PROTEINS;

PROTEINS;

2' FLUORO RNA; APTAMER; OLIGOMER; PRION PROTEIN; PROTEIN; SCRAPIE ASSOCIATED FIBRIL 93; UNCLASSIFIED DRUG; LIGAND; OLIGORIBONUCLEOTIDE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; IN VITRO STUDY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; CATTLE; CHEMISTRY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PRION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY;

ANIMALIA; BOVINAE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CATTLE; LIGANDS; OLIGORIBONUCLEOTIDES; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0141891211     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305297200     Document Type: Article

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