New inhibitors of scrapie-associated prion protein formation in a library of 2,000 drugs and natural products

Journal of Virology

Volumn 77, Issue 19, 2003, Pages 10288-10294

  Kocisko, David A ^a   Baron, Gerald S ^a   Rubenstein, Richard ^b   Chen, Jiancao ^c   Kuizon, Salomon ^b   Caughey, Byron ^a,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^c Hydraulic Science Research Institute of Sichuan Province   (China)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',2''' BISEPIGALLOCATECHIN DIGALLATE; 2,3,5,7,3,4, PENTAHYDROXYFLAVAN; AMODIAQUINE; ANTIHISTAMINIC AGENT; ANTIMALARIAL AGENT; ASTEMIZOLE; BEBEERINE; BUDESONIDE; CHRYSANTHELLIN A; CLOMIFENE; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GALLIC ACID; KATACINE; MEPACRINE; MEVINOLIN; PHENOTHIAZINE DERIVATIVE; POLYPHENOL DERIVATIVE; PRION PROTEIN; PROCHLORPERAZINE; STATIN; TANNIN; TERFENADINE; TETRANDRINE; THIORIDAZINE; TIOTIXENE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; IC 50; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SCRAPIE AGENT; SCREENING TEST; STRAIN DIFFERENCE; VIRUS STRAIN;

ANIMALS; ANTIMALARIALS; BIOLOGICAL PRODUCTS; FLAVONOIDS; HISTAMINE ANTAGONISTS; HUMANS; PHENOLS; POLYMERS; PRPSC PROTEINS;

EID: 0141632823     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.19.10288-10294.2003     Document Type: Article

References (33)

1. Beranger, F., A. Mange, J. Solassol, and S. Lehmann. 2001. Cell culture models of transmissible spongiform encephalopathies. Biochem. Biophys. Res. Commun. 289:311-316.
2. Birkett, C. R., R. M. Hennion, D. A. Bembridge, M. C. Clarke, A. Chree, M. E. Bruce, and C. J. Bostock. 2001. Scrapie strains maintain biological phenotypes on propagation in a cell line in culture. EMBO J. 20:3351-3358.
3. Caughey, B., and B. Chesebro. 2001. Transmissible spongiform encephalopathies and prion protein interconversions. Adv. Virus Res. 56:277-311.
4. Caughey, B., and G. J. Raymond. 1993. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J. Virol. 67:643-650.
5. Caughey, B., G. J. Raymond, D. Ernst, and R. E. Race. 1991. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J. Virol. 65:6597-6603.
6. Caughey, B., L. D. Raymond, G. J. Raymond, L. Maxson, J. Silveira, and G. S. Baron. 2003. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J. Virol. 77:5499-5502.
7. Caughey, W. S., L. D. Raymond, M. Horiuchi, and B. Caughey. 1998. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proc. Natl. Acad. Sci. USA 95:12117-12122.
8. Chesebro, B. 1999. Prion protein and the transmissible spongiform encephalopathy diseases. Neuron 24:503-506.
9. Demaimay, R., B. Chesebro, and B. Caughey. 2000. Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs. Arch. Virol. Suppl. 16:277-283.
10. Demaimay, R., R. Race, and B. Chesebro. 1999. Effectiveness of polyene antibiotics in treatment of transmissible spongiform encephalopathy in transgenic mice expressing Syrian hamster PrP only in neurons. J. Virol. 73:3511-3513.
11. Doh-Ura, K., T. Iwaki, and B. Caughey. 2000. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J. Virol. 74:4894-4897.
12. Forloni, G., S. Iussich, T. Awan, L. Colombo, N. Angeretti, L. Girola, I. Bertani, G. Poli, M. Caramelli, M. Grazia Bruzzone, L. Farina, L. Limido, G. Rossi, G. Giaccone, J. W. Ironside, O. Bugiani, M. Salmona, and F. Tagliavini. 2002. Tetracyclines affect prion infectivity. Proc. Natl. Acad. Sci. USA 99:10849-10854.
13. Furukawa, H., M. Takahashi, M. Nakajima, and T. Yamada. 2002. Prospects of the therapeutic approaches to Creutzfeldt-Jakob disease: a clinical trial of the antimalarial, quinacrine. Nippon Rinsho 60:1649-1657.
14. Heppner, F. L., C. Musahl, I. Arrighi, M. A. Klein, T. Rulicke, B. Oesch, R. M. Zinkernagel, U. Kalinke, and A. Aguzzi. 2001. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294:178-182.
15. Ingrosso, L., A. Ladogana, and M. Pocchiari. 1995. Congo red prolongs the incubation period in scrapie-infected hamsters. J. Virol. 69:506-508.
16. Korth, C., K. Kaneko, and S. B. Prusiner. 2000. Expression of unglycosylated mutated prion protein facilitates PrP(Sc) formation in neuroblastoma cells infected with different prion strains. J. Gen. Virol. 81:2555-2563.
17. Korth, C., B. C. May, F. E. Cohen, and S. B. Prusiner. 2001. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc. Natl. Acad. Sci. USA 98:9836-9841.
18. Mange, A., N. Nishida, O. Milhavet, H. E. McMahon, D. Casanova, and S. Lehmann. 2000. Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures. J. Virol. 74:3135-3140.
19. a. Maxson, L., C. Wong, L. M. Herrmann, B. Caughey, and G. S. Baron. A solid-phase assay for identification of modulators of prion protein interactions. Anal. Biochem., in press.
20. May, B. C., A. T. Fafarman, S. B. Hong, M. Rogers, L. W. Deady, S. B. Prusiner, and F. E. Cohen. 2003. Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc. Natl. Acad. Sci. USA 100:3416-3421.
21. Nishida, N., D. A. Harris, D. Vilette, H. Laude, Y. Frobert, J. Grassi, D. Casanova, O. Milhavet, and S. Lehmann. 2000. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J. Virol. 74:320-325.
22. Priola, S. A., and B. Chesebro. 1995. A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. J. Virol. 69:7754-7758.
23. Priola, S. A., A. Raines, and W. S. Caughey. 2000. Porphyrin and phthalocyanine antiscrapie compounds. Science 287:1503-1506.
24. Prusiner, S. B. 1998. Prions. Proc. Natl. Acad. Sci. USA 95:13363-13383.
25. Rudyk, H., S. Vasiljevic, R. M. Hennion, C. R. Birkett, J. Hope, and I. H. Gilbert. 2000. Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells. J. Gen. Virol. 81:1155-1164.
26. Scott, M. R., R. Kohler, D. Foster, and S. B. Prusiner. 1992. Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci. 1:986-997.
27. 3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 19:1771-1776.
28. Supattapone, S., H. Wille, L. Uyechi, J. Safar, P. Tremblay, F. C. Szoka, F. E. Cohen, S. B. Prusiner, and M. R. Scott. 2001. Branched polyamines cure prion-infected neuroblastoma cells. J. Virol. 75:3453-3461.
29. Taraboulos, A., M. Scott, A. Semenov, D. Avrahami, L. Laszlo, S. B. Prusiner, and D. Avrahami. 1995. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell Biol. 129:121-132.
30. Tremblay, P., Z. Meiner, M. Galou, C. Heinrich, C. Petromilli, T. Lisse, J. Cayetano, M. Torchia, W. Mobley, H. Bujard, S. J. DeArmond, and S. B. Prusiner. 1998. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc. Natl. Acad. Sci. USA 95:12580-12585.
31. Vorberg, I., K. Chan, and S. A. Priola. 2001. Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform. J. Virol. 75:10024-10032.
32. Winklhofer, K. F., F. U. Hartl, and J. Tatzelt. 2001. A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds. FEBS Lett. 503:41-45.
33. Yang, C. S., S. Prabhu, and J. Landau. 2001. Prevention of carcinogenesis by tea polyphenols. Drug Metab. Rev. 33:237-253.