Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays

PLoS Pathogens

Volumn 6, Issue 12, 2010, Pages

  Wilham, Jason M ^a   Orrú, Christina D ^a,b   Bessen, Richard A ^c   Atarashi, Ryuichiro ^d   Sano, Kazunori ^d   Race, Brent ^a   Meade White, Kimberly D ^a   Taubner, Lara M ^a   Timmes, Andrew ^a   Caughey, Byron ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c MONTANA STATE UNIVERSITY   (United States)

^d NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CEREBROSPINAL FLUID; CONTROLLED STUDY; HAMSTER; NONHUMAN; PRION; REAL TIME QUAKING INDUCED CONVERSION ASSAY; SCRAPIE; SENSITIVITY AND SPECIFICITY; VIRUS DETECTION; VIRUS DIAGNOSIS; VIRUS TITRATION; ANIMAL; BRAIN; CHEMISTRY; DEER; HIGH THROUGHPUT SCREENING; HUMAN; METHODOLOGY; MINK; PROTEIN SECONDARY STRUCTURE; SHEEP; STANDARD; TECHNIQUE;

ANIMALIA; CERVIDAE; CRICETINAE; MUSTELA; OVIS ARIES;

AMYLOID;

AMYLOID; ANIMALS; BRAIN; CEREBROSPINAL FLUID; CRICETINAE; DEER; ENDPOINT DETERMINATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHODS; MINK; PRIONS; PROTEIN STRUCTURE, SECONDARY; SHEEP;

EID: 78651249792     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001217     Document Type: Article

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