Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity

Journal of Biological Chemistry

Volumn 279, Issue 15, 2004, Pages 14983-14990

  Bate, Clive ^a   Salmona, Mario ^b   Diomede, Luisa ^b   Williams, Alun ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; DEPOSITION; DISEASES; ENZYME INHIBITION; LIPIDS; NEUROLOGY;

NANOMOLAR CONCENTRATION; NEURODEGENERATION; PRION DISEASES; SIGNALING PATHWAYS;

BIOCHEMISTRY;

PRION PROTEIN; PROSTAGLANDIN E2; SQUALENE SYNTHASE INHIBITOR; SQUALESTATIN; TRITON X 100;

ANIMAL CELL; ARTICLE; BETA SHEET; CELL DEATH; CELL KILLING; CELL PROTECTION; CHOLESTEROL TRANSPORT; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVE INJURY; NEUROTOXICITY; NONHUMAN; PEPTIDE ANALYSIS; PRION DISEASE; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CHOLESTEROL; DETERGENTS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; MEMBRANE MICRODOMAINS; MEVALONIC ACID; MICE; MICROGLIA; MODELS, BIOLOGICAL; NEUROBLASTOMA; NEURONS; OCTOXYNOL; PEPTIDES; PRIONS; PRPC PROTEINS; PRPSC PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRICARBOXYLIC ACIDS;

ANIMALIA;

EID: 2442483932     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313061200     Document Type: Article

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