Inhibition of cholesterol recycling impairs cellular PrPSc propagation

Cellular and Molecular Life Sciences

Volumn 66, Issue 24, 2009, Pages 3979-3991

  Gilch, Sabine ^a   Bach, Christian ^a   Lutzny, Gloria ^a   Vorberg, Ina ^a   Schätzl, Hermann M ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cholesterol; NPC 1; Prion; PrP; Rab 9; Recycling

Indexed keywords

CELL PROTEIN; CHOLESTEROL; PRION PROTEIN; PROTEIN; RAB PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CELL CULTURE; CELL MIGRATION; CHOLESTEROL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOSOME; ENZYME INHIBITION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; LIPID RAFT; MOUSE; NONHUMAN; PRION; PROTEIN DEGRADATION; PROTEIN METABOLISM; TRANSPORT VESICLE;

ANDROSTENES; ANIMALS; ANTICHOLESTEREMIC AGENTS; BRAIN; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; ENDOSOMES; GREEN FLUORESCENT PROTEINS; IMMUNOBLOTTING; MEMBRANE MICRODOMAINS; MICE; MICROSCOPY, CONFOCAL; PRION DISEASES; PROTEIN TRANSPORT; PROTEINS; PRPSC PROTEINS; RAB GTP-BINDING PROTEINS; RNA INTERFERENCE; TRANS-GOLGI NETWORK; TRANSFECTION;

EID: 70849121219     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0158-4     Document Type: Article

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