Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs

Archives of Virology, Supplement

Volumn , Issue 16, 2001, Pages 277-283

  Demaimay, R ^a,b   Chesebro, B ^a   Caughey, B ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 28444498432     PISSN: 09391983     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Caughey B, Chesebro B (1997) Prion protein and the transmissible spongiform encephalopathies. Trends Cell Biol 7: 56-62
2. Caughey B, Race RE (1992) Potent inhibition of scrapie-associated PrP accumulation by Congo red. J Neurochem 59: 768-771
3. Caughey B, Raymond GJ (1993) Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J Virol 67: 643-650
4. Caughey WS, Raymond LD, Horiuchi M, Caughey B (1998) Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proc Natl Acad Sci USA 95: 12117-12122
5. Chesebro B (1999) Prion protein and the transmissible spongiform encephalopathy diseases. Neuron 24: 503-506
6. Demaimay R, Adjou K, Lasmezas C, Lazarini F, Cherifi K, Seman M, Deslys JP, Dormont D (1994) Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol 75: 2499-2503
7. Demaimay R, Harper J, Gordon H, Weaver D, Chesebro B, Caughey B (1998) Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation. J Neurochem 71: 2534-2541
8. Ehlers B, Diringer H (1984) Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J Gen Virol 65: 1325-1330
9. Horiuchi M, Caughey B (1999) Prion protein interconversions and the transmissible spongiform encephalopathies. Structure Fold Des 7: R231-R240
10. Ingrosso L, Ladogana A, Pocchiari M (1995) Congo red prolongs the incubation period in scrapie-infected hamsters. J Virol 69: 506-508
11. Kimberlin RH, Walker CA (1986) Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob Agents Chemother 3: 409-413
12. Kocisko DA, Come JH, Priola SA, Chesebro B, Raymond GJ, Lansbury PT, Caughey B (1994) Cell-free formation of protease-resistant prion protein. Nature 370: 471-474
13. Ladogana A, Casaccia P, Ingrosso L, Cibati M, Salvatore M, Xi YG, Masullo C, Pocchiari M (1992) Sulphate polyanions prolong the incubation period of scrapieinfected hamsters. J Gen Virol 73: 661-665
14. Pocchiari M, Schmittinger S, Masullo C (1987) Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J Gen Virol 68: 219-223
15. Priola SA, Caughey B, Caughey WS (1999) Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies. Curr Opin Microbiol 2: 563-566
16. Race RE, Fadness LH, Chesebro B (1987) Characterization of scrapie infection in mouse neuroblastoma cells. J Gen Virol 68: 1391-1399
17. Supattapone S, Nguyen HO, Cohen FE, Prusiner SB, Scott MR (1999) Elimination of prions by branched polyamines and implications for therapeutics. Proc Natl Acad Sci USA 96: 14529-14534
18. Tagliavini F, McArthur RA, Canciani B, Giaccone G, Porro M, Bugiani M, Lievens PM, Bugiani O, Peri E, Dall'Ara P, Rocchi M, Poli G, Forloni G, Bandiera T, Varasi M, Suarato A, Cassutti P, Cervini MA, Lansen J, Salmona M, Post C (1997) Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science 276: 1119-1122
19. Weissmann C (1999) Molecular genetics of transmissible spongiform encephalopathies. J Biol Chem 274: 3-6
20. Xi YG, Ingrosso L, Ladogana A, Masullo C, Pocchiari M (1992) Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Nature 356: 598-60