Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4125-4132

  Thompson, Mark J ^a   Louth, Jennifer C ^a   Ferrara, Steven ^a   Jackson, Matthew P ^a   Sorrell, Fiona J ^a   Cochrane, Edward J ^a   Gever, Joel ^b   Baxendale, Sarah ^a   Silber, B Michael ^b   Roehl, Henry H ^a   Chen, Beining ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug discovery; Indoles; Prion disease; Structure activity relationships; Zebrafish

Indexed keywords

1 BENZOYL 4 [(4,7 DIMETHOXY 1H PYRROLO[2,3 C]PYRIDIN 3 YL)OXOACETYL]PIPERAZINE; INDIBULIN; INDOLE DERIVATIVE; METHYL INDOXAM; N (3,5 DICHLORO 4 PYRIDYL) [1 (4 FLUOROBENZYL) 5 HYDROXY 3 INDOLYL]GLYOXYLIC ACID AMIDE; TALMAPIMOD; UNCLASSIFIED DRUG; VARESPLADIB;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL LINE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; PRION DISEASE; ZEBRA FISH;

ANIMALS; CELL LINE; DRUG DISCOVERY; INDOLES; MICROSOMES; PRIONS; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

EID: 80052959006     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.013     Document Type: Article

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