Intracellular re-routing of prion protein prevents propagation of PrPsc and delays onset of prion disease

EMBO Journal

Volumn 20, Issue 15, 2001, Pages 3957-3966

  Gilch, Sabine ^a   Winklhofer, Konstanze F ^b   Groschup, Martin H ^c   Nunziante, Max ^a   Lucassen, Ralf ^d   Spielhaupter, Christian ^a   Muranyi, Walter ^a   Riesner, Detlev ^d   Tatzelt, Jörg ^b   Schätzl, Hermann M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aggregation; Prion protein; Quality control; Re routing; Suramin

Indexed keywords

PRION PROTEIN; PROTEIN PRP; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HAMSTER; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

ACIDS; AMIDOHYDROLASES; ANIMALS; CELL COMPARTMENTATION; DETERGENTS; GOLGI APPARATUS; INTRACELLULAR FLUID; MICE; MICE, TRANSGENIC; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; PRION DISEASES; PRIONS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PRPSC PROTEINS; SARCOSINE; SURAMIN; TRANS-GOLGI NETWORK; TUMOR CELLS, CULTURED;

EID: 17844392850     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.15.3957     Document Type: Article

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