The inhibition of prions through blocking prion conversion by permanently charged branched polyamines of low cytotoxicity

Biomaterials

Volumn 31, Issue 8, 2010, Pages 2025-2033

  Lim, Yong beom ^a   Mays, Charles E ^b   Kim, Younghwan ^b   Titlow, William B ^b   Ryou, Chongsuk ^b  

^a Yonsei University   (South Korea)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Branched polyamines; Cytotoxicity; Prion; Prion protein conversion; Quaternization; Therapy

Indexed keywords

ACIDIC PH; ACTION MECHANISMS; ANTI-PRION AGENTS; BRANCHED POLYAMINES; IN-VITRO; INFECTED CELLS; ISOFORMS; NEUROBLASTOMA CELLS; NONTOXIC CONCENTRATIONS; POLYAMIDOAMINE DENDRIMERS; POLYAMINES; POLYETHYLENEIMINE; PRION DISEASE; PRION PROPAGATION; PRION PROTEIN; QUATERNIZATION; STRUCTURAL CONTROL;

DENDRIMERS; PROTEINS; STRUCTURAL DYNAMICS; TOXICITY;

AMINES;

DENDRIMER; POLYAMIDOAMINE; POLYAMINE; POLYETHYLENEIMINE; PRION PROTEIN;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN METABOLISM; VIRUS CELL INTERACTION; VIRUS INHIBITION;

ANIMALS; CELL LINE; DENDRIMERS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MOLECULAR STRUCTURE; NEUROBLASTOMA; POLYAMINES; POLYETHYLENEIMINE; PRION DISEASES; PRIONS;

EID: 74449085875     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.11.085     Document Type: Article

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