The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes

Journal of Infectious Diseases

Volumn 194, Issue 5, 2006, Pages 702-709

  Gauczynski, Sabine ^a   Nikles, Daphne ^a   El Gogo, Susanne ^a   Papy Garcia, Dulce ^c   Rey, Clémence ^a   Alban, Susanne ^b   Barritault, Denis ^c,e   Lasmézas, Corinne Ida ^d   Weiss, Stefan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c Université Paris XII Val de Marne ^*  (France)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e Organes Tissus Régénération paration Remplacement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1,3 GLUCAN; GLYCOSAMINOGLYCAN POLYSULFATE; HM 2602; HM 5004; LAMININ RECEPTOR; PENTOSAN POLYSULFATE; PHYCARIN SULFATE; PRION PROTEIN; PROTEINASE K; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; INTERNALIZATION; INTESTINE CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION; RNA TRANSCRIPTION; SEMLIKI FOREST ALPHAVIRUS; TARGET CELL; WESTERN BLOTTING;

ANIMALS; CELL LINE; CRICETINAE; HEPARITIN SULFATE; KIDNEY; MICE; PLASMIDS; PRIONS; PRPSC PROTEINS; RECEPTORS, LAMININ; RNA, VIRAL; SEMLIKI FOREST VIRUS;

EID: 33748074456     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/505914     Document Type: Article

References (36)

1. Aguzzi A, Weissmann C. Prion diseases. Haemophilia 1998; 4:619-27.
2. Lasmézas CI, Weiss S. Molecular biology of prion diseases. 1st ed. In: Cary JW, Linz JE, Bhatnagar D, eds. Microbial foodborne diseases: mechanisms of pathogenicity and toxin synthesis. Lancaster, PA: Technomic Publishing, 2000:495-537.
3. Prusiner SB. Prions. Proc Natl Acad Sci USA 1998; 95:13363-83.
4. Weissmann C. Molecular genetics of transmissible spongiform encephalopathies. J Biol Chem 1999; 274:3-6.
5. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-44.
6. Gauczynski S, Hundt C, Leucht C, Weiss S. Interaction of prion proteins with cell surface receptors, molecular chaperones, and other molecules. Adv Protein Chem 2001; 57:229-72.
7. Leucht C, Weiss S. Der prion protein rezeptor. Nova Acta Leopoldina 2002; 87:39-54.
8. Rey C, Zuber C, Weiss S. Therapeutic approaches for the treatment of prion diseases. Nova Acta Leopoldina 2006; 94:129-44.
9. Stahl N, Baldwin MA, Hecker R, Pan KM, Burlingame AL, Prusiner SB. Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid. Biochemistry 1992; 31:5043-53.
10. Gauczynski S, Peyrin JM, Haik S, et al. The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J 2001; 20:5863-75.
11. Hundt C, Peyrin JM, Haik S, et al. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor. EMBO J 2001; 20:5876-86.
12. Shyng SL, Heuser JE, Harris DA. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. J Cell Biol 1994; 125:1239-50.
13. Vey M, Pilkuhn S, Wille H, et al. Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. Proc Natl Acad Sci USA 1996; 93:14945-9.
14. Sunyach C, Jen A, Deng J, et al. The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein. EMBO J 2003; 22:3591-601.
15. Brown DR, Qin K, Herms JW, et al. The cellular prion protein binds copper in vivo. Nature 1997; 390:684-7.
16. Perera WS, Hooper NM. Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region. Curr Biol 2001; 11:519-23.
17. Nunziante M, Gilch S, Schatzl HM. Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein. J Biol Chem 2003; 278:3726-34.
18. Leucht C, Simoneau S, Rey C, et al. The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells. EMBO Rep 2003; 4:290-5.
19. Vana K, Weiss S. A trans-dominant negative 37kDa/67kDa laminin receptor mutant impairs PrP(Sc) propagation in scrapie-infected neuronal cells. J Mol Biol 2006; 358:57-66.
20. Liljestrom P, Garoff H. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology (NY) 1991; 9:1356-61.
21. Tubulekas I, Berglund P, Fleeton M, Liljestrom P. Alphavirus expression vectors and their use as recombinant vaccines: a minireview. Gene 1997; 190:191-5.
22. Shyng SL, Lehmann S, Moulder KL, Harris DA. Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPc, in cultured cells. J Biol Chem 1995; 270:30221-9.
23. Diringer H, Ehlers B. Chemoprophylaxis of scrapie in mice. J Gen Virol 1991; 72:457-60.
24. Farquhar C, Dickinson A, Bruce M. Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies. Lancet 1999; 353:117.
25. Ladogana A, Casaccia P, Ingrosso L, et al. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J Gen Virol 1992;73:661-5.
26. Adjou KT, Simoneau S, Sales N, et al. A novel generation of heparan sulfate mimetics for the treatment of prion diseases. J Gen Virol 2003; 84:2595-603.
27. Schonberger O, Horonchik L, Gabizon R, Papy-Garcia D, Barritault D, Taraboulos A. Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis. Biochem Biophys Res Commun 2003; 312:473-9.
28. Gauczynski S, Krasemann S, Bodemer W, Weiss S. Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance. J Cell Sci 2002; 115:4025-36.
29. Yvin J-C, Alban S, Franz G. Anti-inflammatory and healing medicine based on laminarin sulphate. PCT International Application Patent WO 2002036132 2002.
30. Lasmézas CI, Deslys JP, Robain O, et al. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 1997; 275:402-5.
31. Bueler H, Aguzzi A, Sailer A, et al. Mice devoid of PrP are resistant to scrapie. Cell 1993; 73:1339-47.
32. Daude N, Marella M, Chabry J. Specific inhibition of pathological prion protein accumulation by small interfering RNAs. J Cell Sci 2003; 116:2775-9.
33. Horonchik L, Tzaban S, Ben-Zaken O, et al. Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem 2005; 280:17062-7.
34. Hijazi N, Kariv-Inbal Z, Gasset M, Gabizon R. PrPSc incorporation to cells requires endogenous glycosaminoglycan expression. J Biol Chem 2005; 280:17057-61.
35. Morel E, Andrieu T, Casagrande F, et al. Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor. Am J Pathol 2005; 167:1033-42.
36. Adjou KT, Demaimay R, Lasmézas C, Deslys JP, Seman M, Dormont D. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrob Agents Chemother 1995; 39:2810-2.