A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 44234-44242

  Westergard, Laura ^a   Turnbaugh, Jessie A ^b   Harris, David A ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL FRAGMENTS; CELL TYPES; CELLULAR PRION PROTEINS; ISOFORMS; N-TERMINALS; NATURALLY OCCURRING; NEUROLOGICAL DISEASE; PRION DISEASE; PRION PROTEIN; PROTEOLYTIC CLEAVAGE; PROTEOLYTIC FRAGMENTS; THERAPEUTIC STRATEGY; TIME COURSE; TRANSGENE; TRANSGENIC MICE; WILD TYPES;

MAMMALS;

NEURODEGENERATIVE DISEASES;

PRION PROTEIN; PROTEIN C1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MOUSE; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; ONSET AGE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SCRAPIE; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BRAIN; GENES, DOMINANT; GENOTYPE; MICE; MICE, TRANSGENIC; MODELS, GENETIC; NEURODEGENERATIVE DISEASES; PROTEIN STRUCTURE, TERTIARY; PRPSC PROTEINS; SCRAPIE; TIME FACTORS;

EID: 83755162371     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.286195     Document Type: Article

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