Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9685-9689

  Demaimay, R ^a,c   Adjou, K T ^a   Beringue, V ^a   Demart, S ^a   Lasmezas C I ^a   Deslys, J P ^a   Seman, M ^b   Dormont, D ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b INSTITUT JACQUES MONOD   (France)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; POLYENE ANTIBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; GENE EXPRESSION; IMMUNIZATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCRAPIE; SCRAPIE AGENT; SURVIVAL RATE; TREATMENT PLANNING;

EID: 0030778819     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9685-9689.1997     Document Type: Article

References (39)

1. Adjou, K. T., R. Demaimay, C. Lasmézas, J.-P. Deslys, M. Seman, and D. Dormont. 1995. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrob. Agents Chemother. 39:2810-2812.
2. Adjou, K. T., R. Demaimay, C. Lasmézas, J.-P. Deslys, M. Seman, and D. Dormont. 1996. Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: implications for the mechanism of action of polyene antibiotics. Res. Virol. 147:213-218.
3. Amyx, H., A. M. Salazar, D. C. Gajdusek, and C. J. Gibbs. 1984. Chemotherapeutic trials in experimental slow virus disease. Neurology 34:149.
4. Bolard, J. 1986. How do the macrolide antibiotics affect the cellular membranes properties? Biochim. Biophys. Acta 864:257-304.
5. Bolton, D. C., M. P. McKinley, and S. B. Prusiner. 1982. Identification of a protein that purifies with the scrapie prion. Science 218:1309-1311.
6. Bratjburg, J., S. Elberg, D. R. Schwartz, A. Vertut-Croquin, D. Sclessinger, G. S. Kobayashi, and G. Medoff. 1985. Involvement of oxidative damage in erythrocyte lysis induced by amphotericin B. Antimicrob. Agents Chemother. 27:172-176.
7. Brandner, S., S. Isenmann, A. Raeber, M. Fischer, A. Sailer, Y. Kobayashi, S. Marino, C. Weissmann, and A. Aguzzi. 1996. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379:339-343.
8. Brown, D. R., B. Schmidt, and H. A. Kretzschmar. 1996. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 380:345-347.
9. Bruce, S. E., and H. Fraser. 1991. Scrapie strain variation and its implication, p. 125-138. In B. W. Chesebro (ed.), Transmissible spongiform encephalopathies. Springer-Verlag, Berlin, Germany.
10. Büeler, H., A. Aguzzi, A. Sailer, R. A. Greiner, P. Autenried, M. Aguet, and C. Weissmann. 1993. Mice devoid of PrP are resistant to scrapie. Cell 73:1339-1347.
11. Carp, R. I. 1992. Unconventionnal infectious agent, p. 111-136. In S. Specter et al. (ed.), Neuropathogenic viruses and immunity. Plenum Press, New York, N.Y.
12. Casaccia, P., A. Ladogana, Y. G. Xi, L. Ingroso, M. Pocchiari, M. C. Silvestrini, and A. Cittadini. 1991. Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method. Antimicrob. Agents Chemother. 35:1486-1488.
13. Caughey, B., and G. J. Raymond. 1993. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J. Virol. 67:643-650.
14. Chesebro, B., R. Race, K. Wehrly, J. Nishio, M. Bloom, D. Lechner, S. Bergstrom, K. Robbins, L. Mayer, J. M. Keith, C. Garon, and A. Haase. 1985. Identification of scrapie prion protein-specific mRNA in scrapie infected and uninfected brain. Nature 315:331-333.
15. Demaimay, R., K. Adjou, C. Lasmézas, F. Lazarini, K. Cherifi, M. Seman, J. P. Deslys, and D. Dormont. 1994. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J. Gen. Virol. 75:2499-2503.
16. Diringer, H., and B. Ehlers. 1991. Chemoprophylaxis of scrapie in mice. J. Gen. Virol. 72:457-460.
17. Dormont, D. Personal communication.
18. Dormont, D., B. Delpech, A. Delpech, M. N. Courcel, J. Viret, P. Markovits, and L. Court. 1981. Hyperproduction de protéine gliofibrillaire acide (GFAP) au cours de l'évolution de la tremblante expérimentale de la souris. C. R. Acad. Sci. Paris 293:53-56.
19. Ehlers, B., and H. Diringer. 1984. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J. Gen. Virol. 65:1325-1330.
20. Ingrosso, L., A. Ladogana, and M. Pocchiari. 1995. Congo red prolongs the incubation period in scrapie-infected hamsters. J. Virol. 69:506-508.
21. Jendroska K., F. P. Heinzel, M. Torchia, L. Stowring, H. A. Kretzschmar, A. Kon, A. Stern, S. B. Prusiner, and S. J. DeArmond. 1991. Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity. Neurology 41:1482-1490.
22. Kimberlin, R. H., and C. A. Walker. 1978. Pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. J. Comp. Pathol. 88:39-47.
23. Kimberlin, R. H., and C. A. Walker. 1990. Intraperitoneal infection with scrapie is established within minutes of injection and is non-specifically enhanced by a variety of different drugs. Arch. Virol. 112:103-114.
24. Lazarini, F., J. P. Deslys, and D. Dormont. 1992. Variations in prion protein and glial fibrillary acidic protein messenger RNAs in the brain of scrapie-infected newborn mouse. J. Gen. Virol. 73:1645-1648.
25. Masullo, C., G. Macchi, Y. G. Xi, and M. Pocchiari. 1992. Failure to ameliorate Creutzfeldt-Jakob disease with AmB therapy. J. Infect. Dis. 196:784-785.
26. Mckenzie, D., J. Kaczkowski, R. Marsh, and J. Aiken. 1994. Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection. J. Virol. 68:7534-7536.
27. Müller, W. E. G., H. Ushijima, H. C. Schröder, J. M. S. Forrest, W. F. H. Schatton, P. G. Rytik, and M. Heffner-Lauc. 1993. Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures. Eur. J. Pharmacol. 246:261-267.
28. Niki, Y., E. M. Bernard, H.-J. Schmitt, W. P. Tong, F. F. Edwards, and D. Armstrong. 1990. Pharmacokinetics of aerosol amphotericin B in rats. Antimicrob. Agents Chemother. 34:29-32.
29. Oesch, B., D. Westaway, M. Walchli, M. P. Mckinley, S. B. Kent, R. Aebersold, R. A. Barry, P. Tempst, D. B. Teplow, L. E. Hood, S. B. Prusiner, and C. Weissmann. 1985. A cellular gene encodes scrapie PrP 27-30 protein. Cell 40:735-746.
30. Outram, G. W. 1976. The pathogenesis of scrapie in mice, p. 325-357. In R. H. Kimberlin (ed.), Slow virus diseases of animals and man. North-Holland, Amsterdam, The Netherlands.
31. Pocchiari, M., P. Casaccia, and A. Ladogana. 1989. Amphotericin B: a novel class of antiscrapie drugs. J. Infect. Dis. 160:795-802.
32. Pocchiari, M., S. Schmittinger, A. Ladogana, and C. Masullo. 1986. Effects of amphotericin B in intracerebrally scrapie inoculated hamster, p. 314-323. In D. Dormont, L. A. Court, P. Brown, and D. T. Kingsbury (ed.), Unconventional virus diseases of the central nervous system. CEA Ed., Paris, France.
33. Saint-Julien, L., V. Joly, M. Seman, C. Carbon, and P. Yeni. 1992. Activity of MS-8209, a nonester amphotericin B derivative, in treatment of experimental systemic mycoses. Antimicrob. Agents Chemother. 36:2722-2728.
34. Taraboulos, A., M. Scott, A. Semenov, D. Avraham, L. Laszlo, and S. B. Prusiner. 1995. Cholesterol depletion and modification of COOH-termmal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell Biol. 129:121-132.
35. Tokuda, Y., M. Tsuji, M. Yamazaki, S. Kimura, S. Abe, and H. Yamaguchi. 1993. Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo. Antimicrob. Agents Chemother. 37:2228-2230.
36. Vertut-Doï, A., S.-I. Ohnishi, and J. Bolard. 1994. The endocytic process in CHO cells, a toxic pathway of the polyene antibiotic amphotericin B. Antimicrob. Agents Chemother. 38:2373-2379.
37. Walker, R. W., and M. K. Rosenblum. 1992. Amphotericin B-associated leukoencephalopathy. Neurology 42:2005-2010.
38. Wolf, J. E., and S. E. Massof. 1990. In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B. Infect. Immun. 58: 1296-1300.
39. Xi, Y. G., L. Ingrosso, A. Ladogana, C. Masullo, and M. Pocchiari. 1992. Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Nature 356:598-601.