메뉴 건너뛰기




Volumn 16, Issue 12, 2012, Pages 1434-1455

Mitochondria and cell bioenergetics: Increasingly recognized components and a possible etiologic cause of alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; BETA SECRETASE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CYCLOPHILIN D; DEOXYGLUCOSE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; NERVE GROWTH FACTOR; PROSTAGLANDIN SYNTHASE; SODIUM AZIDE;

EID: 84860210262     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.4149     Document Type: Review
Times cited : (163)

References (306)
  • 1
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
    • The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 18: S1-2, 1997.
    • (1997) Neurobiol Aging , vol.18
  • 3
    • 79551591722 scopus 로고    scopus 로고
    • Astrocyte-neuron metabolic relationships: For better and for worse
    • Allaman I, Belanger M, and Magistretti PJ. Astrocyte-neuron metabolic relationships: For better and for worse. Trends Neurosci 34: 76-87, 2011.
    • (2011) Trends Neurosci , vol.34 , pp. 76-87
    • Allaman, I.1    Belanger, M.2    Magistretti, P.J.3
  • 4
    • 77749336627 scopus 로고    scopus 로고
    • Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: Impact on neuronal viability
    • Allaman I, Gavillet M, Belanger M, Laroche T, Viertl D, Lashuel HA, and Magistretti PJ. Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: Impact on neuronal viability. J Neurosci 30: 3326-3338, 2010.
    • (2010) J Neurosci , vol.30 , pp. 3326-3338
    • Allaman, I.1    Gavillet, M.2    Belanger, M.3    Laroche, T.4    Viertl, D.5    Lashuel, H.A.6    Magistretti, P.J.7
  • 6
    • 0000293742 scopus 로고
    • Uber eine eigenartige Erkrankung der Hirnrinde
    • Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat Psych-Gerichtl Med 64: 146-148, 1907.
    • (1907) Allg Z Psychiat Psych-Gerichtl Med , vol.64 , pp. 146-148
    • Alzheimer, A.1
  • 7
    • 0037437192 scopus 로고    scopus 로고
    • Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
    • DOI 10.1083/jcb.200207030
    • Anandatheerthavarada HK, Biswas G, Robin MA, and Avadhani NG. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161: 41-54, 2003. (Pubitemid 36459078)
    • (2003) Journal of Cell Biology , vol.161 , Issue.1 , pp. 41-54
    • Anandatheerthavarada, H.K.1    Biswas, G.2    Robin, M.-A.3    Avadhani, N.G.4
  • 8
    • 35948969760 scopus 로고    scopus 로고
    • Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease
    • DOI 10.1177/1073858407303536
    • Anandatheerthavarada HK and Devi L. Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease. Neuroscientist 13: 626-638, 2007. (Pubitemid 350077307)
    • (2007) Neuroscientist , vol.13 , Issue.6 , pp. 626-638
    • Anandatheerthavarada, H.K.1    Devi, L.2
  • 9
    • 33746256557 scopus 로고    scopus 로고
    • Mitochondrial alterations in Alzheimer's disease
    • Baloyannis SJ. Mitochondrial alterations in Alzheimer's disease. J Alzheimers Dis 9: 119-126, 2006. (Pubitemid 44088243)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.2 , pp. 119-126
    • Baloyannis, S.J.1
  • 10
    • 0037043838 scopus 로고    scopus 로고
    • Evidence for parent of origin effect in late-onset Alzheimer disease
    • Bassett SS, Avramopoulos D, and Fallin D. Evidence for parent of origin effect in late-onset Alzheimer disease. Am J Med Genet 114: 679-686, 2002.
    • (2002) Am J Med Genet , vol.114 , pp. 679-686
    • Bassett, S.S.1    Avramopoulos, D.2    Fallin, D.3
  • 11
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38: 357-366, 1995.
    • (1995) Ann Neurol , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 16
    • 0033028186 scopus 로고    scopus 로고
    • 2 and modulation by glutathione in human neuroblastoma and Alzheimer's disease cybrid cells
    • DOI 10.1016/S0169-328X(99)00168-0, PII S0169328X99001680
    • Bijur GN, Davis RE, and Jope RS. Rapid activation of heat shock factor-1 DNA binding by H2O2 and modulation by glutathione in human neuroblastoma and Alzheimer's disease cybrid cells. Brain Res Mol Brain Res 71: 69-77, 1999. (Pubitemid 29320057)
    • (1999) Molecular Brain Research , vol.71 , Issue.1 , pp. 69-77
    • Bijur, G.N.1    Davis, R.E.2    Jope, R.S.3
  • 18
    • 0027215961 scopus 로고
    • A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue
    • Blanchard BJ, Park T, Fripp WJ, Lerman LS, and Ingram VM. A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue. Neuroreport 4: 799-802, 1993. (Pubitemid 23190922)
    • (1993) NeuroReport , vol.4 , Issue.6 , pp. 799-802
    • Blanchard, B.J.1    Park, T.2    Fripp, W.J.3    Lerman, L.S.4    Ingram, V.M.5
  • 19
    • 0025183062 scopus 로고
    • Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
    • Blass JP, Baker AC, Ko L, and Black RS. Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. Arch Neurol 47: 864-869, 1990. (Pubitemid 20251716)
    • (1990) Archives of Neurology , vol.47 , Issue.8 , pp. 864-869
    • Blass, J.P.1    Baker, A.C.2    Ko, L.-W.3    Black, R.S.4
  • 21
    • 0036592758 scopus 로고    scopus 로고
    • The role of the metabolic lesion in Alzheimer's disease
    • Blass JP, Gibson GE, and Hoyer S. The role of the metabolic lesion in Alzheimer's disease. J Alzheimers Dis 4: 225-232, 2002. (Pubitemid 35006054)
    • (2002) Journal of Alzheimer's Disease , vol.4 , Issue.3 , pp. 225-232
    • Blass, J.P.1    Gibson, G.E.2    Hoyer, S.3
  • 22
    • 0021437073 scopus 로고
    • Alzheimer's disease.A metabolic systems degeneration?
    • Blass JP and Zemcov A. Alzheimer's disease. A metabolic systems degeneration? Neurochem Pathol 2: 103-114, 1984.
    • (1984) Neurochem Pathol , vol.2 , pp. 103-114
    • Blass, J.P.1    Zemcov, A.2
  • 24
    • 0036231792 scopus 로고    scopus 로고
    • 0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
    • DOI 10.1016/S0197-4580(01)00314-1, PII S0197458001003141
    • Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, and Solaini G. Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23: 371-376, 2002. (Pubitemid 34312019)
    • (2002) Neurobiology of Aging , vol.23 , Issue.3 , pp. 371-376
    • Bosetti, F.1    Brizzi, F.2    Barogi, S.3    Mancuso, M.4    Siciliano, G.5    Tendi, E.A.6    Murri, L.7    Rapoport, S.I.8    Solaini, G.9
  • 25
    • 0018410202 scopus 로고
    • Accelerated ageing or selective neuronal loss as an important cause of dementia?
    • Bowen DM, White P, Spillane JA, Goodhardt MJ, Curzon G, Iwangoff P, Meier-Ruge W, and Davison AN. Accelerated ageing or selective neuronal loss as an important cause of dementia? Lancet 1: 11-14, 1979. (Pubitemid 9084463)
    • (1979) Lancet , vol.1 , Issue.8106 , pp. 11-14
    • Bowen, D.M.1    White, P.2    Spillane, J.A.3
  • 28
    • 0035042470 scopus 로고    scopus 로고
    • Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA)
    • DOI 10.1385/JMN:16:1:41
    • Brown AM, Sheu RK, Mohs R, Haroutunian V, and Blass JP. Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA). J Mol Neurosci 16: 41-48, 2001. (Pubitemid 32402344)
    • (2001) Journal of Molecular Neuroscience , vol.16 , Issue.1 , pp. 41-48
    • Brown, A.M.1    Sheu, R.K.-F.2    Mohs, R.3    Haroutunian, V.4    Blass, J.P.5
  • 29
    • 0040844069 scopus 로고
    • Cytoplasmic inheritance of chloramphenicol resistance in mouse tissue culture cells
    • Bunn CL, Wallace DC, and Eisenstadt JM. Cytoplasmic inheritance of chloramphenicol resistance in mouse tissue culture cells. Proc Natl Acad Sci USA 71: 1681-1685, 1974.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1681-1685
    • Bunn, C.L.1    Wallace, D.C.2    Eisenstadt, J.M.3
  • 30
    • 0032810909 scopus 로고    scopus 로고
    • β-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria
    • DOI 10.1016/S0014-5793(99)01028-5, PII S0014579399010285
    • Canevari L, Clark JB, and Bates TE. beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457: 131-134, 1999. (Pubitemid 29387424)
    • (1999) FEBS Letters , vol.457 , Issue.1 , pp. 131-134
    • Canevari, L.1    Clark, J.B.2    Bates, T.E.3
  • 31
    • 0348111546 scopus 로고    scopus 로고
    • Cytochrome c oxidase is decreased in Alzheimer's disease platelets
    • DOI 10.1016/S0197-4580(03)00033-2
    • Cardoso SM, Proenca MT, Santos S, Santana I, and Oliveira CR. Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging 25: 105-110, 2004. (Pubitemid 37522198)
    • (2004) Neurobiology of Aging , vol.25 , Issue.1 , pp. 105-110
    • Cardoso, S.M.1    Proenca, M.T.2    Santos, S.3    Santana, I.4    Oliveira, C.R.5
  • 32
    • 3042513691 scopus 로고    scopus 로고
    • Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity
    • DOI 10.1111/j.1471-4159.2004.02438.x
    • Cardoso SM, Santana I, Swerdlow RH, and Oliveira CR. Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J Neurochem 89: 1417-1426, 2004. (Pubitemid 38802663)
    • (2004) Journal of Neurochemistry , vol.89 , Issue.6 , pp. 1417-1426
    • Cardoso, S.M.1    Santana, I.2    Swerdlow, R.H.3    Oliveira, C.R.4
  • 33
    • 0035378322 scopus 로고    scopus 로고
    • Functional mitochondria are required for amyloid betamediated neurotoxicity
    • Cardoso SM, Santos S, Swerdlow RH, and Oliveira CR. Functional mitochondria are required for amyloid betamediated neurotoxicity. FASEB J 15: 1439-1441, 2001.
    • (2001) FASEB J , vol.15 , pp. 1439-1441
    • Cardoso, S.M.1    Santos, S.2    Swerdlow, R.H.3    Oliveira, C.R.4
  • 35
    • 0036272650 scopus 로고    scopus 로고
    • β-Amyloid inhibits integrated mitochondrial respiration and key enzyme activities
    • DOI 10.1046/j.0022-3042.2001.00681.x
    • Casley CS, Canevari L, Land JM, Clark JB, and Sharpe MA. Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80: 91-100, 2002. (Pubitemid 34614581)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.1 , pp. 91-100
    • Casley, C.S.1    Canevari, L.2    Land, J.M.3    Clark, J.B.4    Sharpe, M.A.5
  • 36
  • 37
    • 0032499885 scopus 로고    scopus 로고
    • Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids
    • DOI 10.1006/bbrc.1998.8866
    • Cassarino DS, Swerdlow RH, Parks JK, Parker WD, Jr., and Bennett JP, Jr. Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem Biophys Res Commun 248: 168-173, 1998. (Pubitemid 28418206)
    • (1998) Biochemical and Biophysical Research Communications , vol.248 , Issue.1 , pp. 168-173
    • Cassarino, D.S.1    Swerdlow, R.H.2    Parks, J.K.3    Parker Jr., W.D.4    Bennett Jr., J.P.5
  • 40
    • 0028948660 scopus 로고
    • Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases
    • Chagnon P, Betard C, Robitaille Y, Cholette A, and Gauvreau D. Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases. Neuroreport 6: 711-715, 1995.
    • (1995) Neuroreport , vol.6 , pp. 711-715
    • Chagnon, P.1    Betard, C.2    Robitaille, Y.3    Cholette, A.4    Gauvreau, D.5
  • 41
    • 0033516529 scopus 로고    scopus 로고
    • Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French- Canadian founder population
    • DOI 10.1002/(SICI)1096-8628(19990702)85: 1<20::AID-AJMG6>3.0.CO;2-K
    • Chagnon P, Gee M, Filion M, Robitaille Y, Belouchi M, and Gauvreau D. Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population. Am J Med Genet 85: 20-30, 1999. (Pubitemid 29256801)
    • (1999) American Journal of Medical Genetics , vol.85 , Issue.1 , pp. 20-30
    • Chagnon, P.1    Gee, M.2    Filion, M.3    Robitaille, Y.4    Belouchi, M.5    Gauvreau, D.6
  • 42
    • 0028199881 scopus 로고
    • Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease
    • DOI 10.1016/0169-328X(94)90147-3
    • Chandrasekaran K, Giordano T, Brady DR, Stoll J, Martin LJ, and Rapoport SI. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Brain Res Mol Brain Res 24: 336-340, 1994. (Pubitemid 24202871)
    • (1994) Molecular Brain Research , vol.24 , Issue.1-4 , pp. 336-340
    • Chandrasekaran, K.1    Giordano, T.2    Brady, D.R.3    Stoll, J.4    Martin, L.J.5    Rapoport, S.I.6
  • 43
    • 0030296713 scopus 로고    scopus 로고
    • Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease
    • DOI 10.1006/exnr.1996.0180
    • Chandrasekaran K, Hatanpaa K, Brady DR, and Rapoport SI. Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp Neurol 142: 80-88, 1996. (Pubitemid 26381382)
    • (1996) Experimental Neurology , vol.142 , Issue.1 , pp. 80-88
    • Chandrasekaran, K.1    Hatanpaa, K.2    Brady, D.R.3    Rapoport, S.I.4
  • 47
    • 84857122467 scopus 로고    scopus 로고
    • Cognitive impairment and increased Abeta levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2)
    • [Epub ahead of print]
    • Chen L, Yoo SE, Na R, Liu Y, and Ran Q. Cognitive impairment and increased Abeta levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2). Neurobiol Aging [Epub ahead of print, 2011].
    • (2011) Neurobiol Aging
    • Chen, L.1    Yoo, S.E.2    Na, R.3    Liu, Y.4    Ran, Q.5
  • 49
    • 0028238418 scopus 로고
    • Platelet-mediated transformation of mtDNAless human cells: Analysis of phenotypic variability among clones from normal individuals-and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers
    • Chomyn A, Lai ST, Shakeley R, Bresolin N, Scarlato G, and Attardi G. Platelet-mediated transformation of mtDNAless human cells: analysis of phenotypic variability among clones from normal individuals-and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers. Am J Hum Genet 54: 966-974, 1994.
    • (1994) Am J Hum Genet , vol.54 , pp. 966-974
    • Chomyn, A.1    Lai, S.T.2    Shakeley, R.3    Bresolin, N.4    Scarlato, G.5    Attardi, G.6
  • 50
    • 0033646639 scopus 로고    scopus 로고
    • Transcription and replication of mitochondrial DNA
    • Clayton DA. Transcription and replication of mitochondrial DNA. Hum Reprod 15 Suppl 2: 11-17, 2000.
    • (2000) Hum Reprod , vol.15 , Issue.SUPPL. 2 , pp. 11-17
    • Clayton, D.A.1
  • 53
  • 57
    • 0031958152 scopus 로고    scopus 로고
    • Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
    • DOI 10.1016/S0197-4580(98)00042-6, PII S0197458098000426
    • Cotman CW. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 19: S29-32, 1998. (Pubitemid 28178934)
    • (1998) Neurobiology of Aging , vol.19 , Issue.SUPPL. 1
    • Cotman, C.W.1
  • 58
    • 0035943058 scopus 로고    scopus 로고
    • Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD
    • Cottrell DA, Blakely EL, JohnsonMA, Ince PG, and Turnbull DM. Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD. Neurology 57: 260-264, 2001. (Pubitemid 32667359)
    • (2001) Neurology , vol.57 , Issue.2 , pp. 260-264
    • Cottrell, D.A.1    Blakely, E.L.2    Johnson, M.A.3    Ince, P.G.4    Turnbull, D.M.5
  • 60
    • 16844377812 scopus 로고    scopus 로고
    • The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease
    • Counts SE and Mufson EJ. The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. J Neuropathol Exp Neurol 64: 263-272, 2005. (Pubitemid 40489553)
    • (2005) Journal of Neuropathology and Experimental Neurology , vol.64 , Issue.4 , pp. 263-272
    • Counts, S.E.1    Mufson, E.J.2
  • 63
    • 0012631206 scopus 로고
    • A mitochondrial bottleneck hypothesis of Alzheimer's disease
    • Davis JN, Hunnicutt EJ, Jr., and Chisholm JC. A mitochondrial bottleneck hypothesis of Alzheimer's disease. Mol Med Today 1: 240-247, 1995.
    • (1995) Mol Med Today , vol.1 , pp. 240-247
    • Davis, J.N.1    Hunnicutt Jr., E.J.2    Chisholm, J.C.3
  • 66
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
    • DOI 10.1016/S0022-510X(97)00131-7, PII S0022510X97001317
    • de la Monte SM, Sohn YK, and Wands JR. Correlates of p53-and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152: 73-83, 1997. (Pubitemid 27469712)
    • (1997) Journal of the Neurological Sciences , vol.152 , Issue.1 , pp. 73-83
    • De La Monte, S.M.1    Sohn, Y.K.2    Wands, J.R.3
  • 68
    • 0034594489 scopus 로고    scopus 로고
    • Alterations in muscarinic receptor-coupled phosphoinositide hydrolysis and AP-1 activation in Alzheimer's disease cybrid cells
    • DOI 10.1016/S0197-4580(00)00095-6, PII S0197458000000956
    • De Sarno P, Bijur GN, Lu R, Davis RE, and Jope RS. Alterations in muscarinic receptor-coupled phosphoinositide hydrolysis and AP-1 activation in Alzheimer's disease cybrid cells. Neurobiol Aging 21: 31-38, 2000. (Pubitemid 30224783)
    • (2000) Neurobiology of Aging , vol.21 , Issue.1 , pp. 31-38
    • De Sarno, P.1    Bijur, G.N.2    Lu, R.3    Davis, R.E.4    Jope, R.S.5
  • 70
  • 71
    • 0021966704 scopus 로고
    • Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts
    • Desjardins P, Frost E, and Morais R. Ethidium bromideinduced loss of mitochondrial DNA from primary chicken embryo fibroblasts. Mol Cell Biol 5: 1163-1169, 1985. (Pubitemid 15110308)
    • (1985) Molecular and Cellular Biology , vol.5 , Issue.5 , pp. 1163-1169
    • Desjardins, P.1    Frost, E.2    Morais, R.3
  • 72
    • 33748283747 scopus 로고    scopus 로고
    • Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
    • DOI 10.1523/JNEUROSCI.1469-06.2006
    • Devi L, Prabhu BM, Galati DF, Avadhani NG, and Anandatheerthavarada HK. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 26: 9057-9068, 2006. (Pubitemid 44319397)
    • (2006) Journal of Neuroscience , vol.26 , Issue.35 , pp. 9057-9068
    • Devi, L.1    Prabhu, B.M.2    Galati, D.F.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 73
    • 39449124353 scopus 로고    scopus 로고
    • Mitochondria morphology and DNA content upon sublethal exposure to beta-amyloid(1-42) peptide
    • Diana A, Simic G, Sinforiani E, Orru N, Pichiri G, and Bono G. Mitochondria morphology and DNA content upon sublethal exposure to beta-amyloid(1-42) peptide. Coll Antropol 32: 51-58, 2008.
    • (2008) Coll Antropol , vol.32 , pp. 51-58
    • Diana, A.1    Simic, G.2    Sinforiani, E.3    Orru, N.4    Pichiri, G.5    Bono, G.6
  • 74
    • 77956197971 scopus 로고    scopus 로고
    • Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
    • Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, and Bradshaw PC. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J Alzheimers Dis 20: S535-550, 2010.
    • (2010) J Alzheimers Dis , vol.20
    • Dragicevic, N.1    Mamcarz, M.2    Zhu, Y.3    Buzzeo, R.4    Tan, J.5    Arendash, G.W.6    Bradshaw, P.C.7
  • 76
    • 78649815388 scopus 로고    scopus 로고
    • Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
    • Du H, Guo L, Yan S, Sosunov AA, McKhann GM, and Yan SS. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci USA 107: 18670-18675, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18670-18675
    • Du, H.1    Guo, L.2    Yan, S.3    Sosunov, A.A.4    McKhann, G.M.5    Yan, S.S.6
  • 78
    • 68849110235 scopus 로고    scopus 로고
    • Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease
    • Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, and Lin MT. Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J 23: 2459-2466, 2009.
    • (2009) FASEB J , vol.23 , pp. 2459-2466
    • Dumont, M.1    Wille, E.2    Stack, C.3    Calingasan, N.Y.4    Beal, M.F.5    Lin, M.T.6
  • 79
    • 0030016323 scopus 로고    scopus 로고
    • Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance
    • Edland SD, Silverman JM, Peskind ER, Tsuang D, Wijsman E, and Morris JC. Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance. Neurology 47: 254-256, 1996. (Pubitemid 26243893)
    • (1996) Neurology , vol.47 , Issue.1 , pp. 254-256
    • Edland, S.D.1    Silverman, J.M.2    Peskind, E.R.3    Tsuang, D.4    Wijsman, E.5    Morris, J.C.6
  • 83
    • 0008586212 scopus 로고
    • Action de l'acriflavine sur les levures I: La mutation petite clonie
    • Ephrussi B, Hottinger H, and Chimenes A. Action de l'acriflavine sur les levures, I: la mutation "petite clonie." Ann Inst Pasteur 76: 531, 1949.
    • (1949) Ann Inst Pasteur , vol.76 , pp. 531
    • Ephrussi, B.1    Hottinger, H.2    Chimenes, A.3
  • 87
    • 0020518539 scopus 로고
    • Alzheimer's disease: Focal cortical changes shown by positron emission tomography
    • Foster NL, Chase TN, Fedio P, Patronas NJ, Brooks RA, and Di Chiro G. Alzheimer's disease: Focal cortical changes shown by positron emission tomography. Neurology 33: 961-965, 1983. (Pubitemid 13030175)
    • (1983) Neurology , vol.33 , Issue.8 , pp. 961-965
    • Foster, N.L.1    Chase, T.N.2    Fedio, P.3
  • 88
    • 0019783428 scopus 로고
    • Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography
    • Frackowiak RS, Pozzilli C, Legg NJ, Du Boulay GH, Marshall J, Lenzi GL, and Jones T. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 104: 753-778, 1981. (Pubitemid 12235670)
    • (1981) Brain , vol.104 , Issue.4 , pp. 753-778
    • Frackowiak, R.S.J.1    Pozzilli, C.2    Legg, N.J.3
  • 89
    • 3342978711 scopus 로고
    • Enzyme histochemical studies of senile plaques
    • Friede RL. Enzyme histochemical studies of senile plaques. J Neuropathol Exp Neurol 24: 477-491, 1965.
    • (1965) J Neuropathol Exp Neurol , vol.24 , pp. 477-491
    • Friede, R.L.1
  • 90
    • 0020594056 scopus 로고
    • 18F]fluorodeoxyglucose
    • Friedland RP, Budinger TF, Ganz E, Yano Y, Mathis CA, Koss B, Ober BA, Huesman RH, Derenzo SE. Regional cerebral metabolic alterations in dementia of the Alzheimer type: Positron emission tomography with [18F]fluorodeoxyglucose. J Comput Assist Tomogr 7: 590-598, 1983. (Pubitemid 13035941)
    • (1983) Journal of Computer Assisted Tomography , vol.7 , Issue.4 , pp. 590-598
    • Friedland, R.P.1    Budinger, T.F.2    Ganz, E.3
  • 91
  • 93
    • 0028200649 scopus 로고
    • Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    • Gabuzda D, Busciglio J, Chen LB, Matsudaira P, and Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269: 13623-13628, 1994. (Pubitemid 24206141)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.18 , pp. 13623-13628
    • Gabuzda, D.1    Busciglio, J.2    Chen, L.B.3    Matsudaira, P.4    Yankner, B.A.5
  • 94
    • 0030930721 scopus 로고    scopus 로고
    • Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells
    • DOI 10.1016/S0304-3940(97)00536-3, PII S0304394097005363
    • Gasparini L, Racchi M, Benussi L, Curti D, Binetti G, Bianchetti A, Trabucchi M, and Govoni S. Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells. Neurosci Lett 231: 113-117, 1997. (Pubitemid 27386502)
    • (1997) Neuroscience Letters , vol.231 , Issue.2 , pp. 113-117
    • Gasparini, L.1    Racchi, M.2    Benussi, L.3    Curti, D.4    Binetti, G.5    Bianchetti, A.6    Trabucchi, M.7    Govoni, S.8
  • 96
    • 0023198092 scopus 로고
    • Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients
    • DOI 10.1016/0006-3223(87)90050-3
    • Gibson GE, Nielsen P, Sherman KA, and Blass JP. Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients. Biol Psychiatry 22: 1079-1086, 1987. (Pubitemid 17138303)
    • (1987) Biological Psychiatry , vol.22 , Issue.9 , pp. 1079-1086
    • Gibson, G.E.1    Nielsen, P.2    Sherman, K.A.3    Blass, J.P.4
  • 97
    • 0023732664 scopus 로고
    • Reduced activities of thiaminedependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease
    • Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, and Perrino P. Reduced activities of thiaminedependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch Neurol 45: 836-840, 1988.
    • (1988) Arch Neurol , vol.45 , pp. 836-840
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3    Baker, A.4    Carlson, K.C.5    Harding, B.6    Perrino, P.7
  • 99
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG and Wong CW. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120: 885-890, 1984. (Pubitemid 14104991)
    • (1984) Biochemical and Biophysical Research Communications , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 101
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • DOI 10.1111/j.1471-4159.2004.02949.x
    • Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, and O'Neill C. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem 93: 105-117, 2005. (Pubitemid 40463520)
    • (2005) Journal of Neurochemistry , vol.93 , Issue.1 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6    O'Connor, R.7    O'Neill, C.8
  • 103
    • 33644585223 scopus 로고    scopus 로고
    • Therapy Insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
    • Haan MN. Therapy Insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nat Clin Pract Neurol 2: 159-166, 2006.
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 159-166
    • Haan, M.N.1
  • 104
    • 0031556536 scopus 로고    scopus 로고
    • Elevated levels of the Kearns-Sayre syndrome mitochondrial DNA deletion in temporal cortex of Alzheimer's patients
    • DOI 10.1016/S0027-5107(97)00158-9, PII S0027510797001589
    • Hamblet NS and Castora FJ. Elevated levels of the Kearns-Sayre syndrome mitochondrial DNA deletion in temporal cortex of Alzheimer's patients. Mutat Res 379: 253-262, 1997. (Pubitemid 27450545)
    • (1997) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.379 , Issue.2 , pp. 253-262
    • Hamblet, N.S.1    Castora, F.J.2
  • 107
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J and Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12: 383-388, 1991.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 108
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J and Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297: 353-356, 2002. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 109
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA and Higgins GA. Alzheimer's disease: The amyloid cascade hypothesis. Science 256: 184-185, 1992.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 114
    • 0031008145 scopus 로고    scopus 로고
    • Role of the mitochondrial permeability transition pore in apoptosis
    • DOI 10.1023/A:1027339418683
    • Hirsch T, Marzo I, and Kroemer G. Role of the mitochondrial permeability transition pore in apoptosis. Biosci Rep 17: 67-76, 1997. (Pubitemid 27267593)
    • (1997) Bioscience Reports , vol.17 , Issue.1 , pp. 67-76
    • Hirsch, T.1    Marzo, I.2    Kroemer, G.3
  • 115
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, Schreiber RD, and Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990. (Pubitemid 120029101)
    • (1990) Nature , vol.348 , Issue.6299 , pp. 334-336
    • Hockenbery, D.1    Ninez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 117
    • 76749099670 scopus 로고    scopus 로고
    • Zen and the art of mitochondrial DNA maintenance
    • Holt IJ. Zen and the art of mitochondrial DNA maintenance. Trends Genet 26: 103-109, 2010.
    • (2010) Trends Genet , vol.26 , pp. 103-109
    • Holt, I.J.1
  • 118
    • 79952381749 scopus 로고    scopus 로고
    • Progressive regional atrophy in normaladults with a maternal history of Alzheimer disease
    • Honea RA, Swerdlow RH, Vidoni E, and Burns JM. Progressive regional atrophy in normaladults with a maternal history of Alzheimer disease. Neurology 76: 822-829, 2011.
    • (2011) Neurology , vol.76 , pp. 822-829
    • Honea, R.A.1    Swerdlow, R.H.2    Vidoni, E.3    Burns, J.M.4
  • 119
    • 75649117447 scopus 로고    scopus 로고
    • Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
    • Honea RA, Swerdlow RH, Vidoni ED, Goodwin J, and Burns JM. Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease. Neurology 74: 113-120, 2010.
    • (2010) Neurology , vol.74 , pp. 113-120
    • Honea, R.A.1    Swerdlow, R.H.2    Vidoni, E.D.3    Goodwin, J.4    Burns, J.M.5
  • 120
    • 0027413399 scopus 로고
    • Brain oxidative energy and related metabolism, neuronal stress, and Alzheimer's disease: A speculative synthesis
    • Hoyer S. Brain oxidative energy and related metabolism, neuronal stress, and Alzheimer's disease: A speculative synthesis. J Geriatr Psychiatry Neurol 6: 3-13, 1993. (Pubitemid 23050674)
    • (1993) Journal of Geriatric Psychiatry and Neurology , vol.6 , Issue.1 , pp. 3-13
    • Hoyer, S.1
  • 121
    • 0033653771 scopus 로고    scopus 로고
    • Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
    • Hoyer S. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update. Exp Gerontol 35: 1363-1372, 2000.
    • (2000) Exp Gerontol , vol.35 , pp. 1363-1372
    • Hoyer, S.1
  • 122
    • 0029091194 scopus 로고
    • A mitochondrial DNA clone is associated with increased risk for Alzheimer disease
    • Hutchin T and Cortopassi G. A mitochondrial DNA clone is associated with increased risk for Alzheimer disease. Proc Natl Acad Sci USA 92: 6892-6895, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6892-6895
    • Hutchin, T.1    Cortopassi, G.2
  • 126
    • 0019142890 scopus 로고
    • Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases
    • DOI 10.1016/0047-6374(80)90120-7
    • Iwangoff P, Armbruster R, Enz A,and Meier-Ruge W. Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases. Mech Ageing Dev 14: 203-209, 1980. (Pubitemid 11175996)
    • (1980) Mechanisms of Ageing and Development , vol.14 , Issue.1-2 , pp. 203-209
    • Iwangoff, P.1    Armbruster, R.2    Enz, A.3    Meier-Ruge, W.4
  • 127
    • 33845791439 scopus 로고    scopus 로고
    • Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFκB and caspase-3
    • DOI 10.1016/j.freeradbiomed.2006.10.047, PII S0891584906006939
    • Jia Z and Misra HP. Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFkappaB and caspase-3. Free Radic Biol Med 42: 288-298, 2007. (Pubitemid 46001553)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.2 , pp. 288-298
    • Jia, Z.1    Misra, H.P.2
  • 128
    • 0014820378 scopus 로고
    • Nucleoside phosphatase activities associated with the tangles and plaques ofAlzheimer's disease: A histochemical study of natural and experimental neurofibrillary tangles
    • Johnson AB and Blum NR. Nucleoside phosphatase activities associated with the tangles and plaques ofAlzheimer's disease: A histochemical study of natural and experimental neurofibrillary tangles. J Neuropathol Exp Neurol 29: 463-478, 1970.
    • (1970) J Neuropathol Exp Neurol , vol.29 , pp. 463-478
    • Johnson, A.B.1    Blum, N.R.2
  • 129
    • 0033302310 scopus 로고    scopus 로고
    • Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease
    • Jope RS. Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease. J Alzheimers Dis 1: 231-247, 1999.
    • (1999) J Alzheimers Dis , vol.1 , pp. 231-247
    • Jope, R.S.1
  • 130
    • 0031720801 scopus 로고    scopus 로고
    • The incidence of dementia: A metaanalysis
    • Jorm AF and Jolley D. The incidence of dementia: A metaanalysis. Neurology 51: 728-733, 1998.
    • (1998) Neurology , vol.51 , pp. 728-733
    • Jorm, A.F.1    Jolley, D.2
  • 133
    • 0032889677 scopus 로고    scopus 로고
    • Redox regulation of cellular signalling
    • DOI 10.1016/S0898-6568(98)00037-0, PII S0898656898000370
    • Kamata H and Hirata H. Redox regulation of cellular signalling. Cell Signal 11: 1-14, 1999. (Pubitemid 28546635)
    • (1999) Cellular Signalling , vol.11 , Issue.1 , pp. 1-14
    • Kamata, H.1    Hirata, H.2
  • 134
    • 33847656213 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions
    • DOI 10.1016/j.mito.2006.11.017, PII S1567724906002406, Mitochondria and Life
    • Kang D, Kim SH, and Hamasaki N. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7: 39-44, 2007. (Pubitemid 46351974)
    • (2007) Mitochondrion , vol.7 , Issue.1-2 , pp. 39-44
    • Kang, D.1    Kim, S.H.2    Hamasaki, N.3
  • 135
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, and Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736, 1987. (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 138
    • 33646058269 scopus 로고    scopus 로고
    • Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease
    • Keller JN. Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease. J Biomed Biotechnol 2006: 12129, 2006.
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 12129
    • Keller, J.N.1
  • 140
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 42: 1097-1105, 1985. (Pubitemid 16236926)
    • (1985) Archives of Neurology , vol.42 , Issue.11 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 143
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
    • King MP and Attardi G. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation. Science 246: 500-503, 1989. (Pubitemid 19273941)
    • (1989) Science , vol.246 , Issue.4929 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 145
    • 0032944035 scopus 로고    scopus 로고
    • Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: A nonspecific change?
    • DOI 10.1046/j.1471-4159.1999.0720700.x
    • Kish SJ, Mastrogiacomo F, Guttman M, Furukawa Y, Taanman JW, Dozic S, Pandolfo M, Lamarche J, DiStefano L, and Chang LJ. Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: A nonspecific change? J Neurochem 72: 700-707, 1999. (Pubitemid 29055233)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.2 , pp. 700-707
    • Kish, S.J.1    Mastrogiacomo, F.2    Guttman, M.3    Furukawa, Y.4    Taanman, J.-W.5    Dozic, S.6    Pandolfo, M.7    Lamarche, J.8    DiStefano, L.9    Chang, L.-J.10
  • 146
    • 0031762232 scopus 로고    scopus 로고
    • Enhanced expression of the yeast Ure2 protein in Escherichia coli: The effect of synonymous codon substitutions at a selected place in the gene
    • Komar AA, Guillemet E, Reiss C, and Cullin C. Enhanced expression of the yeast Ure2 protein in Escherichia coli: The effect of synonymous codon substitutions at a selected place in the gene. Biol Chem 379: 1295-1300, 1998. (Pubitemid 28484449)
    • (1998) Biological Chemistry , vol.379 , Issue.10 , pp. 1295-1300
    • Komar, A.A.1    Guillemet, E.2    Reiss, C.3    Cullin, C.4
  • 147
    • 0032699491 scopus 로고    scopus 로고
    • Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation
    • Komar AA, Lesnik T, and Reiss C. Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation. FEBS Lett 462: 387-391, 1999.
    • (1999) FEBS Lett , vol.462 , pp. 387-391
    • Komar, A.A.1    Lesnik, T.2    Reiss, C.3
  • 150
    • 0028245164 scopus 로고
    • Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals
    • DOI 10.1016/0024-3205(94)90142-2
    • Kumar U, Dunlop DM, and Richardson JS. Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals. Life Sci 54: 1855-1860, 1994. (Pubitemid 24170244)
    • (1994) Life Sciences , vol.54 , Issue.24 , pp. 1855-1860
    • Kumar, U.1    Dunlop, D.M.2    Richardson, J.S.3
  • 151
    • 0029841302 scopus 로고    scopus 로고
    • Neurodegeneration in Alzheimer disease: Is apoptosis involved?
    • Kusiak JW, Izzo JA, and Zhao B. Neurodegeneration in Alzheimer disease. Is apoptosis involved? Mol Chem Neuropathol 28: 153-162, 1996. (Pubitemid 26275063)
    • (1996) Molecular and Chemical Neuropathology , vol.28 , Issue.1-3 , pp. 153-162
    • Kusiak, J.W.1    Izzo, J.A.2    Zhao, B.3
  • 156
    • 0029789253 scopus 로고    scopus 로고
    • Cholinergic stimulation of AP-1 and NFκB transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: Relationship to phosphoinositide hydrolysis
    • Li X, Song L, and Jope RS. Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: Relationship to phosphoinositide hydrolysis. J Neurosci 16: 5914-5922, 1996. (Pubitemid 26313967)
    • (1996) Journal of Neuroscience , vol.16 , Issue.19 , pp. 5914-5922
    • Li, X.1    Song, L.2    Jope, R.S.3
  • 157
    • 33750683018 scopus 로고    scopus 로고
    • Alzheimer's APP mangles mitochondria
    • DOI 10.1038/nm1106-1241, PII NM11061241
    • Lin MT and Beal MF. Alzheimer's APP mangles mitochondria. Nat Med 12: 1241-1243, 2006. (Pubitemid 44706922)
    • (2006) Nature Medicine , vol.12 , Issue.11 , pp. 1241-1243
    • Lin, M.T.1    Beal, M.F.2
  • 158
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • Lin MT, Simon DK, Ahn CH, Kim LM, and Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet 11: 133-145, 2002. (Pubitemid 34157005)
    • (2002) Human Molecular Genetics , vol.11 , Issue.2 , pp. 133-145
    • Lin, M.T.1    Simon, D.K.2    Ahn, C.H.3    Kim, L.M.4    Flint Beal, M.5
  • 159
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    • Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, and Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol 225: 54-62, 2011.
    • (2011) J Pathol , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 160
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • Lovell MA, Ehmann WD, Butler SM, and Markesbery WR. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45: 1594-1601, 1995.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Lovell, M.A.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 164
    • 0347670290 scopus 로고    scopus 로고
    • The T4336C variant is a marker of mitochondrial subhaplogroup h1, a common component of the russian and german gene pools
    • Maliarchuk BA and Derenko MV. [T4336C variant-A marker of mitochondrial subgroup H1, a common component of the Russian and German gene pool]. Genetika 37: 1578-1580, 2001. (Pubitemid 33770694)
    • (2001) Genetika , vol.37 , Issue.11 , pp. 1578-1580
    • Malyarchuk, B.A.1    Derenko, M.V.2
  • 165
    • 0043166643 scopus 로고    scopus 로고
    • Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease
    • DOI 10.1016/S0014-4886(03)00092-X
    • Mancuso M, Filosto M, Bosetti F, Ceravolo R, Rocchi A, Tognoni G, Manca ML, Solaini G, Siciliano G, and Murri L. Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease. Exp Neurol 182: 421-426, 2003. (Pubitemid 36937094)
    • (2003) Experimental Neurology , vol.182 , Issue.2 , pp. 421-426
    • Mancuso, M.1    Filosto, M.2    Bosetti, F.3    Ceravolo, R.4    Rocchi, A.5    Tognoni, G.6    Manca, M.L.7    Solaini, G.8    Siciliano, G.9    Murri, L.10
  • 166
  • 167
    • 33646152108 scopus 로고    scopus 로고
    • Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
    • Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, and Reddy PH. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15: 1437-1449, 2006.
    • (2006) Hum Mol Genet , vol.15 , pp. 1437-1449
    • Manczak, M.1    Anekonda, T.S.2    Henson, E.3    Park, B.S.4    Quinn, J.5    Reddy, P.H.6
  • 168
    • 79958721260 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
    • Manczak M, Calkins MJ, and Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage. Hum Mol Genet 220: 2495-2509, 2011.
    • (2011) Hum Mol Genet , vol.220 , pp. 2495-2509
    • Manczak, M.1    Calkins, M.J.2    Reddy, P.H.3
  • 169
    • 2342628596 scopus 로고    scopus 로고
    • Differential expression of oxidative phosphorylation genes in patients with alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
    • DOI 10.1385/NMM:5:2:147
    • Manczak M, Park BS, Jung Y, and Reddy PH. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5: 147-162, 2004. (Pubitemid 38596548)
    • (2004) NeuroMolecular Medicine , vol.5 , Issue.2 , pp. 147-162
    • Manczak, M.1    Park, B.S.2    Jung, Y.3    Reddy, P.H.4
  • 170
    • 0032733691 scopus 로고    scopus 로고
    • The role of oxidative stress in Alzheimer disease
    • Markesbery WR. The role of oxidative stress in Alzheimer disease. Arch Neurol 56: 1449-1452, 1999.
    • (1999) Arch Neurol , vol.56 , pp. 1449-1452
    • Markesbery, W.R.1
  • 172
    • 0022480081 scopus 로고
    • Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress
    • Martins RN, Harper CG, Stokes GB, and Masters CL. Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress. J Neurochem 46: 1042-1045, 1986. (Pubitemid 16010948)
    • (1986) Journal of Neurochemistry , vol.46 , Issue.4 , pp. 1042-1045
    • Martins, R.N.1    Harper, C.G.2    Stokes, G.B.3    Masters, C.L.4
  • 176
    • 0034612075 scopus 로고    scopus 로고
    • A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
    • DOI 10.1016/S0197-4580(00)00112-3, PII S0197458000001123
    • Maurer I, Zierz S, and Moller HJ. A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol Aging 21: 455-462, 2000. (Pubitemid 30349116)
    • (2000) Neurobiology of Aging , vol.21 , Issue.3 , pp. 455-462
    • Maurer, I.1    Zierz, S.2    Moller, H.-J.3
  • 177
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, and Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944, 1984. (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 179
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • DOI 10.1002/ana.410360510
    • Mecocci P, MacGarvey U, and Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36: 747-751, 1994. (Pubitemid 24337634)
    • (1994) Annals of Neurology , vol.36 , Issue.5 , pp. 747-751
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3
  • 180
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, and Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486, 1991.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 181
    • 0023747203 scopus 로고
    • Development and characterization of continuous avian cell lines depleted of mitochondrial DNA
    • Morais R, Desjardins P, Turmel C, and Zinkewich-Peotti K. Development and characterization of continuous avian cell lines depleted of mitochondrial DNA. In Vitro Cell Dev Biol 24: 649-658, 1988.
    • (1988) Vitro Cell Dev Biol , vol.24 , pp. 649-658
    • Morais, R.1    Desjardins, P.2    Turmel, C.3    Zinkewich-Peotti, K.4
  • 182
    • 71749121998 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
    • Moreira PI, Carvalho C, Zhu X, Smith MA, and Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim Biophys Acta 1802: 2-10, 2010.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 2-10
    • Moreira, P.I.1    Carvalho, C.2    Zhu, X.3    Smith, M.A.4    Perry, G.5
  • 183
    • 85027951376 scopus 로고    scopus 로고
    • Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes
    • Mosconi L, Berti V, Swerdlow RH, Pupi A, Duara R, and de Leon M. Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes. Hum Genomics 4: 170-193, 2010.
    • (2010) Hum Genomics , vol.4 , pp. 170-193
    • Mosconi, L.1    Berti, V.2    Swerdlow, R.H.3    Pupi, A.4    Duara, R.5    De Leon, M.6
  • 185
    • 80055088009 scopus 로고    scopus 로고
    • Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
    • Epub ahead of print
    • Mosconi L, de Leon M, Murray J, E L, Lu J, Javier E, McHugh P, and Swerdlow RH. Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease. JAD [Epub ahead of print, 2011].
    • (2011) JAD
    • Mosconi, L.1    De Leon, M.2    Murray, J.3    E, L.4    Lu, J.5    Javier, E.6    McHugh, P.7    Swerdlow, R.H.8
  • 189
    • 0028110234 scopus 로고
    • Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
    • Mutisya EM, Bowling AC, and Beal MF. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 63: 2179-2184, 1994. (Pubitemid 24369993)
    • (1994) Journal of Neurochemistry , vol.63 , Issue.6 , pp. 2179-2184
    • Mutisya, E.M.1    Bowling, A.C.2    Beal, M.F.3
  • 190
    • 0032973069 scopus 로고    scopus 로고
    • Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology
    • DOI 10.1007/s004010050997
    • Nagy Z, Esiri MM, LeGris M, and Matthews PM. Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology. Acta Neuropathol 97: 346-354, 1999. (Pubitemid 29134514)
    • (1999) Acta Neuropathologica , vol.97 , Issue.4 , pp. 346-354
    • Nagy, Zs.1    Esiri, M.M.2    LeGris, M.3    Matthews, P.M.4
  • 191
    • 70350668827 scopus 로고    scopus 로고
    • Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
    • Nakamura T, Watanabe A, Fujino T, Hosono T, and Michikawa M. Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. Mol Neurodegener 4: 35, 2009.
    • (2009) Mol Neurodegener , vol.4 , pp. 35
    • Nakamura, T.1    Watanabe, A.2    Fujino, T.3    Hosono, T.4    Michikawa, M.5
  • 194
    • 0029670993 scopus 로고    scopus 로고
    • Expression of the protooncogene bcl-2 in Alzheimer's disease brain
    • O'Barr S, Schultz J, and Rogers J. Expression of the protooncogene bcl-2 in Alzheimer's disease brain. Neurobiol Aging 17: 131-136, 1996.
    • (1996) Neurobiol Aging , vol.17 , pp. 131-136
    • O'Barr, S.1    Schultz, J.2    Rogers, J.3
  • 195
    • 77956309945 scopus 로고    scopus 로고
    • Nerve growth factor attenuates oxidant-induced beta-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
    • Onyango IG, Ahn JY, Tuttle JB, Bennett JP, Jr., and Swerdlow RH. Nerve growth factor attenuates oxidant-induced beta-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids. J Neurochem 114: 1605-1618, 2010.
    • (2010) J Neurochem , vol.114 , pp. 1605-1618
    • Onyango, I.G.1    Ahn, J.Y.2    Tuttle, J.B.3    Bennett Jr., J.P.4    Swerdlow, R.H.5
  • 196
    • 17544378704 scopus 로고    scopus 로고
    • Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids
    • DOI 10.1016/j.nbd.2005.01.026
    • Onyango IG, Bennett JP, Jr., and Tuttle JB. Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids. Neurobiol Dis 19: 312-322, 2005. (Pubitemid 40552821)
    • (2005) Neurobiology of Disease , vol.19 , Issue.1-2 , pp. 312-322
    • Onyango, I.G.1    Bennett Jr., J.P.2    Tuttle, J.B.3
  • 197
    • 19444381217 scopus 로고    scopus 로고
    • Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by β-amyloid peptide acting through receptor for advanced glycation end products (RAGE)
    • DOI 10.1016/j.mcn.2005.02.012, PII S1044743105000485
    • Onyango IG, Tuttle JB, and Bennett JP, Jr. Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by beta-amyloid peptide acting through receptor for advanced glycation end products (RAGE). Mol Cell Neurosci 29: 333-343, 2005. (Pubitemid 40725622)
    • (2005) Molecular and Cellular Neuroscience , vol.29 , Issue.2 , pp. 333-343
    • Onyango, I.G.1    Tuttle, J.B.2    Bennett Jr., J.P.3
  • 199
    • 0026823074 scopus 로고
    • Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease
    • Pappolla MA, Omar RA, Kim KS, and Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am J Pathol 140: 621-628, 1992.
    • (1992) Am J Pathol , vol.140 , pp. 621-628
    • Pappolla, M.A.1    Omar, R.A.2    Kim, K.S.3    Robakis, N.K.4
  • 200
    • 0025829045 scopus 로고
    • Similarity of human mitochondrial transcription factor 1 to high mobility group proteins
    • Parisi MA and Clayton DA. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252: 965-969, 1991. (Pubitemid 21917015)
    • (1991) Science , vol.252 , Issue.5008 , pp. 965-969
    • Parisi, M.A.1    Clayton, D.A.2
  • 202
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • DOI 10.1002/ana.410260606
    • Parker WD, Jr., Boyson SJ, and Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26: 719-23, 1989. (Pubitemid 20011004)
    • (1989) Annals of Neurology , vol.26 , Issue.6 , pp. 719-723
    • Parker Jr., W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 203
    • 0025024024 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer's disease
    • Parker WD, Jr., Filley CM, and Parks JK. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40: 1302-1303, 1990. (Pubitemid 20244999)
    • (1990) Neurology , vol.40 , Issue.8 , pp. 1302-1303
    • Parker Jr., W.D.1    Filley, C.M.2    Parks, J.K.3
  • 205
    • 0028236018 scopus 로고
    • Electron transport chain defects in Alzheimer's disease brain
    • Parker WD, Jr., Parks J, Filley CM, and Kleinschmidt-De-Masters BK. Electron transport chain defects in Alzheimer's disease brain. Neurology 44: 1090-1096, 1994. (Pubitemid 24188184)
    • (1994) Neurology , vol.44 , Issue.6 , pp. 1090-1096
    • Parker Jr., W.D.1    Parks, J.2    Filley, C.M.3    Kleinschmidt-DeMasters, B.K.4
  • 206
    • 0029055772 scopus 로고
    • Cytochrome c oxidase in Alzheimer's disease brain: Purification and characterization
    • Parker WD, Jr. and Parks JK. Cytochrome c oxidase in Alzheimer's disease brain: Purification and characterization. Neurology 45: 482-486, 1995.
    • (1995) Neurology , vol.45 , pp. 482-486
    • Parker Jr., W.D.1    Parks, J.K.2
  • 207
    • 0034745636 scopus 로고    scopus 로고
    • Neurotoxic Aβ peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro
    • DOI 10.1046/j.1471-4159.2001.00112.x
    • Parks JK, Smith TS, Trimmer PA, Bennett JP, Jr., and Parker WD, Jr. Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro. J Neurochem 76: 1050-1056, 2001. (Pubitemid 32167378)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.4 , pp. 1050-1056
    • Parks, J.K.1    Smith, T.S.2    Trimmer, P.A.3    Bennett Jr., J.P.4    Davis Parker, W.Jr.5
  • 209
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • DOI 10.1073/pnas.91.22.10625
    • Pellerin L and Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91: 10625-10629, 1994. (Pubitemid 24329051)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.22 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 210
    • 0032104130 scopus 로고    scopus 로고
    • Mitochondrial function impairment induced by amyloid β-peptide on PC12 cells
    • Pereira C, Santos MS, and Oliveira C. Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells. Neuroreport 9: 1749-1755, 1998. (Pubitemid 28289179)
    • (1998) NeuroReport , vol.9 , Issue.8 , pp. 1749-1755
    • Pereira, C.1    Santos, M.S.2    Oliveira, C.3
  • 212
    • 0018826694 scopus 로고
    • Coenzyme A-acetylating enzymes in Alzheimer's disease: Possible cholinergic 'compartment' of pyruvate dehydrogenase
    • DOI 10.1016/0304-3940(80)90220-7
    • Perry EK, Perry RH, Tomlinson BE, Blessed G, and Gibson PH. Coenzyme A-acetylating enzymes in Alzheimer's disease: Possible cholinergic 'compartment' of pyruvate dehydrogenase. Neurosci Lett 18: 105-110, 1980. (Pubitemid 10122792)
    • (1980) Neuroscience Letters , vol.18 , Issue.1 , pp. 105-110
    • Perry, E.K.1    Perry, R.H.2    Tomlinson, B.E.3
  • 214
    • 0022001659 scopus 로고
    • Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease
    • Peterson C, Gibson GE, and Blass JP. Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease. N Engl J Med 312: 1063-1065, 1985. (Pubitemid 15114304)
    • (1985) New England Journal of Medicine , vol.312 , Issue.16 , pp. 1063-1065
    • Peterson, C.1    Gibson, G.E.2    Blass, J.P.3
  • 216
    • 0029036412 scopus 로고
    • Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
    • Petit PX, Lecoeur H, Zorn E, Dauguet C, Mignotte B, and Gougeon ML. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J Cell Biol 130: 157-167, 1995.
    • (1995) J Cell Biol , vol.130 , pp. 157-167
    • Petit, P.X.1    Lecoeur, H.2    Zorn, E.3    Dauguet, C.4    Mignotte, B.5    Gougeon, M.L.6
  • 218
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
    • DOI 10.1093/hmg/ddh140
    • Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, Jung Y, Yau V, Searles R, Mori M, and Quinn J. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet 13: 1225-1240, 2004. (Pubitemid 38877876)
    • (2004) Human Molecular Genetics , vol.13 , Issue.12 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3    Manczak, M.4    Gutala, R.V.5    Partovi, D.6    Jung, Y.7    Yau, V.8    Searles, R.9    Mori, M.10    Quinn, J.11
  • 219
    • 2342558065 scopus 로고    scopus 로고
    • Akt activity in Alzheimer's disease and other neurodegenerative disorders
    • DOI 10.1097/00001756-200404290-00005
    • Rickle A, Bogdanovic N, Volkman I, Winblad B, Ravid R, and Cowburn RF. Akt activity in Alzheimer's disease and other neurodegenerative disorders. Neuroreport 15: 955-959, 2004. (Pubitemid 38591242)
    • (2004) NeuroReport , vol.15 , Issue.6 , pp. 955-959
    • Rickle, A.1    Bogdanovic, N.2    Volkman, I.3    Winblad, B.4    Ravid, R.5    Cowburn, R.F.6
  • 221
    • 0035899154 scopus 로고    scopus 로고
    • Existe relación entre la enfermedad de Alzheimer y defectos en el ADN mitocondrial?
    • Rodriguez Santiago B, Casademont J, and Nunes V. [Is there a relation between Alzheimer s disease and defects of mitochondrial DNA?]. Rev Neurol 33: 301-305, 2001. (Pubitemid 32971525)
    • (2001) Revista de Neurologia , vol.33 , Issue.4 , pp. 301-305
    • Rodriguez-Santiago, B.1    Casademont, J.2    Nunes, V.3
  • 223
    • 77952187277 scopus 로고    scopus 로고
    • An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease
    • Roses AD. An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Arch Neurol 67: 536-541, 2010.
    • (2010) Arch Neurol , vol.67 , pp. 536-541
    • Roses, A.D.1
  • 225
    • 33847293352 scopus 로고    scopus 로고
    • Complex disease-associated pharmacogenetics: Drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)
    • DOI 10.1038/sj.tpj.6500397, PII 6500397
    • Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, and Mahley RW. Complex disease-associated pharmacogenetics: Drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J 7: 10-28, 2007. (Pubitemid 46322076)
    • (2007) Pharmacogenomics Journal , vol.7 , Issue.1 , pp. 10-28
    • Roses, A.D.1    Saunders, A.M.2    Huang, Y.3    Strum, J.4    Weisgraber, K.H.5    Mahley, R.W.6
  • 226
    • 0030601663 scopus 로고    scopus 로고
    • Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
    • DOI 10.1016/0306-4522(96)00273-4, PII S0306452296002734
    • Salehi A, Verhaagen J, Dijkhuizen PA, and Swaab DF. Colocalization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75: 373-387, 1996. (Pubitemid 26361330)
    • (1996) Neuroscience , vol.75 , Issue.2 , pp. 373-387
    • Salehi, A.1    Verhaagen, J.2    Dijkhuizen, P.A.3    Swaab, D.F.4
  • 228
    • 0034648063 scopus 로고    scopus 로고
    • Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
    • DOI 10.1016/S0304-3940(00)01229-5, PII S0304394000012295
    • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, and Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288: 163-166, 2000. (Pubitemid 30392436)
    • (2000) Neuroscience Letters , vol.288 , Issue.2 , pp. 163-166
    • Satoh, T.1    Nakatsuka, D.2    Watanabe, Y.3    Nagata, I.4    Kikuchi, H.5    Namura, S.6
  • 229
    • 0026970404 scopus 로고
    • Nuclear factor κβ: An oxidative stress-responsive transcription factor of eukaryotic cells (A review)
    • Schreck R, Albermann K, and Baeuerle PA. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17: 221-237, 1992. (Pubitemid 23207431)
    • (1992) Free Radical Research Communications , vol.17 , Issue.4 , pp. 221-237
    • Schreck, R.1    Albermann, K.2    Baeuerle, P.A.3
  • 230
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
    • Schreck R, Rieber P, and Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κ B transcription factor and HIV. EMBO J 10: 2247-2258, 1991. (Pubitemid 21905698)
    • (1991) EMBO Journal , vol.10 , Issue.8 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 233
    • 0030923869 scopus 로고    scopus 로고
    • Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
    • Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, and Tuttle JB. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci 17: 4612-4622, 1997. (Pubitemid 27246919)
    • (1997) Journal of Neuroscience , vol.17 , Issue.12 , pp. 4612-4622
    • Sheehan, J.P.1    Swerdlow, R.H.2    Miller, S.W.3    Davis, R.E.4    Parks, J.K.5    Parker, W.D.6    Tuttle, J.B.7
  • 234
    • 0031017696 scopus 로고    scopus 로고
    • Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease
    • Sheehan JP, Swerdlow RH, Parker WD, Miller SW, Davis RE, and Tuttle JB. Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem 68: 1221-1233, 1997. (Pubitemid 27086228)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.3 , pp. 1221-1233
    • Sheehan, J.P.1    Swerdlow, R.H.2    Parker, W.D.3    Miller, S.W.4    Davis, R.E.5    Tuttle, J.B.6
  • 236
    • 0027265320 scopus 로고
    • Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease
    • Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, and Taniguchi T. Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology 43: 1407-1413, 1993. (Pubitemid 23213819)
    • (1993) Neurology , vol.43 , Issue.7 , pp. 1407-1413
    • Shimohama, S.1    Narita, M.2    Matsushima, H.3    Kimura, J.4    Kameyama, M.5    Hagiwara, M.6    Hidaka, H.7    Taniguchi, T.8
  • 238
    • 80053559887 scopus 로고    scopus 로고
    • Amyloid-beta-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway
    • in press
    • Silva DF, Esteves AR, Arduino DM, Oliveira CR, Cardoso SM. Amyloid-beta-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway. J Alzheimers Dis in press, 2011.
    • (2011) J Alzheimers Dis
    • Silva, D.F.1    Esteves, A.R.2    Arduino, D.M.3    Oliveira, C.R.4    Cardoso, S.M.5
  • 239
    • 79959926983 scopus 로고    scopus 로고
    • Mitochondria: The common upstream driver of amyloidbeta and tau pathology in Alzheimer's disease
    • in press
    • Silva DFF, Esteves AR, Oliveira CR, and Cardoso SM. Mitochondria: The common upstream driver of amyloidbeta and tau pathology in Alzheimer's disease. Curr Alzheimer Res in press, 2011.
    • (2011) Curr Alzheimer Res
    • Dff, S.1    Esteves, A.R.2    Oliveira, C.R.3    Cardoso, S.M.4
  • 240
    • 0027420891 scopus 로고
    • Functional alterations in Alzheimer's disease: Diminution of cytochrome oxidase in the hippocampal formation
    • Simonian NA and Hyman BT. Functional alterations in Alzheimer's disease: Diminution of cytochrome oxidase in the hippocampal formation. J Neuropathol Exp Neurol 52: 580-585, 1993. (Pubitemid 23335733)
    • (1993) Journal of Neuropathology and Experimental Neurology , vol.52 , Issue.6 , pp. 580-585
    • Simonian, N.A.1    Hyman, B.T.2
  • 241
    • 0021849778 scopus 로고
    • Altered glucose metabolism in fibroblasts from patients with Alzheimer's disease
    • Sims NR, Finegan JM, and Blass JP. Altered glucose metabolism in fibroblasts from patients with Alzheimer's disease. N Engl J Med 313: 638-639, 1985. (Pubitemid 15012944)
    • (1985) New England Journal of Medicine , vol.313 , Issue.10 , pp. 638-639
    • Sims, N.R.1    Finegan, J.M.2    Blass, J.P.3
  • 242
    • 0023191781 scopus 로고
    • Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease
    • DOI 10.1002/ana.410210507
    • Sims NR, Finegan JM, and Blass JP. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. Ann Neurol 21: 451-457, 1987. (Pubitemid 17068544)
    • (1987) Annals of Neurology , vol.21 , Issue.5 , pp. 451-457
    • Sims, N.R.1    Finegan, J.M.2    Blass, J.P.3
  • 243
    • 0023627915 scopus 로고
    • Mitochondrial function in brain tissue in primary degenerative dementia
    • DOI 10.1016/0006-8993(87)91553-8
    • Sims NR, Finegan JM, Blass JP, Bowen DM, and Neary D. Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res 436: 30-38, 1987. (Pubitemid 17167132)
    • (1987) Brain Research , vol.436 , Issue.1 , pp. 30-38
    • Sims, N.R.1    Finegan, J.M.2    Blass, J.P.3    Bowen, D.M.4    Neary, D.5
  • 247
    • 0020685951 scopus 로고
    • Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
    • DOI 10.1002/ana.410130116
    • Sorbi S, Bird ED, and Blass JP. Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann Neurol 13: 72-78, 1983. (Pubitemid 13224203)
    • (1983) Annals of Neurology , vol.13 , Issue.1 , pp. 72-78
    • Sorbi, S.1    Bird, E.D.2    Blass, J.P.3
  • 249
    • 70350012316 scopus 로고    scopus 로고
    • Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: Correlations with behavior and oxidative stress
    • Strazielle C, Jazi R, Verdier Y, Qian S, and Lalonde R. Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: Correlations with behavior and oxidative stress. Neurochem Int 55: 806-814, 2009.
    • (2009) Neurochem Int , vol.55 , pp. 806-814
    • Strazielle, C.1    Jazi, R.2    Verdier, Y.3    Qian, S.4    Lalonde, R.5
  • 251
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su JH, Anderson AJ, Cummings BJ, and Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport 5: 2529-2533, 1994.
    • (1994) Neuroreport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 252
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in alzheimer's brain: Correlations with DNA damage, bcl-2 expression, and brain pathology
    • Su JH, Deng G, and Cotman CW. Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol 56: 86-93, 1997. (Pubitemid 127470330)
    • (1997) Journal of Neuropathology and Experimental Neurology , vol.56 , Issue.1 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 254
    • 0014193263 scopus 로고
    • Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia
    • Suzuki K and Terry RD. Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia. Acta Neuropathol 8: 276-284, 1967.
    • (1967) Acta Neuropathol , vol.8 , pp. 276-284
    • Suzuki, K.1    Terry, R.D.2
  • 256
    • 34547777983 scopus 로고    scopus 로고
    • Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
    • DOI 10.1016/j.neurobiolaging.2006.06.021, PII S0197458006002351
    • Swerdlow RH. Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging? Neurobiol Aging 28: 1465-1480, 2007. (Pubitemid 47238532)
    • (2007) Neurobiology of Aging , vol.28 , Issue.10 , pp. 1465-1480
    • Swerdlow, R.H.1
  • 257
    • 34347353834 scopus 로고    scopus 로고
    • Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
    • DOI 10.1002/jnr.21167
    • Swerdlow RH. Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies. J Neurosci Res 85: 3416-3428, 2007. (Pubitemid 350058530)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.15 , pp. 3416-3428
    • Swerdlow, R.H.1
  • 258
    • 38449107280 scopus 로고    scopus 로고
    • Pathogenesis of Alzheimer's disease
    • Swerdlow RH. Pathogenesis of Alzheimer's disease. Clin Interv Aging 2: 347-359, 2007.
    • (2007) Clin Interv Aging , vol.2 , pp. 347-359
    • Swerdlow, R.H.1
  • 259
    • 68949158352 scopus 로고    scopus 로고
    • The neurodegenerative mitochondriopathies
    • Swerdlow RH. The neurodegenerative mitochondriopathies. J Alzheimers Dis 17: 737-751, 2009.
    • (2009) J Alzheimers Dis , vol.17 , pp. 737-751
    • Swerdlow, R.H.1
  • 260
    • 77956224679 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis
    • Swerdlow RH, Burns JM, and Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis 20: S265-279, 2010.
    • (2010) J Alzheimers Dis , vol.20
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 261
    • 3042806534 scopus 로고    scopus 로고
    • A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease
    • DOI 10.1016/j.mehy.2003.12.045, PII S0306987704001252
    • Swerdlow RH and Khan SM. A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. Med Hypotheses 63: 8-20, 2004. (Pubitemid 38887104)
    • (2004) Medical Hypotheses , vol.63 , Issue.1 , pp. 8-20
    • Swerdlow, R.H.1    Khan, S.M.2
  • 262
    • 67649687124 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis: An update
    • Swerdlow RH and Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis: An update. Exp Neurol 218: 308-315, 2009.
    • (2009) Exp Neurol , vol.218 , pp. 308-315
    • Swerdlow, R.H.1    Khan, S.M.2
  • 263
    • 0036982389 scopus 로고    scopus 로고
    • Mitochondria in Alzheimer's disease
    • Swerdlow RH and Kish SJ. Mitochondria in Alzheimer's disease. Int Rev Neurobiol 53: 341-385, 2002.
    • (2002) Int Rev Neurobiol , vol.53 , pp. 341-385
    • Swerdlow, R.H.1    Kish, S.J.2
  • 265
    • 4043168542 scopus 로고    scopus 로고
    • A chronic Alzheimer's model evoked by mitochondrial poison sodium azide for pharmacological investigations
    • DOI 10.1016/j.bbr.2004.01.016, PII S016643280400021X
    • Szabados T, Dul C, Majtenyi K, Hargitai J, Penzes Z, and Urbanics R. A chronic Alzheimer's model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav Brain Res 154: 31-40, 2004. (Pubitemid 39070450)
    • (2004) Behavioural Brain Research , vol.154 , Issue.1 , pp. 31-40
    • Szabados, T.1    Dul, C.2    Majtenyi, K.3    Hargitai, J.4    Penzes, Z.5    Urbanics, R.6
  • 266
    • 70449435784 scopus 로고    scopus 로고
    • Mitochondrial haplogroups associated with Japanese Alzheimer's patients
    • Takasaki S. Mitochondrial haplogroups associated with Japanese Alzheimer's patients. J Bioenerg Biomembr 41: 407-410, 2009.
    • (2009) J Bioenerg Biomembr , vol.41 , pp. 407-410
    • Takasaki, S.1
  • 271
    • 12844288997 scopus 로고    scopus 로고
    • Widespread γ-secretase activity in the cell, but do we need it at the mitochondria?
    • DOI 10.1016/j.bbrc.2004.12.131, PII S0006291X04029419
    • Teng FY and Tang BL. Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria? Biochem Biophys Res Commun 328: 1-5, 2005. (Pubitemid 40164626)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.1 , pp. 1-5
    • Teng, F.Y.H.1    Tang, B.L.2
  • 272
    • 16844369318 scopus 로고    scopus 로고
    • +2 exchange are reduced in Alzheimer's disease cybrids
    • DOI 10.1016/j.mito.2004.12.002, PII S1567724904002508
    • Thiffault C and Bennett JP, Jr. Cyclical mitochondrial deltapsiM fluctuations linked to electron transport, F0F1 ATPsynthase and mitochondrial Na +Ca + 2 exchange are reduced in Alzheimer's disease cybrids. Mitochondrion 5: 109-119, 2005. (Pubitemid 40485770)
    • (2005) Mitochondrion , vol.5 , Issue.2 , pp. 109-119
    • Thiffault, C.1    Bennett Jr., J.P.2
  • 273
    • 2642620565 scopus 로고    scopus 로고
    • Bcl-2 and Bax protein expression in Alzheimer's disease
    • DOI 10.1007/s004010050817
    • Tortosa A, Lopez E, and Ferrer I. Bcl-2 and Bax protein expression in Alzheimer's disease. Acta Neuropathol 95: 407-412, 1998. (Pubitemid 28142550)
    • (1998) Acta Neuropathologica , vol.95 , Issue.4 , pp. 407-412
    • Tortosa, A.1    Lopez, E.2    Ferrer, I.3
  • 275
    • 24144438228 scopus 로고    scopus 로고
    • Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement
    • DOI 10.1089/ars.2005.7.1101
    • Trimmer PA and Borland MK. Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement. Antioxid Redox Signal 7: 1101-1109, 2005. (Pubitemid 41232506)
    • (2005) Antioxidants and Redox Signaling , vol.7 , Issue.9-10 , pp. 1101-1109
    • Trimmer, P.A.1    Borland, M.K.2
  • 278
    • 34247485841 scopus 로고    scopus 로고
    • Role of the mitochondrial membrane permeability transition in cell death
    • DOI 10.1007/s10495-006-0525-7, Special Issue on Mitochondria in Apoptosis
    • Tsujimoto Y and Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 12: 835-840, 2007. (Pubitemid 46653286)
    • (2007) Apoptosis , vol.12 , Issue.5 , pp. 835-840
    • Tsujimoto, Y.1    Shimizu, S.2
  • 279
    • 25444520989 scopus 로고    scopus 로고
    • Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma cybrids
    • DOI 10.1534/genetics.105.043653
    • Turner CJ, Granycome C, Hurst R, Pohler E, Juhola MK, Juhola MI, Jacobs HT, Sutherland L, and Holt IJ. Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma cybrids. Genetics 170: 1879-1885, 2005. (Pubitemid 41362839)
    • (2005) Genetics , vol.170 , Issue.4 , pp. 1879-1885
    • Turner, C.J.1    Granycome, C.2    Hurst, R.3    Pohler, E.4    Juhola, M.K.5    Juhola, M.I.6    Jacobs, H.T.7    Sutherland, L.8    Holt, I.J.9
  • 280
    • 0035399655 scopus 로고    scopus 로고
    • Energy hypometabolism in posterior cingulate cortex of Alzheimer's
    • Valla J, Berndt JD, and Gonzalez-Lima F. Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: Superficial laminar cytochrome oxidase associated with disease duration. J Neurosci 21: 4923-4930, 2001. (Pubitemid 32565651)
    • (2001) Journal of Neuroscience , vol.21 , Issue.13 , pp. 4923-4930
    • Valla, J.1    Berndt, J.D.2    Gonzalez-Lima, F.3
  • 282
    • 78650639655 scopus 로고    scopus 로고
    • Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimer's susceptibility gene
    • Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, Corneveaux JJ, Huentelman MJ, Caselli RJ, and Reiman EM. Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimer's susceptibility gene. J Alzheimers Dis 22: 307-313, 2010.
    • (2010) J Alzheimers Dis , vol.22 , pp. 307-313
    • Valla, J.1    Yaari, R.2    Wolf, A.B.3    Kusne, Y.4    Beach, T.G.5    Roher, A.E.6    Corneveaux, J.J.7    Huentelman, M.J.8    Caselli, R.J.9    Reiman, E.M.10
  • 284
    • 0034116863 scopus 로고    scopus 로고
    • Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits
    • DOI 10.1006/exnr.2000.7385
    • Verwer RW, Jansen KA, Sluiter AA, Pool CW, Kamphorst W, and Swaab DF. Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits. Exp Neurol 163: 440-451, 2000. (Pubitemid 30399094)
    • (2000) Experimental Neurology , vol.163 , Issue.2 , pp. 440-451
    • Verwer, R.W.H.1    Jansen, K.A.2    Sluiter, A.A.3    Pool, C.W.4    Kamphorst, W.5    Swaab, D.F.6
  • 285
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace DC. Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science 256: 628-632, 1992.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 286
    • 0016720436 scopus 로고
    • Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells
    • Wallace DC, Bunn CL, and Eisenstadt JM. Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells. J Cell Biol 67: 174-188, 1975.
    • (1975) J Cell Biol , vol.67 , pp. 174-188
    • Wallace, D.C.1    Bunn, C.L.2    Eisenstadt, J.M.3
  • 287
    • 48749085779 scopus 로고    scopus 로고
    • Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
    • Wang X, Su B, Fujioka H, and Zhu X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 173: 470-482, 2008.
    • (2008) Am J Pathol , vol.173 , pp. 470-482
    • Wang, X.1    Su, B.2    Fujioka, H.3    Zhu, X.4
  • 288
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, and Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29: 9090-9103, 2009.
    • (2009) J Neurosci , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 289
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, and Zhu X. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 105: 19318-19323, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6    Casadesus, G.7    Zhu, X.8
  • 290
    • 0031767946 scopus 로고    scopus 로고
    • The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells
    • DOI 10.1007/s007020050098
    • Webster MT, Pearce BR, Bowen DM, and Francis PT. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells. J Neural Transm 105: 839-853, 1998. (Pubitemid 28539833)
    • (1998) Journal of Neural Transmission , vol.105 , Issue.8-9 , pp. 839-853
    • Webster, M.-T.1    Pearce, B.R.2    Bowen, D.M.3    Francis, P.T.4
  • 292
    • 0030830677 scopus 로고    scopus 로고
    • Cytochrome oxidase in Alzheimer's disease: Biochemical, histochemical, and immunohistochemical analyses of the visual and other systems
    • DOI 10.1016/S0042-6989(96)00210-6, PII S0042698996002106
    • Wong-Riley M, Antuono P, Ho KC, Egan R, Hevner R, Liebl W, Huang Z, Rachel R, and Jones J. Cytochrome oxidase in Alzheimer's disease: Biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res 37: 3593-3608, 1997. (Pubitemid 27491637)
    • (1997) Vision Research , vol.37 , Issue.24 , pp. 3593-3608
    • Wong-Riley, M.1    Antuono, P.2    Ho, K.-C.3    Egan, R.4    Hevner, R.5    Liebl, W.6    Huang, Z.7    Rachel, R.8    Jones, J.9
  • 293
    • 0024561501 scopus 로고
    • Cytochrome oxidase: An endogenous metabolic marker for neuronal activity
    • Wong-Riley MT. Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci 12: 94-101, 1989. (Pubitemid 19067056)
    • (1989) Trends in Neurosciences , vol.12 , Issue.3 , pp. 94-101
    • Wong-Riley, M.T.T.1
  • 294
    • 0028843809 scopus 로고
    • No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant
    • Wragg MA, Talbot CJ, Morris JC, Lendon CL, Goate AM. No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant. Neurosci Lett 201: 107-110, 1995.
    • (1995) Neurosci Lett , vol.201 , pp. 107-110
    • Wragg, M.A.1    Talbot, C.J.2    Morris, J.C.3    Lendon, C.L.4    Goate, A.M.5
  • 296
    • 0026486606 scopus 로고
    • Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes
    • Yamaguchi H, Yamazaki T, Ishiguro K, Shoji M, Nakazato Y, Hirai S. Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes. Acta Neuropathol 85: 15-22, 1992.
    • (1992) Acta Neuropathol , vol.85 , pp. 15-22
    • Yamaguchi, H.1    Yamazaki, T.2    Ishiguro, K.3    Shoji, M.4    Nakazato, Y.5    Hirai, S.6
  • 297
    • 0032716550 scopus 로고    scopus 로고
    • Starvation induces tau hyperphosphorylation in mouse brain: Implications for Alzheimer's disease
    • DOI 10.1016/S0014-5793(99)01480-5, PII S0014579399014805
    • Yanagisawa M, Planel E, Ishiguro K, Fujita SC. Starvation induces tau hyperphosphorylation in mouse brain: Implications for Alzheimer's disease. FEBS Lett 461: 329-333, 1999. (Pubitemid 29533357)
    • (1999) FEBS Letters , vol.461 , Issue.3 , pp. 329-333
    • Yanagisawa, M.1    Planel, E.2    Ishiguro, K.3    Fujita, S.C.4
  • 298
    • 79951548587 scopus 로고    scopus 로고
    • Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease
    • Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS. Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci 31: 2313-2320, 2011.
    • (2011) J Neurosci , vol.31 , pp. 2313-2320
    • Yao, J.1    Du, H.2    Yan, S.3    Fang, F.4    Wang, C.5    Lue, L.F.6    Guo, L.7    Chen, D.8    Stern, D.M.9    Gunn Moore, F.J.10    Xi Chen, J.11    Arancio, O.12    Yan, S.S.13
  • 299
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, and Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106: 14670-14675, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 300
    • 34248142174 scopus 로고    scopus 로고
    • Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association
    • DOI 10.1016/j.ygeno.2007.02.002, PII S088875430700050X
    • Yu CE, Seltman H, Peskind ER, Galloway N, Zhou PX, Rosenthal E, Wijsman EM, Tsuang DW, Devlin B, and Schellenberg GD. Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association. Genomics 89: 655-665, 2007. (Pubitemid 46719797)
    • (2007) Genomics , vol.89 , Issue.6 , pp. 655-665
    • Yu, C.-E.1    Seltman, H.2    Peskind, E.R.3    Galloway, N.4    Zhou, P.X.5    Rosenthal, E.6    Wijsman, E.M.7    Tsuang, D.W.8    Devlin, B.9    Schellenberg, G.D.10
  • 301
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere JL, Petit PX, and Kroemer G. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 181: 1661-1672, 1995.
    • (1995) J Exp Med , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.4    Vayssiere, J.L.5    Petit, P.X.6    Kroemer, G.7
  • 302
    • 78649812471 scopus 로고    scopus 로고
    • Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways
    • Zhang H, Liu Y, Lao M, Ma Z, and Yi X. Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Exp Gerontol 46: 30-37, 2011.
    • (2011) Exp Gerontol , vol.46 , pp. 30-37
    • Zhang, H.1    Liu, Y.2    Lao, M.3    Ma, Z.4    Yi, X.5
  • 303
    • 78651079796 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese
    • Zhang Q, Yu JT, Wang P, Chen W, Wu ZC, Jiang H, and Tan L. Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese. Brain Res 1368: 355-360, 2011.
    • (2011) Brain Res , vol.1368 , pp. 355-360
    • Zhang, Q.1    Yu, J.T.2    Wang, P.3    Chen, W.4    Wu, Z.C.5    Jiang, H.6    Tan, L.7
  • 304
    • 0034797352 scopus 로고    scopus 로고
    • Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: The 'two hit' hypothesis
    • DOI 10.1016/S0047-6374(01)00342-6, PII S0047637401003426
    • Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, and Smith MA. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech Ageing Dev 123: 39-46, 2001. (Pubitemid 32972257)
    • (2001) Mechanisms of Ageing and Development , vol.123 , Issue.1 , pp. 39-46
    • Zhu, X.1    Castellani, R.J.2    Takeda, A.3    Nunomura, A.4    Atwood, C.S.5    Perry, G.6    Smith, M.A.7
  • 305
    • 0035142804 scopus 로고    scopus 로고
    • Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
    • DOI 10.1046/j.1471-4159.2001.00046.x
    • Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, and Smith MA. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem76: 435-441, 2001. (Pubitemid 32097021)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.2 , pp. 435-441
    • Zhu, X.1    Raina, A.K.2    Rottkamp, C.A.3    Aliev, G.4    Perry, G.5    Boux, H.6    Smith, M.A.7
  • 306
    • 0344625398 scopus 로고    scopus 로고
    • No mitochondrial haplotype was found to increase risk for Alzheimer's disease
    • DOI 10.1016/S0006-3223(97)00461-7, PII S0006322398004617
    • Zsurka G, Kalman J, Csaszar A, Rasko I, Janka Z, and Venetianer P. No mitochondrial haplotype was found to increase risk for Alzheimer's disease. Biol Psychiatry 44: 371-373, 1998. (Pubitemid 28445518)
    • (1998) Biological Psychiatry , vol.44 , Issue.5 , pp. 371-373
    • Zsurka, G.1    Kalman, J.2    Juhasz, A.3    Csaszar, A.4    Rasko, I.5    Janka, Z.6    Venetianer, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.