Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons

Journal of Neuroscience

Volumn 27, Issue 29, 2007, Pages 7827-7837

  Escobar Khondiker, Myriam ^a,b,c   Höllerhage, Matthias ^a   Muriel, Marie Paule ^b,c   Champy, Pierre ^d   Bach, Antoine ^b,c   Depienne, Christel ^b,c   Respondek, Gesine ^a   Yamada, Elizabeth S ^a   Lannuzel, Annie ^b,c,f   Yagi, Takao ^e   Hirsch, Etienne C ^b,c   Oertel, Wolfgang H ^a   Jacob, Ralf ^a   Michel, Patrick P ^b,c   Ruberg, Merle ^b,c   Höglinger, Günter U ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f Centre Hospitalier Universitaire des Antilles et de la Guyane   (Guadeloupe)

Author keywords

Annonacin; Axonal transport; Microtubule associated protein tau; Mitochondrial complex I; NDI1; Parkinsonism

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 3 NITROPROPIONIC ACID; ADENOSINE TRIPHOSPHATE; ANNONACIN; ANTIOXIDANT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; NEUROTOXIN; PACLITAXEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TAU PROTEIN;

ANAEROBIC GLYCOLYSIS; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; ENERGY YIELD; FEMALE; MAMMAL CELL; MICROTUBULE; MITOCHONDRION; NERVE CELL; NERVE FIBER; NONHUMAN; OUTER MEMBRANE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ENZYME INHIBITORS; FEMALE; FURANS; LACTONES; MICROSCOPY, IMMUNOELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; PACLITAXEL; PREGNANCY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TAU PROTEINS; TUBULIN MODULATORS;

EID: 34447619518     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1644-07.2007     Document Type: Article

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