Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

Journal of Neurochemistry

Volumn 76, Issue 2, 2001, Pages 435-441

  Zhu, Xiongwei ^a   Raina, Arun K ^a   Rottkamp, Catherine A ^a   Aliev, Gjumrakch ^a   Perry, George ^a   Boux, Heather ^b   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b StressGen Biotechnologies Corp   (Canada)

Author keywords

Alzheimer's disease; Cytoskeleton; Oxidative stress; Phosphorylation; Signal transduction

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODY SPECIFICITY; CEREBRAL CORTEX; CHILD; ENZYME ACTIVATION; HIPPOCAMPUS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 10; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROFIBRILLARY TANGLES; NEURONS; OXIDATIVE STRESS; PROTEIN-TYROSINE KINASES; TAU PROTEINS;

EID: 0035142804     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00046.x     Document Type: Article

References (31)

1. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
2. MAP kinase pathways
3. Aberrant stress-induced phosphorylation of perikaryal neurofilaments
4. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
5. p38 kinase is activated in the Alzheimer's disease brain
6. Neurofilaments in health and disease
7. Diagnosis of Alzheimer's disease
8. Protein disulfide isomerase in Alzheimer's disease
9. Human c-Jun N-terminal kinase expression and activation in the nervous system
10. Distinct localization of SAPK isoforms in neurons of adult mouse brain implies signaling modes of SAPK pathways
11. Regulation and function of the JNK subgroup of MAP kinases
12. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
13. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
14. Immunohistochemical evidence of oxidative stress in Alzheimer's disease
15. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components
16. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
17. The role of cell cycle-mediated events in Alzheimer's disease
18. Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
19. Stress-activated protein kinase/c-Jun N-terminal kinase phosphorylates τ protein
20. Phosphorylation sites on tau by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinase ERK2, c-Jun N-terminal kinase and p38, and glycogen synthase kinase-3β
21. Mitogen-activated protein kinase pathways
22. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
23. Advanced Maillard reaction end products are associated with Alzheimer disease pathology
24. Oxidative damage in Alzheimer's
25. A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells
26. Mitogen-activated protein kinase cascades and regulation of gene expression
27. Induction of cyclin D1 by simian virus 40 small tumor antigen
28. A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells
29. Activation of p38 pathway links tau phosphorylation, oxidative stress and cell cycle related events in Alzheimer disease
30. Cdk7 expression in hippocampal neurons is related to aging and Alzheimer's disease