The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells

Journal of Neural Transmission

Volumn 105, Issue 8-9, 1998, Pages 839-853

  Webster, M T ^a,b,d   Pearce, B R ^c   Bowen, D M ^b   Francis, P T ^a,b,e  

^a UMDS   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Bradykinin; Protein kinase C

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHLOROQUINE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT;

EID: 0031767946     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050098     Document Type: Article

References (53)

1. Baskin F, Rosenberg RN, Greenberg BD (1991) Increased release of an amyloidogenic C-terminal Alzheimer amyloid precursor protein fragment from stressed PC-12 cells. J Neurosci Res 29: 127-132
2. Benson DF, Kuhl DE, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxy glucose 18F scan in Alzheimer and multi-infarct dementia. Arch Neurol 40: 711-714
3. Bowen DM, White P, Spillane JA, Goodhardt MJ, Curzon G, Iwangoff P, Meier-Ruge W, Davison AN (1979) Accelerated ageing or selective neuronal loss as an important cause of dementia. Lancet i: 11-14
4. Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhardan TV, Unterbeck AJ, Greengard P (1990) Processing of Alzheimer βA4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci USA 87: 6003-6006
5. Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski P, Jaffe EA, Gandy SE, Greengard P (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc Natl Acad Sci USA 89: 10075-10078
6. Buxbaum JD, Koo EH, Greengard P (1993) Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci USA 90: 9195-9198
7. Caporaso GL, Gandy SE, Buxbaum JD, Greengard P (1992a) Chloroquine inhibits intracellular degradation but not secretion of Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 89: 2252-2256
8. Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P (1992b) Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 89: 3055-3059
9. Chase TN, Foster NL, Fedio P, Brooks R, Mansi L, Di Chiro G (1984) Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography. Ann Neurol 15 [Suppl]: S170-S174
10. Chawluk JB, Alavi A, Dann R, Hurtig HI, Bais S, Kushner MJ, Zimmerman RA, Reivich MJ (1987) Positron emission tomography in aging and dementias: effect of cerebral atrophy. J Nucl Med 28: 431-437
11. Choi DW (1994) Glutamate receptors and the induction of excitotoxic neuronal death. Prog Brain Res 100: 47-51
12. Davis JB (1996) Oxidative mechanisms in β-amyloid cytotoxicity. Neurodegeneration 5: 441-444
13. Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD, Jr (1997) Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 94:4526-4531
14. Francis PT, Sims NR, Procter AW, Bowen DM (1993) Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives. J Neurochem 60: 1589-1604
15. Fuller SJ, Storey E, Li QX, Smith AI, Beyreuther K, Masters CL (1995) Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein. Biochemistry 34: 8091-8098
16. Gabuzda D, Busciglio J, Yankner BA (1993) Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem 61: 2326-2329
17. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269: 13623-13628
18. Gasparini L, Racchi M, Benussi L, Curti D, Binetti G, Bianchetti A, Trabucchi M, Govoni S (1997) Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells. Neurosci Lett 231: 113-117
19. Gibson GE, Sheu KR, Blass JP, Baker A, Carlson KC, Harding B, Perrino P (1988) Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch Neurol 45: 836-840
20. Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255: 728-730
21. Greene LA, Tischler A (1976) Establishment of a noradrenergic clonal cell line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73: 2424-2428
22. Hoyer S (1996) Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol Scand [Suppl] 165: 18-24
23. Hyman BT, Tanzi RB, Marzloff K, Barbour R, Schenk DB (1991) Kunitz protease inhibitor containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol 51: 76-83
24. Irizarry MC, McNamara M, Fedorchak K, Hsiao K, Hyman BT (1997a) APP(sw) transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol 56: 965-973
25. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT (1997b) A beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 17: 7053-7059
26. Iwangoff P, Armbruster R, Enz A, Meier-Ruge W, Sandoz P (1980) Glycolytic enzymes from human autopic brain cortex: normally aged and demented cases. In: Roberts PJ (ed) Biochemistry of dementia. Wiley, Chichester, pp 258-262
27. Jacobsen JS, Spruyt MA, Brown AM, Sahasrabudhe SR, Blume AJ, Vitek MP, Muenkel HA, Sonnenberg-Reines J (1994) The release of Alzheimer's disease beta-amyloid peptide is reduced by phorbol treatment. J Biol Chem 269: 8376-8382
28. Jagust WJ, Friedland RP, Budinger TF, Koss E, Ober B (1988) Longitudinal studies of regional cerebral metabolism in Alzheimer's disease. Neurology 38: 909-912
29. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bateriophage T4. Nature 227: 680-686
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin's phenol reagent. J Biol Chem 193: 265-273
31. Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10: 243-254
32. McGeer PL, Kamo H, Harrop R, Li DKB, Tuokko H, McGeer EG, Adam MJ, Ammann W, Beattie BL, Calne DB, Martin WRW, Pate BD, Roger JG, Ruth TJ, Sayer CI, Stoessl AJ (1986) Positron emission tomography in patients with clinically diagnosed Alzheimer's disease. Can Med Assoc J 134: 597-607
33. Najlerahim A, Bowen DM (1988) Regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the Alzheimer type. Acta Neuropathol 75: 509-512
34. Nitsch RM (1996) From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease. Neurodegeneration 5: 477-482
35. Parker WD Jr, Parks J, Filley CM, Kleinschmidt-DeMasters BK (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44: 1090-1096
36. Parker WD Jr, Parks JK (1995) Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization. Neurology 45: 482-486
37. Perret D, Bhusate L, Patel J, Herbert K (1991) Comparative performance of ion exchange and ion-paired reverse phase high performance liquid chromatography for the determination of nucleotides in biological samples. Biomed Chromatogr 5: 207-211
38. Rapoport SI, Horowitz B, Grady CL, Haxby JV, DeCarli C, Schapiro MB (1991) Abmormal brain glucose metabolism in Alzheimer's disease, as measured by positron emission tomography. Adv Exp Med Biol 291: 231-248
39. Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK (1995) Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. J Neurosci Res 40: 694-706
40. Reynolds EE, Melega WP, Howard BD (1982) Adenosine 5-triphosphate independent secretion from PC 12 pheochromocytoma cells. Biochemistry 21: 4795-4799
41. 133Xe-inhalation: methodology and applications in neuropsychology and psychiatry. Brain Lang 9: 9-34
42. Saharsrabudhe SR, Spruyt MA, Muenkel HA, Blume AJ, Vitex MP (1992) Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. J Biol Chem 267: 25602-25608
43. Salbaum JM, Weidemann A, Lemaire H, Masters CL, Beyreuther K (1988) The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J 7: 2807-2813
44. Sandbrink R, Hartmann T, Masters CL, Beyreuther K (1996) Genes contributing to Alzheimer's disease. Mol Psychiatry 1: 27-40
45. Sims NR (1996) Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease. Neurodegeneration 5: 435-440
46. 14C]glucose in vitro in human neocortex. J Neurochem 41: 1329-1334
47. Sims NR, Blass JP, Murphy C, Bowen DM, Neary D (1987a) Phosphofructokinase activity in the brain in Alzheimer's disease. Ann Neurol 21: 509-510
48. Sims NR, Finegan JM, Blass JP, Bowen DM, Neary D (1987b) Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res 436: 30-38
49. Slunt HH, Thinakaran G, Koch CV, Lo ACY, Tanzi RE, Sisodia SS (1994) Expression of ubiquitous, cross-reactive homologue of the mouse β-amyloid precursor protein (APP). J Biol Chem 269: 2637-2644
50. Smith GS, De Leon MJ, George AE, Kluger A, Volkow ND, McRae T, Golomb J, Ferris SH, Reisberg B, Ciaravino J, La Regina ME (1992) Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's disease. Pathophysiologic implications. Arch Neurol 49: 1142-1150
51. Webster M, Francis PT, Procter AW, Stratmann GC, Doshi R, Mann DMA, Bowen DM (1994) Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementia. Brain Res 644: 347-351
52. Webster M, Groome N, Francis PT, Pearce BR, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM (1995) A novel protein, amyloid precursor-like protein 2, is present in human brain and cerebrospinal fluid and conditioned media. Biochem J 310: 95-99
53. Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57: 115-126