Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins

Free Radical Biology and Medicine

Volumn 37, Issue 6, 2004, Pages 755-767

  Brand, Martin D ^a   Affourtit, Charles ^a   Esteves, Telma C ^a   Green, Katherine ^a   Lambert, Adrian J ^a   Miwa, Satomi ^a   Pakay, Julian L ^a   Parker, Nadeene ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

2,2 azobis(2 methylpropionamidine) dihydrochloride; AAPH; Aging; ANT; Complex I; Free radicals; Hydroxynonenal; Insulin secretion; Lipid peroxidation; Mitochondria; Proton motive force; Superoxide; Thermogenesis; Uncoupling protein

Indexed keywords

1,4 BENZOQUINONE; ADRENALIN; ANTIOXIDANT; CITRININ; CYTOCHROME C; GLYCEROPHOSPHATE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; INSULIN; MYXOTHIAZOL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

AGING; CALORIC RESTRICTION; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE POTENTIAL; ELECTRON TRANSPORT; HUMAN; INSULIN RELEASE; ION CONDUCTANCE; KNOCKOUT MOUSE; LIPID PEROXIDATION; LONGEVITY; MITOCHONDRION; MOLECULAR MECHANICS; NONHUMAN; OXIDATION KINETICS; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON MOTIVE FORCE; REVIEW; SIGNAL TRANSDUCTION; THERMOGENESIS;

AGING; ALDEHYDES; ANIMALS; CARRIER PROTEINS; ELECTRON TRANSPORT; FATTY ACIDS; FREE RADICALS; GLUCOSE; HUMANS; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; LIPID PEROXIDATION; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; OXYGEN; PROTONS; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 4043147798     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.05.034     Document Type: Review

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