Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 29, 2004, Pages 10726-10731

  Coskun, Pinar E ^a   Beal, M Flint ^b   Wallace, Douglas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; CYTOSINE; GUANINE; MITOCHONDRIAL DNA; THYMINE;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; BRAIN MITOCHONDRION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA REPLICATION; DNA SEQUENCE; DNA STRAND; GENETIC TRANSCRIPTION; HETEROPLASMY; HUMAN; HUMAN TISSUE; MITOCHONDRIAL DNA CONTROL REGION; MITOCHONDRIAL DNA L STRAND ND6; MITOCHONDRIAL RESPIRATION; MOLECULAR CLONING; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REGULATOR GENE; SOMATIC MUTATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; DNA MUTATIONAL ANALYSIS; DNA REPLICATION; DNA, MITOCHONDRIAL; HUMANS; LOCUS CONTROL REGION; MUTATION; OXIDATIVE PHOSPHORYLATION; TRANSCRIPTION, GENETIC;

EID: 3242668604     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0403649101     Document Type: Article

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