Mitochondrial alterations in Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 9, Issue 2, 2006, Pages 119-126

  Baloyannis, Stavros J ^a,b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

Author keywords

Alzheimer's disease; Mitochondria; Morphometry; Oxidative stress; Ultrastructure

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM ION;

ALZHEIMER DISEASE; AUDITORY CORTEX; BRAIN REGION; CELL ENERGY; CELL SURVIVAL; CEREBELLUM CORTEX; CYTOSKELETON; DENDRITIC SPINE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENERGY METABOLISM; FRONTAL CORTEX; GLOBUS PALLIDUS; GLUCOSE UTILIZATION; GOLGI COMPLEX; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; LOCUS CERULEUS; METABOLIC DISORDER; MORPHOLOGY; MORPHOMETRICS; NERVE DEGENERATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RED NUCLEUS; REVIEW; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION; THALAMUS;

EID: 33746256557     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-9204     Document Type: Review

References (90)

1. G. Aliev, M. Smith, D. Seyidov, M. Neal, B. Lamb, A. Nunomura, E. Gasimov, H. Vinters, G. Perry, J. La Manna and R. Friedland, The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease, Brain Pathol. 12 (2002), 21-35.
2. H. Anandatheerthavarada, G. Biswas, M. Robin and N. Avadhani, Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells, J. Cell Biology 161 (2003), 41-54.
3. C. Arias, T. Montiel, R. Quiroz-Baez and L. Massieu, beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease, Exp. Neurol. 176 (2002), 163-174.
4. V. Askanas, J. McFerrin, S. Baque, R. Alvarez, E. Sarkozi and W. Engel, Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle, Proc. Natl. Acad. Sci. USA 93 (1996), 1314-1319.
5. S. Baloyannis, T. Theocharidis and L. Manolidis, Synaptic alterations in the acoustic cortex of the rat following insulin-induced hypoglycaemia, Arch. Otorhinolaryngol. 244 (1987), 36-43.
6. S. Baloyannis, S. Manolidis and L. Manolidis, The acoustic cortex in Alzheimer's disease, Acta Otolaryngol. (Stockh) Suppl. 494 (1992), 1-13.
7. S. Baloyannis, V. Costa, A. Arnaoutoglou and H. Arnaoutoglou, Synaptic alterations in the molecular layer of the cerebellum in Alzheimer's disease, Neuropath. Appl. Neurobiol. 22 (1996), 78-79.
8. S. Baloyannis, The mossy fibres of the cerebellar cortex in Alzheimers disease. An electron microscopy study, Neurosc. 2 (1997), 160-161.
9. S. Baloyannis, The climbing fibers of the cerebellar cortex in Alzheimer's disease: A Golgi and electron microscope study, Brain Pathol. 7 (1997), 1203 (Abstract)
10. S. Baloyannis and V. Costa, Abnormal synapses in the granule cell layer of the cerebellum in Alzheimer's disease: A Golgi and Electron microscope study, Eur. J. Neurol. 5 (1998), 26-27 (Abstract).
11. S. Baloyannis, V. Costa and D. Michmizos, Abnormal synapses in the cerebellar cortex in early stages of Alzheimer's disease: a Golgi and electron microscope study, Eur. J. Neurol. 6 (1999), 11 (Abstract).
12. S. Baloyannis, Oxidative stress and mitochondria alterations in Alzheimer's disease, Neurobiol. Aging 21 (2000), 264 (Abstract).
13. S. Baloyannis, S. Manolidis and L. Manolidis, Synaptic alterations in the Vestibulocerebellar System in Alzheimers Disease - A Golgi and Electron Microscope Study, Acta Otolaryngol. (Stockh) 120 (2000), 247-250.
14. S. Baloyannis, S. Manolidis and L. Manolidis, The acoustic cortex in frontal dementia, Acta Otolaryngol. 121 (2001), 289-292.
15. S. Baloyannis, The Golgi apparatus of Purkinje cells in Alzheimer=s disease in: Neuropathology-Back to the roots, J. Bohl, ed., Shaker Vertag, Aachen, 2002, pp. 1-10.
16. S. Baloyannis, Mitochondrial alterations in Alzheimer's disease, Neurobiol. Aging 25 (2004), 405 (Abstract).
17. S. Baloyannis, V. Costa and D. Michmizos, Mitochondrial alterations in Alzheimer's Disease, Am. J. Alzheimers Dis. 19 (2004), 89-93.
18. M. Beal, B. Hyman and W. Koroshetz, Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? TINS 16 (1993), 125-131.
19. M. Beal, Mitochondrial dysfunction in neurodegenerative diseases, Biochim. Biophys. Acta 1366 (1998), 211-223.
20. J. Bereiter-Hahn and M. Vöth, Dynamic of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria, Microsc. Res. Techn. 27 (1994), 198-219.
21. J. Blass, A.C. Baker, L. Ko and R. Black, Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation, Arch. Neurol. 47 (1990), 864-869.
22. J. Blass, R. Fheu and G. Gibson, Inheritent abnormalities in energy metabolism in Alzheimer's disease: Interaction with cerebrovascular compromise, Ann. N. Y. Acad. Sci. 903 (2000), 204-221.
23. S. Cardoso, M. Proenca, S. Santos, I. Santana and C. Oliveira, Cytochrome c oxidase is decreased in Alzheimer's disease platelets, Neurobiol. Aging 25 (2004), 105-110.
24. M. Cohen, T. Golde, M. Usiak, L. Younkin and S. Younkin, In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimer's disease, Proc. Natl. Acad. Sci. USA 85 (1988), 1227-1231.
25. P. Crass, M. Kawai, S. Siedlak, P. Mulvihill, P. Gambetti, D. Loweryd, P. Gonzalez-De Whitt, B. Greenberg and G. Perry, Neuronal and microglial involvement in β-amyloid protein deposition in Alzheimer's disease, Am. J. Pathol. 37 (1990), 241-246.
26. M. Crompton, Mitochondrial intermembrane junctional complexes and their role in cell death, J. Physiol. (Lond) 529 (2000), 11-21.
27. P. Crouch, R. Blake, J. Duce, G. Ciccotosto, Q. Li, K. Barmham, C. Curtain, R. Cherny, R. Cappai, T. Dyrks, C. Masters and I. Trounce, Copper-dependent inhibition of human cytochrome c oxidase by dimeric conformer of amyloid-1-42, J. Neurosci. 25 (2005), 672-679.
28. R. Davis, S. Miller, C. Herrnstadt, S. Ghosh, E. Fahy, L. Shinobu, D. Galasco, L. Thal, M. Beal, N. Howell and D. Parker, Mutations in mitochondrial cytochrome c oxidase genes segregate with late onset Alzheimer disease, Proc. Natl. Acad. Sci. USA. 94 (1997), 4526-4531.
29. S. De La Monte, T. Luong, R. Neely, D. Robinson and J. Wands, Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease, Lab. Invest. 80 (2000), 1323-1335.
30. M. Duchen, Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signaling and cell death, J. Physiol. (Lond) 516 (1999), 1-17.
31. D. Gabuzda, J. Busciglio, L. Chen, P. Matsudaira and B. Yankner, Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative, J. Biol. Chem. 269 (1994), 13623-13628.
32. S. Grant, S. Shankar, R. Chalmers-Redman, W. Tatton, M. Szyf and A. Cuello, Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751), NeuroReport 10 (1999), 41-46.
33. Y. Hasimoto, T. Niikura, Y. Ito and I. Nishimoto, Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein, J. Biol. Chem. 275 (2000), 34541-34551.
34. K. Hirai, G. Aliev, A. Nunomura, H. Fujioka, R. Russell, C. Atwood, A. Johnson, Y. Kress, H. Vinters, M. Tabaton, S. Shimohama, A. Cash, S. Siedlak, P. Harris, P. Jones, R. Petersen, G. Perry and M. Smith, Mitochondrial Abnormalities in Alzheimer's Disease, J. Neurosci. 21 (2001), 3017-3023.
35. N. Hirokawa, Cross-linker system between neurofilaments, microtubules, and membraneous organelles in frog axons revealed by the queek freeze, deep etching method, J. Cell Biol. 94 (1982), 355-382.
36. J. Hugon, F. Esclaire, M. Lesort, G. Kisby and P. Spencer, Toxic neuronal apoptosis and modifications of Tau and APP gene and protein expressions, Drug Metab. Rev. 31 (1999), 635-647.
37. J. Jacobsen, A. Blume and M. Vitek, Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis, Neurobiol. Aging 12 (1991), 585-592.
38. Y. Kashiwaya, T. Tseshima, N. Mori, K. Nakashima, K. Clarke and R. Veech, D-β-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease, Med. Sci. 97 (1999), 5440-5444.
39. B. Khodorov, V. Pinelis, O. Vergun, T. Storozhevykh and N. Vinskaya, Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge, FEBS Lett. 397 (1996), 230-234.
40. S. Kish, C. Bergeron, A. Rajput, S. Dozic, F. Mastrogiacomo, L. Chang, J. Wilson, L. DiStefano and J. Nobrega, Brain cytochrome oxidase in Alzheimer's disease, J. Neurochem. 59 (1992), 776-779.
41. M. Knowles, M. Guenza, R. Capaldi and A. Marcus, Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells, PNAS 99 (2002), 14772-14777.
42. M. Krendel, G. Sgourdas and E. Bonder, Disassembly of actin filaments leads to increased rate and frequency of mitochondria movements along microtubules, Cell Motil. Cytoskeleton 40 (1998), 368-378.
43. J. Leterrier, D. Rusakov, B. Nelson and M. Linden, Interactions between brain mitochondria and cytoskeleton: evidence for specialized outer membrane domains involved in the association of cytoskeleton-associated proteins to mitochondria in situ and in vitro, Microsc. Res. Techn. 27 (1994), 233-261.
44. Y. Luo, J. Bond and V. Ingram, Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases, Proc. Natl. Acad. Sci. USA 94 (1997), 9705-9710.
45. J. Lustbader, M. Cirilli, C. Lin, H. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, M. Chaney, F. Trinchese, S. Liu, F. Gunn-Moore, L. Lue, D. Walker, P. Kuppusamy, Z. Zewier, O. Arancio, D. Sten, S. Yan and H. Wu, ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease, Science 304 (2004), 448-453.
46. T. Lynch, R. Cherny and A. Bush, Oxidative processes in Alzheimer's disease: the role of Ab-metal interactions, Exper. Gerontol. 35 (2000), 445-451.
47. D. Margineantu, W. Cox, L. Sundell, S. Sherwood, J. Beechem and R. Capaldi, Cell cycle dependent morphology changes and associated mtDNA redistribution in mitochondria of human cell lines, Mitochondrion 1 (2002), 425-435.
48. I. Maurer, S. Zierz and H. Moller, A selective defect of cytochrome c oxidase is present in brain of Alzheimer's disease patients, Neurobiol. Aging 21 (2000), 455-462.
49. P. Mecocci, A. Cherubini, M. Beal, R. Cecchetti, F. Chionne, M. Polidori, G. Romano and U. Senin, Altered mitochondrial membrane fluidity in AD brain, Neurosci. Lett. 207 (1996), 129-132.
50. F. Mentzies, M. Cookson, R. Taylor, D. Turmbull, M. Chrzanowska- Lightowlers, L. Dong, A. Figlewicz and J. Shaw, Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis, Brain 125 (2002), 1522-1533.
51. M. Mesulam, Large-scale neurocognitive networks and distributed processing for attention, language and memory, Ann. Neurol. 28 (1990), 597-613.
52. Y. Mizuno, S. Ikebe, N. Hattori, Y. Nakagawa-Hattori, H. Mochizuki, M. Tanaka and Y. Ozawa, Role of mitochondria in the etiology and pathogenesis of Parkinson's disease, Biochim. Biophys. Acta 1271 (1995), 265-274.
53. T. Montine, V. Amarnath, M. Martin, W. Strittmatter and D. Graham, E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures, Am. J. Pathol. 148 (1996), 89-93.
54. S. Morais Cardoso, R. Swerdlow and C. Oliveira, Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria, Brain Res. 931 (2002), 117-125.
55. P. Moreira, M. Santos, A. Moreno and C. Oliveira, Amyloid beta-peptide promotes permeability transition pore in brain mitochondria, Biosci. Res. 21 (2001), 789-800.
56. P. Moreira, M. Santos, A. Moreno, A. Rego and C. Oliveira, Effect of amyloid beta-peptide on permeability transition pore: a comparative study, J. Neurosci. Res. 69 (2002), 257-267.
57. P. Moreira, M. Santos, C. Sena, R. Seica and C. Oliveira, Insulin protects against amyloid b-peptide toxicity in brain mitochondria of diabetic rats, Neubiol. Dis. 18 (2005), 628-637.
58. J. Murray, R. Gilkerson and A. Capaldi, Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 10 (2)-fold lower than that of complex III in human mitochondria, FEBS Lett. 529 (2002), 173-178.
59. J. Murray, S. Yonally, R. Aggeler, M. Marusich and R. Capaldi, Focused proteomics: towards a high throughput monoclonal antibody-based resolution of proteins for diagnosis of mitochondrial diseases, Biochem. Biophys. Acta 1659 (2005), 206-211.
60. E. Mutisya, A. Bowling and M. Beal, Cortical cytochrome oxidase activity is reduced in Alzheimer's disease, J. Neurochem. 63 (1994), 2179-2184.
61. A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda, E. Balraj, P. Jone, H. Ghanbari, T. Wataya, S. Shimohama, S. Chiba, C. Atwood, R. Petersen and M. Smith, Oxidative damage is the earliest event in Alzheimer's disease, J. Neuropath. Exper. Neurol. 60 (2001), 759-767.
62. M. Palmert, T. Golde, M. Cohen, D. Kovacs, R. Tanzi, T. Gusella, M. Usiak, L. Younkin and S. Younkin, Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease, Science 241 (1988), 1080-1084.
63. J. Park, M. Baterman and M. Golberg, Rapid alterations in dendritic morphology during sublethal hypoxic glutamate activation, Neurobiol. Dis. 3 (1996), 215-227.
64. W. Parker Jr., Cytochrome oxidase deficiency in Alzheimer's disease, Ann. NY Acad. Sci. 640 (1991), 59-64.
65. D. Parker Ir, N. Mahr, C. Filley, J. Parks , D. Hughes, D. Youmg and C. Cullum, Reduced platelet cytochrome c oxidase in Alzheimer's disease, Neurology 44 (1994), 1086-1090.
66. C. Pereira, M. Santos and C. Oliveira, Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants, Neurobiol. Dis. 6 (1999), 209-219.
67. G. Perry, A. Nunomura, K. Hirai, A. Takeda, G. Aliev and M. Smith, Oxidative damage in Alzheimer's disease: The metabolic dimention, Intern. J. Developm. Neurosci. 18 (2000), 417-421.
68. G. Perry, H. Roder, A. Nunomura, A. Takeda, A. Friedlich, X. Zhu, A. Raina, N. Holbrook, S. Siedlak, P. Harris and M. Smith, Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation, NeuroReport 10 (1999), 2411-2415.
69. D. Price and S. Sisodia, Mutant genes in familial Alzheimer's disease and transgenic models, Ann. Rev. Neurosci. 21 (1998), 479-505.
70. E. Rockenstein, L. McConlogue, H. Tan, M. Power, E. Masliah and L. Mucke, Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease, J. Biol. Chem. 270 (1995), 28257-28267.
71. L. Sayre, D. Zelasko, P. Harris, G. Perry, R. Salomon and M. Smith, 4-Hydroxynonenal-derived advanced lipid peroxi dation end products are increased in Alzheimer's disease, J. Neurochem. 68 (1997), 2092-2097.
72. B. Schulenberg, R. Aggeler, J. Beechem, R. Capaldi and W. Patton, Analysis of steady-state protein phosphorylation in mitochondria using a novel fluorescent phosphosensor dye, J. Biol. Chem. 278 (2003), 27251-27255.
73. D. Selkoe, Translating cell biology into therapeutic advances in Alzheimer's disease, Nature 399 (1999), A23-A31.
74. D. Selkoe, Alzheimer's disease, results from the cerebral accumulation and cytotoxicity of amyloid beta protein, J. Alzheimers Dis. 3 (2001), 75-80.
75. J. Sheehan, R. Swerdlow, S. Miller, R. Davis, J. Parks, W. Parker and J. Tuttle, Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease, J. Neurosci. 17 (1997), 4612-4622.
76. C. Shepherd, S. Bowes, D. Parkinson, M. Cambray-Deakin and R. Pearson, Expression of amyloid precursor protein in human astrocytes in vitro: isoform-specific increases following heat shock, Neuroscience 99 (2000), 317-325.
77. M. Shigenaga, T. Hagen and B. Ames, Oxidative damage and mitochondrial decay in aging, Proc. Natl. Acad. Sci. USA 91 (1994), 10771-10778.
78. S. Sisodia and P. St George-Hyslop, Secretase, Notch, Aβ and Alzheimer's disease: where do the presenilins fit in? Nat. Rev. Neurosci. 3 (2002), 281-290.
79. D. Stephenson, K. Rash and J. Clemens, Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat, Brain Res. 593 (1992), 128-135.
80. P. Stewart, K. Hayakawa, M. Akers and H. Vinters, A morphometric study of the blood-brain barrier in Alzheimer's disease, Lab. Invest. 67 (1992), 734-742.
81. R. Tanzi, A genetic dichotomy for the inheritance of Alzheimer's disease and common age-related disorders, J. Clin. Invest. 104 (1999), 1175-1179.
82. R. Tanzi and L. Betran, Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective, Cell 120 (2005), 545-555.
83. R. Terry, The pathogenesis of Alzheimer disease: An alternative to the amyloid hypothesis, J. Neuropath. Exper. Neurol. 55 (1996), 1023-1025.
84. P. Trimmer, R. Swerdlow, J. Parks, P. Keeney, J. Bennett Jr, S. Miller, R. Davis and W. Parker Jr., Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines, Exp. Neurol. 162 (2000), 37-50.
85. K. Truscott, N. Pfanner and W. Voos, Transport of proteins into mitochondria, Rev. Physiol. Biochem. Pharmacol. 143 (2001), 81-136.
86. J. Valla, J. Berndt and F. Gonzalez-Lima, Energy hypo metabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration, J. Neurosci. 21 (2001), 4923-4930.
87. O. Wagner, J. Lifshitz, P. Janmey, M. Linden, T. McIntoch and J. Letterier, Mechanisms of mitochondria-neurofilament interactions, J. Neurosci. 23 (2003), 9046-9058.
88. O. Vergun, A. Sobolevsky, M. Yelshansky, J. Keelan, B. Khodorov and M. Duchen, Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurons in culture, J. Physiol. (Lond) 531 (2001), 147-163.
89. H. Wisniewski, J. Wegiel and L. Kotula, Some neuropathological aspects of Alzheimer's disease and its relevance to other disciplines, Neuropathol. Appl. Neurobiol. 22 (1996), 3-11.
90. X. Zhu, C. Rottkamp, H. Boux, A. Takeda, G. Perry and M. Smith, Activation of p38 pathway links tau phosphorylation, oxidative stress and cell cycle related events in Alzheimer disease, J. Neuropathol. Exp. Neurol. 59 (2000), 880-888.