Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons

Neuroscience Letters

Volumn 288, Issue 2, 2000, Pages 163-166

  Satoh, Takumi ^a   Nakatsuka, Daisaku ^a   Watanabe, Yasuyoshi ^a,b   Nagata, Izumi ^c   Kikuchi, Haruhiko ^c   Namura, Shobu ^c  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Stroke and Brain Protection   (Japan)

Author keywords

Extracellular signal regulated kinase; Ischemia; Mitogen activated protein kinase; Necrosis; Oxidative stress; Programmed cell death

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIMYCIN; DACTINOMYCIN; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SB 230580; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL DEATH; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; HYPOXIA; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BUTADIENES; CELL LINE; CEREBRAL CORTEX; ENZYME INHIBITORS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; NITRILES; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 0034648063     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01229-5     Document Type: Article

References (20)

1. Alessandrini A., Namura S., Moskowitz M.A., Bonventre J.V. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc. Natl. Acad. Sci. USA. 95:1999;12866-12869.
2. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
3. Bertrand R., Solary E., O'Connor P., Kohn K.W., Pommier Y. Induction of a common pathway of apoptosis by staurosporine. Exp. Cell. Res. 211:1994;314-321.
4. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
5. Cohen P. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7:1997;353-361.
6. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders, Science. 262:1993;689-695.
7. Davis J.B., Maher P. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res. 652:1994;169-173.
8. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase. J. Biol. Chem. 273:1998;3-18632.
9. Gillio Tos A., Cignetti A., Rovera G., Foa R. Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect. Blood. 87:1996;2486-2495.
10. Gwag B.J., Canzoniero L.M., Sensi S.L., Demaro J.A., Koh J.Y., Goldberg M.P., Jacquin M., Choi D.W. Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons. Neuroscience. 90:1999;1339-1348.
11. Kitanaka C., Kuchino Y. Caspase-independent programmed cell death with necrotic morphology. Cell Death Diff. 6:1999;508-515.
12. Morimoto B.H., Koshland D.E. Induction and expression of long and short term neurosecretory potentiation in a neural cell line. Neuron. 5:1990;875-880.
13. Murphy T.H., Miyamoto M., Sastre A., Schnaar R.L., Coyle J.T. Glutamate toxocity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2:1989;1547-1558.
14. Murphy T.H., Schnaar R.L., Coyle J.T. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J. 4:1990;1624-1633.
15. Murray B., Alessandrini A., Cole A.J., Yee A.G., Furshpan E.J. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc. Natl. Acad. Sci. USA. 95:1998;11975-11980.
16. Samanta S., Perkinton M.S., Morgan M., Williams R.J. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons: role of mitogen-activated protein kinase. J. Neurochem. 70:1998;2082-2090.
17. Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 9:1995;726-735.
18. Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M.R., Johnson J.W., DeFranco D.B. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275:2000;12200-12206.
19. Tan S., Wood M., Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J. Neurochem. 71:1998;95-105.
20. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.