Cybrids in Alzheimer's disease: A cellular model of the disease?

Neurology

Volumn 49, Issue 4, 1997, Pages 918-925

  Swerdlow, R H ^a,b   Parks, J K ^a,d   Cassarino, D S ^a,c   Maguire, D J ^a,b   Maguire, R S ^a   Bennett, J P ^a   Davis, Robert E ^a   Parker, W D ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c GRIFFITH UNIVERSITY   (Australia)

^d Migenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE;

ALZHEIMER DISEASE; ARTICLE; DRUG SCREENING; GENE MUTATION; HUMAN; HUMAN CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 0030724118     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.4.918     Document Type: Article

References (39)

1. Katzman R. Alzheimer's disease. N Engl J Med 1986;314:964973.
2. Béai MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366.
3. Greenlund LJS, Deckwerth TL, Johnson EM. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed cell death. Neuron 1995;14:303-315.
4. Parker WD, Filley CM, Parks JK. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 1990;40:1302-1303.
5. Kish SJ, Bergeron C, Rajput A, et al. Brain cytochrome oxidase in Alzheimer's disease. J Neurochem 1992;59:113-114.
6. Parker WD, Mahr NJ, Filley CM, et al. Reduced platelet cytochrome c oxidase deficiency in Alzheimer's disease. Neurology 1994;44:1086-1090.
7. Parker WD, Parks JK, Filley CM, Kleinschmidt-DeMasters BK. Electron transport chain defects in Alzheimer's disease. Neurology 1994;44:1090-1096.
8. Mutisya EM, Bowling AC, Béai MF. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 1994;63:2179-2184.
9. Lakis J, Glasco S, Miller SW, Thal LJ, Davis RE. Production of reactive oxygen species correlates with decreased cytochrome oxidase activity in Alzheimer's disease cybrids [abstract]. Soc Neurosci Abst 1995;21:979.
10. Davis RE, Miller S, Hernstadt C, et al. Mutations in mitochondrial cytochrome c oxidase genes segregate with lateonset Alzheimer's disease. Proc Natl Acad Sci USA 1997;94: 4564-4569.
11. Bennett MC, Diamond DM, Stryker SC, Parks JK, Parker WD Jr. Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol 1992;5:93101.
12. Edland SD, Silverman JM, Peskind ER, Tsuang D, Wijsman E, Morris JC. Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance. Neurology 1996;47:254-256.
13. Chomyn A, Lai ST, Shakeley R, Bresolin N, Scarlatto G, Attardi G. Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals-and complementation behavior of tRNAlys mutation causing myoclonic epilepsy and ragged red fibers. J Hum Genet 1994;54:966-974.
14. Swerdlow RH, Parks JK, Miller SW, et al. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 1996;40:663-671.
15. Swerdlow RH, Parks JK, Miller SW, Pattee G, Davis RE, Parker WD. Evidence of genetic mitochondrial pathology in sporadic amyotrophic lateral sclerosis [abstract]. Soc Neurosci Abstr 1996;22:2143.
16. Glasco S, Miller SW, Thal LJ, Davis RE. Alzheimer's disease cybrids manifest a cytochrome oxidase defect [abstract]. Soc Neurosci Abstr 1995;21:979.
17. Younkin DP, Tang CM, Hardy M, et al. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc Natl Acad Sci USA 1993;90:2174-2178.
18. Hardy M, Younkin D, Tang CM, et al. Expression of nonNMDA glutamate receptor channel genes by clonal human neurons. J Neurochem 1994;63:482-489.
19. Pleasure SJ, Page C, Lee VM. Pure, postmitotic, polarized human neurons derived from Ntera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 1992;12:1802-1815.
20. Pleasure SJ, Lee VM. Ntera 2 cells: a human cell line with characteristics expected of a human committed neuronal progenitor cell. J Neurosci Res 1993;35:585-602.
21. Wertkin AM, Turner RS, Pleasure SJ, et al. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular -amyloid or A4 peptides. Proc Natl Acad Sci USA 1993;90:9513-9517.
22. McKhann G, Drachmann D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease. Neurology 1984;34:939-944.
23. Miller SW, Trimmer PA, Parker WD Jr., Davis RE. Creation and characterization of mitochondrial DNA depleted cell lines with 'neuronal-like' properties. J Neurochem 1996;67:18971907.
24. Rosenkranz AR, Schmaldienst S, Stuhlmeier KM, Chen W, Knapp W, Zlabinger GJ. A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescein-diacetate. J Immunol Methods 1992;156:39-45.
25. Henveijer H, Stokdijk W, Visser JWM. High-speed photodamaged cell selection using bromodeoxyuridine/Hoechst 33342 photosensitized cell killing. Cytometry 1988;9:143-149.
26. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol 1985;113:484-490.
27. Carmagnol F, Sinet PM, Jerome H. Selenium-dependent and non-selenium dependent glutathione peroxidases in human tissue culture extracts. Biochim Biophys Acta 1983;759:4957.
28. Nagi MN, Al-Bekairi AM, Al-Sawaf HA. Spectrophotometric assay for Superoxide dismutase based on the nitroblue tetrazolium reduction by glucose-glucose oxidase. Biochem Mol Biol Int 1995;36:633-638.
29. Wiseman A, Attardi G. Reversible tenfold reduction in mitochondria DNA content of human cells treated with ethidium bromide. Mol Gen Genet 1978;167:51-63.
30. Desjardins P, Frost E, Morais R. Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts. Mol Cell Biol 1985;5:1163-1169.
31. Desjardins P, de Muys JM, Morais R. An established avian fibroblast cell line without mitochondrial DNA. Somat Cell Mol Genet 1986;12:133-139.
32. Morais R, Desjardins P, Turmel C, Zinkewich-Peotti K Development of continuous avian cell lines depleted of mitochondrial DNA. In Vitro Cell Dev Biol 1988;24:649-658.
33. Grégoire M, Morais R, Quilliam MA, Gravel D. On auxotrophy for pyrimidines of respiration-deficient chick embryo cells. Eur J Biochem 1984;142:49-55.
34. King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989;246:500-503.
35. Martinus RD, Linnane AW, Nagley P. Growth of p human namalwa cells lacking oxidative phosphorylation can be sustained by redox compounds potassium ferricyanide or coenzyme Q10 putatively acting through the plasma membrane oxidase. Biochem Mol Biol Int 1993;31:997-1005.
36. Parker WD, Parks JK. Alzheimer's brain cytochrome oxidase: purification and characterization of the enzyme. Neurology 1995;45:482-486.
37. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147-157.
38. Sheehan JP, Swerdlow RH, Parker WD, Miller SW, Davis RE, Tuttle JB. Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem 1997;68:1221-1233.
39. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 1994;269:13623-13628.